EuRBPDB

Description

Ensembl ID: ENSG00000101752 (Gene tree)
Gene ID: 57534
Gene Symbol: MIB1
Alias: DIP-1|MIB|KIAA1323|ZZANK2|ZZZ6
Full Name: mindbomb E3 ubiquitin protein ligase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 166,001 bases
Position: chr18:21,704,957-21,870,957
Accession: 21086
RBP type: non-canonical RBP
Summary: This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000261537	MIB1-201	9576	XM_017025873	ENSP00000261537	1006 (aa)	XP_016881362	Q86YT6
ENST00000577749	MIB1-202	726	-	-	- (aa)	-	-
ENST00000578260	MIB1-203	544	-	-	- (aa)	-	-
ENST00000578646	MIB1-204	3306	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000101752	Erythrocyte Count	6.9880000E-008	-
ENSG00000101752	Erythrocyte Count	2.5290000E-008	-

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001568	blood vessel development	-	IEA	Process
GO:0001701	in utero embryonic development	-	IEA	Process
GO:0001756	somitogenesis	-	IEA	Process
GO:0001841	neural tube formation	-	IEA	Process
GO:0001947	heart looping	-	IEA	Process
GO:0004842	ubiquitin-protein transferase activity	21873635.	IBA	Function
GO:0005515	protein binding	21903422.28712572.	IPI	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005813	centrosome	21399614.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0006897	endocytosis	21873635.	IBA	Process
GO:0007219	Notch signaling pathway	21873635.	IBA	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0014069	postsynaptic density	-	IEA	Component
GO:0016567	protein ubiquitination	21873635.	IBA	Process
GO:0016567	protein ubiquitination	-	IEA	Process
GO:0031410	cytoplasmic vesicle	-	IEA	Component
GO:0045665	negative regulation of neuron differentiation	-	IEA	Process
GO:0045807	positive regulation of endocytosis	-	IEA	Process