EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100941 (Gene tree)
Gene ID: 5411
Gene Symbol: PNN
Alias: memA
Full Name: pinin, desmosome associated protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 8,036 bases
Position: chr14:39,175,183-39,183,218
Accession: 9162
RBP type: non-canonical RBP
Summary: (Pinin, Desmosome Associated Protein) is a Protein Coding gene. Diseases associated with PNN include Premenstrual Tension and Epileptic Encephalopathy, Childhood-Onset. Among its related pathways are mRNA surveillance pathway and RNA transport. Gene Ontology (GO) annotations related to this gene include structural molecule activity.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23381995	SR-like RNA-binding protein Slr1 affects Candida albicans filamentation and virulence.	Infect Immun	2013 Apr	Ariyachet C	doi: 10.1128/IAI.00864-12

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000554117	PNN-203	624	-	-	- (aa)	-	-
ENST00000556530	PNN-205	601	-	ENSP00000452318	117 (aa)	-	G3V5F0
ENST00000216832	PNN-201	3576	-	ENSP00000216832	717 (aa)	-	Q9H307
ENST00000553331	PNN-202	656	-	ENSP00000452217	124 (aa)	-	G3V579
ENST00000557680	PNN-206	912	-	-	- (aa)	-	-
ENST00000554902	PNN-204	583	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000100941's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa03015	mRNA surveillance pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100941	Platelet Function Tests	3.5510300E-005	-
ENSG00000100941	Taste Perception	9.5390000E-006	-
ENSG00000100941	Taste Perception	9.5390000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100941's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100941	PNN	93	99.083	ENSMUSG00000020994	Pnn	100	92.700	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005198	structural molecule activity	8922384.	NAS	Function
GO:0005515	protein binding	18794151.20467437.22388736.30021884.	IPI	Function
GO:0005882	intermediate filament	10809736.	TAS	Component
GO:0005886	plasma membrane	8922384.	TAS	Component
GO:0005911	cell-cell junction	8922384.	TAS	Component
GO:0007155	cell adhesion	8922384.	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0030057	desmosome	-	IEA	Component
GO:0035145	exon-exon junction complex	21873635.	IBA	Component
GO:0035145	exon-exon junction complex	16314458.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	21873635.	IBA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component