EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000101452 (Gene tree)
Gene ID: 60625
Gene Symbol: DHX35
Alias: FLJ22759|KAIA0875|C20orf15|DDX35
Full Name: DEAH-box helicase 35
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 77,425 bases
Position: chr20:38,962,299-39,039,723
Accession: 15861
RBP type: canonical RBP
Summary: DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000362420	HA2	PF04408.23	1.3e-18	1	1
ENSP00000362422	HA2	PF04408.23	1.3e-18	1	1
ENSP00000252011	HA2	PF04408.23	1.4e-18	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000252011	DHX35-201	3325	XM_011528972	ENSP00000252011	703 (aa)	XP_011527274	Q9H5Z1
ENST00000449559	DHX35-204	607	-	ENSP00000397997	167 (aa)	-	Q5THQ7
ENST00000484417	DHX35-206	3318	-	ENSP00000432603	126 (aa)	-	F2Z2Z2
ENST00000373325	DHX35-203	3287	XM_011528974	ENSP00000362422	679 (aa)	XP_011527276	Q5THR1
ENST00000493450	DHX35-207	2958	-	-	- (aa)	-	-
ENST00000482619	DHX35-205	666	-	-	- (aa)	-	-
ENST00000373323	DHX35-202	2347	XM_017028004	ENSP00000362420	672 (aa)	XP_016883493	Q9H5Z1

Gene Model

Click here to download ENSG00000101452's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000101452	Drug Resistance	5E-6	22952603

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000101452	rs79166949	20	38970967	T	Itch intensity from mosquito bite adjusted by bite size	28199695	[0.044-0.113] unit increase	0.0784384	EFO_0008377\|EFO_0008378

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000101452's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000101452	DHX35	89	42.453	ENSG00000163214	DHX57	73	39.130
ENSG00000101452	DHX35	85	34.512	ENSG00000134815	DHX34	50	34.512
ENSG00000101452	DHX35	94	44.559	ENSG00000109606	DHX15	83	44.559
ENSG00000101452	DHX35	89	40.945	ENSG00000150990	DHX37	70	40.945
ENSG00000101452	DHX35	93	32.362	ENSG00000144045	DQX1	93	32.362
ENSG00000101452	DHX35	92	31.297	ENSG00000089876	DHX32	87	32.500
ENSG00000101452	DHX35	91	44.548	ENSG00000140829	DHX38	81	36.752
ENSG00000101452	DHX35	92	44.665	ENSG00000005100	DHX33	91	44.665
ENSG00000101452	DHX35	91	48.292	ENSG00000204560	DHX16	90	46.360
ENSG00000101452	DHX35	95	46.647	ENSG00000067596	DHX8	86	34.167
ENSG00000101452	DHX35	98	36.364	ENSG00000108406	DHX40	93	40.580
ENSG00000101452	DHX35	71	31.306	ENSG00000174953	DHX36	96	34.434

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000101452	DHX35	100	77.614	ENSAPOG00000016979	zgc:158828	99	77.614	Acanthochromis_polyacanthus
ENSG00000101452	DHX35	99	96.439	ENSAMEG00000011925	DHX35	99	96.439	Ailuropoda_melanoleuca
ENSG00000101452	DHX35	99	78.550	ENSACIG00000009707	zgc:158828	99	78.550	Amphilophus_citrinellus
ENSG00000101452	DHX35	100	77.761	ENSAOCG00000020254	zgc:158828	99	78.286	Amphiprion_ocellaris
ENSG00000101452	DHX35	100	77.761	ENSAPEG00000008001	zgc:158828	99	77.761	Amphiprion_percula
ENSG00000101452	DHX35	99	77.811	ENSATEG00000005292	zgc:158828	99	77.811	Anabas_testudineus
ENSG00000101452	DHX35	99	88.682	ENSAPLG00000008832	DHX35	99	88.682	Anas_platyrhynchos
ENSG00000101452	DHX35	99	88.889	ENSACAG00000014298	DHX35	87	88.889	Anolis_carolinensis
ENSG00000101452	DHX35	99	98.063	ENSANAG00000037687	DHX35	99	98.063	Aotus_nancymaae
ENSG00000101452	DHX35	99	78.143	ENSACLG00000026087	zgc:158828	99	78.143	Astatotilapia_calliptera
ENSG00000101452	DHX35	98	76.426	ENSAMXG00000020520	zgc:158828	99	76.426	Astyanax_mexicanus
ENSG00000101452	DHX35	99	96.439	ENSBTAG00000004039	DHX35	99	96.439	Bos_taurus
ENSG00000101452	DHX35	99	52.564	WBGene00022056	ddx-35	94	52.564	Caenorhabditis_elegans
ENSG00000101452	DHX35	99	98.006	ENSCJAG00000011495	DHX35	99	98.006	Callithrix_jacchus
ENSG00000101452	DHX35	99	93.590	ENSCAFG00000009044	DHX35	99	93.590	Canis_familiaris
ENSG00000101452	DHX35	99	82.812	ENSCAFG00020012796	-	99	96.344	Canis_lupus_dingo
ENSG00000101452	DHX35	99	96.866	ENSCHIG00000023863	DHX35	99	96.866	Capra_hircus
ENSG00000101452	DHX35	98	96.517	ENSTSYG00000007049	DHX35	100	96.517	Carlito_syrichta
ENSG00000101452	DHX35	99	96.608	ENSCPOG00000012411	DHX35	99	96.608	Cavia_porcellus
ENSG00000101452	DHX35	99	98.525	ENSCCAG00000030551	DHX35	99	98.525	Cebus_capucinus
ENSG00000101452	DHX35	99	98.575	ENSCATG00000032920	DHX35	99	98.575	Cercocebus_atys
ENSG00000101452	DHX35	99	97.198	ENSCLAG00000006320	DHX35	99	97.198	Chinchilla_lanigera
ENSG00000101452	DHX35	99	98.575	ENSCSAG00000013928	DHX35	99	98.575	Chlorocebus_sabaeus
ENSG00000101452	DHX35	99	82.292	ENSCHOG00000006813	DHX35	90	89.116	Choloepus_hoffmanni
ENSG00000101452	DHX35	99	75.000	ENSCPBG00000018175	-	99	89.031	Chrysemys_picta_bellii
ENSG00000101452	DHX35	94	58.824	ENSCING00000006878	-	100	58.824	Ciona_intestinalis
ENSG00000101452	DHX35	99	98.291	ENSCANG00000042479	DHX35	99	98.291	Colobus_angolensis_palliatus
ENSG00000101452	DHX35	99	95.014	ENSCGRG00001006986	Dhx35	99	95.014	Cricetulus_griseus_chok1gshd
ENSG00000101452	DHX35	99	95.014	ENSCGRG00000014712	Dhx35	99	95.014	Cricetulus_griseus_crigri
ENSG00000101452	DHX35	99	75.847	ENSCSEG00000021003	zgc:158828	95	75.847	Cynoglossus_semilaevis
ENSG00000101452	DHX35	99	77.714	ENSCVAG00000010301	zgc:158828	99	77.714	Cyprinodon_variegatus
ENSG00000101452	DHX35	98	64.737	ENSDARG00000063419	DHX35	99	77.572	Danio_rerio
ENSG00000101452	DHX35	99	96.154	ENSDNOG00000017447	DHX35	99	96.154	Dasypus_novemcinctus
ENSG00000101452	DHX35	99	96.581	ENSDORG00000005573	Dhx35	99	96.581	Dipodomys_ordii
ENSG00000101452	DHX35	97	48.613	FBgn0031631	CG3225	99	48.613	Drosophila_melanogaster
ENSG00000101452	DHX35	99	80.199	ENSETEG00000010293	DHX35	99	80.199	Echinops_telfairi
ENSG00000101452	DHX35	99	69.784	ENSEBUG00000000373	zgc:158828	99	69.784	Eptatretus_burgeri
ENSG00000101452	DHX35	99	94.404	ENSEASG00005023467	DHX35	97	95.552	Equus_asinus_asinus
ENSG00000101452	DHX35	99	97.009	ENSECAG00000013881	DHX35	99	97.009	Equus_caballus
ENSG00000101452	DHX35	99	80.208	ENSEEUG00000006399	DHX35	84	89.679	Erinaceus_europaeus
ENSG00000101452	DHX35	99	78.254	ENSELUG00000001988	zgc:158828	99	78.698	Esox_lucius
ENSG00000101452	DHX35	99	96.870	ENSFCAG00000025103	DHX35	99	96.870	Felis_catus
ENSG00000101452	DHX35	91	85.251	ENSFALG00000005627	-	90	85.413	Ficedula_albicollis
ENSG00000101452	DHX35	99	96.903	ENSFDAG00000016726	DHX35	99	96.903	Fukomys_damarensis
ENSG00000101452	DHX35	99	77.571	ENSFHEG00000022602	zgc:158828	99	77.571	Fundulus_heteroclitus
ENSG00000101452	DHX35	98	78.343	ENSGMOG00000003036	zgc:158828	99	78.343	Gadus_morhua
ENSG00000101452	DHX35	99	89.030	ENSGALG00000003658	DHX35	99	89.030	Gallus_gallus
ENSG00000101452	DHX35	99	77.571	ENSGAFG00000021118	zgc:158828	99	77.571	Gambusia_affinis
ENSG00000101452	DHX35	99	76.775	ENSGACG00000001290	zgc:158828	100	77.615	Gasterosteus_aculeatus
ENSG00000101452	DHX35	99	89.031	ENSGAGG00000015721	DHX35	99	89.031	Gopherus_agassizii
ENSG00000101452	DHX35	99	99.145	ENSGGOG00000013960	DHX35	99	99.145	Gorilla_gorilla
ENSG00000101452	DHX35	99	78.429	ENSHBUG00000005482	zgc:158828	99	78.429	Haplochromis_burtoni
ENSG00000101452	DHX35	99	91.207	ENSHGLG00000010264	DHX35	99	91.207	Heterocephalus_glaber_female
ENSG00000101452	DHX35	99	96.608	ENSHGLG00100019231	DHX35	99	96.608	Heterocephalus_glaber_male
ENSG00000101452	DHX35	99	77.000	ENSHCOG00000011691	zgc:158828	99	77.000	Hippocampus_comes
ENSG00000101452	DHX35	99	77.429	ENSIPUG00000016363	dhx35	99	77.429	Ictalurus_punctatus
ENSG00000101452	DHX35	99	96.581	ENSSTOG00000002005	DHX35	99	96.581	Ictidomys_tridecemlineatus
ENSG00000101452	DHX35	100	90.754	ENSJJAG00000000208	Dhx35	100	90.754	Jaculus_jaculus
ENSG00000101452	DHX35	99	78.000	ENSKMAG00000018089	zgc:158828	99	78.000	Kryptolebias_marmoratus
ENSG00000101452	DHX35	99	73.677	ENSLBEG00000006365	zgc:158828	99	73.677	Labrus_bergylta
ENSG00000101452	DHX35	99	82.386	ENSLACG00000015340	DHX35	99	82.386	Latimeria_chalumnae
ENSG00000101452	DHX35	99	78.714	ENSLOCG00000004639	zgc:158828	99	78.714	Lepisosteus_oculatus
ENSG00000101452	DHX35	99	97.050	ENSLAFG00000004103	DHX35	100	97.009	Loxodonta_africana
ENSG00000101452	DHX35	99	98.718	ENSMFAG00000031593	DHX35	99	98.718	Macaca_fascicularis
ENSG00000101452	DHX35	99	98.673	ENSMMUG00000003385	DHX35	99	98.673	Macaca_mulatta
ENSG00000101452	DHX35	99	98.718	ENSMNEG00000024351	DHX35	99	98.718	Macaca_nemestrina
ENSG00000101452	DHX35	99	98.575	ENSMLEG00000037761	DHX35	99	98.575	Mandrillus_leucophaeus
ENSG00000101452	DHX35	99	78.107	ENSMAMG00000010572	zgc:158828	99	78.107	Mastacembelus_armatus
ENSG00000101452	DHX35	99	78.143	ENSMZEG00005026563	zgc:158828	99	78.143	Maylandia_zebra
ENSG00000101452	DHX35	99	89.631	ENSMGAG00000003174	DHX35	99	89.631	Meleagris_gallopavo
ENSG00000101452	DHX35	99	89.744	ENSMAUG00000004742	Dhx35	99	89.744	Mesocricetus_auratus
ENSG00000101452	DHX35	99	97.721	ENSMICG00000013282	DHX35	99	97.721	Microcebus_murinus
ENSG00000101452	DHX35	99	95.014	ENSMOCG00000007520	Dhx35	99	95.014	Microtus_ochrogaster
ENSG00000101452	DHX35	99	71.976	ENSMMOG00000020376	zgc:158828	99	71.976	Mola_mola
ENSG00000101452	DHX35	99	91.168	ENSMODG00000000495	DHX35	99	91.168	Monodelphis_domestica
ENSG00000101452	DHX35	99	76.183	ENSMALG00000000446	zgc:158828	99	76.183	Monopterus_albus
ENSG00000101452	DHX35	99	94.587	MGP_CAROLIEiJ_G0024595	Dhx35	99	94.587	Mus_caroli
ENSG00000101452	DHX35	99	95.157	ENSMUSG00000027655	Dhx35	99	95.157	Mus_musculus
ENSG00000101452	DHX35	99	95.014	MGP_PahariEiJ_G0026039	Dhx35	99	95.014	Mus_pahari
ENSG00000101452	DHX35	99	95.014	MGP_SPRETEiJ_G0025517	Dhx35	99	95.014	Mus_spretus
ENSG00000101452	DHX35	99	94.460	ENSMPUG00000017704	DHX35	99	96.911	Mustela_putorius_furo
ENSG00000101452	DHX35	99	97.151	ENSMLUG00000009227	DHX35	99	97.151	Myotis_lucifugus
ENSG00000101452	DHX35	99	95.726	ENSNGAG00000018900	Dhx35	99	95.726	Nannospalax_galili
ENSG00000101452	DHX35	99	78.254	ENSNBRG00000014723	zgc:158828	99	78.254	Neolamprologus_brichardi
ENSG00000101452	DHX35	96	98.373	ENSNLEG00000006429	DHX35	98	98.373	Nomascus_leucogenys
ENSG00000101452	DHX35	83	94.937	ENSMEUG00000004250	-	79	94.937	Notamacropus_eugenii
ENSG00000101452	DHX35	99	84.758	ENSOPRG00000013605	DHX35	99	84.758	Ochotona_princeps
ENSG00000101452	DHX35	99	96.154	ENSODEG00000015255	DHX35	99	96.154	Octodon_degus
ENSG00000101452	DHX35	99	77.557	ENSONIG00000017426	zgc:158828	99	77.557	Oreochromis_niloticus
ENSG00000101452	DHX35	99	91.053	ENSOANG00000015094	DHX35	99	91.053	Ornithorhynchus_anatinus
ENSG00000101452	DHX35	99	96.581	ENSOCUG00000009416	DHX35	86	96.581	Oryctolagus_cuniculus
ENSG00000101452	DHX35	98	78.343	ENSORLG00000009467	zgc:158828	99	78.343	Oryzias_latipes
ENSG00000101452	DHX35	99	78.000	ENSORLG00020001572	zgc:158828	99	78.488	Oryzias_latipes_hni
ENSG00000101452	DHX35	99	77.857	ENSORLG00015018995	zgc:158828	99	77.857	Oryzias_latipes_hsok
ENSG00000101452	DHX35	99	77.714	ENSOMEG00000012536	zgc:158828	99	77.714	Oryzias_melastigma
ENSG00000101452	DHX35	99	96.903	ENSOGAG00000000954	DHX35	99	96.903	Otolemur_garnettii
ENSG00000101452	DHX35	99	96.581	ENSOARG00000000998	DHX35	99	96.581	Ovis_aries
ENSG00000101452	DHX35	99	98.860	ENSPPAG00000038372	DHX35	99	98.860	Pan_paniscus
ENSG00000101452	DHX35	99	97.019	ENSPPRG00000007005	DHX35	99	97.019	Panthera_pardus
ENSG00000101452	DHX35	98	96.956	ENSPTIG00000009935	DHX35	98	96.956	Panthera_tigris_altaica
ENSG00000101452	DHX35	99	98.718	ENSPTRG00000013497	DHX35	99	98.718	Pan_troglodytes
ENSG00000101452	DHX35	99	98.433	ENSPANG00000016616	DHX35	99	98.378	Papio_anubis
ENSG00000101452	DHX35	99	78.857	ENSPKIG00000005719	zgc:158828	99	78.857	Paramormyrops_kingsleyae
ENSG00000101452	DHX35	99	88.395	ENSPSIG00000005552	DHX35	97	88.395	Pelodiscus_sinensis
ENSG00000101452	DHX35	99	77.367	ENSPMGG00000006967	zgc:158828	99	77.367	Periophthalmus_magnuspinnatus
ENSG00000101452	DHX35	100	95.306	ENSPEMG00000021828	Dhx35	100	95.306	Peromyscus_maniculatus_bairdii
ENSG00000101452	DHX35	98	59.286	ENSPMAG00000004127	zgc:158828	98	59.286	Petromyzon_marinus
ENSG00000101452	DHX35	99	90.598	ENSPCIG00000010725	DHX35	99	90.598	Phascolarctos_cinereus
ENSG00000101452	DHX35	99	78.066	ENSPFOG00000007451	zgc:158828	99	78.066	Poecilia_formosa
ENSG00000101452	DHX35	99	77.714	ENSPLAG00000023800	zgc:158828	99	77.714	Poecilia_latipinna
ENSG00000101452	DHX35	99	77.714	ENSPMEG00000003831	zgc:158828	99	77.714	Poecilia_mexicana
ENSG00000101452	DHX35	99	77.571	ENSPREG00000018197	zgc:158828	99	79.095	Poecilia_reticulata
ENSG00000101452	DHX35	99	98.718	ENSPPYG00000011007	DHX35	99	98.718	Pongo_abelii
ENSG00000101452	DHX35	99	80.208	ENSPCAG00000002107	DHX35	85	83.761	Procavia_capensis
ENSG00000101452	DHX35	91	98.261	ENSPCOG00000022032	DHX35	98	88.676	Propithecus_coquereli
ENSG00000101452	DHX35	99	90.185	ENSPVAG00000012078	DHX35	99	90.185	Pteropus_vampyrus
ENSG00000101452	DHX35	99	78.286	ENSPNYG00000001597	zgc:158828	99	78.286	Pundamilia_nyererei
ENSG00000101452	DHX35	99	79.143	ENSPNAG00000023549	zgc:158828	99	79.143	Pygocentrus_nattereri
ENSG00000101452	DHX35	99	95.157	ENSRNOG00000015928	Dhx35	99	95.157	Rattus_norvegicus
ENSG00000101452	DHX35	99	98.148	ENSRBIG00000036635	DHX35	99	98.083	Rhinopithecus_bieti
ENSG00000101452	DHX35	99	98.006	ENSRROG00000031055	DHX35	99	98.006	Rhinopithecus_roxellana
ENSG00000101452	DHX35	99	98.575	ENSSBOG00000029157	DHX35	99	98.575	Saimiri_boliviensis_boliviensis
ENSG00000101452	DHX35	99	79.571	ENSSFOG00015021820	dhx35	99	79.571	Scleropages_formosus
ENSG00000101452	DHX35	99	77.143	ENSSMAG00000008419	zgc:158828	99	77.143	Scophthalmus_maximus
ENSG00000101452	DHX35	99	78.402	ENSSDUG00000016954	zgc:158828	99	78.402	Seriola_dumerili
ENSG00000101452	DHX35	99	78.286	ENSSLDG00000025317	zgc:158828	99	78.286	Seriola_lalandi_dorsalis
ENSG00000101452	DHX35	100	84.831	ENSSPUG00000008996	DHX35	98	84.831	Sphenodon_punctatus
ENSG00000101452	DHX35	99	77.959	ENSSPAG00000000687	zgc:158828	97	79.968	Stegastes_partitus
ENSG00000101452	DHX35	99	97.151	ENSSSCG00000007352	DHX35	100	96.408	Sus_scrofa
ENSG00000101452	DHX35	99	89.031	ENSTGUG00000004620	-	99	89.031	Taeniopygia_guttata
ENSG00000101452	DHX35	99	77.857	ENSTRUG00000001011	zgc:158828	100	78.528	Takifugu_rubripes
ENSG00000101452	DHX35	91	73.043	ENSTNIG00000017863	zgc:158828	100	79.137	Tetraodon_nigroviridis
ENSG00000101452	DHX35	91	90.375	ENSTBEG00000001832	DHX35	87	90.375	Tupaia_belangeri
ENSG00000101452	DHX35	99	90.456	ENSTTRG00000007694	DHX35	99	90.456	Tursiops_truncatus
ENSG00000101452	DHX35	99	96.866	ENSUAMG00000009681	DHX35	99	96.866	Ursus_americanus
ENSG00000101452	DHX35	98	95.501	ENSUMAG00000003211	DHX35	98	95.501	Ursus_maritimus
ENSG00000101452	DHX35	99	96.439	ENSVVUG00000029235	DHX35	91	96.439	Vulpes_vulpes
ENSG00000101452	DHX35	99	80.284	ENSXETG00000012145	dhx35	99	80.284	Xenopus_tropicalis
ENSG00000101452	DHX35	99	77.663	ENSXCOG00000008020	zgc:158828	99	77.663	Xiphophorus_couchianus
ENSG00000101452	DHX35	99	78.000	ENSXMAG00000015468	zgc:158828	99	78.000	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0034459	ATP-dependent 3'-5' RNA helicase activity	21873635.	IBA	Function
GO:0071013	catalytic step 2 spliceosome	21873635.	IBA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component