EuRBPDB

Description

Ensembl ID: ENSG00000101310 (Gene tree)
Gene ID: 10483
Gene Symbol: SEC23B
Alias: CDA-II|CDAII|HEMPAS|CDAN2
Full Name: Sec23 homolog B, coat complex II component
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 53,934 bases
Position: chr20:18,507,482-18,561,415
Accession: 10702
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000450074	SEC23B-206	1133	-	ENSP00000403971	331 (aa)	-	Q5QPE2
ENST00000494645	SEC23B-208	473	-	-	- (aa)	-	-
ENST00000474619	SEC23B-207	232	-	ENSP00000496118	32 (aa)	-	A0A2R8YF30
ENST00000643747	SEC23B-209	2680	-	ENSP00000496460	749 (aa)	-	A0A2R8YFH5
ENST00000645851	SEC23B-210	572	-	ENSP00000496507	59 (aa)	-	A0A2R8Y7S7
ENST00000262544	SEC23B-201	3176	-	ENSP00000262544	767 (aa)	-	Q15437
ENST00000377465	SEC23B-203	3351	-	ENSP00000366685	767 (aa)	-	Q15437
ENST00000422877	SEC23B-205	834	-	ENSP00000409882	246 (aa)	-	Q5QPE1
ENST00000646240	SEC23B-211	503	-	ENSP00000495008	52 (aa)	-	A0A2R8Y633
ENST00000336714	SEC23B-202	3464	-	ENSP00000338844	767 (aa)	-	Q15437
ENST00000377475	SEC23B-204	3484	XM_017027593	ENSP00000366695	767 (aa)	XP_016883082	Q15437
ENST00000650089	SEC23B-212	3026	-	ENSP00000497473	767 (aa)	-	UPI0000135455

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000101310	rs3736775	20	18548589	?	Neuroticism	30595370			EFO_0007660

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000101310	SEC23B	100	81.356	FBgn0262125	Sec23	99	73.930	Drosophila_melanogaster
ENSG00000101310	SEC23B	100	96.875	ENSG00000100934	SEC23A	100	92.500	Homo_sapiens
ENSG00000101310	SEC23B	99	53.676	YPR181C		99	50.065	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0005096	GTPase activator activity	21873635.	IBA	Function
GO:0005515	protein binding	16189514.21516116.25416956.26522472.27551091.	IPI	Function
GO:0005783	endoplasmic reticulum	26522472.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	IEA	Component
GO:0005829	cytosol	-	IEA	Component
GO:0006886	intracellular protein transport	-	IEA	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0012505	endomembrane system	21364188.	IDA	Component
GO:0030127	COPII vesicle coat	21873635.	IBA	Component
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0070971	endoplasmic reticulum exit site	21873635.	IBA	Component
GO:0090110	cargo loading into COPII-coated vesicle	21873635.	IBA	Process