EuRBPDB

Description

Ensembl ID: ENSG00000101191 (Gene tree)
Gene ID: 11083
Gene Symbol: DIDO1
Alias: DIO1|dJ885L7.8|FLJ11265|KIAA0333|DIO-1|BYE1|C20orf158|DATF1
Full Name: death inducer-obliterator 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 60,219 bases
Position: chr20:62,877,734-62,937,952
Accession: 2680
RBP type: non-canonical RBP
Summary: Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24003114	Structures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue.	Proc Natl Acad Sci U S A	2013 Sep 17	Kinkelin K	doi: 10.1073/pnas.1311010110

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000395343	DIDO1-207	8477	XM_011528504	ENSP00000378752	2240 (aa)	XP_011526806	Q9BTC0
ENST00000354665	DIDO1-202	2707	-	ENSP00000346692	562 (aa)	-	Q9BTC0
ENST00000395340	DIDO1-206	7551	-	ENSP00000378749	1189 (aa)	-	Q9BTC0
ENST00000370368	DIDO1-204	2704	-	ENSP00000359394	562 (aa)	-	Q9BTC0
ENST00000370371	DIDO1-205	2833	-	ENSP00000359397	562 (aa)	-	Q9BTC0
ENST00000370366	DIDO1-203	2383	-	ENSP00000359391	544 (aa)	-	Q9BTC0
ENST00000266070	DIDO1-201	8574	XM_011528505	ENSP00000266070	2240 (aa)	XP_011526807	Q9BTC0

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000101191	rs13040088	20	62917850	G	Menopause (age at onset)	26414677	[0.12-0.2] years decrease	0.16	EFO_0004704
ENSG00000101191	rs10854167	20	62901687	?	Age at menopause	30595370			EFO_0004704
ENSG00000101191	rs73619441	20	62933549	?	Fat-free mass	30593698	[0.11-0.24] unit decrease	0.17466	EFO_0004995
ENSG00000101191	rs73619441	20	62933549	?	Fat-free mass	30593698	[0.086-0.22] unit decrease	0.15286	EFO_0004995

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000101191	DIDO1	99	78.517	ENSMUSG00000038914	Dido1	98	79.592	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0005819	spindle	-	IEA	Component
GO:0006351	transcription, DNA-templated	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0097190	apoptotic signaling pathway	-	IEA	Process