EuRBPDB

Description

Ensembl ID: ENSG00000101882 (Gene tree)
Gene ID: 79576
Gene Symbol: NKAP
Alias: FLJ22626
Full Name: NFKB activating protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 23,101 bases
Position: chrX:119,920,672-119,943,772
Accession: 29873
RBP type: non-canonical RBP
Summary: This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24353314	NKAP is a novel RS-related protein that interacts with RNA and RNA binding proteins.	Nucleic Acids Res	2014 Mar	Burgute BD	doi: 10.1093/nar/gkt1311

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000371410	NKAP-201	5963	XM_017029842	ENSP00000360464	415 (aa)	XP_016885331	Q8N5F7
ENST00000482407	NKAP-204	763	-	-	- (aa)	-	-
ENST00000455986	NKAP-202	810	-	-	- (aa)	-	-
ENST00000477789	NKAP-203	2345	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000101882	Cholesterol, LDL	2.48673758944662E-5	17903299
ENSG00000101882	Cholesterol	6.39170221083951E-6	17903299
ENSG00000101882	Cholesterol	2.83913346923459E-5	17903299
ENSG00000101882	Cholesterol, LDL	9.30633063380704E-5	17903299
ENSG00000101882	Cholesterol	5.67902604409198E-6	17903299
ENSG00000101882	Cholesterol	2.10576269843443E-6	17903299

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0003682	chromatin binding	19409814.	IDA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	19409814.22365833.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0007219	Notch signaling pathway	-	IEA	Process
GO:0019827	stem cell population maintenance	-	IEA	Process
GO:0030851	granulocyte differentiation	-	IEA	Process
GO:0031490	chromatin DNA binding	-	IEA	Function
GO:0033077	T cell differentiation in thymus	-	IEA	Process
GO:0045892	negative regulation of transcription, DNA-templated	19409814.	IDA	Process
GO:0046638	positive regulation of alpha-beta T cell differentiation	19409814.	IMP	Process
GO:0071425	hematopoietic stem cell proliferation	-	IEA	Process