EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000101182 (Gene tree)
Gene ID: 5688
Gene Symbol: PSMA7
Alias: XAPC7|C6|HSPC|RC6-1
Full Name: proteasome subunit alpha 7
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 6,732 bases
Position: chr20:62,136,727-62,143,458
Accession: 9536
RBP type: non-canonical RBP
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000442551	PSMA7-204	685	-	ENSP00000397047	187 (aa)	-	H0Y586
ENST00000370858	PSMA7-201	925	-	ENSP00000359895	149 (aa)	-	O14818
ENST00000486193	PSMA7-206	548	-	-	- (aa)	-	-
ENST00000370861	PSMA7-202	773	-	ENSP00000359898	178 (aa)	-	O14818
ENST00000370873	PSMA7-203	996	-	ENSP00000359910	248 (aa)	-	O14818
ENST00000484488	PSMA7-205	1023	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000101182's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03050	Proteasome	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000101182's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0000502	proteasome complex	17323924.	IDA	Component
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	Process
GO:0004175	endopeptidase activity	21873635.	IBA	Function
GO:0004298	threonine-type endopeptidase activity	-	IEA	Function
GO:0005515	protein binding	12376572.14733938.15225636.16251969.17948026.19416853.21900206.21988832.25599644.29568061.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005839	proteasome core complex	21873635.	IBA	Component
GO:0005839	proteasome core complex	-	ISS	Component
GO:0006521	regulation of cellular amino acid metabolic process	-	TAS	Process
GO:0010498	proteasomal protein catabolic process	21873635.	IBA	Process
GO:0010499	proteasomal ubiquitin-independent protein catabolic process	21873635.	IBA	Process
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016032	viral process	-	IEA	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0019773	proteasome core complex, alpha-subunit complex	21873635.	IBA	Component
GO:0019773	proteasome core complex, alpha-subunit complex	-	ISS	Component
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0038061	NIK/NF-kappaB signaling	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0042802	identical protein binding	15225636.17948026.	IPI	Function
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	Process
GO:0070062	extracellular exosome	20458337.23533145.	HDA	Component
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0098794	postsynapse	21873635.	IBA	Component
GO:1901990	regulation of mitotic cell cycle phase transition	-	TAS	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18202793	The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer.	Oncol Rep	2008 Feb	Hu XT	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr20	62137416	Missense_Mutation	novel	S201L	0.33
BLCA	chr20	62139877	Silent	NA	I84I	0.41
BLCA	chr20	62136822	3'UTR	novel		0.08
BLCA	chr20	62143226	Silent	novel	V26V	0.22
BRCA	chr20	62139832	Silent	NA	E99E	0.14
BRCA	chr20	62139832	Silent	NA	E99E	0.33
BRCA	chr20	62139097	Missense_Mutation	NA	S150W	0.21
CESC	chr20	62139157	Missense_Mutation	novel	S130F	0.22
COAD	chr20	62136907	Nonsense_Mutation	novel	E233*	0.17
COAD	chr20	62138227	Missense_Mutation	rs12041	E179K	0.31
ESCA	chr20	62136942	Missense_Mutation	novel	N221S	0.52
GBM	chr20	62140845	Missense_Mutation	novel	D66H	0.08
GBM	chr20	62136851	3'UTR	novel		0.1
GBM	chr20	62137375	Frame_Shift_Del	novel	*Q215Nfs6**	0.19
GBM	chr20	62139110	Missense_Mutation	novel	Q146E	0.16
HNSC	chr20	62136776	3'UTR	novel		0.22
KIRP	chr20	62139785	Missense_Mutation	NA	K115T	0.33
LIHC	chr20	62138235	Missense_Mutation	NA	Y176C	0.69
LUAD	chr20	62138209	Missense_Mutation	novel	D185Y	0.24
LUAD	chr20	62140942	Splice_Region	novel	V33V	0.06
LUAD	chr20	62139773	Splice_Region	novel		0.16
LUAD	chr20	62139780	Splice_Site	novel	X116_splice	0.33
LUSC	chr20	62143334	5'UTR	novel		0.33
OV	chr20	62140826	Missense_Mutation	novel	A72G	0.14
OV	chr20	62140906	Nonsense_Mutation	novel	V45_E46insPTLFVLSL	0.11
OV	chr20	62137424	Nonsense_Mutation	novel	*V199Rfs9**	0.2
OV	chr20	62138248	Missense_Mutation	novel	L172M	0.07
OV	chr20	62139857	Missense_Mutation	novel	C91Y	0.22
OV	chr20	62139755	Intron	novel		0.14
OV	chr20	62139828	Missense_Mutation	novel	P101T	0.1
PCPG	chr20	62140881	Nonsense_Mutation	novel	Q54*	0.38
READ	chr20	62138209	Missense_Mutation	novel	D185Y	0.31
SKCM	chr20	62136757	3'UTR	novel		0.28
SKCM	chr20	62139748	Intron	novel		0.11
STAD	chr20	62139845	Missense_Mutation	rs757469011	R95Q	0.26
STAD	chr20	62136875	Frame_Shift_Del	novel	*N239Tfs?**	0.11
STAD	chr20	62139165	Silent	rs374005966	F127F	0.42
STAD	chr20	62138257	Missense_Mutation	rs772079136	R169C	0.2
STAD	chr20	62139176	Missense_Mutation	rs766775552	R124C	0.09
STAD	chr20	62139707	Intron	novel		0.18
STAD	chr20	62139190	Missense_Mutation	NA	T119M	0.17
STAD	chr20	62139176	Missense_Mutation	rs766775552	R124C	0.16
UCEC	chr20	62139757	Intron	novel		0.1
UCEC	chr20	62140910	Missense_Mutation	novel	G44D	0.53
UCEC	chr20	62138266	Missense_Mutation	novel	K166E	0.46
UCEC	chr20	62140935	Nonsense_Mutation	novel	R36*	0.34
UCEC	chr20	62136809	3'UTR	novel		0.04
UCEC	chr20	62138227	Missense_Mutation	rs12041	E179K	0.57
UCEC	chr20	62139169	Frame_Shift_Del	novel	*P126Rfs36**	0.4
UCEC	chr20	62137381	Nonsense_Mutation	novel	R213*	0.33
UCEC	chr20	62139196	Missense_Mutation	rs755710917	R117H	0.46
UCEC	chr20	62136916	Missense_Mutation	novel	A230T	0.55
UCEC	chr20	62139137	Missense_Mutation	NA	D137N	0.46
UCEC	chr20	62139112	Missense_Mutation	NA	Y145C	0.28
UCEC	chr20	62139124	Missense_Mutation	novel	T141I	0.34
UCEC	chr20	62136886	Missense_Mutation	novel	E240K	0.39
UCEC	chr20	62136950	Splice_Site	novel	X219_splice	0.08
UCEC	chr20	62136760	3'UTR	novel		0.09
UCEC	chr20	62139769	Intron	novel		0.21
UCEC	chr20	62139137	Missense_Mutation	NA	D137N	0.48
UCEC	chr20	62137376	Silent	NA	D214D	0.3
UCEC	chr20	62139795	Missense_Mutation	novel	A112T	0.54
UCEC	chr20	62137416	Missense_Mutation	novel	S201L	0.55
UCS	chr20	62138227	Missense_Mutation	rs12041	E179K	0.46

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
COAD	AMP	0.7029	0.030224
HNSC	AMP	0.2835	0.018866
LIHC	AMP	0.2892	0.013414
LUAD	AMP	0.3605	6.849e-09
LUSC	AMP	0.3633	3.0539e-09
PRAD	AMP	0.0569	0.07085
READ	AMP	0.8606	0.033971
SARC	AMP	0.3191	0.033553
SKCM	AMP	0.4469	0.058021
STAD	AMP	0.585	3.3128e-05
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.009	Kaplan-Meier Survival Analysis
MESO	0.0025	Kaplan-Meier Survival Analysis
ACC	0.013	Kaplan-Meier Survival Analysis
HNSC	0.0065	Kaplan-Meier Survival Analysis
ESCA	0.036	Kaplan-Meier Survival Analysis
BLCA	0.036	Kaplan-Meier Survival Analysis
READ	0.042	Kaplan-Meier Survival Analysis
LAML	0.0001	Kaplan-Meier Survival Analysis
UCEC	0.027	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.00012	Kaplan-Meier Survival Analysis
UVM	0.0001	Kaplan-Meier Survival Analysis
OV	0.018	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742