EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000101347 (Gene tree)
Gene ID: 25939
Gene Symbol: SAMHD1
Alias: SBBI88|Mg11|HDDC1|MOP-5|AGS5
Full Name: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 62,129 bases
Position: chr20:36,889,773-36,951,901
Accession: 15925
RBP type: non-canonical RBP
Summary: This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23364794	Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction.	J Biol Chem	2013 Mar 22	Beloglazova N	doi: 10.1074/jbc.M112.431148
23158101	Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.	Virology	2013 Feb 5	White TE	doi: 10.1016/j.virol.2012.10.029
26733158	Functional organization of human SAMHD1 and mechanisms of HIV-1 restriction.	Biol Chem	2016 Apr	Ahn J	doi: 10.1515/hsz-2015-0260.
22461318	SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutieres syndrome-associated mutations.	Hum Mutat	2012 Jul	Goncalves A	doi: 10.1002/humu.22087
26101257	SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity.	Nucleic Acids Res	2015 Jul 27	Seamon KJ	doi: 10.1093/nar/gkv633
29793958	SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4+ T Cells.	J Virol	2018 Jul 17	Antonucci JM	doi: 10.1128/JVI.00292-18

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000646673	SAMHD1-221	5298	-	ENSP00000493536	626 (aa)	-	Q9Y3Z3
ENST00000644114	SAMHD1-213	1735	-	ENSP00000494354	413 (aa)	-	A0A2R8YD90
ENST00000646066	SAMHD1-219	1671	-	ENSP00000495432	556 (aa)	-	Q9Y3Z3
ENST00000643907	SAMHD1-211	540	-	-	- (aa)	-	-
ENST00000644688	SAMHD1-216	951	-	-	- (aa)	-	-
ENST00000647095	SAMHD1-225	5492	-	-	- (aa)	-	-
ENST00000643003	SAMHD1-206	546	-	-	- (aa)	-	-
ENST00000643161	SAMHD1-208	816	-	-	- (aa)	-	-
ENST00000646866	SAMHD1-222	975	-	ENSP00000495737	129 (aa)	-	A0A2R8Y755
ENST00000262878	SAMHD1-201	4334	XM_005260384	ENSP00000262878	591 (aa)	XP_005260441	Q9Y3Z3
ENST00000646904	SAMHD1-224	4672	-	ENSP00000494823	285 (aa)	-	A0A2R8YF51
ENST00000646869	SAMHD1-223	3209	-	ENSP00000495667	626 (aa)	-	Q9Y3Z3
ENST00000646121	SAMHD1-220	643	-	ENSP00000495645	89 (aa)	-	A0A2R8YG48
ENST00000645444	SAMHD1-218	3763	-	ENSP00000495381	212 (aa)	-	A0A2R8Y6J9
ENST00000645033	SAMHD1-217	4680	-	ENSP00000494520	289 (aa)	-	A0A2R8Y5D2
ENST00000643243	SAMHD1-209	1260	-	-	- (aa)	-	-
ENST00000465985	SAMHD1-202	513	-	ENSP00000496075	104 (aa)	-	A0A2R8YF18
ENST00000644250	SAMHD1-214	1824	-	ENSP00000493810	44 (aa)	-	A0A2R8YDI8
ENST00000647459	SAMHD1-227	3146	-	-	- (aa)	-	-
ENST00000644370	SAMHD1-215	527	-	-	- (aa)	-	-
ENST00000643918	SAMHD1-212	2967	XM_011528761	ENSP00000493928	589 (aa)	XP_011527063	A0A2R8YCS7
ENST00000642246	SAMHD1-204	4508	-	ENSP00000494979	127 (aa)	-	A0A2R8Y7R5
ENST00000642186	SAMHD1-203	3312	-	ENSP00000494436	289 (aa)	-	A0A2R8Y5D2
ENST00000647163	SAMHD1-226	3440	-	ENSP00000494313	289 (aa)	-	A0A2R8Y5D2
ENST00000642616	SAMHD1-205	1424	-	ENSP00000494271	156 (aa)	-	A0A2R8Y586
ENST00000643078	SAMHD1-207	1395	-	ENSP00000496474	127 (aa)	-	A0A2R8Y7R5
ENST00000643825	SAMHD1-210	522	-	ENSP00000495448	139 (aa)	-	A0A2R8YFV6

Gene Model

Click here to download ENSG00000101347's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05170	Human immunodeficiency virus 1 infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000101347	Platelet Function Tests	7.5755000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000101347	rs11696169	20	36923214	C	Low tan response	29739929	[0.088-0.284] unit increase	0.186	EFO_0004279
ENSG00000101347	rs6030369	20	36949294	?	Hair color	30595370			EFO_0007822

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000101347's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000724	double-strand break repair via homologous recombination	28834754.29670289.	IDA	Process
GO:0003676	nucleic acid binding	22461318.	IDA	Function
GO:0003697	single-stranded DNA binding	29670289.	IDA	Function
GO:0003723	RNA binding	22461318.	IDA	Function
GO:0004540	ribonuclease activity	25038827.	IDA	Function
GO:0004540	ribonuclease activity	29670289.	IDA	Function
GO:0005515	protein binding	21903422.23414517.23601106.28834754.28871089.29670289.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	19525956.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006203	dGTP catabolic process	21873635.	IBA	Process
GO:0006203	dGTP catabolic process	24217394.	IDA	Process
GO:0006955	immune response	11064105.	NAS	Process
GO:0006974	cellular response to DNA damage stimulus	28834754.29670289.	IDA	Process
GO:0008270	zinc ion binding	24217394.	IDA	Function
GO:0008832	dGTPase activity	21873635.	IBA	Function
GO:0008832	dGTPase activity	23601106.24217394.26294762.	IDA	Function
GO:0009264	deoxyribonucleotide catabolic process	23601106.26294762.	IDA	Process
GO:0009264	deoxyribonucleotide catabolic process	-	TAS	Process
GO:0016446	somatic hypermutation of immunoglobulin genes	-	ISS	Process
GO:0016793	triphosphoric monoester hydrolase activity	23601106.26294762.	IDA	Function
GO:0032567	dGTP binding	24141705.	IDA	Function
GO:0035861	site of double-strand break	28834754.29670289.	IDA	Component
GO:0042802	identical protein binding	22056990.24141705.	IPI	Function
GO:0045088	regulation of innate immune response	21873635.	IBA	Process
GO:0045088	regulation of innate immune response	29670289.	IDA	Process
GO:0045088	regulation of innate immune response	19525956.	IMP	Process
GO:0046061	dATP catabolic process	24141705.	IDA	Process
GO:0051289	protein homotetramerization	23601106.24217394.26294762.	IDA	Process
GO:0051607	defense response to virus	21873635.	IBA	Process
GO:0051607	defense response to virus	23601106.26294762.	IDA	Process
GO:0051607	defense response to virus	19525956.	IMP	Process
GO:0060337	type I interferon signaling pathway	-	TAS	Process
GO:0060339	negative regulation of type I interferon-mediated signaling pathway	29670289.	IDA	Process
GO:0090501	RNA phosphodiester bond hydrolysis	-	IEA	Process
GO:0097197	tetraspanin-enriched microdomain	28871089.	IDA	Component
GO:0110025	DNA strand resection involved in replication fork processing	28834754.29670289.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25449277	SAMHD1 is down regulated in lung cancer by methylation and inhibits tumor cell proliferation.	Biochem Biophys Res Commun	2014 Dec 12	Wang JL	doi: 10.1016/j.bbrc.2014.10.153
29352181	SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia.	Blood Cancer J	2018 Jan 19	Johansson P	doi: 10.1038/s41408-017-0036-5.
27071091	Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance.	Proc Natl Acad Sci U S A	2016 Apr 26	Rentoft M	doi: 10.1073/pnas.1519128113
26416562	Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications.	Mol Cancer	2015 Sep 29	Kohnken R	doi: 10.1186/s12943-015-0446-6.
24317272	Identification of natural splice variants of SAMHD1 in virus-infected HCC.	Oncol Rep	2014 Feb	Shi Y	doi: 10.3892/or.2013.2895

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr20	36951508	Missense_Mutation	NA	G46S	0.18
BLCA	chr20	36912503	Missense_Mutation	NA	R371H	0.06
BLCA	chr20	36892983	Silent	NA	L610L	0.36
BLCA	chr20	36905492	Frame_Shift_Ins	novel	*L428Sfs8**	0.42
BLCA	chr20	36951564	Missense_Mutation	NA	S27F	0.43
BLCA	chr20	36916727	Missense_Mutation	novel	D353H	0.14
BLCA	chr20	36904245	Splice_Site	novel	X471_splice	0.36
BLCA	chr20	36919448	Silent	rs140804613	Q256Q	0.24
BRCA	chr20	36897957	In_Frame_Ins	novel	V537_S538insH	0.04
BRCA	chr20	36897958	Frame_Shift_Ins	novel	*V537Dfs25**	0.03
BRCA	chr20	36892981	Missense_Mutation	rs150713148	R611Q	0.08
BRCA	chr20	36919470	Missense_Mutation	NA	G249E	0.38
BRCA	chr20	36941074	Nonsense_Mutation	novel	Q105*	0.07
BRCA	chr20	36893057	Missense_Mutation	NA	V586I	0.11
BRCA	chr20	36927226	Missense_Mutation	NA	D218H	0.29
BRCA	chr20	36905487	Missense_Mutation	NA	E429D	0.11
BRCA	chr20	36951763	5'UTR	novel		0.12
CESC	chr20	36935052	Missense_Mutation	novel	H162Q	0.47
COAD	chr20	36897834	Silent	NA	F578F	0.27
COAD	chr20	36935129	Missense_Mutation	rs751309717	D137N	0.1
COAD	chr20	36898475	Missense_Mutation	NA	A525T	0.21
COAD	chr20	36905422	Missense_Mutation	NA	R451P	0.19
COAD	chr20	36935104	Missense_Mutation	rs515726145	R145Q	0.24
COAD	chr20	36916742	Missense_Mutation	rs761561066	R348C	0.28
COAD	chr20	36935141	Missense_Mutation	NA	V133I	0.25
COAD	chr20	36935141	Missense_Mutation	NA	V133I	0.21
COAD	chr20	36912518	Missense_Mutation	NA	R366H	0.4
COAD	chr20	36893026	Frame_Shift_Del	NA	*K596Rfs35**	0.26
COAD	chr20	36904171	Missense_Mutation	NA	D497Y	0.36
COAD	chr20	36916771	Missense_Mutation	NA	A338V	0.2
COAD	chr20	36892711	3'UTR	novel		0.35
COAD	chr20	36916772	Missense_Mutation	NA	A338T	0.09
DLBC	chr20	36930785	Missense_Mutation	novel	Q200H	0.48
ESCA	chr20	36911265	Missense_Mutation	novel	R408P	0.06
ESCA	chr20	36905476	Missense_Mutation	novel	S433C	0.07
GBM	chr20	36951774	5'UTR	novel		0.6
GBM	chr20	36919486	Missense_Mutation	NA	L244F	0.36
GBM	chr20	36897834	Missense_Mutation	novel	F578L	0.23
GBM	chr20	36951534	Missense_Mutation	novel	E37A	0.04
HNSC	chr20	36930786	Missense_Mutation	rs758250759	Q200R	0.31
HNSC	chr20	36951628	In_Frame_Ins	novel	D5dup	0.17
HNSC	chr20	36930796	Missense_Mutation	novel	L197V	0.13
HNSC	chr20	36892886	3'UTR	novel		0.28
HNSC	chr20	36898462	Missense_Mutation	novel	A529E	0.4
HNSC	chr20	36898463	Missense_Mutation	novel	A529T	0.4
HNSC	chr20	36904174	Nonsense_Mutation	novel	E496*	0.17
HNSC	chr20	36905366	Missense_Mutation	novel	R470G	0.1
KICH	chr20	36892759	3'UTR	novel		0.24
KIRC	chr20	36897875	Missense_Mutation	rs779491090	A565T	0.07
KIRC	chr20	36951483	Frame_Shift_Del	novel	*L54Pfs12**	0.24
KIRC	chr20	36935075	Frame_Shift_Del	novel	*Y155Mfs15**	0.24
KIRC	chr20	36919474	Missense_Mutation	NA	N248D	0.21
KIRC	chr20	36941083	Frame_Shift_Ins	novel	*S102Efs12**	0.05
KIRP	chr20	36904228	Missense_Mutation	NA	K478E	0.61
LAML	chr20	36930852	Missense_Mutation	novel	L178Q	0.04
LAML	chr20	36927236	Silent	novel	S214S	0.09
LAML	chr20	36927238	Missense_Mutation	novel	S214P	0.08
LGG	chr20	36930781	Missense_Mutation	novel	A202T	0.1
LIHC	chr20	36912484	Missense_Mutation	novel	K377N	0.25
LIHC	chr20	36935132	Missense_Mutation	novel	I136F	0.43
LIHC	chr20	36905376	Frame_Shift_Ins	novel	*I468Dfs2**	0.17
LIHC	chr20	36893026	Frame_Shift_Del	NA	*K596Rfs35**	0.32
LUAD	chr20	36893052	Silent	NA	I587I	0.51
LUAD	chr20	36897916	Missense_Mutation	novel	R551P	0.05
LUAD	chr20	36912490	Silent	rs201876333	Q375Q	0.28
LUAD	chr20	36911280	Missense_Mutation	NA	G403V	0.18
LUAD	chr20	36935101	Missense_Mutation	novel	Y146F	0.17
LUAD	chr20	36916769	Frame_Shift_Del	novel	*R339Vfs5**	0.31
LUAD	chr20	36935080	Missense_Mutation	novel	G153V	0.65
LUAD	chr20	36916830	Missense_Mutation	novel	R318S	0.18
LUAD	chr20	36911239	Frame_Shift_Del	novel	*E417Kfs6**	0.22
LUAD	chr20	36905453	Missense_Mutation	NA	A441T	0.08
LUSC	chr20	36893074	Splice_Region	novel		0.53
LUSC	chr20	36911257	Missense_Mutation	novel	T411S	0.06
LUSC	chr20	36916769	Missense_Mutation	novel	R339C	0.26
LUSC	chr20	36892923	3'UTR	novel		0.3
LUSC	chr20	36892902	3'UTR	novel		0.24
LUSC	chr20	36905473	Missense_Mutation	NA	T434I	0.1
LUSC	chr20	36898449	Silent	novel	T533T	0.25
LUSC	chr20	36941103	Missense_Mutation	novel	G95V	0.23
LUSC	chr20	36927205	Missense_Mutation	novel	A225S	0.05
OV	chr20	36897951	Missense_Mutation	novel	Q539H	0.09
OV	chr20	36951468	Missense_Mutation	NA	F59C	0.04
PAAD	chr20	36919476	Missense_Mutation	NA	S247Y	0.18
PAAD	chr20	36935047	Missense_Mutation	novel	R164Q	0.23
PAAD	chr20	36935105	Nonsense_Mutation	rs121434517	R145*	0.22
PCPG	chr20	36951688	5'UTR	rs374493682		0.28
PRAD	chr20	36916768	Missense_Mutation	rs201250022	R339H	0.37
READ	chr20	36916988	Missense_Mutation	NA	R305I	0.18
READ	chr20	36893068	Splice_Region	novel		0.11
READ	chr20	36946787	Missense_Mutation	rs141599277	A76T	0.18
READ	chr20	36892769	3'UTR	novel		0.11
READ	chr20	36916997	Missense_Mutation	novel	S302Y	0.27
SARC	chr20	36916742	Missense_Mutation	rs761561066	R348C	0.17
SARC	chr20	36927183	Missense_Mutation	rs766842258	T232M	0.24
SARC	chr20	36916953	Missense_Mutation	novel	A317S	0.64
SKCM	chr20	36897829	Missense_Mutation	NA	K580T	0.25
SKCM	chr20	36898440	Splice_Region	NA	Q536Q	0.29
SKCM	chr20	36905423	Missense_Mutation	NA	R451C	0.27
SKCM	chr20	36919435	Missense_Mutation	NA	P261S	0.18
SKCM	chr20	36930845	Silent	NA	H180H	0.06
SKCM	chr20	36919435	Missense_Mutation	NA	P261S	0.39
SKCM	chr20	36935154	Silent	rs756023341	L128L	0.32
SKCM	chr20	36941070	Missense_Mutation	rs753821325	R106Q	0.49
SKCM	chr20	36941108	Silent	novel	S93S	0.31
SKCM	chr20	36946805	Splice_Site	NA	X70_splice	0.45
SKCM	chr20	36916794	Silent	rs756532676	D330D	0.42
SKCM	chr20	36919443	Missense_Mutation	NA	G258D	0.06
SKCM	chr20	36927202	Frame_Shift_Del	novel	*L224Pfs8**	0.28
SKCM	chr20	36951694	5'UTR	novel		0.32
SKCM	chr20	36898499	Missense_Mutation	NA	H517Y	0.3
SKCM	chr20	36897869	Missense_Mutation	novel	Q567K	0.31
SKCM	chr20	36898512	Silent	NA	K512K	0.13
SKCM	chr20	36897917	Nonsense_Mutation	rs149846637	R551*	0.07
SKCM	chr20	36897917	Nonsense_Mutation	rs149846637	R551*	0.19
SKCM	chr20	36935177	Missense_Mutation	NA	P121S	0.17
SKCM	chr20	36904249	Missense_Mutation	novel	E471K	0.45
SKCM	chr20	36905467	Missense_Mutation	NA	P436L	0.34
SKCM	chr20	36951529	Missense_Mutation	novel	H39Y	0.16
SKCM	chr20	36951530	Silent	novel	L38L	0.16
SKCM	chr20	36904251	Splice_Site	NA	X471_splice	0.16
SKCM	chr20	36919457	Silent	rs760859048	V253V	0.13
SKCM	chr20	36919394	Silent	novel	G274G	0.23
SKCM	chr20	36916813	Missense_Mutation	NA	G324E	0.43
SKCM	chr20	36904207	Missense_Mutation	novel	P485S	0.43
STAD	chr20	36892991	Missense_Mutation	NA	T608A	0.38
STAD	chr20	36911223	Missense_Mutation	NA	L422P	0.35
STAD	chr20	36905362	Splice_Site	novel	X470_splice	0.07
STAD	chr20	36892839	3'UTR	novel		0.13
STAD	chr20	36927197	Silent	rs144587056	P227P	0.1
STAD	chr20	36911239	Nonsense_Mutation	NA	E417*	0.46
STAD	chr20	36951707	5'UTR	novel		0.11
STAD	chr20	36951708	5'UTR	novel		0.11
STAD	chr20	36951595	Missense_Mutation	novel	D17N	0.08
STAD	chr20	36893026	Frame_Shift_Del	NA	*K596Rfs35**	0.31
STAD	chr20	36917033	Missense_Mutation	rs559553527	R290H	0.13
STAD	chr20	36897961	Splice_Site	novel	X537_splice	0.36
STAD	chr20	36927185	Missense_Mutation	NA	W231C	0.26
STAD	chr20	36893048	Missense_Mutation	NA	P589T	0.22
STAD	chr20	36930850	Missense_Mutation	NA	V179F	0.47
STAD	chr20	36892934	Nonstop_Mutation	NA	627Gext17	0.22
UCEC	chr20	36916787	Missense_Mutation	rs770005027	R333C	0.52
UCEC	chr20	36930808	Nonsense_Mutation	rs754917229	E193*	0.34
UCEC	chr20	36935129	Missense_Mutation	NA	D137H	0.13
UCEC	chr20	36935105	Nonsense_Mutation	rs121434517	R145*	0.2
UCEC	chr20	36935111	Missense_Mutation	rs387906948	R143C	0.38
UCEC	chr20	36941041	Missense_Mutation	novel	K116E	0.31
UCEC	chr20	36905450	Nonsense_Mutation	rs369587937	R442*	0.38
UCEC	chr20	36892628	3'UTR	novel		0.71
UCEC	chr20	36905376	Frame_Shift_Ins	novel	*I466Mfs7**	0.04
UCEC	chr20	36935047	Missense_Mutation	novel	R164Q	0.17
UCEC	chr20	36919387	Nonsense_Mutation	novel	E277*	0.39
UCEC	chr20	36930808	Nonsense_Mutation	rs754917229	E193*	0.16
UCEC	chr20	36935047	Missense_Mutation	novel	R164Q	0.49
UCEC	chr20	36951585	Missense_Mutation	novel	R20K	0.13
UCEC	chr20	36892718	3'UTR	novel		0.42
UCEC	chr20	36897912	Silent	novel	V552V	0.4
UCEC	chr20	36916786	Missense_Mutation	rs755046462	R333H	0.44
UCEC	chr20	36892722	3'UTR	novel		0.38
UCEC	chr20	36927219	Missense_Mutation	rs745608353	R220Q	0.49
UCEC	chr20	36912540	Missense_Mutation	novel	L359M	0.54
UCEC	chr20	36951585	Missense_Mutation	novel	R20I	0.32
UCEC	chr20	36951596	Silent	NA	D16D	0.44
UCEC	chr20	36927193	In_Frame_Del	NA	E228del	0.23
UCEC	chr20	36893060	Missense_Mutation	rs202165710	D585N	0.32
UCEC	chr20	36911303	Silent	novel	D395D	0.1
UCEC	chr20	36892734	3'UTR	novel		0.5
UCEC	chr20	36951501	Missense_Mutation	novel	E48V	0.28
UCEC	chr20	36893061	Silent	rs753611896	G584G	0.47
UCEC	chr20	36892636	3'UTR	novel		0.57
UCEC	chr20	36919429	Nonsense_Mutation	novel	E263*	0.43
UCEC	chr20	36946805	Splice_Site	novel	X70_splice	0.55
UCEC	chr20	36951585	Missense_Mutation	novel	R20I	0.53
UCEC	chr20	36946747	Missense_Mutation	NA	L89P	0.31
UCEC	chr20	36905445	Missense_Mutation	novel	E443D	0.27
UCEC	chr20	36893025	Missense_Mutation	novel	K596N	0.29
UCEC	chr20	36905466	Silent	novel	P436P	0.04
UCEC	chr20	36905468	Nonsense_Mutation	novel	D435_P436insVI	0.04
UCEC	chr20	36912531	Missense_Mutation	novel	M362L	0.56
UCEC	chr20	36892892	3'UTR	novel		0.31
UCEC	chr20	36905394	Silent	rs544083526	T460T	0.37
UCEC	chr20	36893026	Frame_Shift_Del	NA	*K596Rfs35**	0.4
UCEC	chr20	36905401	Missense_Mutation	novel	G458D	0.34
UCEC	chr20	36935142	Silent	novel	L132L	0.38
UCEC	chr20	36911247	Missense_Mutation	novel	D414G	0.29
UCEC	chr20	36897939	Missense_Mutation	NA	E543D	0.5
UCEC	chr20	36893070	Splice_Region	novel		0.05
UCEC	chr20	36911299	Missense_Mutation	NA	I397L	0.35
UCEC	chr20	36893060	Missense_Mutation	rs202165710	D585N	0.33
UCEC	chr20	36892839	3'UTR	novel		0.35
UCEC	chr20	36897927	Missense_Mutation	novel	E547D	0.06
UCEC	chr20	36904204	Missense_Mutation	novel	K486E	0.17
UCEC	chr20	36930844	Missense_Mutation	novel	A181T	0.19
UCEC	chr20	36930845	Silent	NA	H180H	0.22
UCEC	chr20	36935076	Silent	rs149267802	Y154Y	0.35
UCEC	chr20	36916967	Missense_Mutation	novel	K312T	0.3
UCEC	chr20	36930805	Nonsense_Mutation	NA	R194*	0.11
UCEC	chr20	36930773	Silent	novel	L204L	0.18
UCEC	chr20	36892900	3'UTR	novel		0.32
UCS	chr20	36916997	Missense_Mutation	novel	S302C	0.42
UCS	chr20	36892882	3'UTR	novel		0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LAML	DEL	0.0209	0.14746

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0029	Kaplan-Meier Survival Analysis
SARC	0.015	Kaplan-Meier Survival Analysis
MESO	0.03	Kaplan-Meier Survival Analysis
ACC	0.013	Kaplan-Meier Survival Analysis
HNSC	0.021	Kaplan-Meier Survival Analysis
SKCM	0.00012	Kaplan-Meier Survival Analysis
ESCA	0.0049	Kaplan-Meier Survival Analysis
CESC	0.0068	Kaplan-Meier Survival Analysis
LAML	0.0018	Kaplan-Meier Survival Analysis
UCEC	0.02	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.036	Kaplan-Meier Survival Analysis
UVM	0.025	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742