EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000101104 (Gene tree)
Gene ID: 80336
Gene Symbol: PABPC1L
Alias: dJ1069P2.3|PABPC1L1|ePAB|C20orf119
Full Name: poly(A) binding protein cytoplasmic 1 like
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 48,978 bases
Position: chr20:44,910,058-44,959,035
Accession: 15797
RBP type: canonical RBP
Summary: (Poly(A) Binding Protein Cytoplasmic 1 Like) is a Protein Coding gene. Diseases associated with PABPC1L include Rigid Spine Muscular Dystrophy 1. Among its related pathways are mRNA surveillance pathway and RNA transport. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPC1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000361911	PABP	PF00658.18	6.2e-28	1	1
ENSP00000217073	PABP	PF00658.18	3.4e-27	1	1
ENSP00000255136	PABP	PF00658.18	3.4e-27	1	1
ENSP00000361906	PABP	PF00658.18	1.9e-24	1	1
ENSP00000361913	PABP	PF00658.18	3.9e-24	1	1
ENSP00000217075	PABP	PF00658.18	1.3e-23	1	1
ENSP00000217073	RRM_5	PF13893.6	3.3e-09	1	1
ENSP00000255136	RRM_5	PF13893.6	3.3e-09	1	1
ENSP00000217074	RRM_5	PF13893.6	9.1e-08	1	1
ENSP00000445661	RRM_5	PF13893.6	9.1e-08	1	1
ENSP00000217073	RRM_1	PF00076.22	2e-89	1	4
ENSP00000217073	RRM_1	PF00076.22	2e-89	2	4
ENSP00000217073	RRM_1	PF00076.22	2e-89	3	4
ENSP00000217073	RRM_1	PF00076.22	2e-89	4	4
ENSP00000255136	RRM_1	PF00076.22	2e-89	1	4
ENSP00000255136	RRM_1	PF00076.22	2e-89	2	4
ENSP00000255136	RRM_1	PF00076.22	2e-89	3	4
ENSP00000255136	RRM_1	PF00076.22	2e-89	4	4
ENSP00000217074	RRM_1	PF00076.22	4.3e-76	1	4
ENSP00000217074	RRM_1	PF00076.22	4.3e-76	2	4
ENSP00000217074	RRM_1	PF00076.22	4.3e-76	3	4
ENSP00000217074	RRM_1	PF00076.22	4.3e-76	4	4
ENSP00000445661	RRM_1	PF00076.22	4.3e-76	1	4
ENSP00000445661	RRM_1	PF00076.22	4.3e-76	2	4
ENSP00000445661	RRM_1	PF00076.22	4.3e-76	3	4
ENSP00000445661	RRM_1	PF00076.22	4.3e-76	4	4

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20977669	Interaction of 42Sp50 with the vegetal RNA localization machinery in Xenopus laevis oocytes.	FEBS J	2010 Nov	Loeber J	doi: 10.1111/j.1742-4658.2010.07878.x

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000217074	PABPC1L-202	1263	-	ENSP00000217074	330 (aa)	-	Q4VXU2
ENST00000372824	PABPC1L-207	2223	-	ENSP00000361911	168 (aa)	-	Q4VXT4
ENST00000372826	PABPC1L-208	854	-	ENSP00000361913	152 (aa)	-	H0Y386
ENST00000479873	PABPC1L-212	1178	-	ENSP00000432620	174 (aa)	-	F2Z2Z0
ENST00000217073	PABPC1L-201	1851	-	ENSP00000217073	614 (aa)	-	Q4VXU2
ENST00000537323	PABPC1L-217	1910	-	ENSP00000445661	330 (aa)	-	Q4VXU2
ENST00000489068	PABPC1L-215	442	-	-	- (aa)	-	-
ENST00000372822	PABPC1L-206	536	-	ENSP00000361909	134 (aa)	-	Q4VXT8
ENST00000474208	PABPC1L-210	308	-	-	- (aa)	-	-
ENST00000476056	PABPC1L-211	1214	-	-	- (aa)	-	-
ENST00000490798	PABPC1L-216	1384	-	-	- (aa)	-	-
ENST00000217075	PABPC1L-203	670	-	ENSP00000217075	171 (aa)	-	Q4VXT5
ENST00000255136	PABPC1L-204	2129	-	ENSP00000255136	614 (aa)	-	Q4VXU2
ENST00000482486	PABPC1L-214	541	-	-	- (aa)	-	-
ENST00000481196	PABPC1L-213	488	-	-	- (aa)	-	-
ENST00000465761	PABPC1L-209	801	-	-	- (aa)	-	-
ENST00000372819	PABPC1L-205	2100	-	ENSP00000361906	149 (aa)	-	Q4VXT6

Gene Model

Click here to download ENSG00000101104's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa03015	mRNA surveillance pathway	KEGG
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000101104	Macular Degeneration	1.268967E-5	-
ENSG00000101104	Cholesterol, HDL	5.2290000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000101104	rs2072727	20	44910092	?	Morning person	30595370			EFO_0008328
ENSG00000101104	rs2072727	20	44910092	T	Chronotype	30696823		1.0286014	EFO_0008328
ENSG00000101104	rs2072727	20	44910092	T	Morning person	30696823		1.0302	EFO_0008328
ENSG00000101104	rs2072727	20	44910092	T	Sleep duration	30846698	unit increase	0.696	EFO_0005271

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000101104's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000101104	PABPC1L	95	32.000	ENSG00000179950	PUF60	65	33.333
ENSG00000101104	PABPC1L	96	38.571	ENSG00000196361	ELAVL3	90	38.571
ENSG00000101104	PABPC1L	97	38.095	ENSG00000143368	SF3B4	81	37.821
ENSG00000101104	PABPC1L	64	34.783	ENSG00000048740	CELF2	60	33.784
ENSG00000101104	PABPC1L	57	30.000	ENSG00000115053	NCL	85	30.000
ENSG00000101104	PABPC1L	81	43.750	ENSG00000100461	RBM23	64	43.750
ENSG00000101104	PABPC1L	73	31.098	ENSG00000177733	HNRNPA0	50	32.051
ENSG00000101104	PABPC1L	64	36.232	ENSG00000149187	CELF1	66	36.232
ENSG00000101104	PABPC1L	98	86.822	ENSG00000070756	PABPC1	100	88.372
ENSG00000101104	PABPC1L	96	41.429	ENSG00000162374	ELAVL4	88	41.429
ENSG00000101104	PABPC1L	95	71.066	ENSG00000184388	PABPC1L2B	99	71.066
ENSG00000101104	PABPC1L	67	40.789	ENSG00000102317	RBM3	59	40.000
ENSG00000101104	PABPC1L	98	61.728	ENSG00000254535	PABPC4L	99	63.514
ENSG00000101104	PABPC1L	81	42.500	ENSG00000131051	RBM39	99	42.500
ENSG00000101104	PABPC1L	69	38.356	ENSG00000161082	CELF5	79	38.356
ENSG00000101104	PABPC1L	73	30.488	ENSG00000170144	HNRNPA3	52	30.128
ENSG00000101104	PABPC1L	84	38.356	ENSG00000099783	HNRNPM	66	31.452
ENSG00000101104	PABPC1L	75	39.437	ENSG00000151923	TIAL1	96	39.437
ENSG00000101104	PABPC1L	73	30.769	ENSG00000135486	HNRNPA1	99	35.514
ENSG00000101104	PABPC1L	59	35.616	ENSG00000159409	CELF3	92	35.616
ENSG00000101104	PABPC1L	95	30.645	ENSG00000066044	ELAVL1	82	34.568
ENSG00000101104	PABPC1L	67	40.260	ENSG00000099622	CIRBP	96	42.647
ENSG00000101104	PABPC1L	98	73.765	ENSG00000151846	PABPC3	98	65.862
ENSG00000101104	PABPC1L	96	40.000	ENSG00000107105	ELAVL2	93	40.000
ENSG00000101104	PABPC1L	95	30.137	ENSG00000153250	RBMS1	87	33.010
ENSG00000101104	PABPC1L	78	39.286	ENSG00000116001	TIA1	88	40.426
ENSG00000101104	PABPC1L	98	86.047	ENSG00000090621	PABPC4	100	86.047
ENSG00000101104	PABPC1L	95	71.066	ENSG00000186288	PABPC1L2A	99	71.066
ENSG00000101104	PABPC1L	95	57.235	ENSG00000174740	PABPC5	96	59.504

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000101104	PABPC1L	98	76.543	ENSAPOG00000010842	pabpc1l	99	66.348	Acanthochromis_polyacanthus
ENSG00000101104	PABPC1L	99	94.136	ENSAMEG00000004099	PABPC1L	100	78.594	Ailuropoda_melanoleuca
ENSG00000101104	PABPC1L	98	76.543	ENSACIG00000021004	-	99	80.220	Amphilophus_citrinellus
ENSG00000101104	PABPC1L	98	76.235	ENSAOCG00000006167	-	99	66.509	Amphiprion_ocellaris
ENSG00000101104	PABPC1L	98	80.693	ENSAPEG00000010558	-	97	80.693	Amphiprion_percula
ENSG00000101104	PABPC1L	98	76.543	ENSATEG00000007428	pabpc1l	99	69.144	Anabas_testudineus
ENSG00000101104	PABPC1L	95	80.635	ENSAPLG00000008415	PABPC1L	98	74.677	Anas_platyrhynchos
ENSG00000101104	PABPC1L	98	82.716	ENSACAG00000011841	PABPC1L	98	74.478	Anolis_carolinensis
ENSG00000101104	PABPC1L	100	96.580	ENSANAG00000026826	PABPC1L	100	96.580	Aotus_nancymaae
ENSG00000101104	PABPC1L	98	76.235	ENSACLG00000024791	pabpc1l	99	67.512	Astatotilapia_calliptera
ENSG00000101104	PABPC1L	98	79.012	ENSAMXG00000013552	pabpc1l	99	70.240	Astyanax_mexicanus
ENSG00000101104	PABPC1L	87	80.128	ENSBTAG00000016849	PABPC1L	85	78.136	Bos_taurus
ENSG00000101104	PABPC1L	98	96.429	ENSBTAG00000055300	-	100	96.429	Bos_taurus
ENSG00000101104	PABPC1L	99	74.830	ENSBTAG00000050862	-	81	77.703	Bos_taurus
ENSG00000101104	PABPC1L	100	97.068	ENSCJAG00000017628	PABPC1L	100	97.068	Callithrix_jacchus
ENSG00000101104	PABPC1L	80	76.437	ENSCJAG00000038506	-	100	76.437	Callithrix_jacchus
ENSG00000101104	PABPC1L	99	93.519	ENSCAFG00000009573	PABPC1L	100	74.654	Canis_familiaris
ENSG00000101104	PABPC1L	99	93.827	ENSCAFG00020013828	PABPC1L	99	88.033	Canis_lupus_dingo
ENSG00000101104	PABPC1L	99	94.136	ENSCHIG00000025759	PABPC1L	91	86.957	Capra_hircus
ENSG00000101104	PABPC1L	99	91.667	ENSTSYG00000006645	PABPC1L	100	88.111	Carlito_syrichta
ENSG00000101104	PABPC1L	96	89.370	ENSCAPG00000014519	PABPC1L	100	80.692	Cavia_aperea
ENSG00000101104	PABPC1L	99	89.815	ENSCPOG00000013633	PABPC1L	100	83.871	Cavia_porcellus
ENSG00000101104	PABPC1L	99	97.531	ENSCCAG00000023338	PABPC1L	100	95.928	Cebus_capucinus
ENSG00000101104	PABPC1L	100	98.697	ENSCATG00000034065	PABPC1L	100	98.697	Cercocebus_atys
ENSG00000101104	PABPC1L	99	88.272	ENSCLAG00000005298	PABPC1L	100	83.065	Chinchilla_lanigera
ENSG00000101104	PABPC1L	99	99.691	ENSCSAG00000014242	PABPC1L	100	98.534	Chlorocebus_sabaeus
ENSG00000101104	PABPC1L	98	82.407	ENSCPBG00000017755	-	99	81.757	Chrysemys_picta_bellii
ENSG00000101104	PABPC1L	100	57.718	ENSCPBG00000017765	-	78	59.420	Chrysemys_picta_bellii
ENSG00000101104	PABPC1L	68	78.788	ENSCPBG00000007810	-	81	78.788	Chrysemys_picta_bellii
ENSG00000101104	PABPC1L	95	56.395	ENSCING00000002796	-	97	50.813	Ciona_intestinalis
ENSG00000101104	PABPC1L	99	68.098	ENSCSAVG00000004246	-	89	78.313	Ciona_savignyi
ENSG00000101104	PABPC1L	95	81.507	ENSCSAVG00000003102	-	100	81.507	Ciona_savignyi
ENSG00000101104	PABPC1L	99	99.691	ENSCANG00000037530	PABPC1L	100	93.740	Colobus_angolensis_palliatus
ENSG00000101104	PABPC1L	99	84.568	ENSCGRG00001021938	Pabpc1l	99	76.623	Cricetulus_griseus_chok1gshd
ENSG00000101104	PABPC1L	99	84.568	ENSCGRG00000007946	Pabpc1l	99	76.623	Cricetulus_griseus_crigri
ENSG00000101104	PABPC1L	97	76.636	ENSCSEG00000021295	pabpc1l	99	65.563	Cynoglossus_semilaevis
ENSG00000101104	PABPC1L	98	85.496	ENSCVAG00000015943	-	86	85.496	Cyprinodon_variegatus
ENSG00000101104	PABPC1L	98	86.154	ENSDARG00000002597	pabpc1l	88	86.154	Danio_rerio
ENSG00000101104	PABPC1L	99	94.753	ENSDNOG00000048450	PABPC1L	99	89.396	Dasypus_novemcinctus
ENSG00000101104	PABPC1L	99	89.815	ENSDORG00000001067	Pabpc1l	99	85.948	Dipodomys_ordii
ENSG00000101104	PABPC1L	99	90.650	ENSETEG00000009969	PABPC1L	73	90.650	Echinops_telfairi
ENSG00000101104	PABPC1L	70	87.838	ENSEASG00005023407	-	67	87.879	Equus_asinus_asinus
ENSG00000101104	PABPC1L	98	95.238	ENSEASG00005023408	-	100	95.238	Equus_asinus_asinus
ENSG00000101104	PABPC1L	100	76.510	ENSEASG00005023406	-	85	77.536	Equus_asinus_asinus
ENSG00000101104	PABPC1L	100	75.595	ENSECAG00000022681	PABPC1L	93	76.282	Equus_caballus
ENSG00000101104	PABPC1L	88	88.182	ENSECAG00000040139	-	82	86.957	Equus_caballus
ENSG00000101104	PABPC1L	99	90.432	ENSEEUG00000005978	PABPC1L	100	83.225	Erinaceus_europaeus
ENSG00000101104	PABPC1L	98	77.538	ENSELUG00000001811	pabpc1l	99	70.288	Esox_lucius
ENSG00000101104	PABPC1L	99	94.444	ENSFCAG00000011692	PABPC1L	99	88.852	Felis_catus
ENSG00000101104	PABPC1L	98	83.951	ENSFALG00000005372	PABPC1L	90	74.954	Ficedula_albicollis
ENSG00000101104	PABPC1L	99	90.432	ENSFDAG00000008291	PABPC1L	100	82.276	Fukomys_damarensis
ENSG00000101104	PABPC1L	98	76.852	ENSFHEG00000003398	pabpc1l	99	69.059	Fundulus_heteroclitus
ENSG00000101104	PABPC1L	98	75.926	ENSGMOG00000004437	pabpc1l	98	68.679	Gadus_morhua
ENSG00000101104	PABPC1L	98	82.716	ENSGALG00000004123	PABPC1L	99	83.213	Gallus_gallus
ENSG00000101104	PABPC1L	98	69.663	ENSGAFG00000021057	pabpc1l	99	65.794	Gambusia_affinis
ENSG00000101104	PABPC1L	98	76.235	ENSGACG00000002792	pabpc1l	99	67.308	Gasterosteus_aculeatus
ENSG00000101104	PABPC1L	98	82.407	ENSGAGG00000000589	PABPC1L	95	84.019	Gopherus_agassizii
ENSG00000101104	PABPC1L	100	99.674	ENSGGOG00000004584	PABPC1L	100	99.674	Gorilla_gorilla
ENSG00000101104	PABPC1L	99	76.235	ENSHBUG00000006134	pabpc1l	99	67.353	Haplochromis_burtoni
ENSG00000101104	PABPC1L	99	90.432	ENSHGLG00000008434	PABPC1L	100	83.710	Heterocephalus_glaber_female
ENSG00000101104	PABPC1L	98	81.461	ENSHGLG00100019506	-	100	81.461	Heterocephalus_glaber_male
ENSG00000101104	PABPC1L	99	90.432	ENSHGLG00100012151	PABPC1L	100	83.710	Heterocephalus_glaber_male
ENSG00000101104	PABPC1L	98	77.778	ENSHCOG00000009270	pabpc1l	99	67.488	Hippocampus_comes
ENSG00000101104	PABPC1L	98	79.321	ENSIPUG00000012602	pabpc1l	99	71.040	Ictalurus_punctatus
ENSG00000101104	PABPC1L	95	62.069	ENSIPUG00000006780	-	85	62.069	Ictalurus_punctatus
ENSG00000101104	PABPC1L	98	64.615	ENSIPUG00000005537	-	100	64.615	Ictalurus_punctatus
ENSG00000101104	PABPC1L	95	61.494	ENSIPUG00000006760	-	88	61.494	Ictalurus_punctatus
ENSG00000101104	PABPC1L	99	92.901	ENSSTOG00000003739	PABPC1L	100	88.436	Ictidomys_tridecemlineatus
ENSG00000101104	PABPC1L	99	67.818	ENSJJAG00000022406	Pabpc1l	99	64.123	Jaculus_jaculus
ENSG00000101104	PABPC1L	98	77.160	ENSKMAG00000016847	pabpc1l	99	69.368	Kryptolebias_marmoratus
ENSG00000101104	PABPC1L	99	76.235	ENSLBEG00000010084	pabpc1l	99	66.719	Labrus_bergylta
ENSG00000101104	PABPC1L	98	79.938	ENSLACG00000005762	PABPC1L	99	71.140	Latimeria_chalumnae
ENSG00000101104	PABPC1L	98	78.395	ENSLOCG00000007519	pabpc1l	98	70.353	Lepisosteus_oculatus
ENSG00000101104	PABPC1L	98	92.901	ENSLAFG00000003553	PABPC1L	100	84.936	Loxodonta_africana
ENSG00000101104	PABPC1L	100	98.860	ENSMFAG00000040365	PABPC1L	100	98.860	Macaca_fascicularis
ENSG00000101104	PABPC1L	100	97.315	ENSMMUG00000013209	-	100	97.315	Macaca_mulatta
ENSG00000101104	PABPC1L	99	99.691	ENSMNEG00000032298	PABPC1L	100	95.948	Macaca_nemestrina
ENSG00000101104	PABPC1L	100	98.697	ENSMLEG00000043139	PABPC1L	100	98.697	Mandrillus_leucophaeus
ENSG00000101104	PABPC1L	98	75.926	ENSMAMG00000011854	pabpc1l	97	67.980	Mastacembelus_armatus
ENSG00000101104	PABPC1L	98	76.235	ENSMZEG00005023713	pabpc1l	99	67.512	Maylandia_zebra
ENSG00000101104	PABPC1L	98	83.025	ENSMGAG00000003674	PABPC1L	98	74.880	Meleagris_gallopavo
ENSG00000101104	PABPC1L	100	84.564	ENSMICG00000000974	-	92	86.131	Microcebus_murinus
ENSG00000101104	PABPC1L	99	85.185	ENSMOCG00000013186	Pabpc1l	99	74.838	Microtus_ochrogaster
ENSG00000101104	PABPC1L	100	86.154	ENSMMOG00000020574	-	93	86.154	Mola_mola
ENSG00000101104	PABPC1L	98	87.963	ENSMODG00000016198	PABPC1L	99	79.500	Monodelphis_domestica
ENSG00000101104	PABPC1L	98	75.617	ENSMALG00000021622	pabpc1l	100	66.234	Monopterus_albus
ENSG00000101104	PABPC1L	99	84.568	MGP_CAROLIEiJ_G0024627	Pabpc1l	99	76.961	Mus_caroli
ENSG00000101104	PABPC1L	99	84.568	ENSMUSG00000054582	Pabpc1l	99	76.797	Mus_musculus
ENSG00000101104	PABPC1L	99	84.568	MGP_PahariEiJ_G0026071	Pabpc1l	99	77.162	Mus_pahari
ENSG00000101104	PABPC1L	99	84.568	MGP_SPRETEiJ_G0025549	Pabpc1l	99	76.961	Mus_spretus
ENSG00000101104	PABPC1L	98	93.827	ENSMPUG00000017646	PABPC1L	99	86.364	Mustela_putorius_furo
ENSG00000101104	PABPC1L	99	86.850	ENSMLUG00000006324	PABPC1L	97	78.871	Myotis_lucifugus
ENSG00000101104	PABPC1L	99	87.654	ENSNGAG00000010458	Pabpc1l	99	79.417	Nannospalax_galili
ENSG00000101104	PABPC1L	99	76.235	ENSNBRG00000016633	pabpc1l	99	79.310	Neolamprologus_brichardi
ENSG00000101104	PABPC1L	93	96.855	ENSNLEG00000006653	-	93	96.855	Nomascus_leucogenys
ENSG00000101104	PABPC1L	98	85.494	ENSMEUG00000007905	-	100	68.404	Notamacropus_eugenii
ENSG00000101104	PABPC1L	99	92.284	ENSOPRG00000011846	PABPC1L	100	86.667	Ochotona_princeps
ENSG00000101104	PABPC1L	99	89.506	ENSODEG00000015482	PABPC1L	100	76.221	Octodon_degus
ENSG00000101104	PABPC1L	98	74.375	ENSODEG00000002920	-	97	74.375	Octodon_degus
ENSG00000101104	PABPC1L	98	76.235	ENSONIG00000017314	pabpc1l	99	67.512	Oreochromis_niloticus
ENSG00000101104	PABPC1L	98	71.560	ENSOANG00000015793	-	100	68.174	Ornithorhynchus_anatinus
ENSG00000101104	PABPC1L	99	92.901	ENSOCUG00000003005	PABPC1L	100	80.401	Oryctolagus_cuniculus
ENSG00000101104	PABPC1L	99	76.852	ENSORLG00000010322	pabpc1l	99	72.662	Oryzias_latipes
ENSG00000101104	PABPC1L	99	76.852	ENSORLG00020021193	pabpc1l	99	72.662	Oryzias_latipes_hni
ENSG00000101104	PABPC1L	99	76.852	ENSORLG00015017018	pabpc1l	99	72.662	Oryzias_latipes_hsok
ENSG00000101104	PABPC1L	98	70.822	ENSOMEG00000010789	pabpc1l	99	64.319	Oryzias_melastigma
ENSG00000101104	PABPC1L	99	93.519	ENSOGAG00000032999	PABPC1L	100	87.340	Otolemur_garnettii
ENSG00000101104	PABPC1L	99	94.444	ENSOARG00000004578	PABPC1L	99	87.377	Ovis_aries
ENSG00000101104	PABPC1L	100	100.000	ENSPPAG00000039677	PABPC1L	100	100.000	Pan_paniscus
ENSG00000101104	PABPC1L	99	80.405	ENSPPRG00000020242	-	92	81.618	Panthera_pardus
ENSG00000101104	PABPC1L	100	82.121	ENSPPRG00000019327	-	100	82.121	Panthera_pardus
ENSG00000101104	PABPC1L	97	94.654	ENSPTIG00000006524	PABPC1L	99	88.907	Panthera_tigris_altaica
ENSG00000101104	PABPC1L	100	99.697	ENSPTRG00000013531	PABPC1L	100	99.697	Pan_troglodytes
ENSG00000101104	PABPC1L	100	100.000	ENSPTRG00000044192	-	100	100.000	Pan_troglodytes
ENSG00000101104	PABPC1L	100	98.697	ENSPANG00000018788	PABPC1L	100	98.697	Papio_anubis
ENSG00000101104	PABPC1L	98	78.704	ENSPKIG00000007322	pabpc1l	99	70.853	Paramormyrops_kingsleyae
ENSG00000101104	PABPC1L	98	82.308	ENSPKIG00000016810	-	93	82.308	Paramormyrops_kingsleyae
ENSG00000101104	PABPC1L	98	82.407	ENSPSIG00000013289	PABPC1L	99	83.453	Pelodiscus_sinensis
ENSG00000101104	PABPC1L	98	86.364	ENSPMGG00000023117	pabpc1l	92	86.364	Periophthalmus_magnuspinnatus
ENSG00000101104	PABPC1L	96	77.027	ENSPMGG00000023121	-	93	66.667	Periophthalmus_magnuspinnatus
ENSG00000101104	PABPC1L	99	85.185	ENSPEMG00000020671	Pabpc1l	99	76.797	Peromyscus_maniculatus_bairdii
ENSG00000101104	PABPC1L	98	75.926	ENSPFOG00000013241	pabpc1l	99	69.044	Poecilia_formosa
ENSG00000101104	PABPC1L	98	75.926	ENSPLAG00000017490	-	99	69.206	Poecilia_latipinna
ENSG00000101104	PABPC1L	98	86.260	ENSPLAG00000023686	-	92	86.260	Poecilia_latipinna
ENSG00000101104	PABPC1L	98	75.926	ENSPMEG00000007677	pabpc1l	99	68.943	Poecilia_mexicana
ENSG00000101104	PABPC1L	98	86.260	ENSPMEG00000009185	-	89	86.260	Poecilia_mexicana
ENSG00000101104	PABPC1L	98	75.926	ENSPREG00000015886	pabpc1l	99	76.513	Poecilia_reticulata
ENSG00000101104	PABPC1L	54	80.000	ENSPREG00000015197	-	73	80.000	Poecilia_reticulata
ENSG00000101104	PABPC1L	100	99.186	ENSPPYG00000011042	PABPC1L	100	99.186	Pongo_abelii
ENSG00000101104	PABPC1L	82	93.750	ENSPCAG00000011787	-	75	93.750	Procavia_capensis
ENSG00000101104	PABPC1L	99	93.519	ENSPCOG00000020630	PABPC1L	99	89.786	Propithecus_coquereli
ENSG00000101104	PABPC1L	99	91.049	ENSPVAG00000012663	PABPC1L	99	85.574	Pteropus_vampyrus
ENSG00000101104	PABPC1L	98	76.235	ENSPNYG00000004101	pabpc1l	99	78.409	Pundamilia_nyererei
ENSG00000101104	PABPC1L	98	78.704	ENSPNAG00000021248	pabpc1l	99	63.301	Pygocentrus_nattereri
ENSG00000101104	PABPC1L	99	85.802	ENSRNOG00000012750	Pabpc1l	100	76.985	Rattus_norvegicus
ENSG00000101104	PABPC1L	100	98.697	ENSRBIG00000035381	PABPC1L	100	98.697	Rhinopithecus_bieti
ENSG00000101104	PABPC1L	100	98.534	ENSRROG00000044498	PABPC1L	100	98.534	Rhinopithecus_roxellana
ENSG00000101104	PABPC1L	100	96.091	ENSSBOG00000009532	-	100	96.091	Saimiri_boliviensis_boliviensis
ENSG00000101104	PABPC1L	100	76.190	ENSSBOG00000020828	-	92	77.564	Saimiri_boliviensis_boliviensis
ENSG00000101104	PABPC1L	95	82.653	ENSSHAG00000011446	PABPC1L	100	73.824	Sarcophilus_harrisii
ENSG00000101104	PABPC1L	98	79.938	ENSSFOG00015017304	pabpc1l	99	71.429	Scleropages_formosus
ENSG00000101104	PABPC1L	98	87.597	ENSSMAG00000010516	pabpc1l	98	87.597	Scophthalmus_maximus
ENSG00000101104	PABPC1L	99	77.160	ENSSDUG00000014743	pabpc1l	99	68.146	Seriola_dumerili
ENSG00000101104	PABPC1L	99	76.235	ENSSLDG00000006981	pabpc1l	95	76.712	Seriola_lalandi_dorsalis
ENSG00000101104	PABPC1L	98	81.173	ENSSPUG00000004233	PABPC1L	98	73.997	Sphenodon_punctatus
ENSG00000101104	PABPC1L	98	76.235	ENSSPAG00000017137	pabpc1l	99	64.250	Stegastes_partitus
ENSG00000101104	PABPC1L	99	93.210	ENSSSCG00000007382	PABPC1L	99	86.678	Sus_scrofa
ENSG00000101104	PABPC1L	98	81.250	ENSTGUG00000005114	PABPC1L	99	74.371	Taeniopygia_guttata
ENSG00000101104	PABPC1L	98	77.160	ENSTRUG00000011085	pabpc1l	97	67.045	Takifugu_rubripes
ENSG00000101104	PABPC1L	98	73.538	ENSTNIG00000017903	pabpc1l	98	65.974	Tetraodon_nigroviridis
ENSG00000101104	PABPC1L	99	94.178	ENSTBEG00000002851	PABPC1L	80	94.178	Tupaia_belangeri
ENSG00000101104	PABPC1L	98	90.123	ENSTTRG00000007618	PABPC1L	100	86.318	Tursiops_truncatus
ENSG00000101104	PABPC1L	99	94.444	ENSUAMG00000017682	PABPC1L	99	85.667	Ursus_americanus
ENSG00000101104	PABPC1L	96	92.105	ENSUMAG00000025436	PABPC1L	94	90.244	Ursus_maritimus
ENSG00000101104	PABPC1L	99	94.136	ENSVVUG00000018939	PABPC1L	99	92.885	Vulpes_vulpes
ENSG00000101104	PABPC1L	98	73.457	ENSXETG00000022831	pabpc1l	98	70.048	Xenopus_tropicalis
ENSG00000101104	PABPC1L	98	82.270	ENSXCOG00000005459	pabpc1l	99	82.270	Xiphophorus_couchianus
ENSG00000101104	PABPC1L	98	76.543	ENSXMAG00000017135	pabpc1l	99	69.206	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001556	oocyte maturation	-	IEA	Process
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003730	mRNA 3'-UTR binding	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0006338	chromatin remodeling	-	IEA	Process
GO:0006378	mRNA polyadenylation	-	IEA	Process
GO:0008143	poly(A) binding	21873635.	IBA	Function
GO:0008266	poly(U) RNA binding	21873635.	IBA	Function
GO:0010494	cytoplasmic stress granule	21873635.	IBA	Component
GO:0048096	chromatin-mediated maintenance of transcription	-	IEA	Process
GO:0051647	nucleus localization	-	IEA	Process
GO:0070062	extracellular exosome	23533145.	HDA	Component
GO:1990904	ribonucleoprotein complex	21873635.	IBA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr20	44921596	Splice_Region	rs556604143	A247A	0.39
ACC	chr20	44930579	Silent	rs766822017	Y364Y	0.42
BLCA	chr20	44933124	Silent	novel	I461I	1
BLCA	chr20	44912674	Missense_Mutation	novel	D70H	0.31
BLCA	chr20	44932328	Intron	novel		0.29
BLCA	chr20	44912760	Silent	rs781422254	V98V	0.08
BRCA	chr20	44910291	Missense_Mutation	NA	R50C	0.24
BRCA	chr20	44930609	Silent	NA	R374R	0.17
BRCA	chr20	44933178	Missense_Mutation	NA	Q479H	0.16
BRCA	chr20	44932276	Intron	novel		0.1
BRCA	chr20	44921639	Missense_Mutation	NA	Y262H	0.26
CESC	chr20	44938730	Silent	rs377541297	A611A	0.28
CESC	chr20	44935477	Missense_Mutation	novel	A511T	0.36
CESC	chr20	44938724	Silent	rs771610516	P609P	0.12
CESC	chr20	44932367	Missense_Mutation	novel	G422D	0.14
COAD	chr20	44919185	Missense_Mutation	novel	K216Q	0.16
COAD	chr20	44919221	Missense_Mutation	rs775637956	G228S	0.39
COAD	chr20	44916818	Silent	rs370332339	A150A	0.21
COAD	chr20	44938730	Silent	rs377541297	A611A	0.47
COAD	chr20	44933109	Frame_Shift_Del	NA	*P458Rfs24**	0.28
COAD	chr20	44916783	Missense_Mutation	NA	G139S	0.37
COAD	chr20	44930532	Missense_Mutation	NA	A349T	0.2
COAD	chr20	44930631	Missense_Mutation	NA	Y382H	0.39
COAD	chr20	44930580	Missense_Mutation	NA	V365M	0.24
COAD	chr20	44935451	Missense_Mutation	rs770697376	P502L	0.08
COAD	chr20	44924198	Missense_Mutation	rs553763669	I305T	0.1	PABP
COAD	chr20	44932495	Intron	novel		0.43
COAD	chr20	44921643	Missense_Mutation	rs747061139	A263V	0.26
COAD	chr20	44924258	Splice_Site	rs769281636	X324_splice	0.33
COAD	chr20	44921641	Silent	rs758644455	Y262Y	0.52
COAD	chr20	44938096	Missense_Mutation	rs762490644	T561A	0.14
COAD	chr20	44916760	Missense_Mutation	rs754003327	A131V	0.18
GBM	chr20	44912749	Nonsense_Mutation	novel	K95*	0.27
GBM	chr20	44912714	Missense_Mutation	rs374095444	R83H	0.35
GBM	chr20	44930620	Nonsense_Mutation	NA	L378*	0.47
GBM	chr20	44916781	Missense_Mutation	rs772807340	R138Q	0.27
GBM	chr20	44912737	Missense_Mutation	novel	P91A	0.18
GBM	chr20	44938134	Missense_Mutation	novel	E573D	0.18
GBM	chr20	44912747	Missense_Mutation	novel	R94H	0.19
GBM	chr20	44919032	Silent	novel	L210L	0.18
GBM	chr20	44932582	Intron	novel		0.4
HNSC	chr20	44938087	Missense_Mutation	rs368203711	D558N	0.4
HNSC	chr20	44930645	Silent	novel	L386L	0.13
KIRC	chr20	44932982	Intron	novel		0.4
LGG	chr20	44932359	Silent	rs757503898	A419A	0.19
LIHC	chr20	44938102	Missense_Mutation	NA	L563V	0.18
LIHC	chr20	44938125	Missense_Mutation	novel	M570I	0.08
LIHC	chr20	44921597	Missense_Mutation	novel	V248L	0.47
LUAD	chr20	44932397	Frame_Shift_Del	novel	*R434Gfs48**	0.24
LUAD	chr20	44924257	Splice_Site	NA	X324_splice	0.55
LUAD	chr20	44924181	Silent	novel	K299K	0.04
LUAD	chr20	44930663	Silent	novel	L392L	0.07
LUAD	chr20	44938138	Missense_Mutation	NA	D575H	0.12
LUAD	chr20	44910164	Silent	NA	G7G	0.31
LUAD	chr20	44919209	Missense_Mutation	novel	R224W	0.12
LUAD	chr20	44930541	Missense_Mutation	NA	E352Q	0.13
LUSC	chr20	44912846	Missense_Mutation	novel	S127F	0.22
LUSC	chr20	44935447	Missense_Mutation	rs772962499	R501W	0.53
LUSC	chr20	44918964	Missense_Mutation	novel	L188V	0.35
LUSC	chr20	44921644	Silent	novel	A263A	0.24
LUSC	chr20	44916819	Missense_Mutation	NA	A151S	0.28
LUSC	chr20	44919011	Silent	novel	D203D	0.05
LUSC	chr20	44930476	Missense_Mutation	novel	G330V	0.16
LUSC	chr20	44919015	Missense_Mutation	NA	Q205E	0.3
LUSC	chr20	44938044	Intron	novel		0.28
LUSC	chr20	44938138	Missense_Mutation	NA	D575H	0.31
LUSC	chr20	44918929	Missense_Mutation	novel	R176L	0.33
OV	chr20	44919258	Missense_Mutation	novel	K240R	0.09
OV	chr20	44938113	Missense_Mutation	novel	K566N	0.04
OV	chr20	44932235	Intron	novel		0.27
OV	chr20	44921730	Missense_Mutation	NA	Q292P	0.21
PAAD	chr20	44938051	Intron	novel		0.04
PRAD	chr20	44932263	Intron	novel		0.6
READ	chr20	44921724	Missense_Mutation	novel	R290H	0.56
READ	chr20	44930502	Missense_Mutation	novel	C339R	0.06
READ	chr20	44938703	Silent	NA	A602A	0.49
SARC	chr20	44936649	Missense_Mutation	novel	A522S	0.15
SARC	chr20	44932418	Missense_Mutation	novel	P439L	0.12
SARC	chr20	44918916	Missense_Mutation	novel	H172Y	0.17
SKCM	chr20	44930533	Missense_Mutation	novel	A349V	0.36
SKCM	chr20	44912746	Missense_Mutation	rs751324214	R94C	0.19
SKCM	chr20	44930648	Silent	NA	S387S	0.16
SKCM	chr20	44919202	Silent	novel	K221K	0.26
SKCM	chr20	44916818	Silent	rs370332339	A150A	0.21
SKCM	chr20	44921603	Missense_Mutation	NA	H250Y	0.29
SKCM	chr20	44932407	Nonsense_Mutation	NA	W435*	0.22
SKCM	chr20	44916839	Silent	novel	T157T	0.28
SKCM	chr20	44932468	Intron	novel		0.32
STAD	chr20	44921723	Missense_Mutation	rs201793065	R290C	0.12
STAD	chr20	44916760	Missense_Mutation	rs754003327	A131V	0.32
STAD	chr20	44924190	Silent	NA	D302D	0.57
STAD	chr20	44930549	Silent	rs778483862	N354N	0.35
STAD	chr20	44933109	Frame_Shift_Del	NA	*P458Rfs24**	0.27
STAD	chr20	44916791	Silent	NA	G141G	0.18
STAD	chr20	44930669	Frame_Shift_Del	novel	*L396Sfs31**	0.06
STAD	chr20	44938067	Missense_Mutation	rs370341823	R551H	0.11
STAD	chr20	44924205	Silent	rs749876401	D307D	0.18
STAD	chr20	44916820	Missense_Mutation	NA	A151V	0.32
STAD	chr20	44916757	Missense_Mutation	NA	V130A	0.27
UCEC	chr20	44938732	Missense_Mutation	novel	Y612C	0.31
UCEC	chr20	44912682	Missense_Mutation	NA	M72I	0.34
UCEC	chr20	44930510	Silent	novel	S341S	0.05
UCEC	chr20	44919221	Missense_Mutation	rs775637956	G228S	0.38
UCEC	chr20	44921669	Missense_Mutation	rs575662446	R272W	0.31
UCEC	chr20	44921596	Splice_Region	rs556604143	A247A	0.11
UCEC	chr20	44936647	Missense_Mutation	rs139734797	P521L	0.38
UCEC	chr20	44935447	Missense_Mutation	rs772962499	R501W	0.39
UCEC	chr20	44912827	Missense_Mutation	NA	T121A	0.38
UCEC	chr20	44921670	Missense_Mutation	rs763727369	R272Q	0.19
UCEC	chr20	44924249	Missense_Mutation	novel	S322N	0.4	PABP
UCEC	chr20	44910222	Missense_Mutation	novel	L27I	0.35
UCEC	chr20	44939240	3'Flank	novel		0.38
UCEC	chr20	44936702	Silent	rs550882592	A539A	0.28
UCEC	chr20	44912708	Missense_Mutation	novel	P81H	0.37
UCEC	chr20	44910238	Missense_Mutation	novel	S32Y	0.48
UCEC	chr20	44938724	Silent	rs771610516	P609P	0.53
UCEC	chr20	44919262	Silent	novel	H241H	0.54
UCEC	chr20	44932184	Intron	novel		0.27
UCEC	chr20	44910234	Missense_Mutation	novel	F31L	0.24
UCEC	chr20	44930570	Silent	NA	K361K	0.31
UCEC	chr20	44918990	Missense_Mutation	novel	K196N	0.16
UCEC	chr20	44912759	Missense_Mutation	novel	V98A	0.35
UCEC	chr20	44919229	Silent	NA	S230S	0.33
UCEC	chr20	44938119	Silent	rs781091821	T568T	0.36
UCEC	chr20	44930546	Missense_Mutation	novel	M353I	0.26
UCEC	chr20	44932551	Intron	novel		0.21
UCEC	chr20	44930535	Missense_Mutation	rs372472103	V350M	0.38
UCEC	chr20	44921597	Missense_Mutation	rs770340631	V248M	0.37
UCEC	chr20	44912762	Missense_Mutation	NA	G99D	0.29
UCEC	chr20	44933109	Frame_Shift_Del	NA	*P458Rfs24**	0.41
UCEC	chr20	44935495	Missense_Mutation	rs757755217	R517W	0.5
UCEC	chr20	44938174	Nonsense_Mutation	novel	E587*	0.33
UCEC	chr20	44916801	Missense_Mutation	NA	F145V	0.42
UCEC	chr20	44912752	Missense_Mutation	novel	S96P	0.4
UCEC	chr20	44930548	Missense_Mutation	NA	N354S	0.35
UCEC	chr20	44935434	Silent	novel	C496C	0.38
UCEC	chr20	44938118	Missense_Mutation	NA	T568M	0.44
UCEC	chr20	44912714	Missense_Mutation	rs374095444	R83H	0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LAML	DEL	0.0209	0.14746
LUAD	DEL	0.1221	0.18308
PRAD	AMP	0.0488	0.07085

Survival Analysis

Cancer	P-value	Q-value
SARC	0.016	Kaplan-Meier Survival Analysis
ACC	0.00038	Kaplan-Meier Survival Analysis
HNSC	0.036	Kaplan-Meier Survival Analysis
COAD	0.0033	Kaplan-Meier Survival Analysis
PAAD	0.011	Kaplan-Meier Survival Analysis
BLCA	0.00046	Kaplan-Meier Survival Analysis
UCEC	0.049	Kaplan-Meier Survival Analysis
LIHC	0.016	Kaplan-Meier Survival Analysis
DLBC	0.026	Kaplan-Meier Survival Analysis
LUAD	0.013	Kaplan-Meier Survival Analysis
UVM	0.013	Kaplan-Meier Survival Analysis