EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100994 (Gene tree)
Gene ID: 5834
Gene Symbol: PYGB
Alias: N
Full Name: glycogen phosphorylase B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 49,946 bases
Position: chr20:25,248,069-25,298,014
Accession: 9723
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000428458	PYGB-202	734	-	ENSP00000395451	245 (aa)	-	H0Y4Z6
ENST00000216962	PYGB-201	4134	-	ENSP00000216962	843 (aa)	-	P11216
ENST00000471359	PYGB-203	726	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000100994's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00500	Starch and sucrose metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04217	Necroptosis	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa04922	Glucagon signaling pathway	KEGG
hsa04931	Insulin resistance	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100994	Calcium	5E-6	24068962
ENSG00000100994	dimethylarginine	8E-6	24159190

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100994	rs2281558	20	25259553	T	Calcium levels	24068962	[0.0091-0.0209] unit increase	0.015	EFO_0004838
ENSG00000100994	rs139672965	20	25286264	A	Asymmetrical dimethylarginine levels	24159190	[0.37-0.94] unit increase	0.654	EFO_0006522\|EFO_0005418
ENSG00000100994	rs2281558	20	25259553	?	Peripheral arterial disease (traffic-related air pollution interaction)	27082954	[3.88-5.4]	4.64	EFO_0004265\|EFO_0007908
ENSG00000100994	rs73598373	20	25294985	C	Telomere length	30185882	[0.133-0.311] unit decrease	0.222	EFO_0004505

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100994's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100994	PYGB	99	72.434	FBgn0004507	GlyP	99	72.434	Drosophila_melanogaster
ENSG00000100994	PYGB	99	81.883	ENSG00000100504	PYGL	99	81.883	Homo_sapiens
ENSG00000100994	PYGB	100	95.611	ENSMUSG00000033059	Pygb	100	95.611	Mus_musculus
ENSG00000100994	PYGB	99	83.671	ENSMUSG00000032648	Pygm	99	83.671	Mus_musculus
ENSG00000100994	PYGB	95	48.931	YPR160W		92	48.456	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	25416956.25910212.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	10638593.	IDA	Component
GO:0005980	glycogen catabolic process	21873635.	IBA	Process
GO:0005980	glycogen catabolic process	3346228.	NAS	Process
GO:0008184	glycogen phosphorylase activity	21873635.	IBA	Function
GO:0008184	glycogen phosphorylase activity	3346228.	NAS	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0030170	pyridoxal phosphate binding	21873635.	IBA	Function
GO:0035578	azurophil granule lumen	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0070062	extracellular exosome	23533145.	HDA	Component
GO:0102250	linear malto-oligosaccharide phosphorylase activity	-	IEA	Function
GO:0102499	SHG alpha-glucan phosphorylase activity	-	IEA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
30106110	Silencing of PYGB suppresses growth and promotes the apoptosis of prostate cancer cells via the NF??B/Nrf2 signaling pathway.	Mol Med Rep	2018 Oct	Wang Z	doi: 10.3892/mmr.2018.9388

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr20	25290576	Silent	novel	L641L	0.25
BLCA	chr20	25279102	Missense_Mutation	novel	E349K	0.14
BLCA	chr20	25296496	Missense_Mutation	novel	P836S	0.41
BLCA	chr20	25277293	Missense_Mutation	novel	E274D	0.06
BLCA	chr20	25282102	Silent	novel	R491R	0.38
BLCA	chr20	25281109	Nonsense_Mutation	novel	S467*	0.26
BLCA	chr20	25292566	Silent	novel	F710F	0.16
BLCA	chr20	25296515	Missense_Mutation	rs200006792	R842Q	0.23
BLCA	chr20	25269147	Nonsense_Mutation	novel	E122*	0.46
BLCA	chr20	25284220	Silent	novel	L579L	0.13
BLCA	chr20	25296379	Missense_Mutation	novel	E797Q	0.13
BLCA	chr20	25278424	Missense_Mutation	novel	D321Y	0.14
BLCA	chr20	25283235	Silent	novel	V526V	0.3
BLCA	chr20	25248370	Silent	rs751691357	L64L	0.59
BRCA	chr20	25259234	Splice_Region	novel		0.22
BRCA	chr20	25280402	Missense_Mutation	novel	R410L	0.1
BRCA	chr20	25292604	Missense_Mutation	novel	D723G	0.16
BRCA	chr20	25296633	3'UTR	NA		0.44
BRCA	chr20	25248370	Silent	rs751691357	L64L	0.25
BRCA	chr20	25259274	Missense_Mutation	rs769655708	R94H	0.37
BRCA	chr20	25284237	Missense_Mutation	novel	V585D	0.13
BRCA	chr20	25294206	Silent	rs146169925	A742A	0.31
BRCA	chr20	25271402	Missense_Mutation	rs767929147	M148I	0.34
BRCA	chr20	25276759	Splice_Site	novel	X258_splice	0.15
BRCA	chr20	25292554	Silent	NA	A706A	0.27
BRCA	chr20	25292506	Silent	rs778626594	I690I	0.1
CESC	chr20	25248370	Silent	novel	L64L	0.22
CESC	chr20	25259274	Missense_Mutation	rs769655708	R94H	0.33
CESC	chr20	25276700	Missense_Mutation	rs532747607	V239I	0.39
CESC	chr20	25278367	Missense_Mutation	novel	A302T	0.09
CESC	chr20	25280294	Missense_Mutation	rs540251614	A374G	0.13
CESC	chr20	25280366	Missense_Mutation	NA	P398R	0.16
CESC	chr20	25274692	Missense_Mutation	NA	T210S	0.47
CESC	chr20	25278345	Silent	novel	L294L	0.42
CESC	chr20	25292500	Silent	novel	L688L	0.37
COAD	chr20	25294286	Missense_Mutation	NA	H769R	0.54
COAD	chr20	25278321	Missense_Mutation	novel	F286L	0.37
COAD	chr20	25295643	Silent	rs767101832	C784C	0.36
COAD	chr20	25292453	Missense_Mutation	rs200843501	E673K	0.19
COAD	chr20	25259273	Missense_Mutation	rs200651502	R94C	0.28
COAD	chr20	25288423	Splice_Site	rs775018186	X590_splice	0.52
COAD	chr20	25280983	Missense_Mutation	rs776622403	R425H	0.07
COAD	chr20	25294207	Missense_Mutation	rs200955420	V743M	0.22
COAD	chr20	25259274	Missense_Mutation	rs769655708	R94H	0.38
COAD	chr20	25281015	Missense_Mutation	NA	D436N	0.46
COAD	chr20	25289918	Intron	novel		0.29
COAD	chr20	25292464	Silent	novel	G676G	0.45
COAD	chr20	25295668	Missense_Mutation	rs202186644	R793W	0.29
COAD	chr20	25277326	Splice_Region	rs367923761	N285N	0.18
COAD	chr20	25259307	Missense_Mutation	novel	L105P	0.09
COAD	chr20	25271454	Missense_Mutation	novel	I166V	0.05
COAD	chr20	25278411	Missense_Mutation	novel	K316N	0.16
COAD	chr20	25279111	Missense_Mutation	novel	R352W	0.47
COAD	chr20	25281098	Silent	rs201316067	I463I	0.32
COAD	chr20	25248167	5'UTR	novel		0.46
COAD	chr20	25292579	Missense_Mutation	rs201026212	R715W	0.29
COAD	chr20	25259306	Missense_Mutation	rs201324493	L105F	0.21
COAD	chr20	25294266	Silent	rs199570469	I762I	0.32
COAD	chr20	25292540	Missense_Mutation	NA	E702K	0.11
COAD	chr20	25281079	Missense_Mutation	rs200462235	A457V	0.08
COAD	chr20	25278414	Silent	rs147846111	F317F	0.2
COAD	chr20	25274603	Silent	rs35481467	A180A	0.22
COAD	chr20	25292466	Frame_Shift_Del	NA	*T677Kfs4**	0.44
COAD	chr20	25292553	Missense_Mutation	NA	A706V	0.2
DLBC	chr20	25284150	Missense_Mutation	novel	V556A	0.29
ESCA	chr20	25280279	Missense_Mutation	rs201517237	T369M	0.2
ESCA	chr20	25296392	Missense_Mutation	novel	K801R	0.23
ESCA	chr20	25277288	Missense_Mutation	novel	A273T	0.4
ESCA	chr20	25248184	Silent	novel	A2A	0.14
GBM	chr20	25271465	Missense_Mutation	novel	Q169H	0.12
GBM	chr20	25292453	Missense_Mutation	rs200843501	E673K	0.47
GBM	chr20	25274648	Silent	novel	P195P	0.43
GBM	chr20	25278376	Missense_Mutation	novel	L305F	0.14
GBM	chr20	25278377	Missense_Mutation	novel	L305R	0.13
GBM	chr20	25292428	Silent	rs200674616	S664S	0.21
GBM	chr20	25294286	Missense_Mutation	novel	H769P	0.2
GBM	chr20	25259336	Missense_Mutation	novel	Q115K	0.2
HNSC	chr20	25288434	Missense_Mutation	novel	R593T	0.21
HNSC	chr20	25290616	Missense_Mutation	novel	E655K	0.21
HNSC	chr20	25296578	3'UTR	novel		0.41
HNSC	chr20	25295624	Missense_Mutation	rs199953270	Y778C	0.21
HNSC	chr20	25259277	Missense_Mutation	rs370514593	T95M	0.24
HNSC	chr20	25282108	Silent	novel	L493L	0.44
HNSC	chr20	25259237	Missense_Mutation	rs201508171	R82C	0.27
HNSC	chr20	25295635	Frame_Shift_Ins	novel	*M782Ifs34**	0.49
HNSC	chr20	25296539	3'UTR	novel		0.23
KIRC	chr20	25278393	Silent	novel	R310R	0.37
KIRC	chr20	25269180	Missense_Mutation	NA	G133W	0.26
KIRP	chr20	25290602	Missense_Mutation	rs139162483	R650H	0.59
KIRP	chr20	25297374	3'UTR	novel		0.6
KIRP	chr20	25248406	Silent	novel	Y76Y	0.14
LGG	chr20	25280956	Missense_Mutation	NA	A416G	0.15
LGG	chr20	25274621	Silent	rs199968470	Y186Y	0.41
LGG	chr20	25278405	Silent	rs572592143	S314S	0.08
LGG	chr20	25281032	Silent	novel	N441N	0.08
LIHC	chr20	25280952	Missense_Mutation	rs201813153	V415M	0.14
LUAD	chr20	25248237	Missense_Mutation	novel	A20V	0.14
LUAD	chr20	25276645	Splice_Site	NA	X221_splice	0.21
LUAD	chr20	25295643	Silent	rs767101832	C784C	0.13
LUAD	chr20	25259236	Splice_Site	novel	X82_splice	0.18
LUAD	chr20	25280394	Missense_Mutation	novel	I407M	0.13
LUAD	chr20	25283260	Missense_Mutation	rs758229367	V535M	0.5
LUSC	chr20	25279111	Silent	novel	R352R	0.33
LUSC	chr20	25296405	Missense_Mutation	novel	N805K	0.28
LUSC	chr20	25276735	Silent	novel	P250P	0.49
LUSC	chr20	25274601	Missense_Mutation	NA	A180S	0.18
LUSC	chr20	25276723	Silent	novel	S246S	0.32
LUSC	chr20	25279061	Missense_Mutation	NA	A335D	0.59
MESO	chr20	25284230	Missense_Mutation	novel	H583N	0.34
OV	chr20	25292466	Missense_Mutation	novel	T677R	0.11
OV	chr20	25296435	Frame_Shift_Del	NA	*R816Gfs84**	0.18
OV	chr20	25259284	Missense_Mutation	novel	Q97H	0.07
OV	chr20	25281049	Missense_Mutation	NA	V447A	0.23
OV	chr20	25280299	Missense_Mutation	novel	T376A	0.28
PAAD	chr20	25274687	Silent	novel	E208E	0.03
PAAD	chr20	25296486	Silent	novel	D832D	0.16
PRAD	chr20	25277301	Missense_Mutation	novel	S277F	0.2
PRAD	chr20	25278392	Missense_Mutation	rs761148570	R310H	0.3
PRAD	chr20	25283242	Missense_Mutation	rs377297438	E529K	0.39
PRAD	chr20	25295633	Missense_Mutation	novel	Y781C	0.41
READ	chr20	25290486	Silent	rs752184187	A611A	0.22
SARC	chr20	25271392	Missense_Mutation	rs773439527	L145P	0.26
SKCM	chr20	25296437	Missense_Mutation	NA	R816Q	0.38
SKCM	chr20	25278444	Silent	novel	F327F	0.26
SKCM	chr20	25248355	Silent	novel	T59T	0.59
SKCM	chr20	25271390	Silent	NA	F144F	0.48
SKCM	chr20	25284131	Silent	NA	L550L	0.29
SKCM	chr20	25282066	Silent	NA	K479K	0.41
SKCM	chr20	25283184	Silent	novel	G509G	0.31
SKCM	chr20	25281098	Silent	rs201316067	I463I	0.13
SKCM	chr20	25288434	Missense_Mutation	novel	R593K	0.07
SKCM	chr20	25292423	Silent	rs199748264	L663L	0.22
SKCM	chr20	25274694	Missense_Mutation	novel	P211S	0.24
SKCM	chr20	25277263	Silent	rs200881466	I264I	0.14
SKCM	chr20	25294266	Silent	rs199570469	I762I	0.19
SKCM	chr20	25296483	Silent	rs141315124	S831S	0.38
SKCM	chr20	25276698	Missense_Mutation	rs202165304	T238I	0.12
STAD	chr20	25259274	Missense_Mutation	rs769655708	R94H	0.23
STAD	chr20	25281110	Splice_Region	NA	S467S	0.19
STAD	chr20	25296497	Missense_Mutation	rs116595887	P836L	0.37
STAD	chr20	25292527	Silent	rs776312433	N697N	0.07
STAD	chr20	25296498	Silent	rs200465936	P836P	0.13
STAD	chr20	25278360	Silent	rs777454522	F299F	0.37
STAD	chr20	25296582	3'UTR	novel		0.23
STAD	chr20	25278391	Missense_Mutation	rs773607885	R310C	0.14
STAD	chr20	25292521	Silent	novel	G695G	0.17
STAD	chr20	25271394	Missense_Mutation	NA	D146N	0.24
STAD	chr20	25295642	Missense_Mutation	NA	C784Y	0.14
STAD	chr20	25277311	Silent	rs749516060	L280L	0.17
STAD	chr20	25279090	Missense_Mutation	NA	L345I	0.29
STAD	chr20	25296398	Missense_Mutation	novel	I803T	0.46
STAD	chr20	25296575	3'UTR	novel		0.12
STAD	chr20	25280957	Silent	rs777782398	A416A	0.07
STAD	chr20	25294262	Missense_Mutation	rs767386910	D761G	0.13
STAD	chr20	25279087	Missense_Mutation	rs199970228	A344T	0.11
STAD	chr20	25292593	Silent	rs199809129	V719V	0.24
UCEC	chr20	25288471	Missense_Mutation	NA	M605I	0.34
UCEC	chr20	25277323	Silent	novel	D284D	0.14
UCEC	chr20	25284181	Silent	novel	V566V	0.18
UCEC	chr20	25274692	Frame_Shift_Del	novel	*D212Tfs3**	0.29
UCEC	chr20	25292428	Silent	rs200674616	S664S	0.11
UCEC	chr20	25274687	Missense_Mutation	NA	E208D	0.39
UCEC	chr20	25277315	Missense_Mutation	NA	P282S	0.47
UCEC	chr20	25295651	Missense_Mutation	novel	Q787R	0.07
UCEC	chr20	25281071	Silent	NA	N454N	0.18
UCEC	chr20	25279111	Missense_Mutation	novel	R352W	0.25
UCEC	chr20	25295621	Missense_Mutation	novel	D777G	0.45
UCEC	chr20	25282063	Missense_Mutation	NA	E478D	0.26
UCEC	chr20	25292518	Silent	rs199972111	D694D	0.29
UCEC	chr20	25284236	Missense_Mutation	rs763681247	V585I	0.24
UCEC	chr20	25248402	Missense_Mutation	novel	Y75C	0.25
UCEC	chr20	25274667	Missense_Mutation	novel	H202Y	0.29
UCEC	chr20	25296426	Missense_Mutation	NA	F812L	0.41
UCEC	chr20	25274617	Missense_Mutation	rs747769681	R185H	0.33
UCEC	chr20	25294266	Silent	rs199570469	I762I	0.13
UCEC	chr20	25296630	3'UTR	novel		0.24
UCEC	chr20	25296436	Silent	novel	R816R	0.27
UCEC	chr20	25294228	Frame_Shift_Del	NA	*S752Lfs12**	0.14
UCEC	chr20	25278391	Missense_Mutation	rs773607885	R310C	0.36
UCEC	chr20	25292434	Silent	rs768358990	Q666Q	0.46
UCEC	chr20	25294207	Missense_Mutation	rs200955420	V743M	0.39
UCEC	chr20	25274696	Silent	rs199794539	P211P	0.35
UCEC	chr20	25284186	Missense_Mutation	novel	V568A	0.1
UCEC	chr20	25280358	Silent	novel	K395K	0.34
UCEC	chr20	25281099	Missense_Mutation	rs201900026	V464M	0.11
UCEC	chr20	25284154	Missense_Mutation	novel	K557N	0.57
UCEC	chr20	25296497	Missense_Mutation	rs116595887	P836L	0.53
UCEC	chr20	25296451	Missense_Mutation	NA	Y821D	0.2
UCEC	chr20	25271424	Missense_Mutation	novel	Y156H	0.35
UCEC	chr20	25274654	Silent	novel	Y197Y	0.07
UCEC	chr20	25290539	Missense_Mutation	rs752703479	D629G	0.35
UCEC	chr20	25296499	Frame_Shift_Del	NA	*N839Tfs61**	0.37
UCEC	chr20	25290537	Silent	rs201261056	G628G	0.34
UCEC	chr20	25280369	Missense_Mutation	NA	R399P	0.12
UCEC	chr20	25292413	Silent	rs143059247	P659P	0.36
UCEC	chr20	25292540	Missense_Mutation	NA	E702K	0.41
UCEC	chr20	25259290	Silent	rs780877333	T99T	0.31
UCEC	chr20	25271445	Nonsense_Mutation	novel	E163*	0.25
UCEC	chr20	25284136	Missense_Mutation	rs146700755	E551D	0.43
UCEC	chr20	25294221	Silent	NA	S747S	0.42
UCEC	chr20	25259278	Silent	rs201935645	T95T	0.41
UCEC	chr20	25281080	Silent	rs201940866	A457A	0.46
UCEC	chr20	25279077	Silent	novel	D340D	0.3
UCEC	chr20	25274617	Missense_Mutation	novel	R185L	0.11
UCEC	chr20	25281099	Missense_Mutation	rs201900026	V464M	0.1
UCEC	chr20	25274616	Missense_Mutation	rs201326100	R185C	0.16
UCEC	chr20	25248263	Frame_Shift_Ins	novel	*K30Efs82**	0.07
UCEC	chr20	25282092	Frame_Shift_Del	NA	*R490Afs24**	0.44
UCEC	chr20	25296645	3'UTR	novel		0.56
UCEC	chr20	25259278	Silent	rs201935645	T95T	0.47
UCEC	chr20	25284186	Missense_Mutation	novel	V568A	0.14
UCEC	chr20	25274700	Missense_Mutation	rs200712486	G213S	0.25
UCEC	chr20	25280264	Splice_Site	NA	X365_splice	0.29
UCEC	chr20	25271429	Silent	novel	G157G	0.22
UCEC	chr20	25280958	Missense_Mutation	rs143661747	A417T	0.35
UCEC	chr20	25284214	Silent	novel	Q577Q	0.28
UCEC	chr20	25248218	Missense_Mutation	novel	I14V	0.35
UCEC	chr20	25276699	Silent	rs200350706	T238T	0.5
UCEC	chr20	25279111	Missense_Mutation	novel	R352W	0.46
UCEC	chr20	25290490	Missense_Mutation	novel	G613S	0.35
UCEC	chr20	25259294	Missense_Mutation	novel	V101M	0.29
UCEC	chr20	25278339	Silent	novel	L292L	0.36
UCS	chr20	25296483	Silent	rs141315124	S831S	0.56

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LUAD	AMP	0.2771	0.19771

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.029	Kaplan-Meier Survival Analysis
MESO	0.0054	Kaplan-Meier Survival Analysis
ACC	0.04	Kaplan-Meier Survival Analysis
LUSC	0.00012	Kaplan-Meier Survival Analysis
PAAD	0.001	Kaplan-Meier Survival Analysis
BLCA	0.0035	Kaplan-Meier Survival Analysis
LIHC	0.0017	Kaplan-Meier Survival Analysis
LGG	0.0025	Kaplan-Meier Survival Analysis
CHOL	0.033	Kaplan-Meier Survival Analysis
LUAD	0.0047	Kaplan-Meier Survival Analysis
UVM	0.018	Kaplan-Meier Survival Analysis
OV	0.004	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742