EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000101161 (Gene tree)
Gene ID: 24148
Gene Symbol: PRPF6
Alias: TOM|bB152O15.1|ANT-1|U5-102K|Prp6|hPrp6|SNRNP102|RP60|C20orf14
Full Name: pre-mRNA processing factor 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 52,032 bases
Position: chr20:63,981,069-64,033,100
Accession: 15860
RBP type: canonical RBP
Summary: The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000266079	PRP1_N	PF06424.12	5.8e-57	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000266079	PRPF6-201	3044	XM_006723769	ENSP00000266079	941 (aa)	XP_006723832	O94906

Gene Model

Click here to download ENSG00000101161's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000101161	Platelet Function Tests	1.5800000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000101161's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000101161	PRPF6	100	92.349	ENSAPOG00000010395	prpf6	96	92.774	Acanthochromis_polyacanthus
ENSG00000101161	PRPF6	100	96.391	ENSAMEG00000001916	PRPF6	99	96.391	Ailuropoda_melanoleuca
ENSG00000101161	PRPF6	100	92.030	ENSACIG00000019862	prpf6	96	92.455	Amphilophus_citrinellus
ENSG00000101161	PRPF6	100	92.242	ENSAOCG00000012988	prpf6	96	92.667	Amphiprion_ocellaris
ENSG00000101161	PRPF6	100	85.547	ENSAPEG00000008301	prpf6	100	86.079	Amphiprion_percula
ENSG00000101161	PRPF6	100	91.711	ENSATEG00000005581	prpf6	96	92.136	Anabas_testudineus
ENSG00000101161	PRPF6	100	97.024	ENSACAG00000006464	PRPF6	95	97.024	Anolis_carolinensis
ENSG00000101161	PRPF6	100	99.150	ENSANAG00000012661	PRPF6	100	99.411	Aotus_nancymaae
ENSG00000101161	PRPF6	100	91.923	ENSACLG00000025875	prpf6	96	92.349	Astatotilapia_calliptera
ENSG00000101161	PRPF6	99	92.234	ENSAMXG00000001929	prpf6	96	92.660	Astyanax_mexicanus
ENSG00000101161	PRPF6	100	97.343	ENSBTAG00000011656	PRPF6	100	97.343	Bos_taurus
ENSG00000101161	PRPF6	100	99.150	ENSCJAG00000010616	PRPF6	100	99.150	Callithrix_jacchus
ENSG00000101161	PRPF6	100	97.662	ENSCAFG00000013165	PRPF6	100	97.662	Canis_familiaris
ENSG00000101161	PRPF6	100	97.662	ENSCAFG00020002050	PRPF6	100	97.662	Canis_lupus_dingo
ENSG00000101161	PRPF6	100	97.343	ENSCHIG00000018187	PRPF6	100	97.343	Capra_hircus
ENSG00000101161	PRPF6	100	98.300	ENSTSYG00000007814	PRPF6	100	98.300	Carlito_syrichta
ENSG00000101161	PRPF6	97	96.838	ENSCAPG00000015077	PRPF6	100	96.838	Cavia_aperea
ENSG00000101161	PRPF6	100	98.087	ENSCPOG00000007518	PRPF6	100	98.087	Cavia_porcellus
ENSG00000101161	PRPF6	100	95.855	ENSCCAG00000024564	PRPF6	100	95.855	Cebus_capucinus
ENSG00000101161	PRPF6	100	99.894	ENSCATG00000037473	PRPF6	100	99.894	Cercocebus_atys
ENSG00000101161	PRPF6	100	94.049	ENSCLAG00000003854	PRPF6	100	94.049	Chinchilla_lanigera
ENSG00000101161	PRPF6	100	94.826	ENSCSAG00000016742	PRPF6	100	94.826	Chlorocebus_sabaeus
ENSG00000101161	PRPF6	85	80.650	ENSCHOG00000003315	-	100	80.650	Choloepus_hoffmanni
ENSG00000101161	PRPF6	100	97.237	ENSCPBG00000013964	PRPF6	96	97.237	Chrysemys_picta_bellii
ENSG00000101161	PRPF6	99	73.044	ENSCING00000008817	-	99	73.044	Ciona_intestinalis
ENSG00000101161	PRPF6	100	99.894	ENSCANG00000038230	PRPF6	100	99.894	Colobus_angolensis_palliatus
ENSG00000101161	PRPF6	100	98.193	ENSCGRG00001022666	Prpf6	100	98.193	Cricetulus_griseus_chok1gshd
ENSG00000101161	PRPF6	100	86.716	ENSCSEG00000018561	prpf6	100	87.141	Cynoglossus_semilaevis
ENSG00000101161	PRPF6	100	92.349	ENSCVAG00000010550	prpf6	96	92.774	Cyprinodon_variegatus
ENSG00000101161	PRPF6	100	91.711	ENSDARG00000091367	prpf6	99	92.136	Danio_rerio
ENSG00000101161	PRPF6	100	96.812	ENSDNOG00000040544	PRPF6	100	96.812	Dasypus_novemcinctus
ENSG00000101161	PRPF6	91	97.079	ENSDORG00000005406	Prpf6	100	97.079	Dipodomys_ordii
ENSG00000101161	PRPF6	99	71.781	FBgn0036828	CG6841	98	72.210	Drosophila_melanogaster
ENSG00000101161	PRPF6	85	94.444	ENSETEG00000004447	PRPF6	85	94.444	Echinops_telfairi
ENSG00000101161	PRPF6	99	86.744	ENSEBUG00000008835	prpf6	99	86.744	Eptatretus_burgeri
ENSG00000101161	PRPF6	100	97.450	ENSEASG00005023115	PRPF6	100	97.450	Equus_asinus_asinus
ENSG00000101161	PRPF6	100	93.305	ENSECAG00000013983	PRPF6	100	93.305	Equus_caballus
ENSG00000101161	PRPF6	90	100.000	ENSEEUG00000000180	PRPF6	81	100.000	Erinaceus_europaeus
ENSG00000101161	PRPF6	100	90.967	ENSELUG00000001945	prpf6	93	90.967	Esox_lucius
ENSG00000101161	PRPF6	100	97.450	ENSFCAG00000001183	PRPF6	100	97.450	Felis_catus
ENSG00000101161	PRPF6	100	89.586	ENSFALG00000006046	-	97	89.586	Ficedula_albicollis
ENSG00000101161	PRPF6	100	97.237	ENSFALG00000010326	-	97	97.237	Ficedula_albicollis
ENSG00000101161	PRPF6	100	96.599	ENSFDAG00000006451	PRPF6	100	97.959	Fukomys_damarensis
ENSG00000101161	PRPF6	100	92.880	ENSFHEG00000000560	prpf6	96	92.880	Fundulus_heteroclitus
ENSG00000101161	PRPF6	100	88.584	ENSGMOG00000015622	prpf6	99	88.584	Gadus_morhua
ENSG00000101161	PRPF6	100	97.237	ENSGALG00000006001	PRPF6	100	97.237	Gallus_gallus
ENSG00000101161	PRPF6	100	87.354	ENSGAFG00000021109	prpf6	96	87.779	Gambusia_affinis
ENSG00000101161	PRPF6	100	90.861	ENSGACG00000002576	prpf6	99	90.861	Gasterosteus_aculeatus
ENSG00000101161	PRPF6	100	97.131	ENSGAGG00000008653	PRPF6	96	97.131	Gopherus_agassizii
ENSG00000101161	PRPF6	100	100.000	ENSGGOG00000016876	PRPF6	100	100.000	Gorilla_gorilla
ENSG00000101161	PRPF6	100	91.923	ENSHBUG00000004496	prpf6	96	92.349	Haplochromis_burtoni
ENSG00000101161	PRPF6	100	97.875	ENSHGLG00000009222	PRPF6	100	97.875	Heterocephalus_glaber_female
ENSG00000101161	PRPF6	97	97.819	ENSHGLG00100016600	PRPF6	100	97.819	Heterocephalus_glaber_male
ENSG00000101161	PRPF6	100	90.755	ENSHCOG00000011513	prpf6	96	91.180	Hippocampus_comes
ENSG00000101161	PRPF6	100	92.774	ENSIPUG00000004912	prpf6	96	92.774	Ictalurus_punctatus
ENSG00000101161	PRPF6	100	95.329	ENSSTOG00000002922	PRPF6	100	95.329	Ictidomys_tridecemlineatus
ENSG00000101161	PRPF6	100	98.087	ENSJJAG00000000836	Prpf6	100	98.087	Jaculus_jaculus
ENSG00000101161	PRPF6	100	91.923	ENSKMAG00000017800	prpf6	96	92.349	Kryptolebias_marmoratus
ENSG00000101161	PRPF6	100	91.392	ENSLBEG00000012582	prpf6	96	91.392	Labrus_bergylta
ENSG00000101161	PRPF6	100	93.943	ENSLOCG00000004827	prpf6	96	92.986	Lepisosteus_oculatus
ENSG00000101161	PRPF6	100	97.024	ENSLAFG00000005272	PRPF6	100	97.024	Loxodonta_africana
ENSG00000101161	PRPF6	100	99.894	ENSMFAG00000037542	PRPF6	100	99.894	Macaca_fascicularis
ENSG00000101161	PRPF6	100	93.206	ENSMMUG00000015558	PRPF6	98	99.653	Macaca_mulatta
ENSG00000101161	PRPF6	100	85.487	ENSMNEG00000045555	PRPF6	100	85.487	Macaca_nemestrina
ENSG00000101161	PRPF6	100	92.030	ENSMAMG00000010718	prpf6	96	92.455	Mastacembelus_armatus
ENSG00000101161	PRPF6	94	91.383	ENSMZEG00005026539	prpf6	100	91.837	Maylandia_zebra
ENSG00000101161	PRPF6	100	91.401	ENSMZEG00005015261	-	99	91.826	Maylandia_zebra
ENSG00000101161	PRPF6	97	97.165	ENSMGAG00000006634	PRPF6	100	97.165	Meleagris_gallopavo
ENSG00000101161	PRPF6	100	98.300	ENSMAUG00000013969	Prpf6	100	98.300	Mesocricetus_auratus
ENSG00000101161	PRPF6	87	97.689	ENSMICG00000017793	PRPF6	99	97.689	Microcebus_murinus
ENSG00000101161	PRPF6	100	98.193	ENSMOCG00000001701	Prpf6	100	98.193	Microtus_ochrogaster
ENSG00000101161	PRPF6	100	91.073	ENSMMOG00000020419	prpf6	100	91.498	Mola_mola
ENSG00000101161	PRPF6	99	98.397	ENSMODG00000017051	PRPF6	99	98.397	Monodelphis_domestica
ENSG00000101161	PRPF6	99	92.159	ENSMALG00000000089	prpf6	100	92.159	Monopterus_albus
ENSG00000101161	PRPF6	100	91.605	MGP_CAROLIEiJ_G0024814	Prpf6	100	100.000	Mus_caroli
ENSG00000101161	PRPF6	100	98.300	ENSMUSG00000002455	Prpf6	100	100.000	Mus_musculus
ENSG00000101161	PRPF6	100	98.300	MGP_PahariEiJ_G0026262	Prpf6	100	100.000	Mus_pahari
ENSG00000101161	PRPF6	100	98.300	MGP_SPRETEiJ_G0025741	Prpf6	100	100.000	Mus_spretus
ENSG00000101161	PRPF6	91	97.259	ENSMPUG00000008673	PRPF6	99	97.259	Mustela_putorius_furo
ENSG00000101161	PRPF6	100	98.193	ENSNGAG00000003365	Prpf6	100	98.193	Nannospalax_galili
ENSG00000101161	PRPF6	100	92.030	ENSNBRG00000015025	prpf6	96	92.455	Neolamprologus_brichardi
ENSG00000101161	PRPF6	100	99.894	ENSNLEG00000010208	PRPF6	100	99.894	Nomascus_leucogenys
ENSG00000101161	PRPF6	100	88.270	ENSMEUG00000009824	-	90	88.270	Notamacropus_eugenii
ENSG00000101161	PRPF6	100	92.667	ENSODEG00000004841	PRPF6	100	92.667	Octodon_degus
ENSG00000101161	PRPF6	100	91.923	ENSONIG00000017406	prpf6	96	92.349	Oreochromis_niloticus
ENSG00000101161	PRPF6	100	97.450	ENSOANG00000004920	PRPF6	100	97.450	Ornithorhynchus_anatinus
ENSG00000101161	PRPF6	99	96.137	ENSOCUG00000014151	PRPF6	100	96.137	Oryctolagus_cuniculus
ENSG00000101161	PRPF6	100	91.923	ENSORLG00000009592	prpf6	96	91.923	Oryzias_latipes
ENSG00000101161	PRPF6	100	92.030	ENSORLG00020001458	prpf6	96	92.030	Oryzias_latipes_hni
ENSG00000101161	PRPF6	100	92.030	ENSORLG00015018762	prpf6	96	92.030	Oryzias_latipes_hsok
ENSG00000101161	PRPF6	100	91.923	ENSOMEG00000012174	prpf6	96	92.349	Oryzias_melastigma
ENSG00000101161	PRPF6	100	90.446	ENSOGAG00000007573	PRPF6	100	90.446	Otolemur_garnettii
ENSG00000101161	PRPF6	100	96.918	ENSOARG00000008776	PRPF6	99	96.918	Ovis_aries
ENSG00000101161	PRPF6	100	100.000	ENSPPAG00000008686	PRPF6	100	100.000	Pan_paniscus
ENSG00000101161	PRPF6	100	97.450	ENSPPRG00000008497	PRPF6	100	97.450	Panthera_pardus
ENSG00000101161	PRPF6	97	97.383	ENSPTIG00000011184	PRPF6	97	97.383	Panthera_tigris_altaica
ENSG00000101161	PRPF6	100	100.000	ENSPTRG00000013765	PRPF6	100	100.000	Pan_troglodytes
ENSG00000101161	PRPF6	100	99.362	ENSPANG00000024135	PRPF6	100	99.362	Papio_anubis
ENSG00000101161	PRPF6	100	93.305	ENSPKIG00000005627	prpf6	99	93.730	Paramormyrops_kingsleyae
ENSG00000101161	PRPF6	94	97.279	ENSPSIG00000007717	PRPF6	100	97.279	Pelodiscus_sinensis
ENSG00000101161	PRPF6	100	89.703	ENSPMGG00000008925	prpf6	96	89.915	Periophthalmus_magnuspinnatus
ENSG00000101161	PRPF6	100	98.193	ENSPEMG00000016036	Prpf6	100	98.193	Peromyscus_maniculatus_bairdii
ENSG00000101161	PRPF6	99	87.779	ENSPMAG00000006144	prpf6	99	87.779	Petromyzon_marinus
ENSG00000101161	PRPF6	100	97.768	ENSPCIG00000017909	PRPF6	100	97.768	Phascolarctos_cinereus
ENSG00000101161	PRPF6	100	92.242	ENSPFOG00000006431	prpf6	96	92.667	Poecilia_formosa
ENSG00000101161	PRPF6	100	92.136	ENSPLAG00000005974	prpf6	96	92.561	Poecilia_latipinna
ENSG00000101161	PRPF6	100	92.349	ENSPMEG00000009977	prpf6	96	92.774	Poecilia_mexicana
ENSG00000101161	PRPF6	100	92.242	ENSPREG00000017993	prpf6	92	92.667	Poecilia_reticulata
ENSG00000101161	PRPF6	100	99.469	ENSPPYG00000011256	PRPF6	100	99.469	Pongo_abelii
ENSG00000101161	PRPF6	95	99.673	ENSPCAG00000006536	PRPF6	88	99.673	Procavia_capensis
ENSG00000101161	PRPF6	100	97.768	ENSPCOG00000016881	PRPF6	100	97.768	Propithecus_coquereli
ENSG00000101161	PRPF6	100	91.392	ENSPVAG00000014316	PRPF6	100	91.392	Pteropus_vampyrus
ENSG00000101161	PRPF6	100	75.478	ENSPNYG00000001939	prpf6	96	80.765	Pundamilia_nyererei
ENSG00000101161	PRPF6	100	92.561	ENSPNAG00000015606	prpf6	96	92.986	Pygocentrus_nattereri
ENSG00000101161	PRPF6	100	98.193	ENSRNOG00000051498	Prpf6	100	98.193	Rattus_norvegicus
ENSG00000101161	PRPF6	100	99.894	ENSRBIG00000043613	PRPF6	100	99.894	Rhinopithecus_bieti
ENSG00000101161	PRPF6	100	96.508	ENSRROG00000040969	PRPF6	100	96.508	Rhinopithecus_roxellana
ENSG00000101161	PRPF6	91	95.398	ENSSBOG00000020632	PRPF6	91	95.398	Saimiri_boliviensis_boliviensis
ENSG00000101161	PRPF6	100	97.768	ENSSHAG00000016810	PRPF6	100	97.768	Sarcophilus_harrisii
ENSG00000101161	PRPF6	99	93.555	ENSSFOG00015020859	prpf6	100	93.985	Scleropages_formosus
ENSG00000101161	PRPF6	100	91.286	ENSSMAG00000008112	prpf6	96	91.286	Scophthalmus_maximus
ENSG00000101161	PRPF6	100	91.923	ENSSDUG00000016142	prpf6	96	92.349	Seriola_dumerili
ENSG00000101161	PRPF6	100	91.923	ENSSLDG00000025283	prpf6	100	88.842	Seriola_lalandi_dorsalis
ENSG00000101161	PRPF6	94	96.032	ENSSPUG00000018260	PRPF6	100	96.032	Sphenodon_punctatus
ENSG00000101161	PRPF6	100	91.923	ENSSPAG00000015850	prpf6	96	92.349	Stegastes_partitus
ENSG00000101161	PRPF6	100	97.131	ENSSSCG00000029119	PRPF6	100	96.939	Sus_scrofa
ENSG00000101161	PRPF6	100	97.343	ENSTGUG00000007221	PRPF6	99	97.343	Taeniopygia_guttata
ENSG00000101161	PRPF6	100	90.861	ENSTRUG00000002920	prpf6	96	91.286	Takifugu_rubripes
ENSG00000101161	PRPF6	100	84.567	ENSTNIG00000017873	prpf6	100	84.989	Tetraodon_nigroviridis
ENSG00000101161	PRPF6	89	98.895	ENSTBEG00000005348	PRPF6	85	98.895	Tupaia_belangeri
ENSG00000101161	PRPF6	100	96.599	ENSTTRG00000013068	PRPF6	100	96.599	Tursiops_truncatus
ENSG00000101161	PRPF6	98	96.087	ENSUMAG00000021631	PRPF6	98	96.087	Ursus_maritimus
ENSG00000101161	PRPF6	100	97.662	ENSVVUG00000014948	PRPF6	100	97.662	Vulpes_vulpes
ENSG00000101161	PRPF6	100	95.005	ENSXETG00000012054	prpf6	97	95.430	Xenopus_tropicalis
ENSG00000101161	PRPF6	100	92.349	ENSXCOG00000008082	prpf6	96	92.774	Xiphophorus_couchianus
ENSG00000101161	PRPF6	100	92.349	ENSXMAG00000015581	prpf6	96	92.774	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000244	spliceosomal tri-snRNP complex assembly	21873635.	IBA	Process
GO:0000244	spliceosomal tri-snRNP complex assembly	10788320.	IC	Process
GO:0000244	spliceosomal tri-snRNP complex assembly	15257298.	IMP	Process
GO:0000245	spliceosomal complex assembly	10788320.	NAS	Process
GO:0000375	RNA splicing, via transesterification reactions	10788320.	NAS	Process
GO:0000398	mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000398	mRNA splicing, via spliceosome	10788320.11991638.15257298.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	21549338.28781166.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003713	transcription coactivator activity	16414017.	IGI	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003723	RNA binding	20797886.	IDA	Function
GO:0005515	protein binding	12620389.15840814.22365833.27173435.	IPI	Function
GO:0005634	nucleus	16414017.28781166.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	10788320.	NAS	Component
GO:0005682	U5 snRNP	10788320.	IDA	Component
GO:0006403	RNA localization	20797886.	IMP	Process
GO:0008380	RNA splicing	10788320.	NAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016607	nuclear speck	21549338.	IDA	Component
GO:0043021	ribonucleoprotein complex binding	10788320.	IDA	Function
GO:0045944	positive regulation of transcription by RNA polymerase II	16414017.	IDA	Process
GO:0046540	U4/U6 x U5 tri-snRNP complex	21873635.	IBA	Component
GO:0046540	U4/U6 x U5 tri-snRNP complex	10788320.	IDA	Component
GO:0050681	androgen receptor binding	16414017.	IPI	Function
GO:0071005	U2-type precatalytic spliceosome	28781166.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	21873635.	IBA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component