EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000101126 (Gene tree)
Gene ID: 23394
Gene Symbol: ADNP
Alias: KIAA0784|ADNP1
Full Name: activity dependent neuroprotector homeobox
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 42,506 bases
Position: chr20:50,888,916-50,931,421
Accession: 15766
RBP type: non-canonical RBP
Summary: Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000534467	ADNP-205	773	-	ENSP00000436181	172 (aa)	-	E9PQK8
ENST00000371602	ADNP-202	7360	XM_011528747	ENSP00000360662	1102 (aa)	XP_011527049	Q9H2P0
ENST00000621696	ADNP-206	6224	-	ENSP00000483881	1102 (aa)	-	Q9H2P0
ENST00000645081	ADNP-209	4773	-	ENSP00000495540	874 (aa)	-	A0A2R8Y6X0
ENST00000644386	ADNP-208	1198	-	ENSP00000493755	111 (aa)	-	A0A2R8YCL6
ENST00000396029	ADNP-203	6396	-	ENSP00000379346	1102 (aa)	-	Q9H2P0
ENST00000349014	ADNP-201	4662	-	ENSP00000342905	1102 (aa)	-	Q9H2P0
ENST00000642364	ADNP-207	628	-	ENSP00000493685	210 (aa)	-	A0A2R8Y469
ENST00000396032	ADNP-204	4979	-	ENSP00000379349	1102 (aa)	-	Q9H2P0

Gene Model

Click here to download ENSG00000101126's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000101126	Prostatic Neoplasms	5E-11	25217961
ENSG00000101126	Prostatic Neoplasms	2E-7	25217961

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000101126	rs12480328	20	50911385	T	Prostate cancer	25217961	[1.10-1.17]	1.13	EFO_0001663
ENSG00000101126	rs12480328	20	50911385	T	Prostate cancer	25217961	[1.08-1.17]	1.13	EFO_0001663

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000101126's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000101126	ADNP	100	98.837	ENSMUSG00000051149	Adnp	100	93.604	Mus_musculus
ENSG00000101126	ADNP	100	37.791	ENSMUSG00000053950	Adnp2	69	32.881	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	ISM	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0003682	chromatin binding	-	IEA	Function
GO:0005507	copper ion binding	-	IEA	Function
GO:0005515	protein binding	20562864.21888893.27705803.	IPI	Function
GO:0005615	extracellular space	-	IEA	Component
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0007614	short-term memory	-	IEA	Process
GO:0009743	response to carbohydrate	-	IEA	Process
GO:0010035	response to inorganic substance	-	IEA	Process
GO:0010629	negative regulation of gene expression	-	IEA	Process
GO:0010835	regulation of protein ADP-ribosylation	-	IEA	Process
GO:0019934	cGMP-mediated signaling	-	IEA	Process
GO:0030424	axon	-	IEA	Component
GO:0030425	dendrite	-	IEA	Component
GO:0031668	cellular response to extracellular stimulus	-	IEA	Process
GO:0032091	negative regulation of protein binding	-	IEA	Process
GO:0032147	activation of protein kinase activity	-	IEA	Process
GO:0033484	nitric oxide homeostasis	-	IEA	Process
GO:0042277	peptide binding	-	IEA	Function
GO:0043025	neuronal cell body	-	IEA	Component
GO:0043524	negative regulation of neuron apoptotic process	-	IEA	Process
GO:0044849	estrous cycle	-	IEA	Process
GO:0045773	positive regulation of axon extension	-	IEA	Process
GO:0048487	beta-tubulin binding	-	IEA	Function
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	-	IEA	Process
GO:0050805	negative regulation of synaptic transmission	-	IEA	Process
GO:0051965	positive regulation of synapse assembly	-	IEA	Process