EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000101367 (Gene tree)
Gene ID: 22919
Gene Symbol: MAPRE1
Alias: EB1
Full Name: microtubule associated protein RP/EB family member 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 30,626 bases
Position: chr20:32,819,780-32,850,405
Accession: 6890
RBP type: non-canonical RBP
Summary: The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22869553	Interactome-wide analysis identifies end-binding protein 1 as a crucial component for the speck-like particle formation of activated absence in melanoma 2 (AIM2) inflammasomes.	Mol Cell Proteomics	2012 Nov	Wang LJ	doi: 10.1074/mcp.M112.020594
16247022	Melanophilin and myosin Va track the microtubule plus end on EB1.	J Cell Biol	2005 Oct 24	Wu XS	-
20351264	Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes.	Proc Natl Acad Sci U S A	2010 Apr 13	Lavieu G	doi: 10.1073/pnas.1002536107
26504169	Microtubule plus end-associated CLIP-170 initiates HSV-1 retrograde transport in primary human cells.	J Cell Biol	2015 Oct 26	Jovasevic V	doi: 10.1083/jcb.201505123.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000375571	MAPRE1-201	2623	XM_011528696	ENSP00000364721	268 (aa)	XP_011526998	Q15691

Gene Model

Click here to download ENSG00000101367's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000101367	Attention Deficit Disorder with Hyperactivity	7E-6	23527680
ENSG00000101367	Attention Deficit Disorder with Hyperactivity	4E-6	23527680
ENSG00000101367	Attention Deficit Disorder with Hyperactivity	7E-6	23527680
ENSG00000101367	Attention Deficit Disorder with Hyperactivity	4E-6	23527680
ENSG00000101367	Attention Deficit Disorder with Hyperactivity	5E-6	23527680
ENSG00000101367	Attention Deficit Disorder with Hyperactivity	5E-6	23527680
ENSG00000101367	Attention Deficit Disorder with Hyperactivity	5E-6	23527680
ENSG00000101367	Attention Deficit Disorder with Hyperactivity	4E-6	23527680

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000101367	rs6057651	20	32822531	A	Attention deficit hyperactivity disorder (combined symptoms)	23527680			EFO_0003888
ENSG00000101367	rs6057652	20	32832003	A	Attention deficit hyperactivity disorder (combined symptoms)	23527680			EFO_0003888
ENSG00000101367	rs7270085	20	32849801	A	Attention deficit hyperactivity disorder (combined symptoms)	23527680			EFO_0003888
ENSG00000101367	rs6057652	20	32832003	A	Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms)	23527680			EFO_0003888
ENSG00000101367	rs6057651	20	32822531	A	Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms)	23527680			EFO_0003888
ENSG00000101367	rs140911738	20	32849813	G	Iron status biomarkers (transferrin saturation)	28334935	[0.31-0.71] unit decrease	0.509	EFO_0006333
ENSG00000101367	rs853854	20	32832951	T	Polycystic ovary syndrome	30566500	[0.066-0.129] unit decrease	0.0975	EFO_0000660
ENSG00000101367	rs79396740	20	32839143	?	DNA methylation variation (age effect)	30348214			GO_0006306

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000101367's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000101367	MAPRE1	99	53.608	FBgn0027066	Eb1	97	54.417	Drosophila_melanogaster
ENSG00000101367	MAPRE1	100	97.015	ENSMUSG00000027479	Mapre1	100	97.015	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	10226031.10644998.10773885.11943150.15631994.16455083.17563362.17828277.18477699.19543227.19553473.19632184.21646404.21820309.23874158.24997520.25225338.25416956.26242911.26485573.26496610.26638075.27107012.27173435.29162697.29997244.	IPI	Function
GO:0005794	Golgi apparatus	-	IEA	Component
GO:0005813	centrosome	21399614.	IDA	Component
GO:0005815	microtubule organizing center	21873635.	IBA	Component
GO:0005819	spindle	11943150.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005874	microtubule	21873635.	IBA	Component
GO:0005874	microtubule	10773885.	IDA	Component
GO:0005881	cytoplasmic microtubule	21873635.	IBA	Component
GO:0005925	focal adhesion	25490267.	IDA	Component
GO:0008017	microtubule binding	21873635.	IBA	Function
GO:0008022	protein C-terminus binding	7606712.	TAS	Function
GO:0008104	protein localization	26323690.	TAS	Process
GO:0008283	cell proliferation	7606712.	TAS	Process
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016477	cell migration	26242911.	IMP	Process
GO:0019901	protein kinase binding	26323690.	IPI	Function
GO:0030335	positive regulation of cell migration	-	TAS	Process
GO:0030981	cortical microtubule cytoskeleton	15631994.	IDA	Component
GO:0031110	regulation of microtubule polymerization or depolymerization	21873635.	IBA	Process
GO:0031115	negative regulation of microtubule polymerization	11943150.	IDA	Process
GO:0031116	positive regulation of microtubule polymerization	29162697.	IMP	Process
GO:0031253	cell projection membrane	-	IEA	Component
GO:0035371	microtubule plus-end	21873635.	IBA	Component
GO:0035372	protein localization to microtubule	21873635.	IBA	Process
GO:0035372	protein localization to microtubule	19632184.21820309.	IDA	Process
GO:0042802	identical protein binding	25416956.27107012.	IPI	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0051010	microtubule plus-end binding	21873635.	IBA	Function
GO:0051010	microtubule plus-end binding	15631994.19632184.	IDA	Function
GO:0051225	spindle assembly	21873635.	IBA	Process
GO:0051233	spindle midzone	21873635.	IBA	Component
GO:0051301	cell division	-	IEA	Process
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	Process
GO:1903033	positive regulation of microtubule plus-end binding	-	IEA	Process
GO:1904825	protein localization to microtubule plus-end	21873635.	IBA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27208742	End Binding 1 (EB1) overexpression in oral lesions and cancer: A biomarker of tumor progression and poor prognosis.	Clin Chim Acta	2016 Aug 1	Kumar M	doi: 10.1016/j.cca.2016.05.012
23900080	Depletion of end-binding protein 1 (EB1) promotes apoptosis of human non-small-cell lung cancer cells via reactive oxygen species and Bax-mediated mitochondrial dysfunction.	Cancer Lett	2013 Oct 1	Kim MJ	doi: 10.1016/j.canlet.2013.07.027
22277732	Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women.	Cancer Prev Res (Phila)	2012 Apr	Ladd JJ	doi: 10.1158/1940-6207.CAPR-11-0412
26342024	MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas.	Cancer Prev Res (Phila)	2015 Nov	Taguchi A	doi: 10.1158/1940-6207.CAPR-15-0077
22735596	Proteomic-based identification of the APC-binding protein EB1 as a candidate of novel tissue biomarker and therapeutic target for colorectal cancer.	J Proteomics	2012 Sep 18	Sugihara Y	doi: 10.1016/j.jprot.2012.06.013

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr20	32846725	Frame_Shift_Del	novel	*N235Kfs9**	0.11
BLCA	chr20	32836715	Missense_Mutation	novel	A117T	0.68
BLCA	chr20	32836733	Missense_Mutation	novel	D123N	0.49
BLCA	chr20	32839732	Splice_Region	novel		0.17
BLCA	chr20	32848773	3'UTR	novel		0.48
BLCA	chr20	32833797	Missense_Mutation	novel	E68Q	0.22
BRCA	chr20	32846653	Silent	NA	E211E	0.2
BRCA	chr20	32833731	Nonsense_Mutation	NA	Q46*	0.13
BRCA	chr20	32849937	3'UTR	novel		0.14
CESC	chr20	32848880	3'UTR	novel		0.12
CESC	chr20	32849820	3'UTR	novel		0.11
COAD	chr20	32846674	Silent	rs762741175	F218F	0.38
COAD	chr20	32848696	Frame_Shift_Del	novel	*G260Afs28**	0.28
COAD	chr20	32826032	Silent	rs565248642	I35I	0.21
COAD	chr20	32848697	Missense_Mutation	NA	G259E	0.17
COAD	chr20	32833852	Missense_Mutation	novel	G86D	0.06
ESCA	chr20	32846766	Missense_Mutation	novel	T249I	0.21
ESCA	chr20	32836712	Missense_Mutation	rs758889318	D116N	0.18
GBM	chr20	32826003	Missense_Mutation	novel	E26Q	0.11
GBM	chr20	32833772	Missense_Mutation	novel	K59N	0.15
HNSC	chr20	32848741	3'UTR	novel		0.35
HNSC	chr20	32836721	Frame_Shift_Del	novel	Y119*	0.12
HNSC	chr20	32826009	Missense_Mutation	novel	L28V	0.4
HNSC	chr20	32846680	Silent	novel	K220K	0.3
KIRP	chr20	32825953	In_Frame_Del	novel	V10_T11del	0.58
LIHC	chr20	32848916	3'UTR	novel		0.23
LUAD	chr20	32848690	Missense_Mutation	NA	D257N	0.48
LUSC	chr20	32833792	Missense_Mutation	NA	K66T	0.45
LUSC	chr20	32848834	3'UTR	novel		0.22
LUSC	chr20	32848792	3'UTR	novel		0.13
LUSC	chr20	32846740	Silent	novel	Q240Q	0.24
LUSC	chr20	32846654	Missense_Mutation	novel	K212Q	0.15
LUSC	chr20	32836682	Missense_Mutation	novel	E106Q	0.31
LUSC	chr20	32826049	Splice_Site	novel	X41_splice	0.24
MESO	chr20	32826044	Nonsense_Mutation	novel	C39*	0.31
OV	chr20	32846685	Missense_Mutation	novel	R222L	0.04
PAAD	chr20	32825977	Missense_Mutation	novel	R17Q	0.19
PAAD	chr20	32836646	Missense_Mutation	novel	D94N	0.15
PAAD	chr20	32846686	Silent	novel	R222R	0.19
PRAD	chr20	32833734	Frame_Shift_Del	novel	*F47Lfs12**	0.39
PRAD	chr20	32836663	Silent	NA	G99G	0.16
READ	chr20	32826020	Missense_Mutation	novel	N31K	0.1
SKCM	chr20	32839781	Silent	NA	K174K	0.25
SKCM	chr20	32836781	Missense_Mutation	NA	P139S	0.33
SKCM	chr20	32836782	Missense_Mutation	NA	P139L	0.33
SKCM	chr20	32833820	Silent	NA	F75F	0.43
SKCM	chr20	32836687	Silent	rs754319096	F107F	0.26
STAD	chr20	32839771	Missense_Mutation	rs199851862	A171V	0.39
STAD	chr20	32839737	Missense_Mutation	NA	P160S	0.14
UCEC	chr20	32826033	Missense_Mutation	rs753378763	E36K	0.4
UCEC	chr20	32846660	Missense_Mutation	novel	R214G	0.19
UCEC	chr20	32839805	Missense_Mutation	rs753923516	K182N	0.44
UCEC	chr20	32833855	Missense_Mutation	rs770912318	V87A	0.36
UCEC	chr20	32836740	Missense_Mutation	novel	D125G	0.54
UCEC	chr20	32833815	Missense_Mutation	novel	N74H	0.26
UCEC	chr20	32825978	Silent	NA	R17R	0.12
UCEC	chr20	32836731	Missense_Mutation	novel	K122T	0.08
UCEC	chr20	32848795	3'UTR	novel		0.44
UCEC	chr20	32850098	3'UTR	novel		0.37
UCEC	chr20	32849500	3'UTR	novel		0.56
UCEC	chr20	32849778	3'UTR	novel		0.29
UCEC	chr20	32850086	3'UTR	novel		0.21
UCEC	chr20	32848723	Missense_Mutation	novel	Y268H	0.45
UCEC	chr20	32849635	3'UTR	novel		0.45
UCEC	chr20	32833861	Missense_Mutation	novel	K89T	0.52
UCEC	chr20	32850355	3'UTR	novel		0.24
UCEC	chr20	32849929	3'UTR	novel		0.5
UCEC	chr20	32850355	3'UTR	novel		0.48
UCEC	chr20	32836766	Nonsense_Mutation	novel	E134*	0.21
UCEC	chr20	32846653	Silent	NA	E211E	0.2
UCEC	chr20	32849778	3'UTR	novel		0.21
UCEC	chr20	32850288	3'UTR	novel		0.16
UCEC	chr20	32848992	3'UTR	novel		0.21
UCEC	chr20	32848727	Silent	novel	*269*	0.57
UCEC	chr20	32836702	Missense_Mutation	rs375430356	K112N	0.54
UCEC	chr20	32825977	Missense_Mutation	novel	R17Q	0.14
UCEC	chr20	32825955	Missense_Mutation	NA	V10M	0.27
UCEC	chr20	32839801	Missense_Mutation	rs547725771	R181Q	0.29
UCEC	chr20	32850355	3'UTR	novel		0.28
UCEC	chr20	32848849	3'UTR	novel		0.37
UCEC	chr20	32833836	Missense_Mutation	novel	G81C	0.07
UCS	chr20	32836661	Nonsense_Mutation	novel	G99*	0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LAML	DEL	0.0105	0.14746
READ	AMP	0.8667	1.9519e-21

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0031	Kaplan-Meier Survival Analysis
STAD	0.036	Kaplan-Meier Survival Analysis
MESO	0.00041	Kaplan-Meier Survival Analysis
ACC	0.00067	Kaplan-Meier Survival Analysis
HNSC	0.041	Kaplan-Meier Survival Analysis
LUSC	0.028	Kaplan-Meier Survival Analysis
ESCA	0.0024	Kaplan-Meier Survival Analysis
UCEC	0.0015	Kaplan-Meier Survival Analysis
LIHC	0.0014	Kaplan-Meier Survival Analysis
LUAD	0.045	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742