EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000101574 (Gene tree)
Gene ID: 64863
Gene Symbol: METTL4
Alias: FLJ23017|HsT661
Full Name: methyltransferase like 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 33,985 bases
Position: chr18:2,537,525-2,571,509
Accession: 24726
RBP type: canonical RBP
Summary: METTL4 (Methyltransferase Like 4) is a Protein Coding gene. Diseases associated with METTL4 include Chromosome 18P Deletion Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and methyltransferase activity.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000458290	MT-A70	PF05063.14	1.5e-38	1	1
ENSP00000320349	MT-A70	PF05063.14	1.7e-24	1	1
ENSP00000460774	MT-A70	PF05063.14	2.1e-19	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000577166	METTL4-206	544	-	ENSP00000458415	90 (aa)	-	I3L0Y1
ENST00000574538	METTL4-203	2742	XM_005258133	ENSP00000458290	472 (aa)	XP_005258190	Q8N3J2
ENST00000576251	METTL4-205	1884	-	ENSP00000460774	92 (aa)	-	I3L3W2
ENST00000573134	METTL4-202	5190	-	-	- (aa)	-	-
ENST00000319888	METTL4-201	3601	XM_005258132	ENSP00000320349	419 (aa)	XP_005258189	J3KNJ7
ENST00000574676	METTL4-204	613	-	ENSP00000461097	21 (aa)	-	I3L4A0
ENST00000609769	METTL4-207	506	-	ENSP00000477089	142 (aa)	-	V9GYU3

Gene Model

Click here to download ENSG00000101574's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000101574	Alcoholism	5.02E-05	-
ENSG00000101574	Platelet Function Tests	1.9259000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000101574's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000101574	METTL4	90	65.060	ENSAPOG00000017300	mettl4	80	51.534	Acanthochromis_polyacanthus
ENSG00000101574	METTL4	97	89.888	ENSAMEG00000010116	METTL4	100	83.263	Ailuropoda_melanoleuca
ENSG00000101574	METTL4	96	64.773	ENSACIG00000015975	mettl4	87	49.405	Amphilophus_citrinellus
ENSG00000101574	METTL4	96	64.773	ENSAOCG00000013215	mettl4	93	52.994	Amphiprion_ocellaris
ENSG00000101574	METTL4	96	64.773	ENSAPEG00000014583	mettl4	93	52.695	Amphiprion_percula
ENSG00000101574	METTL4	96	62.500	ENSATEG00000003905	mettl4	92	44.211	Anabas_testudineus
ENSG00000101574	METTL4	97	77.528	ENSAPLG00000015046	METTL4	99	57.474	Anas_platyrhynchos
ENSG00000101574	METTL4	96	76.136	ENSACAG00000008742	METTL4	99	53.846	Anolis_carolinensis
ENSG00000101574	METTL4	97	96.629	ENSANAG00000028394	METTL4	100	93.220	Aotus_nancymaae
ENSG00000101574	METTL4	96	65.909	ENSACLG00000001329	mettl4	73	53.822	Astatotilapia_calliptera
ENSG00000101574	METTL4	96	57.955	ENSAMXG00000002844	mettl4	92	46.253	Astyanax_mexicanus
ENSG00000101574	METTL4	97	89.888	ENSBTAG00000021668	METTL4	100	82.203	Bos_taurus
ENSG00000101574	METTL4	85	37.037	WBGene00015939	C18A3.1	56	34.842	Caenorhabditis_elegans
ENSG00000101574	METTL4	97	96.629	ENSCJAG00000000092	METTL4	100	91.647	Callithrix_jacchus
ENSG00000101574	METTL4	97	89.888	ENSCAFG00000018387	METTL4	100	82.415	Canis_familiaris
ENSG00000101574	METTL4	97	89.888	ENSCAFG00020020313	METTL4	100	81.623	Canis_lupus_dingo
ENSG00000101574	METTL4	97	89.888	ENSCHIG00000000254	METTL4	100	81.144	Capra_hircus
ENSG00000101574	METTL4	100	86.667	ENSTSYG00000005777	METTL4	100	84.958	Carlito_syrichta
ENSG00000101574	METTL4	97	83.146	ENSCAPG00000007595	METTL4	99	73.885	Cavia_aperea
ENSG00000101574	METTL4	97	83.146	ENSCPOG00000005833	METTL4	99	73.885	Cavia_porcellus
ENSG00000101574	METTL4	100	88.889	ENSCCAG00000020235	METTL4	100	87.076	Cebus_capucinus
ENSG00000101574	METTL4	100	97.246	ENSCATG00000011642	METTL4	100	97.246	Cercocebus_atys
ENSG00000101574	METTL4	97	88.764	ENSCLAG00000011739	METTL4	99	80.042	Chinchilla_lanigera
ENSG00000101574	METTL4	100	96.822	ENSCSAG00000017613	METTL4	100	96.822	Chlorocebus_sabaeus
ENSG00000101574	METTL4	88	88.889	ENSCHOG00000004861	METTL4	99	67.585	Choloepus_hoffmanni
ENSG00000101574	METTL4	97	82.022	ENSCPBG00000001211	METTL4	98	61.905	Chrysemys_picta_bellii
ENSG00000101574	METTL4	85	44.872	ENSCING00000013236	-	99	44.660	Ciona_intestinalis
ENSG00000101574	METTL4	89	54.878	ENSCSAVG00000007106	-	96	47.280	Ciona_savignyi
ENSG00000101574	METTL4	97	98.876	ENSCANG00000040946	METTL4	99	96.226	Colobus_angolensis_palliatus
ENSG00000101574	METTL4	97	84.270	ENSCGRG00001005723	Mettl4	99	76.533	Cricetulus_griseus_chok1gshd
ENSG00000101574	METTL4	97	84.270	ENSCGRG00000003783	-	99	76.533	Cricetulus_griseus_crigri
ENSG00000101574	METTL4	95	66.667	ENSCSEG00000000384	mettl4	87	47.074	Cynoglossus_semilaevis
ENSG00000101574	METTL4	96	65.909	ENSCVAG00000003121	METTL4	95	45.610	Cyprinodon_variegatus
ENSG00000101574	METTL4	96	65.909	ENSDARG00000088999	mettl4	75	50.291	Danio_rerio
ENSG00000101574	METTL4	89	74.016	ENSDNOG00000033759	-	100	91.667	Dasypus_novemcinctus
ENSG00000101574	METTL4	97	91.011	ENSDORG00000005216	Mettl4	100	82.381	Dipodomys_ordii
ENSG00000101574	METTL4	86	37.647	FBgn0015351	CG14906	59	35.160	Drosophila_melanogaster
ENSG00000101574	METTL4	75	90.000	ENSETEG00000005139	METTL4	84	90.000	Echinops_telfairi
ENSG00000101574	METTL4	85	51.282	ENSEBUG00000007546	-	52	40.323	Eptatretus_burgeri
ENSG00000101574	METTL4	97	89.888	ENSEASG00005002722	METTL4	100	84.726	Equus_asinus_asinus
ENSG00000101574	METTL4	97	91.011	ENSECAG00000006301	METTL4	100	86.441	Equus_caballus
ENSG00000101574	METTL4	87	83.750	ENSEEUG00000000702	METTL4	100	57.957	Erinaceus_europaeus
ENSG00000101574	METTL4	96	62.500	ENSELUG00000008466	mettl4	71	52.395	Esox_lucius
ENSG00000101574	METTL4	97	89.888	ENSFCAG00000019392	METTL4	100	80.932	Felis_catus
ENSG00000101574	METTL4	96	73.864	ENSFALG00000006257	METTL4	99	55.624	Ficedula_albicollis
ENSG00000101574	METTL4	97	87.640	ENSFDAG00000013835	METTL4	99	78.981	Fukomys_damarensis
ENSG00000101574	METTL4	96	62.500	ENSFHEG00000012147	mettl4	91	43.803	Fundulus_heteroclitus
ENSG00000101574	METTL4	96	60.674	ENSGMOG00000005506	mettl4	97	51.471	Gadus_morhua
ENSG00000101574	METTL4	97	78.652	ENSGALG00000014799	METTL4	99	55.236	Gallus_gallus
ENSG00000101574	METTL4	96	63.636	ENSGAFG00000002111	mettl4	95	53.894	Gambusia_affinis
ENSG00000101574	METTL4	96	62.500	ENSGACG00000004176	mettl4	97	55.147	Gasterosteus_aculeatus
ENSG00000101574	METTL4	97	82.022	ENSGAGG00000025874	METTL4	99	59.958	Gopherus_agassizii
ENSG00000101574	METTL4	100	100.000	ENSGGOG00000000937	METTL4	100	99.045	Gorilla_gorilla
ENSG00000101574	METTL4	96	65.909	ENSHBUG00000016596	mettl4	93	44.280	Haplochromis_burtoni
ENSG00000101574	METTL4	97	91.011	ENSHGLG00000004250	METTL4	99	84.501	Heterocephalus_glaber_female
ENSG00000101574	METTL4	97	91.011	ENSHGLG00100008730	METTL4	99	84.713	Heterocephalus_glaber_male
ENSG00000101574	METTL4	96	61.364	ENSHCOG00000013475	mettl4	91	51.393	Hippocampus_comes
ENSG00000101574	METTL4	96	59.091	ENSIPUG00000006797	mettl4	90	40.671	Ictalurus_punctatus
ENSG00000101574	METTL4	97	92.135	ENSSTOG00000004283	METTL4	99	83.864	Ictidomys_tridecemlineatus
ENSG00000101574	METTL4	96	62.500	ENSKMAG00000014329	mettl4	94	44.231	Kryptolebias_marmoratus
ENSG00000101574	METTL4	96	68.182	ENSLBEG00000021733	mettl4	87	49.608	Labrus_bergylta
ENSG00000101574	METTL4	97	73.034	ENSLACG00000015273	METTL4	99	60.000	Latimeria_chalumnae
ENSG00000101574	METTL4	96	75.000	ENSLOCG00000011054	mettl4	99	57.637	Lepisosteus_oculatus
ENSG00000101574	METTL4	100	82.222	ENSLAFG00000004505	METTL4	100	82.203	Loxodonta_africana
ENSG00000101574	METTL4	100	96.897	ENSMFAG00000046183	METTL4	100	97.400	Macaca_fascicularis
ENSG00000101574	METTL4	100	96.610	ENSMMUG00000018950	METTL4	100	96.610	Macaca_mulatta
ENSG00000101574	METTL4	100	97.034	ENSMNEG00000027723	METTL4	100	97.034	Macaca_nemestrina
ENSG00000101574	METTL4	100	97.246	ENSMLEG00000036729	METTL4	100	97.246	Mandrillus_leucophaeus
ENSG00000101574	METTL4	96	64.773	ENSMAMG00000005327	mettl4	94	52.063	Mastacembelus_armatus
ENSG00000101574	METTL4	96	65.909	ENSMZEG00005001519	mettl4	93	42.398	Maylandia_zebra
ENSG00000101574	METTL4	97	78.652	ENSMGAG00000009739	METTL4	98	56.989	Meleagris_gallopavo
ENSG00000101574	METTL4	96	80.682	ENSMAUG00000004504	Mettl4	99	55.063	Mesocricetus_auratus
ENSG00000101574	METTL4	97	94.382	ENSMICG00000037155	METTL4	100	88.544	Microcebus_murinus
ENSG00000101574	METTL4	97	83.146	ENSMOCG00000000095	-	99	72.187	Microtus_ochrogaster
ENSG00000101574	METTL4	96	65.909	ENSMMOG00000003092	mettl4	98	53.086	Mola_mola
ENSG00000101574	METTL4	97	80.899	ENSMODG00000021472	METTL4	99	64.108	Monodelphis_domestica
ENSG00000101574	METTL4	97	83.146	MGP_CAROLIEiJ_G0021963	Mettl4	99	77.941	Mus_caroli
ENSG00000101574	METTL4	97	83.146	ENSMUSG00000055660	Mettl4	99	75.372	Mus_musculus
ENSG00000101574	METTL4	97	82.022	MGP_PahariEiJ_G0020952	Mettl4	99	76.761	Mus_pahari
ENSG00000101574	METTL4	97	89.888	ENSMPUG00000005375	METTL4	99	82.516	Mustela_putorius_furo
ENSG00000101574	METTL4	97	88.764	ENSMLUG00000003351	METTL4	100	82.563	Myotis_lucifugus
ENSG00000101574	METTL4	97	89.888	ENSNGAG00000000989	Mettl4	99	79.952	Nannospalax_galili
ENSG00000101574	METTL4	96	65.909	ENSNBRG00000014728	mettl4	67	51.477	Neolamprologus_brichardi
ENSG00000101574	METTL4	100	96.667	ENSNLEG00000006868	METTL4	100	96.610	Nomascus_leucogenys
ENSG00000101574	METTL4	100	62.222	ENSMEUG00000001797	-	64	67.361	Notamacropus_eugenii
ENSG00000101574	METTL4	97	91.011	ENSODEG00000006068	METTL4	99	72.187	Octodon_degus
ENSG00000101574	METTL4	96	65.909	ENSONIG00000006094	mettl4	98	52.226	Oreochromis_niloticus
ENSG00000101574	METTL4	97	79.775	ENSOANG00000010844	METTL4	99	59.504	Ornithorhynchus_anatinus
ENSG00000101574	METTL4	96	85.227	ENSOCUG00000022390	METTL4	79	81.410	Oryctolagus_cuniculus
ENSG00000101574	METTL4	96	62.500	ENSORLG00000011211	mettl4	82	53.271	Oryzias_latipes
ENSG00000101574	METTL4	96	62.500	ENSORLG00020009396	mettl4	92	44.820	Oryzias_latipes_hni
ENSG00000101574	METTL4	96	63.636	ENSORLG00015009397	mettl4	92	45.032	Oryzias_latipes_hsok
ENSG00000101574	METTL4	97	89.888	ENSOARG00000009572	METTL4	100	81.356	Ovis_aries
ENSG00000101574	METTL4	100	100.000	ENSPPAG00000030467	METTL4	100	99.045	Pan_paniscus
ENSG00000101574	METTL4	97	89.888	ENSPPRG00000010770	METTL4	100	80.932	Panthera_pardus
ENSG00000101574	METTL4	97	87.640	ENSPTIG00000010967	METTL4	100	80.720	Panthera_tigris_altaica
ENSG00000101574	METTL4	100	100.000	ENSPTRG00000009828	METTL4	100	99.284	Pan_troglodytes
ENSG00000101574	METTL4	100	97.458	ENSPANG00000021862	METTL4	100	97.458	Papio_anubis
ENSG00000101574	METTL4	96	61.364	ENSPKIG00000009903	mettl4	96	46.197	Paramormyrops_kingsleyae
ENSG00000101574	METTL4	97	80.899	ENSPSIG00000007210	METTL4	99	60.805	Pelodiscus_sinensis
ENSG00000101574	METTL4	98	38.202	ENSPMGG00000002892	mettl4	83	48.397	Periophthalmus_magnuspinnatus
ENSG00000101574	METTL4	97	84.270	ENSPEMG00000012275	Mettl4	99	76.645	Peromyscus_maniculatus_bairdii
ENSG00000101574	METTL4	96	61.364	ENSPMAG00000009399	mettl4	100	46.980	Petromyzon_marinus
ENSG00000101574	METTL4	97	79.775	ENSPCIG00000016096	METTL4	99	66.879	Phascolarctos_cinereus
ENSG00000101574	METTL4	96	64.773	ENSPFOG00000017039	mettl4	92	52.819	Poecilia_formosa
ENSG00000101574	METTL4	96	64.773	ENSPLAG00000021017	mettl4	78	53.687	Poecilia_latipinna
ENSG00000101574	METTL4	96	64.773	ENSPMEG00000021646	mettl4	78	54.277	Poecilia_mexicana
ENSG00000101574	METTL4	84	51.948	ENSPREG00000007501	mettl4	78	47.785	Poecilia_reticulata
ENSG00000101574	METTL4	100	98.093	ENSPPYG00000009040	METTL4	100	98.093	Pongo_abelii
ENSG00000101574	METTL4	100	74.444	ENSPCAG00000003014	METTL4	100	70.426	Procavia_capensis
ENSG00000101574	METTL4	88	91.358	ENSPCOG00000020273	METTL4	100	68.565	Propithecus_coquereli
ENSG00000101574	METTL4	97	89.888	ENSPVAG00000004036	METTL4	100	82.415	Pteropus_vampyrus
ENSG00000101574	METTL4	96	65.909	ENSPNYG00000001318	mettl4	93	44.280	Pundamilia_nyererei
ENSG00000101574	METTL4	96	57.955	ENSPNAG00000021504	mettl4	73	49.408	Pygocentrus_nattereri
ENSG00000101574	METTL4	97	82.022	ENSRNOG00000026280	Mettl4	99	75.159	Rattus_norvegicus
ENSG00000101574	METTL4	97	98.876	ENSRBIG00000037093	METTL4	100	92.124	Rhinopithecus_bieti
ENSG00000101574	METTL4	100	97.034	ENSRROG00000032893	METTL4	100	97.034	Rhinopithecus_roxellana
ENSG00000101574	METTL4	97	96.629	ENSSBOG00000033623	METTL4	100	93.079	Saimiri_boliviensis_boliviensis
ENSG00000101574	METTL4	96	62.500	ENSSFOG00015001178	mettl4	95	44.540	Scleropages_formosus
ENSG00000101574	METTL4	96	64.773	ENSSMAG00000017369	mettl4	86	50.612	Scophthalmus_maximus
ENSG00000101574	METTL4	96	64.773	ENSSDUG00000008018	mettl4	99	54.354	Seriola_dumerili
ENSG00000101574	METTL4	96	64.773	ENSSLDG00000023019	mettl4	79	52.525	Seriola_lalandi_dorsalis
ENSG00000101574	METTL4	97	85.393	ENSSARG00000004753	METTL4	100	66.314	Sorex_araneus
ENSG00000101574	METTL4	96	68.182	ENSSPUG00000009271	METTL4	99	56.823	Sphenodon_punctatus
ENSG00000101574	METTL4	96	67.045	ENSSPAG00000013070	mettl4	100	39.173	Stegastes_partitus
ENSG00000101574	METTL4	97	91.011	ENSSSCG00000034816	METTL4	100	84.355	Sus_scrofa
ENSG00000101574	METTL4	97	79.775	ENSTGUG00000010144	METTL4	99	56.904	Taeniopygia_guttata
ENSG00000101574	METTL4	96	64.773	ENSTRUG00000023548	mettl4	95	42.616	Takifugu_rubripes
ENSG00000101574	METTL4	96	64.773	ENSTNIG00000017118	mettl4	99	50.147	Tetraodon_nigroviridis
ENSG00000101574	METTL4	88	93.827	ENSTBEG00000002671	-	55	95.745	Tupaia_belangeri
ENSG00000101574	METTL4	97	89.888	ENSTTRG00000008249	METTL4	100	83.898	Tursiops_truncatus
ENSG00000101574	METTL4	97	91.011	ENSUMAG00000019651	METTL4	100	84.322	Ursus_maritimus
ENSG00000101574	METTL4	88	93.827	ENSVPAG00000003529	METTL4	78	91.282	Vicugna_pacos
ENSG00000101574	METTL4	97	89.888	ENSVVUG00000006988	METTL4	100	81.623	Vulpes_vulpes
ENSG00000101574	METTL4	96	64.773	ENSXCOG00000011836	mettl4	97	38.520	Xiphophorus_couchianus
ENSG00000101574	METTL4	96	64.773	ENSXMAG00000002213	mettl4	76	53.571	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	21873635.	IBA	Function
GO:0032775	DNA methylation on adenine	-	IEA	Process