EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000101868 (Gene tree)
Gene ID: 5422
Gene Symbol: POLA1
Alias: p180|POLA|NSX
Full Name: DNA polymerase alpha 1, catalytic subunit
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 303,113 bases
Position: chrX:24,693,874-24,996,986
Accession: 9173
RBP type: non-canonical RBP
Summary: This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29775245	Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline.	FEBS J	2018 Jul	Yoon DS	doi: 10.1111/febs.14512
11137007	Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint.	Curr Biol	2000 Dec 14-28	Hekmat-Nejad M	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000379059	POLA1-201	5440	-	ENSP00000368349	1462 (aa)	-	P09884
ENST00000379068	POLA1-202	5486	XM_011545540	ENSP00000368358	1468 (aa)	XP_011543842	A6NMQ1
ENST00000494204	POLA1-205	806	-	-	- (aa)	-	-
ENST00000480125	POLA1-203	580	-	-	- (aa)	-	-
ENST00000493342	POLA1-204	978	-	-	- (aa)	-	-
ENST00000611764	POLA1-206	5434	XM_006724499	ENSP00000478401	1461 (aa)	XP_006724562	A0A087WU64

Gene Model

Click here to download ENSG00000101868's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03030	DNA replication	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000101868	Hemoglobins	1.06498503457472E-8	17903294
ENSG00000101868	Hemoglobins	1.18104463616914E-8	17903294

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000101868's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000101868	POLA1	98	39.575	FBgn0259113	DNApol-alpha180	98	39.801	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000082	G1/S transition of mitotic cell cycle	-	TAS	Process
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	-	TAS	Process
GO:0000166	nucleotide binding	3139084.	IDA	Function
GO:0000731	DNA synthesis involved in DNA repair	11470886.	IMP	Process
GO:0000785	chromatin	9815285.	IDA	Component
GO:0001882	nucleoside binding	-	IEA	Function
GO:0003677	DNA binding	16762037.	IDA	Function
GO:0003677	DNA binding	3359994.	NAS	Function
GO:0003682	chromatin binding	16762037.	IDA	Function
GO:0003688	DNA replication origin binding	21873635.	IBA	Function
GO:0003887	DNA-directed DNA polymerase activity	893425.3359994.	IDA	Function
GO:0003887	DNA-directed DNA polymerase activity	4084590.	IMP	Function
GO:0005515	protein binding	1311258.2243771.7644508.8380896.9395244.9518481.10518787.10869558.10873756.16438930.17666013.	IPI	Function
GO:0005634	nucleus	4084590.16762037.	IDA	Component
GO:0005635	nuclear envelope	9518481.	IDA	Component
GO:0005654	nucleoplasm	7045121.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005658	alpha DNA polymerase:primase complex	21873635.	IBA	Component
GO:0005658	alpha DNA polymerase:primase complex	2175912.	IDA	Component
GO:0005658	alpha DNA polymerase:primase complex	2243771.	TAS	Component
GO:0005730	nucleolus	9518481.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006260	DNA replication	3917431.4084590.16762037.	IMP	Process
GO:0006269	DNA replication, synthesis of RNA primer	2175912.	IDA	Process
GO:0006270	DNA replication initiation	2175912.	IDA	Process
GO:0006270	DNA replication initiation	-	TAS	Process
GO:0006271	DNA strand elongation involved in DNA replication	4084590.	IMP	Process
GO:0006272	leading strand elongation	21873635.	IBA	Process
GO:0006272	leading strand elongation	2175912.7910375.	IDA	Process
GO:0006273	lagging strand elongation	21873635.	IBA	Process
GO:0006273	lagging strand elongation	2175912.7910375.	IDA	Process
GO:0006281	DNA repair	3335506.	IDA	Process
GO:0006281	DNA repair	11470886.	IMP	Process
GO:0006289	nucleotide-excision repair	1508673.	IMP	Process
GO:0006303	double-strand break repair via nonhomologous end joining	21873635.	IBA	Process
GO:0006303	double-strand break repair via nonhomologous end joining	11470886.	IMP	Process
GO:0008283	cell proliferation	3359994.	IDA	Process
GO:0016032	viral process	-	IEA	Process
GO:0016363	nuclear matrix	1903085.	IDA	Component
GO:0017076	purine nucleotide binding	21873635.	IBA	Function
GO:0019901	protein kinase binding	9506968.	IPI	Function
GO:0032201	telomere maintenance via semi-conservative replication	-	TAS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0046982	protein heterodimerization activity	21873635.	IBA	Function
GO:0051539	4 iron, 4 sulfur cluster binding	-	IEA	Function
GO:1902975	mitotic DNA replication initiation	21873635.	IBA	Process
GO:1902981	synthesis of RNA primer involved in mitotic DNA replication	21873635.	IBA	Process
GO:1904161	DNA synthesis involved in UV-damage excision repair	1730053.	IMP	Process