EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000101558 (Gene tree)
Gene ID: 9218
Gene Symbol: VAPA
Alias: hVAP-33|VAP-A
Full Name: VAMP associated protein A
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 46,064 bases
Position: chr18:9,913,958-9,960,021
Accession: 12648
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000577539	VAPA-203	3760	-	-	- (aa)	-	-
ENST00000584796	VAPA-208	654	-	-	- (aa)	-	-
ENST00000340541	VAPA-201	1227	XM_011525769	ENSP00000345656	294 (aa)	XP_011524071	Q9P0L0
ENST00000583879	VAPA-207	719	-	-	- (aa)	-	-
ENST00000577901	VAPA-204	917	-	-	- (aa)	-	-
ENST00000583475	VAPA-206	939	-	-	- (aa)	-	-
ENST00000400000	VAPA-202	6815	XM_017026079	ENSP00000382880	249 (aa)	XP_016881568	Q9P0L0
ENST00000585042	VAPA-209	567	-	ENSP00000463155	29 (aa)	-	J3QKM9
ENST00000578314	VAPA-205	532	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000101558's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04979	Cholesterol metabolism	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000101558	Platelet Function Tests	1.0029657E-009	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000101558	rs80261783	18	9922405	T	Diverticular disease	30177863	[NR] unit increase	0.0086976	EFO_1001460

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000101558's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000101558	VAPA	100	97.189	ENSMUSG00000024091	Vapa	100	97.189	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0005515	protein binding	10544080.16227268.16895911.16996479.18160438.19289470.19515777.20029029.21957124.21976701.22045669.23736259.23840749.23935497.24105263.24209621.25616068.25681634.25910212.26496610.28298427.28377464.29997244.	IPI	Function
GO:0005783	endoplasmic reticulum	16791210.	HDA	Component
GO:0005783	endoplasmic reticulum	18713837.19289470.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005886	plasma membrane	10523508.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005923	bicellular tight junction	10523508.	IDA	Component
GO:0006888	ER to Golgi vesicle-mediated transport	18713837.	IMP	Process
GO:0007029	endoplasmic reticulum organization	18713837.	IMP	Process
GO:0008017	microtubule binding	18713837.	IMP	Function
GO:0008219	cell death	19289470.	IMP	Process
GO:0015630	microtubule cytoskeleton	-	IEA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0019904	protein domain specific binding	20178991.	IPI	Function
GO:0030148	sphingolipid biosynthetic process	-	TAS	Process
GO:0031175	neuron projection development	19289470.	IMP	Process
GO:0031965	nuclear membrane	-	IEA	Component
GO:0031982	vesicle	10523508.	IDA	Component
GO:0033149	FFAT motif binding	18713837.	IMP	Function
GO:0034975	protein folding in endoplasmic reticulum	18713837.	IMP	Process
GO:0035577	azurophil granule membrane	-	TAS	Component
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	12761501.	HMP	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0044791	positive regulation by host of viral release from host cell	19515777.	IDA	Process
GO:0044828	negative regulation by host of viral genome replication	19515777.	IDA	Process
GO:0044829	positive regulation by host of viral genome replication	19515777.	IDA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046982	protein heterodimerization activity	9920726.16227268.	IPI	Function
GO:0048471	perinuclear region of cytoplasm	16895911.	IDA	Component
GO:0061025	membrane fusion	9657962.	TAS	Process
GO:0070971	endoplasmic reticulum exit site	18713837.	IDA	Component
GO:0070972	protein localization to endoplasmic reticulum	19289470.	IMP	Process
GO:0090114	COPII-coated vesicle budding	18713837.	IMP	Process