EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100883 (Gene tree)
Gene ID: 6729
Gene Symbol: SRP54
Alias: N
Full Name: signal recognition particle 54
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 47,611 bases
Position: chr14:34,981,957-35,029,567
Accession: 11301
RBP type: canonical RBP
Summary: (Signal Recognition Particle 54) is a Protein Coding gene. Diseases associated with SRP54 include Shwachman-Diamond Syndrome 1 and Severe Congenital Neutropenia Autosomal Dominant. Among its related pathways are Protein export and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include GTPase activity. An important paralog of this gene is SRPRA.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000451775	SRP54	PF00448.22	5.1e-78	1	1
ENSP00000440629	SRP54	PF00448.22	5.7e-78	1	1
ENSP00000216774	SRP54	PF00448.22	7.8e-78	1	1
ENSP00000451818	SRP54	PF00448.22	7.8e-78	1	1
ENSP00000216774	SRP54_N	PF02881.19	6.4e-20	1	1
ENSP00000451818	SRP54_N	PF02881.19	6.4e-20	1	1
ENSP00000451647	SRP54_N	PF02881.19	4.6e-18	1	1
ENSP00000451037	SRP54_N	PF02881.19	1.2e-09	1	1
ENSP00000486764	SRP54_N	PF02881.19	1.3e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18755190	Evolutionary substitution of two amino acids in chloroplast SRP54 of higher plants cause its inability to bind SRP RNA.	FEBS Lett	2008 Sep 22	Richter CV	doi: 10.1016/j.febslet.2008.08.014
1699948	The 54-kD protein of signal recognition particle contains a methionine-rich RNA binding domain.	J Cell Biol	1990 Nov	Romisch K	-
17434535	A threefold RNA-protein interface in the signal recognition particle gates native complex assembly.	J Mol Biol	2007 Jun 1	Maity TS	-
1702385	The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence.	EMBO J	1990 Dec	Zopf D	-
7687350	The signal recognition particle database (SRPDB).	Nucleic Acids Res	1993 Jul 1	Larsen N	-
26275773	Noncanoncial signal recognition particle RNAs in a major eukaryotic phylum revealed by purification of SRP from the human pathogen Cryptococcus neoformans.	Nucleic Acids Res	2015 Oct 15	Dumesic PA	doi: 10.1093/nar/gkv819
1849137	The signal sequence interacts with the methionine-rich domain of the 54-kD protein of signal recognition particle.	J Cell Biol	1991 Apr	High S	-
12234178	Systematic site-directed mutagenesis of human protein SRP54: interactions with signal recognition particle RNA and modes of signal peptide recognition.	Biochemistry	2002 Sep 24	Huang Q	-
15228518	A structural step into the SRP cycle.	Mol Microbiol	2004 Jul	Wild K	-
9511762	Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites.	Gene	1998 Jan 30	Gowda K	-
15037766	Two strategically placed base pairs in helix 8 of mammalian signal recognition particle RNA are crucial for the SPR19-dependent binding of protein SRP54.	RNA	2004 Apr	Yin J	-
14657338	Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication.	Proc Natl Acad Sci U S A	2003 Dec 9	Rosendal KR	-
18953414	Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus.	PLoS One	2008	Egea PF	doi: 10.1371/journal.pone.0003528
17154533	Compartmentalization directs assembly of the signal recognition particle.	Biochemistry	2006 Dec 19	Maity TS	-
11696367	An archaeal protein homologous to mammalian SRP54 and bacterial Ffh recognizes a highly conserved region of SRP RNA.	FEBS Lett	2001 Nov 2	Maeshima H	-
1377027	Fluorescence-detected assembly of the signal recognition particle: binding of the two SRP protein heterodimers to SRP RNA is noncooperative.	Biochemistry	1992 Jun 30	Janiak F	-
1279430	Signal-sequence recognition by an Escherichia coli ribonucleoprotein complex.	Nature	1992 Oct 22	Luirink J	-
9079393	Comparative analysis of tertiary structure elements in signal recognition particle RNA.	Fold Des	1996	Zwieb C	-
12244299	Induced structural changes of 7SL RNA during the assembly of human signal recognition particle.	Nat Struct Biol	2002 Oct	Kuglstatter A	-
8805251	The nascent polypeptide-associated complex modulates interactions between the signal recognition particle and the ribosome.	Curr Biol	1996 Mar 1	Powers T	-
8382204	GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding.	J Cell Biol	1993 Mar	Zopf D	-
7808407	Structural and functional characterisation of the signal recognition particle-specific 54 kDa protein (SRP54) of tomato.	Mol Gen Genet	1994 Dec 1	Krolkiewicz S	-
9920766	Functional divergence of the plastid and cytosolic forms of the 54-kDa subunit of signal recognition particle.	Biochem Biophys Res Commun	1999 Jan 8	Schuenemann D	-
9016569	Binding site of the M-domain of human protein SRP54 determined by systematic site-directed mutagenesis of signal recognition particle RNA.	Nucleic Acids Res	1997 Jan 15	Gowda K	-
8662730	Identification of a region of Bacillus subtilis Ffh, a homologue of mammalian SRP54 protein, that is essential for binding to small cytoplasmic RNA.	J Biol Chem	1996 May 31	Kurita K	-
12581661	S-domain assembly of the signal recognition particle.	Curr Opin Struct Biol	2003 Feb	Sauer-Eriksson AE	-
12364595	Reconstitution of the signal recognition particle of the halophilic archaeon Haloferax volcanii.	Nucleic Acids Res	2002 Oct 1	Tozik I	-
12244113	RNA interference of signal peptide-binding protein SRP54 elicits deleterious effects and protein sorting defects in trypanosomes.	J Biol Chem	2002 Dec 6	Liu L	-
12086622	Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle.	Mol Cell	2002 Jun	Oubridge C	-
12050674	Structure of the SRP19 RNA complex and implications for signal recognition particle assembly.	Nature	2002 Jun 13	Hainzl T	-
11373619	Visualizing induced fit in early assembly of the human signal recognition particle.	Nat Struct Biol	2001 Jun	Rose MA	-
11041851	Role of SRP19 in assembly of the Archaeoglobus fulgidus signal recognition particle.	Biochemistry	2000 Oct 24	Diener JL	-
10684931	Assembly of archaeal signal recognition particle from recombinant components.	Nucleic Acids Res	2000 Mar 15	Bhuiyan SH	-
15928341	Structural insights into SRP RNA: an induced fit mechanism for SRP assembly.	RNA	2005 Jul	Hainzl T	-
17846429	Interaction of signal-recognition particle 54 GTPase domain and signal-recognition particle RNA in the free signal-recognition particle.	Proc Natl Acad Sci U S A	2007 Sep 18	Hainzl T	-
17254600	Protein-induced conformational changes of RNA during the assembly of human signal recognition particle.	J Mol Biol	2007 Mar 16	Menichelli E	-
20672053	Archaea signal recognition particle shows the way.	Archaea	2010 Jun 28	Zwieb C	doi: 10.1155/2010/485051.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000216774	SRP54-201	2279	XM_005268024	ENSP00000216774	504 (aa)	XP_005268081	P61011
ENST00000555317	SRP54-206	644	-	-	- (aa)	-	-
ENST00000630962	SRP54-214	162	-	ENSP00000486764	53 (aa)	-	A0A0D9SFN7
ENST00000554803	SRP54-205	572	-	ENSP00000451037	43 (aa)	-	G3V346
ENST00000553544	SRP54-203	491	-	-	- (aa)	-	-
ENST00000556380	SRP54-210	600	-	ENSP00000451313	55 (aa)	-	G3V3L9
ENST00000555535	SRP54-207	552	-	-	- (aa)	-	-
ENST00000546080	SRP54-202	2187	-	ENSP00000440629	455 (aa)	-	P61011
ENST00000555557	SRP54-208	1949	XM_017021615	ENSP00000451775	440 (aa)	XP_016877104	G3V4F7
ENST00000553923	SRP54-204	573	-	-	- (aa)	-	-
ENST00000556994	SRP54-213	2327	-	ENSP00000451818	504 (aa)	-	P61011
ENST00000556992	SRP54-212	529	-	-	- (aa)	-	-
ENST00000556445	SRP54-211	530	-	-	- (aa)	-	-
ENST00000555746	SRP54-209	558	-	ENSP00000451647	74 (aa)	-	G3V480

Gene Model

Click here to download ENSG00000100883's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03060	Protein export	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100883	rs799498	14	34996430	T	Blood protein levels	30072576	[0.6-0.73] unit decrease	0.662	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100883's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100883	SRP54	100	97.674	ENSAPOG00000011314	srp54	100	95.833	Acanthochromis_polyacanthus
ENSG00000100883	SRP54	100	100.000	ENSAMEG00000015544	SRP54	100	100.000	Ailuropoda_melanoleuca
ENSG00000100883	SRP54	100	97.674	ENSACIG00000022831	srp54	97	94.655	Amphilophus_citrinellus
ENSG00000100883	SRP54	100	97.674	ENSAOCG00000019401	srp54	100	95.833	Amphiprion_ocellaris
ENSG00000100883	SRP54	100	97.674	ENSAPEG00000001977	srp54	100	95.833	Amphiprion_percula
ENSG00000100883	SRP54	100	97.674	ENSATEG00000013877	srp54	100	96.230	Anabas_testudineus
ENSG00000100883	SRP54	100	100.000	ENSAPLG00000010125	SRP54	95	98.734	Anas_platyrhynchos
ENSG00000100883	SRP54	74	81.873	ENSACAG00000001124	-	100	81.873	Anolis_carolinensis
ENSG00000100883	SRP54	99	95.622	ENSACAG00000010631	-	100	95.622	Anolis_carolinensis
ENSG00000100883	SRP54	100	100.000	ENSACAG00000002103	-	100	98.611	Anolis_carolinensis
ENSG00000100883	SRP54	100	100.000	ENSANAG00000022133	SRP54	100	100.000	Aotus_nancymaae
ENSG00000100883	SRP54	100	97.674	ENSACLG00000015866	srp54	100	96.032	Astatotilapia_calliptera
ENSG00000100883	SRP54	100	97.674	ENSAMXG00000032669	SRP54	100	95.635	Astyanax_mexicanus
ENSG00000100883	SRP54	100	100.000	ENSBTAG00000019085	SRP54	100	100.000	Bos_taurus
ENSG00000100883	SRP54	98	72.581	WBGene00009012	F21D5.7	100	71.687	Caenorhabditis_elegans
ENSG00000100883	SRP54	100	100.000	ENSCJAG00000006581	SRP54	100	100.000	Callithrix_jacchus
ENSG00000100883	SRP54	100	100.000	ENSCAFG00000013331	SRP54	100	100.000	Canis_familiaris
ENSG00000100883	SRP54	100	100.000	ENSCAFG00020023427	SRP54	100	100.000	Canis_lupus_dingo
ENSG00000100883	SRP54	100	100.000	ENSCHIG00000026345	SRP54	100	100.000	Capra_hircus
ENSG00000100883	SRP54	100	100.000	ENSTSYG00000002680	-	100	99.802	Carlito_syrichta
ENSG00000100883	SRP54	100	97.674	ENSTSYG00000035333	-	93	88.632	Carlito_syrichta
ENSG00000100883	SRP54	100	100.000	ENSCAPG00000008780	SRP54	100	64.286	Cavia_aperea
ENSG00000100883	SRP54	100	100.000	ENSCPOG00000003691	SRP54	100	99.603	Cavia_porcellus
ENSG00000100883	SRP54	95	100.000	ENSCCAG00000024179	SRP54	100	100.000	Cebus_capucinus
ENSG00000100883	SRP54	100	100.000	ENSCATG00000034083	SRP54	100	100.000	Cercocebus_atys
ENSG00000100883	SRP54	100	100.000	ENSCLAG00000015076	SRP54	100	100.000	Chinchilla_lanigera
ENSG00000100883	SRP54	100	100.000	ENSCSAG00000015575	SRP54	100	100.000	Chlorocebus_sabaeus
ENSG00000100883	SRP54	100	100.000	ENSCHOG00000008986	SRP54	100	87.942	Choloepus_hoffmanni
ENSG00000100883	SRP54	100	100.000	ENSCPBG00000026195	SRP54	100	99.206	Chrysemys_picta_bellii
ENSG00000100883	SRP54	100	82.432	ENSCING00000007380	-	100	81.746	Ciona_intestinalis
ENSG00000100883	SRP54	100	100.000	ENSCANG00000028532	SRP54	100	100.000	Colobus_angolensis_palliatus
ENSG00000100883	SRP54	100	100.000	ENSCGRG00001009525	-	100	99.603	Cricetulus_griseus_chok1gshd
ENSG00000100883	SRP54	100	100.000	ENSCGRG00000009453	-	89	99.481	Cricetulus_griseus_crigri
ENSG00000100883	SRP54	100	97.674	ENSCSEG00000012392	srp54	100	95.040	Cynoglossus_semilaevis
ENSG00000100883	SRP54	100	97.674	ENSCVAG00000010395	srp54	100	95.833	Cyprinodon_variegatus
ENSG00000100883	SRP54	100	97.674	ENSDARG00000098367	srp54	100	96.032	Danio_rerio
ENSG00000100883	SRP54	100	100.000	ENSDNOG00000032525	SRP54	100	100.000	Dasypus_novemcinctus
ENSG00000100883	SRP54	100	100.000	ENSDORG00000005159	-	97	85.045	Dipodomys_ordii
ENSG00000100883	SRP54	100	81.395	FBgn0010747	Srp54k	98	77.108	Drosophila_melanogaster
ENSG00000100883	SRP54	100	99.545	ENSETEG00000016307	-	100	98.810	Echinops_telfairi
ENSG00000100883	SRP54	95	58.373	ENSETEG00000012102	-	99	58.373	Echinops_telfairi
ENSG00000100883	SRP54	100	90.698	ENSEBUG00000009437	-	100	87.500	Eptatretus_burgeri
ENSG00000100883	SRP54	100	100.000	ENSEASG00005002057	SRP54	100	100.000	Equus_asinus_asinus
ENSG00000100883	SRP54	100	100.000	ENSECAG00000018042	SRP54	98	99.799	Equus_caballus
ENSG00000100883	SRP54	100	87.955	ENSEEUG00000001511	SRP54	100	83.333	Erinaceus_europaeus
ENSG00000100883	SRP54	100	97.674	ENSELUG00000003395	srp54	100	95.238	Esox_lucius
ENSG00000100883	SRP54	100	100.000	ENSFCAG00000032033	SRP54	100	99.802	Felis_catus
ENSG00000100883	SRP54	100	100.000	ENSFALG00000005995	SRP54	100	98.810	Ficedula_albicollis
ENSG00000100883	SRP54	100	100.000	ENSFDAG00000016767	SRP54	100	100.000	Fukomys_damarensis
ENSG00000100883	SRP54	100	97.674	ENSFHEG00000004263	srp54	100	95.437	Fundulus_heteroclitus
ENSG00000100883	SRP54	100	89.545	ENSGMOG00000011391	srp54	100	90.167	Gadus_morhua
ENSG00000100883	SRP54	100	100.000	ENSGALG00000023135	SRP54	100	98.810	Gallus_gallus
ENSG00000100883	SRP54	100	97.674	ENSGAFG00000011586	srp54	100	96.032	Gambusia_affinis
ENSG00000100883	SRP54	100	97.674	ENSGACG00000004181	srp54	100	95.437	Gasterosteus_aculeatus
ENSG00000100883	SRP54	100	100.000	ENSGAGG00000014766	SRP54	100	99.206	Gopherus_agassizii
ENSG00000100883	SRP54	100	100.000	ENSGGOG00000002926	SRP54	100	100.000	Gorilla_gorilla
ENSG00000100883	SRP54	100	97.674	ENSHBUG00000005678	srp54	100	96.032	Haplochromis_burtoni
ENSG00000100883	SRP54	100	100.000	ENSHGLG00000002850	SRP54	100	100.000	Heterocephalus_glaber_female
ENSG00000100883	SRP54	100	81.395	ENSHGLG00100007281	-	100	69.109	Heterocephalus_glaber_male
ENSG00000100883	SRP54	100	100.000	ENSHGLG00100005263	SRP54	100	100.000	Heterocephalus_glaber_male
ENSG00000100883	SRP54	100	94.091	ENSHCOG00000021127	srp54	100	94.048	Hippocampus_comes
ENSG00000100883	SRP54	100	97.674	ENSIPUG00000001420	srp54	100	95.238	Ictalurus_punctatus
ENSG00000100883	SRP54	100	100.000	ENSSTOG00000016023	SRP54	100	100.000	Ictidomys_tridecemlineatus
ENSG00000100883	SRP54	100	100.000	ENSJJAG00000013417	-	100	94.841	Jaculus_jaculus
ENSG00000100883	SRP54	100	76.591	ENSJJAG00000016404	-	100	76.591	Jaculus_jaculus
ENSG00000100883	SRP54	100	97.674	ENSKMAG00000007707	srp54	100	95.437	Kryptolebias_marmoratus
ENSG00000100883	SRP54	100	97.674	ENSLBEG00000018690	srp54	100	95.833	Labrus_bergylta
ENSG00000100883	SRP54	100	97.674	ENSLBEG00000021122	srp54	100	95.833	Labrus_bergylta
ENSG00000100883	SRP54	100	100.000	ENSLACG00000017890	SRP54	100	96.032	Latimeria_chalumnae
ENSG00000100883	SRP54	100	97.674	ENSLOCG00000009440	srp54	100	96.825	Lepisosteus_oculatus
ENSG00000100883	SRP54	100	100.000	ENSLAFG00000012007	SRP54	100	100.000	Loxodonta_africana
ENSG00000100883	SRP54	100	100.000	ENSMFAG00000044371	SRP54	100	100.000	Macaca_fascicularis
ENSG00000100883	SRP54	100	100.000	ENSMMUG00000015073	FAM177A1	100	100.000	Macaca_mulatta
ENSG00000100883	SRP54	100	100.000	ENSMNEG00000006947	SRP54	100	100.000	Macaca_nemestrina
ENSG00000100883	SRP54	100	100.000	ENSMLEG00000042251	SRP54	100	100.000	Mandrillus_leucophaeus
ENSG00000100883	SRP54	100	97.674	ENSMAMG00000004803	srp54	100	96.032	Mastacembelus_armatus
ENSG00000100883	SRP54	100	97.674	ENSMZEG00005027528	srp54	100	96.032	Maylandia_zebra
ENSG00000100883	SRP54	100	100.000	ENSMGAG00000012481	SRP54	100	94.071	Meleagris_gallopavo
ENSG00000100883	SRP54	100	100.000	ENSMAUG00000014447	-	100	99.802	Mesocricetus_auratus
ENSG00000100883	SRP54	100	100.000	ENSMICG00000010270	SRP54	100	100.000	Microcebus_murinus
ENSG00000100883	SRP54	100	99.773	ENSMOCG00000000948	-	100	99.773	Microtus_ochrogaster
ENSG00000100883	SRP54	100	97.674	ENSMMOG00000020303	srp54	98	94.183	Mola_mola
ENSG00000100883	SRP54	100	100.000	ENSMODG00000023150	-	100	99.802	Monodelphis_domestica
ENSG00000100883	SRP54	100	100.000	ENSMODG00000012925	-	100	99.802	Monodelphis_domestica
ENSG00000100883	SRP54	100	97.674	ENSMALG00000009163	srp54	98	95.485	Monopterus_albus
ENSG00000100883	SRP54	100	100.000	MGP_CAROLIEiJ_G0017754	-	100	99.802	Mus_caroli
ENSG00000100883	SRP54	100	100.000	ENSMUSG00000073079	Srp54a	100	100.000	Mus_musculus
ENSG00000100883	SRP54	100	100.000	ENSMUSG00000112449	Srp54b	100	99.802	Mus_musculus
ENSG00000100883	SRP54	100	100.000	ENSMUSG00000079108	Srp54c	100	99.008	Mus_musculus
ENSG00000100883	SRP54	100	100.000	MGP_PahariEiJ_G0029510	-	100	99.802	Mus_pahari
ENSG00000100883	SRP54	100	100.000	ENSMPUG00000016302	SRP54	100	100.000	Mustela_putorius_furo
ENSG00000100883	SRP54	100	100.000	ENSMLUG00000008958	SRP54	100	99.405	Myotis_lucifugus
ENSG00000100883	SRP54	100	100.000	ENSNGAG00000019806	-	100	89.881	Nannospalax_galili
ENSG00000100883	SRP54	100	95.682	ENSNBRG00000006000	srp54	100	95.682	Neolamprologus_brichardi
ENSG00000100883	SRP54	100	100.000	ENSNLEG00000003496	SRP54	100	100.000	Nomascus_leucogenys
ENSG00000100883	SRP54	100	100.000	ENSMEUG00000000138	-	76	100.000	Notamacropus_eugenii
ENSG00000100883	SRP54	60	100.000	ENSOPRG00000014502	-	60	100.000	Ochotona_princeps
ENSG00000100883	SRP54	100	100.000	ENSODEG00000004865	SRP54	100	100.000	Octodon_degus
ENSG00000100883	SRP54	100	97.674	ENSONIG00000011768	srp54	100	96.032	Oreochromis_niloticus
ENSG00000100883	SRP54	100	100.000	ENSOANG00000014051	SRP54	100	100.000	Ornithorhynchus_anatinus
ENSG00000100883	SRP54	100	100.000	ENSOCUG00000007838	SRP54	100	99.405	Oryctolagus_cuniculus
ENSG00000100883	SRP54	100	97.674	ENSORLG00000010027	srp54	100	95.833	Oryzias_latipes
ENSG00000100883	SRP54	100	97.674	ENSORLG00020001878	srp54	100	95.833	Oryzias_latipes_hni
ENSG00000100883	SRP54	100	97.674	ENSORLG00015021866	srp54	100	95.833	Oryzias_latipes_hsok
ENSG00000100883	SRP54	100	97.674	ENSOMEG00000020952	srp54	100	95.635	Oryzias_melastigma
ENSG00000100883	SRP54	100	100.000	ENSOGAG00000012188	SRP54	100	100.000	Otolemur_garnettii
ENSG00000100883	SRP54	100	100.000	ENSOARG00000007160	SRP54	100	100.000	Ovis_aries
ENSG00000100883	SRP54	100	100.000	ENSPPAG00000017434	SRP54	100	100.000	Pan_paniscus
ENSG00000100883	SRP54	100	100.000	ENSPPRG00000014047	SRP54	100	98.810	Panthera_pardus
ENSG00000100883	SRP54	100	100.000	ENSPTIG00000000744	SRP54	96	99.802	Panthera_tigris_altaica
ENSG00000100883	SRP54	100	100.000	ENSPTRG00000006259	FAM177A1	100	100.000	Pan_troglodytes
ENSG00000100883	SRP54	100	100.000	ENSPANG00000023853	SRP54	100	100.000	Papio_anubis
ENSG00000100883	SRP54	100	95.682	ENSPKIG00000001953	srp54	100	95.635	Paramormyrops_kingsleyae
ENSG00000100883	SRP54	100	100.000	ENSPSIG00000006476	SRP54	100	99.008	Pelodiscus_sinensis
ENSG00000100883	SRP54	100	97.674	ENSPMGG00000004127	srp54	99	93.043	Periophthalmus_magnuspinnatus
ENSG00000100883	SRP54	100	100.000	ENSPEMG00000019634	-	100	86.905	Peromyscus_maniculatus_bairdii
ENSG00000100883	SRP54	100	90.698	ENSPMAG00000006078	-	100	88.690	Petromyzon_marinus
ENSG00000100883	SRP54	100	100.000	ENSPCIG00000016175	SRP54	100	99.802	Phascolarctos_cinereus
ENSG00000100883	SRP54	100	97.674	ENSPFOG00000008870	srp54	100	96.032	Poecilia_formosa
ENSG00000100883	SRP54	100	97.674	ENSPLAG00000009889	srp54	100	96.032	Poecilia_latipinna
ENSG00000100883	SRP54	100	97.674	ENSPMEG00000008601	srp54	100	96.032	Poecilia_mexicana
ENSG00000100883	SRP54	100	97.674	ENSPREG00000004505	srp54	100	96.032	Poecilia_reticulata
ENSG00000100883	SRP54	100	100.000	ENSPPYG00000005739	SRP54	100	94.841	Pongo_abelii
ENSG00000100883	SRP54	100	100.000	ENSPCAG00000006268	SRP54	100	95.833	Procavia_capensis
ENSG00000100883	SRP54	100	100.000	ENSPCOG00000022473	SRP54	100	98.020	Propithecus_coquereli
ENSG00000100883	SRP54	100	100.000	ENSPVAG00000010056	SRP54	82	100.000	Pteropus_vampyrus
ENSG00000100883	SRP54	100	97.674	ENSPNYG00000009717	srp54	100	96.032	Pundamilia_nyererei
ENSG00000100883	SRP54	100	97.674	ENSPNAG00000008544	srp54	100	95.833	Pygocentrus_nattereri
ENSG00000100883	SRP54	100	100.000	ENSRNOG00000032776	Srp54a	100	99.603	Rattus_norvegicus
ENSG00000100883	SRP54	100	100.000	ENSRROG00000041292	SRP54	100	100.000	Rhinopithecus_roxellana
ENSG00000100883	SRP54	86	53.061	YPR088C	SRP54	95	48.276	Saccharomyces_cerevisiae
ENSG00000100883	SRP54	100	100.000	ENSSBOG00000035145	SRP54	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000100883	SRP54	78	100.000	ENSSHAG00000000671	SRP54	100	100.000	Sarcophilus_harrisii
ENSG00000100883	SRP54	100	96.364	ENSSFOG00015013920	srp54	100	96.230	Scleropages_formosus
ENSG00000100883	SRP54	100	97.674	ENSSMAG00000002441	srp54	100	89.888	Scophthalmus_maximus
ENSG00000100883	SRP54	100	97.674	ENSSDUG00000018586	srp54	100	95.635	Seriola_dumerili
ENSG00000100883	SRP54	100	97.674	ENSSLDG00000010476	srp54	100	95.437	Seriola_lalandi_dorsalis
ENSG00000100883	SRP54	100	100.000	ENSSARG00000002744	SRP54	100	100.000	Sorex_araneus
ENSG00000100883	SRP54	100	100.000	ENSSPUG00000013101	SRP54	100	99.206	Sphenodon_punctatus
ENSG00000100883	SRP54	100	97.674	ENSSPAG00000002354	srp54	100	95.833	Stegastes_partitus
ENSG00000100883	SRP54	100	100.000	ENSSSCG00000001955	SRP54	100	100.000	Sus_scrofa
ENSG00000100883	SRP54	100	100.000	ENSTGUG00000011945	-	95	98.734	Taeniopygia_guttata
ENSG00000100883	SRP54	100	97.674	ENSTRUG00000007057	srp54	100	95.040	Takifugu_rubripes
ENSG00000100883	SRP54	100	97.674	ENSTNIG00000002589	srp54	100	94.643	Tetraodon_nigroviridis
ENSG00000100883	SRP54	100	91.591	ENSTBEG00000011409	SRP54	100	91.499	Tupaia_belangeri
ENSG00000100883	SRP54	100	100.000	ENSTTRG00000000928	SRP54	100	89.881	Tursiops_truncatus
ENSG00000100883	SRP54	100	100.000	ENSUAMG00000012385	SRP54	100	100.000	Ursus_americanus
ENSG00000100883	SRP54	100	100.000	ENSUMAG00000011234	SRP54	100	100.000	Ursus_maritimus
ENSG00000100883	SRP54	100	100.000	ENSVPAG00000005668	SRP54	100	99.789	Vicugna_pacos
ENSG00000100883	SRP54	100	100.000	ENSVVUG00000019962	SRP54	100	100.000	Vulpes_vulpes
ENSG00000100883	SRP54	100	98.649	ENSXETG00000012290	srp54	100	82.249	Xenopus_tropicalis
ENSG00000100883	SRP54	100	97.674	ENSXCOG00000004658	srp54	96	95.937	Xiphophorus_couchianus
ENSG00000100883	SRP54	100	97.674	ENSXMAG00000018315	srp54	100	96.032	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003924	GTPase activity	8247130.	IDA	Function
GO:0005515	protein binding	24965446.	IPI	Function
GO:0005525	GTP binding	8622769.	IDA	Function
GO:0005634	nucleus	18089836.	IDA	Component
GO:0005730	nucleolus	10618370.	IDA	Component
GO:0005737	cytoplasm	10618370.	IDA	Component
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	18089836.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	9511762.	IC	Process
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	-	TAS	Process
GO:0006616	SRP-dependent cotranslational protein targeting to membrane, translocation	-	ISS	Process
GO:0006617	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition	-	ISS	Process
GO:0008144	drug binding	18089836.	IDA	Function
GO:0008312	7S RNA binding	9511762.18089836.	IDA	Function
GO:0016607	nuclear speck	-	IEA	Component
GO:0019003	GDP binding	8622769.	IDA	Function
GO:0030942	endoplasmic reticulum signal peptide binding	9511762.	IDA	Function
GO:0042493	response to drug	18089836.	IDA	Process
GO:0043021	ribonucleoprotein complex binding	9511762.	IDA	Function
GO:0045047	protein targeting to ER	18089836.	IMP	Process