EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000102081 (Gene tree)
Gene ID: 2332
Gene Symbol: FMR1
Alias: FMRP|FRAXA|MGC87458|POF1|POF
Full Name: fragile X mental retardation 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 39,177 bases
Position: chrX:147,911,951-147,951,127
Accession: 3775
RBP type: canonical RBP
Summary: The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq, May 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000479528	KH_1	PF00013.29	5.7e-17	1	2
ENSP00000479528	KH_1	PF00013.29	5.7e-17	2	2
ENSP00000481058	KH_1	PF00013.29	9.1e-16	1	2
ENSP00000481058	KH_1	PF00013.29	9.1e-16	2	2
ENSP00000359502	KH_1	PF00013.29	1.9e-15	1	2
ENSP00000359502	KH_1	PF00013.29	1.9e-15	2	2
ENSP00000359501	KH_1	PF00013.29	3e-15	1	2
ENSP00000359501	KH_1	PF00013.29	3e-15	2	2
ENSP00000218200	KH_1	PF00013.29	3.4e-15	1	2
ENSP00000218200	KH_1	PF00013.29	3.4e-15	2	2
ENSP00000413764	KH_1	PF00013.29	3.4e-15	1	2
ENSP00000413764	KH_1	PF00013.29	3.4e-15	2	2
ENSP00000359508	KH_1	PF00013.29	3.5e-15	1	2
ENSP00000359508	KH_1	PF00013.29	3.5e-15	2	2
ENSP00000359506	KH_1	PF00013.29	3.6e-15	1	2
ENSP00000359506	KH_1	PF00013.29	3.6e-15	2	2
ENSP00000395923	KH_1	PF00013.29	9.3e-11	1	1
ENSP00000355115	KH_1	PF00013.29	2.7e-05	1	1
ENSP00000477839	KH_1	PF00013.29	2.7e-05	1	1
ENSP00000481474	KH_1	PF00013.29	0.00012	1	1
ENSP00000355115	Agenet	PF05641.12	5.6e-12	1	1
ENSP00000477839	Agenet	PF05641.12	5.6e-12	1	1
ENSP00000481058	Agenet	PF05641.12	2.5e-11	1	1
ENSP00000359502	Agenet	PF05641.12	3.9e-11	1	1
ENSP00000479528	Agenet	PF05641.12	5.6e-11	1	1
ENSP00000218200	Agenet	PF05641.12	5.7e-11	1	1
ENSP00000413764	Agenet	PF05641.12	5.7e-11	1	1
ENSP00000359508	Agenet	PF05641.12	5.8e-11	1	1
ENSP00000359501	Agenet	PF05641.12	6.2e-11	1	1
ENSP00000359506	Agenet	PF05641.12	6.2e-11	1	1
ENSP00000395923	Agenet	PF05641.12	6.7e-11	1	1
ENSP00000479528	FXMRP1_C_core	PF12235.8	2.3e-45	1	1
ENSP00000395923	FXMRP1_C_core	PF12235.8	2.3e-45	1	1
ENSP00000218200	FXMRP1_C_core	PF12235.8	2.6e-45	1	1
ENSP00000359506	FXMRP1_C_core	PF12235.8	2.7e-45	1	1
ENSP00000359508	FXMRP1_C_core	PF12235.8	4e-34	1	1
ENSP00000413764	FXMRP1_C_core	PF12235.8	1.3e-30	1	1
ENSP00000359501	FXMRP1_C_core	PF12235.8	1.8e-30	1	1
ENSP00000480886	FXMRP1_C_core	PF12235.8	7.7e-17	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23235829	FMRP targets distinct mRNA sequence elements to regulate protein expression.	Nature	2012 Dec 20	Ascano M Jr	doi: 10.1038/nature11737
26374839	Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP.	Proc Natl Acad Sci U S A	2015 Sep 29	Vasilyev N	doi: 10.1073/pnas.1515737112
29218006	Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat.	Front Aging Neurosci	2017 Nov 23	Smidak R	doi: 10.3389/fnagi.2017.00384
29545014	Identification and analysis of host proteins that interact with the 3'-untranslated region of tick-borne encephalitis virus genomic RNA.	Virus Res	2018 Apr 2	Muto M	doi: 10.1016/j.virusres.2018.03.006
7489725	The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.	EMBO J	1995 Nov 1	Zhang Y	-
9624140	Purified recombinant Fmrp exhibits selective RNA binding as an intrinsic property of the fragile X mental retardation protein.	J Biol Chem	1998 Jun 19	Brown V	-
8526888	A fragile gene.	Bioessays	1995 Nov	Oostra BA	-
10331608	Search for a Caenorhabditis elegans FMR1 homologue: identification of a new putative RNA-binding protein (PRP-1) that hybridizes to the mouse FMR1 double K homology domain.	Am J Med Genet	1999 May 28	Shtang S	-
7781595	FXR1, an autosomal homolog of the fragile X mental retardation gene.	EMBO J	1995 Jun 1	Siomi MC	-
15805463	Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes.	Genes Dev	2005 Apr 15	Darnell JC	-
14511639	Deja vu all over again: FMRP binds U-rich target mRNAs.	Biochem Biophys Res Commun	2003 Oct 10	Denman RB	-
19838324	Signals, synapses, and synthesis: how new proteins control plasticity.	Front Neural Circuits	2009 Oct 7	Zukin RS	doi: 10.3389/neuro.04.014.2009
19487368	Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.	Hum Mol Genet	2009 Sep 1	Darnell JC	doi: 10.1093/hmg/ddp255
18839028	Fragile X syndrome and epilepsy.	Neurosci Bull	2008 Oct	Qiu LF	doi: 10.1007/s12264-008-1221-0.
22134704	Analysis of the Fragile X mental retardation protein isoforms 1, 2 and 3 interactions with the G-quadruplex forming semaphorin 3F mRNA.	Mol Biosyst	2012 Feb	Evans TL	doi: 10.1039/c1mb05322a
23874212	The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster.	PLoS Genet	2013	Baumgartner R	doi: 10.1371/journal.pgen.1003598
7692601	FMR1 protein: conserved RNP family domains and selective RNA binding.	Science	1993 Oct 22	Ashley CT Jr	-
12052912	A decade of molecular studies of fragile X syndrome.	Annu Rev Neurosci	2002	O'Donnell WT	-
16098133	FMRP RNA targets: identification and validation.	Genes Brain Behav	2005 Aug	Darnell JC	-
16819831	Thermodynamics of the fragile X mental retardation protein RGG box interactions with G quartet forming RNA.	Biochemistry	2006 Jul 11	Zanotti KJ	-
15241549	Regulating a translational regulator: mechanisms cells use to control the activity of the fragile X mental retardation protein.	Cell Mol Life Sci	2004 Jul	Denman RB	-
14631199	Understanding the biological underpinnings of fragile X syndrome.	Curr Opin Pediatr	2003 Dec	Chiurazzi P	-
20064924	Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA.	Hum Mol Genet	2010 Apr 1	Blackwell E	doi: 10.1093/hmg/ddq007
19362146	Tissue and developmental regulation of fragile X mental retardation 1 exon 12 and 15 isoforms.	Neurobiol Dis	2009 Jul	Xie W	doi: 10.1016/j.nbd.2009.03.015
19166269	A novel function for fragile X mental retardation protein in translational activation.	PLoS Biol	2009 Jan 20	Bechara EG	doi: 10.1371/journal.pbio.1000016.
18354025	Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP.	J Neurosci	2008 Mar 19	Reeve SP	doi: 10.1523/JNEUROSCI.5528-07.2008.
17693432	Interactions of the G quartet forming semaphorin 3F RNA with the RGG box domain of the fragile X protein family.	Nucleic Acids Res	2007	Menon L	-
17376973	Fragile X mental retardation protein induces synapse loss through acute postsynaptic translational regulation.	J Neurosci	2007 Mar 21	Pfeiffer BE	-
17194772	Substitution of critical isoleucines in the KH domains of Drosophila fragile X protein results in partial loss-of-function phenotypes.	Genetics	2007 Mar	Banerjee P	-
17170008	Fragile X related protein 1 isoforms differentially modulate the affinity of fragile X mental retardation protein for G-quartet RNA structure.	Nucleic Acids Res	2007	Bechara E	-
22737234	Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected].	PLoS One	2012	El Fatimy R	doi: 10.1371/journal.pone.0039338
22513101	Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain.	Brain Res	2012 Jun 26	Callan MA	doi: 10.1016/j.brainres.2012.03.042
21842222	Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders.	J Neurodev Disord	2011 Sep	De Rubeis S	doi: 10.1007/s11689-011-9087-2
21784246	FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism.	Cell	2011 Jul 22	Darnell JC	doi: 10.1016/j.cell.2011.06.013.
21316452	AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome.	Neurobiol Dis	2011 Jun	Levenga J	doi: 10.1016/j.nbd.2011.01.022
20570707	The role of G-quadruplex in RNA metabolism: involvement of FMRP and FMR2P.	Biochimie	2010 Aug	Melko M	doi: 10.1016/j.biochi.2010.05.018
20541608	Recombinant bacterial expression and purification of human fragile X mental retardation protein isoform 1.	Protein Expr Purif	2010 Dec	Evans TL	doi: 10.1016/j.pep.2010.06.002
28257890	A novel role of fragile X mental retardation protein in pre-mRNA alternative splicing through RNA-binding protein 14.	Neuroscience	2017 May 4	Zhou LT	doi: 10.1016/j.neuroscience.2017.02.044
24462888	Fragile X Syndrome: from molecular pathology to therapy.	Neurosci Biobehav Rev	2014 Oct	Maurin T	doi: 10.1016/j.neubiorev.2014.01.006
24249225	Biophysical characterization of G-quadruplex forming FMR1 mRNA and of its interactions with different fragile X mental retardation protein isoforms.	RNA	2014 Jan	Blice-Baum AC	doi: 10.1261/rna.041442.113
24204304	Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies.	PLoS Genet	2013 Oct	Dury AY	doi: 10.1371/journal.pgen.1003890
23440729	Current Gaps in Understanding the Molecular Basis of FXTAS.	Tremor Other Hyperkinet Mov (N Y)	2012	Hagerman PJ	doi: 10.7916/D80C4TH0
28039324	Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction.	Nucleic Acids Res	2017 Mar 17	Ahmad M	doi: 10.1093/nar/gkw1293.
28090421	RNA G-quadruplexes and their potential regulatory roles in translation.	Translation (Austin)	2016 Oct 4	Song J	doi: 10.1080/21690731.2016.1244031
29713264	Modeling Fragile X Syndrome in Drosophila.	Front Mol Neurosci	2018 Apr 16	Drozd M	doi: 10.3389/fnmol.2018.00124
29796988	The Fragile X Protein and Genome Function.	Mol Neurobiol	2019 Jan	Dockendorff TC	doi: 10.1007/s12035-018-1122-9
8776596	FMRP is associated to the ribosomes via RNA.	Hum Mol Genet	1996 Jun	Tamanini F	-
11860268	Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency.	Mol Cell Neurosci	2002 Feb	Li J	-
15381419	The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre.	J Mol Biol	2004 Oct 8	Menon RP	-
17923234	Analysis of mRNA translation in cultured hippocampal neurons.	Methods Enzymol	2007	Huang YS	-
26851502	Neuron class-specific requirements for Fragile X Mental Retardation Protein in critical period development of calcium signaling in learning and memory circuitry.	Neurobiol Dis	2016 May	Doll CA	doi: 10.1016/j.nbd.2016.02.006
26554012	A 3' untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuR.	Proc Natl Acad Sci U S A	2015 Nov 24	Suhl JA	doi: 10.1073/pnas.1514260112
26518186	Netrin-1 induces local translation of down syndrome cell adhesion molecule in axonal growth cones.	Dev Neurobiol	2016 Jul	Jain S	doi: 10.1002/dneu.22360
30478144	hnRNP Q Regulates Internal Ribosome Entry Site-Mediated fmr1 Translation in Neurons.	Mol Cell Biol	2019 Feb 4	Choi JH	doi: 10.1128/MCB.00371-18
10546896	Biology of the fragile X mental retardation protein, an RNA-binding protein.	Biochem Cell Biol	1999	Khandjian EW	-
10556305	A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein.	Hum Mol Genet	1999 Dec	Bardoni B	-
10196376	Different targets for the fragile X-related proteins revealed by their distinct nuclear localizations.	Hum Mol Genet	1999 May	Tamanini F	-
10496225	Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains.	RNA	1999 Sep	Adinolfi S	-
9659908	FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association.	Mol Cell	1997 Dec	Feng Y	-
9512393	No evidence for disruption of normal patterns of mRNA localization in dendrites or dendritic transport of recently synthesized mRNA in FMR1 knockout mice, a model for human fragile-X mental retardation syndrome.	Neuroreport	1998 Feb 16	Steward O	-
9452307	Overexpression of fragile X gene (FMR-1) transcripts increases cAMP production in neural cells.	J Neurosci Res	1998 Jan 1	Berry-Kravis E	-
9440121	Analysis of domains affecting intracellular localization of the FMRP protein.	Neurobiol Dis	1997	Bardoni B	-
9285783	The fragile X mental retardation protein is associated with poly(A)+ mRNA in actively translating polyribosomes.	Hum Mol Genet	1997 Sep	Corbin F	-
9259278	Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.	Hum Mol Genet	1997 Aug	Tamanini F	-
9030614	Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes.	J Neurosci	1997 Mar 1	Feng Y	-
8895584	A nuclear role for the Fragile X mental retardation protein.	EMBO J	1996 Oct 1	Fridell RA	-
8842725	The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals.	Hum Mol Genet	1996 Aug	Eberhart DE	-
8844093	Severe mental retardation and macroorchidism without mutation in the FMR1 gene.	Am J Med Genet	1996 Aug 9	Reyniers E	-
8808273	The chicken FMR1 gene is highly conserved with a CCT 5'-untranslated repeat and encodes an RNA-binding protein.	Genomics	1996 Jan 1	Price DK	-
8789445	Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms.	Hum Mol Genet	1996 Jan	Sittler A	-
8301769	Advances in molecular analysis of fragile X syndrome.	JAMA	1994 Feb 16	Warren ST	-
10331605	Reduced mRNA for G3BP in fragile X cells: evidence of FMR1 gene regulation.	Am J Med Genet	1999 May 28	Zhong N	-
7688265	The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein.	Cell	1993 Jul 30	Siomi H	-
16922515	Alternative splicing modulates protein arginine methyltransferase-dependent methylation of fragile X syndrome mental retardation protein.	Biochemistry	2006 Aug 29	Dolzhanskaya N	-
16636078	Methylation regulates the intracellular protein-protein and protein-RNA interactions of FMRP.	J Cell Sci	2006 May 1	Dolzhanskaya N	-
16571602	The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons.	Hum Mol Genet	2006 May 1	Davidovic L	-
13130134	G-quartet-dependent recognition between the FMRP RGG box and RNA.	RNA	2003 Oct	Ramos A	-
12941608	NUFIP1 (nuclear FMRP interacting protein 1) is a nucleocytoplasmic shuttling protein associated with active synaptoneurosomes.	Exp Cell Res	2003 Sep 10	Bardoni B	-
12867085	The RNA binding protein FMRP: new connections and missing links.	Biol Cell	2003 May-Jun	Schaeffer C	-
12837692	82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization.	Hum Mol Genet	2003 Jul 15	Bardoni B	-
12633995	New insights into fragile X syndrome: from molecules to neurobehaviors.	Trends Biochem Sci	2003 Mar	Jin P	-
12594214	The fragile X mental retardation protein FMRP binds elongation factor 1A mRNA and negatively regulates its translation in vivo.	J Biol Chem	2003 May 2	Sung YJ	-
12575950	RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice.	Neuron	2003 Feb 6	Miyashiro KY	-
12591163	Whisker stimulation-dependent translation of FMRP in the barrel cortex requires activation of type I metabotropic glutamate receptors.	Brain Res Mol Brain Res	2003 Feb 20	Todd PK	-
16500891	The gene encoding the fragile X RNA-binding protein is controlled by nuclear respiratory factor 2 and the CREB family of transcription factors.	Nucleic Acids Res	2006 Feb 25	Smith KT	-
16510718	Fragile X mental retardation protein shifts between polyribosomes and stress granules after neuronal injury by arsenite stress or in vivo hippocampal electrode insertion.	J Neurosci	2006 Mar 1	Kim SH	-
12460546	Novel features of dFMR1, the Drosophila orthologue of the fragile X mental retardation protein.	Neurobiol Dis	2002 Oct	Schenck A	-
12417522	Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression.	Hum Mol Genet	2002 Nov 15	Mazroui R	-
12417734	Transport of fragile X mental retardation protein via granules in neurites of PC12 cells.	Mol Cell Biol	2002 Dec	De Diego Otero Y	-
12378270	Methylation of the arginine-glycine-rich region in the fragile X mental retardation protein FMRP differentially affects RNA binding.	Cell Mol Biol Lett	2002	Denman RB	-
12368260	Fragile X-related protein and VIG associate with the RNA interference machinery.	Genes Dev	2002 Oct 1	Caudy AA	-
12368261	A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins.	Genes Dev	2002 Oct 1	Ishizuka A	-
12270684	Gene expression profiles in a transgenic animal model of fragile X syndrome.	Neurobiol Dis	2002 Aug	D'Agata V	-
16495445	Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin.	J Neurosci	2006 Feb 22	Stein JM	-
12112448	Molecular phenotype of Fragile X syndrome: FMRP, FXRPs, and protein targets.	Microsc Res Tech	2002 May 1	Kaufmann WE	-
12112449	Fragile X mental retardation: misregulation of protein synthesis in the developing brain?	Microsc Res Tech	2002 May 1	Feng Y	-
12112450	Fragile X syndrome, the Fragile X related proteins, and animal models.	Microsc Res Tech	2002 May 1	Hoogeveen AT	-
12076671	Advances in understanding of fragile X pathogenesis and FMRP function, and in identification of X linked mental retardation genes.	Curr Opin Genet Dev	2002 Jun	Bardoni B	-
12086633	Understanding fragile X syndrome: insights from retarded flies.	Neuron	2002 Jun 13	Gao FB	-
12086644	Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest.	Neuron	2002 Jun 13	Dockendorff TC	-
11948657	Role of HuD and other RNA-binding proteins in neural development and plasticity.	J Neurosci Res	2002 Apr 15	Perrone-Bizzozero N	-
11944923	Species-specific and isoform-specific RNA binding of human and mouse fragile X mental retardation proteins.	Biochem Biophys Res Commun	2002 Apr 12	Denman RB	-
11875043	Knockout mouse model for Fxr2: a model for mental retardation.	Hum Mol Genet	2002 Mar 1	Bontekoe CJ	-
16452252	Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome.	J Neurophysiol	2006 May	Nosyreva ED	-
11719189	Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function.	Cell	2001 Nov 16	Darnell JC	-
11719275	The Fragile X mental retardation protein.	Brain Res Bull	2001 Oct-Nov 1	Bardoni B	-
11562939	Annexin-1 is abnormally expressed in fragile X syndrome: two-dimensional electrophoresis study in lymphocytes.	Am J Med Genet	2001 Sep 15	Sun HT	-
16407062	The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction.	Structure	2006 Jan	Ramos A	-
11532944	The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif.	EMBO J	2001 Sep 3	Schaeffer C	-
11416194	Synaptic regulation of protein synthesis and the fragile X protein.	Proc Natl Acad Sci U S A	2001 Jun 19	Greenough WT	-
11438699	A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.	Proc Natl Acad Sci U S A	2001 Jul 17	Schenck A	-
11440196	Subcellular localization of fragile X mental retardation protein with the I304N mutation in the RNA-binding domain in cultured hippocampal neurons.	Cell Mol Neurobiol	2001 Feb	Castren M	-
11376146	The fragile X mental retardation protein inhibits translation via interacting with mRNA.	Nucleic Acids Res	2001 Jun 1	Li Z	-
11299521	Premature ovarian failure and the FMR1 gene.	Semin Reprod Med	2000	Murray A	-
11162447	Identification of mouse YB1/p50 as a component of the FMRP-associated mRNP particle.	Biochem Biophys Res Commun	2000 Dec 29	Ceman S	-
11157796	Evidence that fragile X mental retardation protein is a negative regulator of translation.	Hum Mol Genet	2001 Feb 15	Laggerbauer B	-
11039725	Sensory stimulation increases cortical expression of the fragile X mental retardation protein in vivo.	Brain Res Mol Brain Res	2000 Aug 14	Todd PK	-
11019488	Molecular mechanisms of fragile X syndrome.	J Med Invest	2000 Aug	Inoue SB	-
10973830	RNAs that interact with the fragile X syndrome RNA binding protein FMRP.	Biochem Biophys Res Commun	2000 Sep 7	Sung YJ	-
10912798	Immunocytochemical and biochemical characterization of FMRP, FXR1P, and FXR2P in the mouse.	Exp Cell Res	2000 Jul 10	Bakker CE	-
10888599	The fragile X-related proteins FXR1P and FXR2P contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins.	Hum Mol Genet	2000 Jun 12	Tamanini F	-
10767313	Understanding the molecular basis of fragile X syndrome.	Hum Mol Genet	2000 Apr 12	Jin P	-
10676814	Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome.	Cell	2000 Feb 4	Lewis HA	-
16319129	Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp.	Hum Mol Genet	2006 Jan 1	Stetler A	-
16130171	Expression of fragile X mental retardation-1 gene with nuclear export signal mutation changes the expression profiling of mouse cerebella immortal neuronal cell.	Proteomics	2005 Oct	Hu L	-
16006558	Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1/BC200 via a novel RNA-binding motif.	J Biol Chem	2005 Sep 30	Zalfa F	-
16000371	The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis.	Mol Biol Cell	2005 Sep	Huot ME	-
15964283	The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain.	Curr Biol	2005 Jun 21	Reeve SP	-
15901791	Postadolescent changes in regional cerebral protein synthesis: an in vivo study in the FMR1 null mouse.	J Neurosci	2005 May 18	Qin M	-
15703194	FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts.	Hum Mol Genet	2005 Mar 15	Castets M	-
15680513	Fathoming fragile X in fruit flies.	Trends Genet	2005 Jan	Zhang YQ	-
15588577	A fragile X mental retardation-like gene in a cnidarian.	Gene	2004 Dec 22	Guduric-Fuchs J	-
15564573	Visual experience regulates transient expression and dendritic localization of fragile X mental retardation protein.	J Neurosci	2004 Nov 24	Gabel LA	-
15548614	Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses.	Proc Natl Acad Sci U S A	2004 Dec 14	Weiler IJ	-
15498496	The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation.	Curr Biol	2004 Oct 26	Pan L	-
15516998	RNA and microRNAs in fragile X mental retardation.	Nat Cell Biol	2004 Nov	Jin P	-
15475576	The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development.	Proc Natl Acad Sci U S A	2004 Oct 19	Lu R	-
15378363	Expression of three zebrafish orthologs of human FMR1-related genes and their phylogenetic relationships.	Dev Genes Evol	2004 Nov	Tucker B	-
15317853	Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells.	J Neurosci	2004 Aug 18	Stefani G	-
15329415	Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles.	Proc Natl Acad Sci U S A	2004 Sep 7	Khandjian EW	-
15215302	Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants.	J Neurosci	2004 Jun 23	Michel CI	-
15119819	Molecular insights into mental retardation: multiple functions for the Fragile X mental retardation protein?	Curr Issues Mol Biol	2004 Jul	Zalfa F	-
15128702	Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo.	Hum Mol Genet	2004 Jul 1	Mientjes EJ	-
15096575	The fragile X mental retardation protein has nucleic acid chaperone properties.	Nucleic Acids Res	2004 Apr 19	Gabus C	-
14994288	The fragile X mental retardation protein, FMRP, recognizes G-quartets.	Ment Retard Dev Disabil Res Rev	2004	Darnell JC	-
14994291	RNA interference: a new mechanism by which FMRP acts in the normal brain? What can Drosophila teach us?	Ment Retard Dev Disabil Res Rev	2004	Siomi H	-
14703574	Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway.	Nat Neurosci	2004 Feb	Jin P	-
14613971	Developmentally-programmed FMRP expression in oligodendrocytes: a potential role of FMRP in regulating translation in oligodendroglia progenitors.	Hum Mol Genet	2004 Jan 1	Wang H	-
14570712	Phosphorylation influences the translation state of FMRP-associated polyribosomes.	Hum Mol Genet	2003 Dec 15	Ceman S	-
14526171	Understanding fragile X syndrome: insights from animal models.	Cytogenet Genome Res	2003	Bakker CE	-
14532325	Fragile X Mental Retardation protein determinants required for its association with polyribosomal mRNPs.	Hum Mol Genet	2003 Dec 1	Mazroui R	-
23401597	Expression of fragile X mental retardation protein and Fmr1 mRNA during folliculogenesis in the rat.	Reproduction	2013 Apr 15	Ferder I	doi: 10.1530/REP-12-0305
23408971	Characterization of fragile X mental retardation protein recruitment and dynamics in Drosophila stress granules.	PLoS One	2013	Gareau C	doi: 10.1371/journal.pone.0055342
23115170	Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels.	J Neurosci	2012 Oct 31	Zhang Y	doi: 10.1523/JNEUROSCI.2162-12.2012.
20159451	Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice.	Neuron	2010 Feb 11	Harlow EG	doi: 10.1016/j.neuron.2010.01.024.
20141036	[The role of ZF5 and CGGBP-20 transcription factors in expression regulation of human FMR1 gene responsible for X-fragile syndrome].	Tsitologiia	2009	Gulyi PV	-
20122915	Proteomic analysis reveals CCT is a target of Fragile X mental retardation protein regulation in Drosophila.	Dev Biol	2010 Apr 15	Monzo K	doi: 10.1016/j.ydbio.2010.01.028
20071534	Dysregulation of mTOR signaling in fragile X syndrome.	J Neurosci	2010 Jan 13	Sharma A	doi: 10.1523/JNEUROSCI.3696-09.2010.
20047076	Fragile X mental retardation protein in learning-related synaptic plasticity.	Mol Cells	2009 Dec 31	Mercaldo V	doi: 10.1007/s10059-009-0193-x
20011099	A mouse model of the human Fragile X syndrome I304N mutation.	PLoS Genet	2009 Dec	Zang JB	doi: 10.1371/journal.pgen.1000758
19837168	Fragile X mental retardation protein control of neuronal mRNA metabolism: Insights into mRNA stability.	Mol Cell Neurosci	2010 Jan	De Rubeis S	doi: 10.1016/j.mcn.2009.09.013
19640847	Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities.	J Biol Chem	2009 Sep 18	Schutt J	doi: 10.1074/jbc.M109.042663
19669947	Macro role(s) of microRNAs in fragile X syndrome?	Neuromolecular Med	2009	Li X	doi: 10.1007/s12017-009-8081-2
23060966	Synaptic activity regulated mRNA-silencing foci for the fine tuning of local protein synthesis at the synapse.	Commun Integr Biol	2012 Jul 1	Pascual ML	doi: 10.4161/cib.20257.
19325170	The state of synapses in fragile X syndrome.	Neuroscientist	2009 Oct	Pfeiffer BE	doi: 10.1177/1073858409333075
19301657	Protein components of the microRNA pathway and human diseases.	Methods Mol Biol	2009	Perron MP	doi: 10.1007/978-1-60327-547-7_18.
19306863	Drosophila Fragile X protein controls cellular proliferation by regulating cbl levels in the ovary.	Dev Biol	2009 Jun 1	Epstein AM	doi: 10.1016/j.ydbio.2009.03.011
19276651	Translation regulation of mRNAs by the fragile X family of proteins through the microRNA pathway.	RNA Biol	2009 Apr-Jun	Cheever A	-
19214804	The fragile X mental retardation protein in circadian rhythmicity and memory consolidation.	Mol Neurobiol	2009 Apr	Gatto CL	doi: 10.1007/s12035-009-8057-0
19155329	Phosphorylation of FMRP inhibits association with Dicer.	RNA	2009 Mar	Cheever A	doi: 10.1261/rna.1500809
19005212	Cells lacking the fragile X mental retardation protein (FMRP) have normal RISC activity but exhibit altered stress granule assembly.	Mol Biol Cell	2009 Jan	Didiot MC	doi: 10.1091/mbc.E08-07-0737
18957214	Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function.	Neuron	2008 Oct 23	Bassell GJ	doi: 10.1016/j.neuron.2008.10.004.
18936162	Fragile X mental retardation protein FMRP binds mRNAs in the nucleus.	Mol Cell Biol	2009 Jan	Kim M	doi: 10.1128/MCB.01377-08
22993428	Learning and memory deficits consequent to reduction of the fragile X mental retardation protein result from metabotropic glutamate receptor-mediated inhibition of cAMP signaling in Drosophila.	J Neurosci	2012 Sep 19	Kanellopoulos AK	-
18760699	FMRP acts as a key messenger for dopamine modulation in the forebrain.	Neuron	2008 Aug 28	Wang H	doi: 10.1016/j.neuron.2008.06.027.
18638539	Modest alterations in patterns of motor neuron dendrite morphology in the Fmr1 knockout mouse model for fragile X.	Int J Dev Neurosci	2008 Nov	Thomas CC	doi: 10.1016/j.ijdevneu.2008.06.003
18653529	The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer.	Nucleic Acids Res	2008 Sep	Didiot MC	doi: 10.1093/nar/gkn472
18655836	Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons.	Mol Cell Neurosci	2008 Oct	Estes PS	doi: 10.1016/j.mcn.2008.06.012
18656952	Chemical and structural probing of the N-terminal residues encoded by FMR1 exon 15 and their effect on downstream arginine methylation.	Biochemistry	2008 Aug 19	Dolzhanskaya N	doi: 10.1021/bi702298f
18571098	Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice.	Neurobiol Dis	2008 Jul	de Vrij FM	doi: 10.1016/j.nbd.2008.04.002
18474609	S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade.	J Biol Chem	2008 Jul 4	Narayanan U	doi: 10.1074/jbc.C800055200
18452182	Early-phase ERK activation as a biomarker for metabolic status in fragile X syndrome.	Am J Med Genet B Neuropsychiatr Genet	2008 Oct 5	Weng N	doi: 10.1002/ajmg.b.30765.
18398441	Fragile X syndrome.	Eur J Hum Genet	2008 Jun	Garber KB	doi: 10.1038/ejhg.2008.61
18272470	Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse.	Sci Signal	2008 Feb 5	Ronesi JA	doi: 10.1126/stke.15pe6.
18160642	FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A.	J Neurosci	2007 Dec 26	Narayanan U	-
18163424	Identification of FMRP-associated mRNAs using yeast three-hybrid system.	Am J Med Genet B Neuropsychiatr Genet	2008 Sep 5	Zou K	doi: 10.1002/ajmg.b.30678.
18184799	On BC1 RNA and the fragile X mental retardation protein.	Proc Natl Acad Sci U S A	2008 Jan 15	Iacoangeli A	doi: 10.1073/pnas.0710991105
18088371	TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor.	J Neurochem	2008 May	Wang IF	-
18094233	Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR.	J Neurosci	2007 Dec 19	Price TJ	-
17978095	Dynamic association of the fragile X mental retardation protein as a messenger ribonucleoprotein between microtubules and polyribosomes.	Mol Biol Cell	2008 Jan	Wang H	-
17989302	Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A convergently regulate the synaptic ratio of ionotropic glutamate receptor subclasses.	J Neurosci	2007 Nov 7	Pan L	-
17959805	Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation.	J Neurosci	2007 Oct 24	Volk LJ	-
17881561	Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors.	Proc Natl Acad Sci U S A	2007 Sep 25	Nakamoto M	-
17881655	The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules.	Hum Mol Genet	2007 Dec 15	Davidovic L	-
17899445	Differential expression of Fmr-1 mRNA and FMRP in female mice brain during aging.	Mol Biol Rep	2008 Dec	Singh K	-
22843500	Drosophila FMRP participates in the DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis.	Hum Mol Genet	2012 Nov 1	Liu W	doi: 10.1093/hmg/dds307
17477822	The pathophysiology of fragile x syndrome.	Annu Rev Genomics Hum Genet	2007	Penagarikano O	-
17417632	A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability.	Nat Neurosci	2007 May	Zalfa F	-
17132937	Lost once, the Fragile X Mental Retardation protein is now back onto brain polyribosomes.	RNA Biol	2005 Jan	Davidovic L	-
17057366	Dicer-derived microRNAs are utilized by the fragile X mental retardation protein for assembly on target RNAs.	J Biomed Biotechnol	2006	Plante I	-
22579290	Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex.	Cell	2012 May 11	Kwan KY	doi: 10.1016/j.cell.2012.02.060.
22522693	Systematic mapping of fragile X granules in the mouse brain reveals a potential role for presynaptic FMRP in sensorimotor functions.	J Comp Neurol	2012 Nov 1	Akins MR	doi: 10.1002/cne.23123.
22539853	Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.	J Neurosci	2012 Apr 25	Niere F	doi: 10.1523/JNEUROSCI.4650-11.2012.
22543975	Evaluation of copy number variations reveals novel candidate genes in autism spectrum disorder-associated pathways.	Hum Mol Genet	2012 Aug 1	Griswold AJ	doi: 10.1093/hmg/dds164
22384253	Glutamate induces the elongation of early dendritic protrusions via mGluRs in wild type mice, but not in fragile X mice.	PLoS One	2012	Cruz-Martin A	doi: 10.1371/journal.pone.0032446
22351071	Molecular and cellular aspects of mental retardation in the Fragile X syndrome: from gene mutation/s to spine dysmorphogenesis.	Adv Exp Med Biol	2012	De Rubeis S	doi: 10.1007/978-3-7091-0932-8_23.
22268788	Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome.	Genes Brain Behav	2012 Apr	Hoeffer CA	doi: 10.1111/j.1601-183X.2012.00768.x
22227453	Lithium reverses increased rates of cerebral protein synthesis in a mouse model of fragile X syndrome.	Neurobiol Dis	2012 Mar	Liu ZH	doi: 10.1016/j.nbd.2011.12.037
22238374	BC1-FMRP interaction is modulated by 2'-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapses.	Nucleic Acids Res	2012 May	Lacoux C	doi: 10.1093/nar/gkr1254
22210492	Unusual subcellular confinement of the fragile X mental retardation protein (FMRP) in circulating human platelets: complete polyribosome dissociation.	Biochimie	2012 Apr	Lauziere V	doi: 10.1016/j.biochi.2011.12.014
23300470	Excessive astrocyte-derived neurotrophin-3 contributes to the abnormal neuronal dendritic development in a mouse model of fragile X syndrome.	PLoS Genet	2012	Yang Q	doi: 10.1371/journal.pgen.1003172
23313071	Linking the Fragile X mental retardation protein to the lipoxygenase pathway.	Med Hypotheses	2013 Mar	Beaulieu MA	doi: 10.1016/j.mehy.2012.11.046
22080836	In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation.	Hum Mol Genet	2012 Feb 15	Coffee RL Jr	doi: 10.1093/hmg/ddr527
22037499	Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein.	Nat Neurosci	2011 Oct 30	Bhogal B	doi: 10.1038/nn.2950.
22053151	Glycogen synthase kinase-3: a promising therapeutic target for fragile x syndrome.	Front Mol Neurosci	2011 Nov 1	Mines MA	doi: 10.3389/fnmol.2011.00035
22009351	Fragile X mental retardation protein and stem cells.	Results Probl Cell Differ	2012	Qurashi A	doi: 10.1007/978-3-642-21649-7_8.
22022532	Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus.	PLoS One	2011	Cook D	doi: 10.1371/journal.pone.0026120
21900387	A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse model.	Genome Res	2011 Dec	Davidovic L	doi: 10.1101/gr.116764.110
21868366	A new regulatory function of the region proximal to the RGG box in the fragile X mental retardation protein.	J Cell Sci	2011 Sep 15	Blackwell E	doi: 10.1242/jcs.086751
21772992	Conformational-dependent and independent RNA binding to the fragile x mental retardation protein.	J Nucleic Acids	2011	Yan X	doi: 10.4061/2011/246127
21645877	Modulation of dendritic spines and synaptic function by Rac1: a possible link to Fragile X syndrome pathology.	Brain Res	2011 Jul 5	Bongmba OY	doi: 10.1016/j.brainres.2011.05.020
21617890	FMR1 premutation and full mutation molecular mechanisms related to autism.	J Neurodev Disord	2011 Sep	Hagerman R	doi: 10.1007/s11689-011-9084-5
21596027	Fragile X mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons.	Dev Biol	2011 Aug 15	Gatto CL	doi: 10.1016/j.ydbio.2011.05.001
23260144	Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95.	Cell	2012 Dec 21	Tsai NP	doi: 10.1016/j.cell.2012.11.040.
21446998	On the aggregation properties of FMRP--a link with the FXTAS syndrome?	FEBS J	2011 Jun	Sjekloca L	doi: 10.1111/j.1742-4658.2011.08108.x
21404421	Heads-up: new roles for the fragile X mental retardation protein in neural stem and progenitor cells.	Genesis	2011 Jun	Callan MA	doi: 10.1002/dvg.20745
21333716	A non-canonical start codon in the Drosophila fragile X gene yields two functional isoforms.	Neuroscience	2011 May 5	Beerman RW	doi: 10.1016/j.neuroscience.2011.02.029
21307257	Fragile X mental retardation protein regulates new neuron differentiation in the adult olfactory bulb.	J Neurosci	2011 Feb 9	Scotto-Lomassese S	doi: 10.1523/JNEUROSCI.5514-10.2011.
21273427	FMRP regulates the transition from radial glial cells to intermediate progenitor cells during neocortical development.	J Neurosci	2011 Jan 26	Saffary R	doi: 10.1523/JNEUROSCI.4854-10.2011.
21159962	Fragile X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid.	J Neurosci	2010 Dec 15	Soden ME	doi: 10.1523/JNEUROSCI.3660-10.2010.
21090964	Toward fulfilling the promise of molecular medicine in fragile X syndrome.	Annu Rev Med	2011	Krueger DD	doi: 10.1146/annurev-med-061109-134644.
20935173	Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria.	Hum Mol Genet	2011 Jan 1	Yao A	doi: 10.1093/hmg/ddq431
20713728	Altered mRNA transport, docking, and protein translation in neurons lacking fragile X mental retardation protein.	Proc Natl Acad Sci U S A	2010 Aug 31	Kao DI	doi: 10.1073/pnas.1010564107
20685971	Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b.	J Neurosci	2010 Aug 4	Strumbos JG	doi: 10.1523/JNEUROSCI.1125-10.2010.
20691595	Bicaudal-D regulates fragile X mental retardation protein levels, motility, and function during neuronal morphogenesis.	Curr Biol	2010 Aug 24	Bianco A	doi: 10.1016/j.cub.2010.07.016
20643379	Fragile X: leading the way for targeted treatments in autism.	Neurotherapeutics	2010 Jul	Wang LW	doi: 10.1016/j.nurt.2010.05.005.
20504994	Fragile X protein controls neural stem cell proliferation in the Drosophila brain.	Hum Mol Genet	2010 Aug 1	Callan MA	doi: 10.1093/hmg/ddq213
20512134	Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack.	Nat Neurosci	2010 Jul	Brown MR	doi: 10.1038/nn.2563
20534828	Delayed stabilization of dendritic spines in fragile X mice.	J Neurosci	2010 Jun 9	Cruz-Martin A	doi: 10.1523/JNEUROSCI.0577-10.2010.
23142366	Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout mice.	Behav Brain Res	2013 Feb 15	Gantois I	doi: 10.1016/j.bbr.2012.10.059
20473314	hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies.	Nat Struct Mol Biol	2010 Jun	Lee EK	doi: 10.1038/nsmb.1815
20457613	Roles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalization.	J Biol Chem	2010 Jul 9	Wang H	doi: 10.1074/jbc.M110.116293
20463240	Short- and long-term memory are modulated by multiple isoforms of the fragile X mental retardation protein.	J Neurosci	2010 May 12	Banerjee P	doi: 10.1523/JNEUROSCI.6369-09.2010.
20434996	Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2.	Neuron	2010 Apr 29	Pfeiffer BE	doi: 10.1016/j.neuron.2010.03.017.
20386739	Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells.	PLoS Genet	2010 Apr 8	Luo Y	doi: 10.1371/journal.pgen.1000898.
20197067	FMR1/FXR1 and the miRNA pathway are required for eye and neural crest development.	Dev Biol	2010 May 1	Gessert S	doi: 10.1016/j.ydbio.2010.02.031
25681562	Fragile X mental retardation protein (FMRP) interacting proteins exhibit different expression patterns during development.	Int J Dev Neurosci	2015 May	Bonaccorso CM	doi: 10.1016/j.ijdevneu.2015.02.004
25529181	Clinical, molecular, and pharmacological aspects of FMR1 related disorders.	Neurologia	2017 May	Pugin A	doi: 10.1016/j.nrl.2014.10.009
25250047	Low-normal FMR1 CGG repeat length: phenotypic associations.	Front Genet	2014 Sep 9	Mailick MR	doi: 10.3389/fgene.2014.00309
25215498	SnapShot: FMRP mRNA targets and diseases.	Cell	2014 Sep 11	Pasciuto E	doi: 10.1016/j.cell.2014.08.035.
25224527	Identification of fragile X syndrome specific molecular markers in human fibroblasts: a useful model to test the efficacy of therapeutic drugs.	Hum Mutat	2014 Dec	Kumari D	doi: 10.1002/humu.22699.
25168779	Quantitative phosphoproteomics of murine Fmr1-KO cell lines provides new insights into FMRP-dependent signal transduction mechanisms.	J Proteome Res	2014 Oct 3	Matic K	doi: 10.1021/pr5006372
25109237	N-myristoylation regulates the axonal distribution of the Fragile X-related protein FXR2P.	Mol Cell Neurosci	2014 Sep	Stackpole EE	doi: 10.1016/j.mcn.2014.08.003
24876161	Analysis of FMRP mRNA target datasets reveals highly associated mRNAs mediated by G-quadruplex structures formed via clustered WGGA sequences.	Hum Mol Genet	2014 Oct 15	Suhl JA	doi: 10.1093/hmg/ddu272
24811383	Fragile X mental retardation protein regulates synaptic and behavioral plasticity to repeated cocaine administration.	Neuron	2014 May 7	Smith LN	doi: 10.1016/j.neuron.2014.03.028.
24833720	A feed-forward mechanism involving Drosophila fragile X mental retardation protein triggers a replication stress-induced DNA damage response.	Hum Mol Genet	2014 Oct 1	Zhang W	doi: 10.1093/hmg/ddu241
24746697	Fragile X mental retardation protein regulates translation by binding directly to the ribosome.	Mol Cell	2014 May 8	Chen E	doi: 10.1016/j.molcel.2014.03.023
24727796	FMRP regulates miR196a-mediated repression of HOXB8 via interaction with the AGO2 MID domain.	Mol Biosyst	2014 Jul	Li Y	doi: 10.1039/c4mb00066h
24733999	CYFIP family proteins between autism and intellectual disability: links with Fragile X syndrome.	Front Cell Neurosci	2014 Mar 27	Abekhoukh S	doi: 10.3389/fncel.2014.00081
24658850	RNA-binding proteins in neurological diseases.	Sci China Life Sci	2014 Apr	Zhou H	-
24648324	Concise review: Fragile X proteins in stem cell maintenance and differentiation.	Stem Cells	2014 Jul	Li Y	doi: 10.1002/stem.1698.
24408886	Analysis of FMR1 deletion in a subpopulation of post-mitotic neurons in mouse cortex and hippocampus.	Autism Res	2014 Feb	Amiri A	doi: 10.1002/aur.1342
27941672	Detection and Quantification of the Fragile X Mental Retardation Protein 1 (FMRP).	Genes (Basel)	2016 Dec 9	LaFauci G	-
24338128	Translational regulation of NeuroD1 expression by FMRP: involvement in glutamatergic neuronal differentiation of cultured rat primary neural progenitor cells.	Cell Mol Neurobiol	2014 Mar	Jeon SJ	doi: 10.1007/s10571-013-0014-9
24175909	Myosin Va is required for the transport of fragile X mental retardation protein (FMRP) granules.	Biol Cell	2014 Feb	Lindsay AJ	doi: 10.1111/boc.201200076
24167470	The FMRP regulon: from targets to disease convergence.	Front Neurosci	2013 Oct 24	Fernandez E	doi: 10.3389/fnins.2013.00191.
24062571	FMRP regulates actin filament organization via the armadillo protein p0071.	RNA	2013 Nov	Nolze A	doi: 10.1261/rna.037945.112
23838275	Contrast, motion, perceptual integration, and neurocognition in schizophrenia: the role of fragile-X related mechanisms.	Prog Neuropsychopharmacol Biol Psychiatry	2013 Oct 1	Kelemen O	doi: 10.1016/j.pnpbp.2013.06.017
23778581	mRNA and protein expression for novel GABAA receptors theta and rho2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway.	Transl Psychiatry	2013 Jun 18	Fatemi SH	doi: 10.1038/tp.2013.46.
25956630	Protein expression of targets of the FMRP regulon is altered in brains of subjects with schizophrenia and mood disorders.	Schizophr Res	2015 Jul	Folsom TD	doi: 10.1016/j.schres.2015.04.012
23666178	Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting.	Nat Neurosci	2013 Jun	Cvetkovska V	doi: 10.1038/nn.3396
23578490	Fmr1 deletion enhances and ultimately desensitizes CB(1) signaling in autaptic hippocampal neurons.	Neurobiol Dis	2013 Aug	Straiker A	doi: 10.1016/j.nbd.2013.04.002
23584741	The translation of translational control by FMRP: therapeutic targets for FXS.	Nat Neurosci	2013 Nov	Darnell JC	doi: 10.1038/nn.3379
23542787	Targeting the endocannabinoid system in the treatment of fragile X syndrome.	Nat Med	2013 May	Busquets-Garcia A	doi: 10.1038/nm.3127
23511190	Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity.	Mol Cell Neurosci	2013 Sep	Zang T	doi: 10.1016/j.mcn.2013.03.002
23439114	Broadening roles for FMRP: big news for big potassium (BK) channels.	Neuron	2013 Feb 20	Contractor A	doi: 10.1016/j.neuron.2013.02.001.
28266018	Cell type-dependent axonal localization of translational regulators and mRNA in mouse peripheral olfactory neurons.	J Comp Neurol	2017 Jun 15	Korsak LIT	doi: 10.1002/cne.24199
27462983	Tracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA Granules.	PLoS Genet	2016 Jul 27	El Fatimy R	doi: 10.1371/journal.pgen.1006192
27273096	Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.	Sci Signal	2016 Jun 7	Kashima R	doi: 10.1126/scisignal.aaf6060.
25416280	Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain.	Hum Mol Genet	2015 Mar 15	Myrick LK	doi: 10.1093/hmg/ddu586
25561520	Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures.	Proc Natl Acad Sci U S A	2015 Jan 27	Myrick LK	doi: 10.1073/pnas.1423094112
27643955	Splice form-dependent regulation of axonal arbor complexity by FMRP.	Dev Neurobiol	2017 Jun	Zimmer SE	doi: 10.1002/dneu.22453
27338369	RNA Secondary Structure Modulates FMRP's Bi-Functional Role in the MicroRNA Pathway.	Int J Mol Sci	2016 Jun 22	Kenny P	doi: 10.3390/ijms17060985.
26834559	Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.	Front Cell Neurosci	2016 Jan 12	Schoen M	doi: 10.3389/fncel.2015.00496
26719241	Fragile X Mental Retardation Protein expression in the retina is regulated by light.	Exp Eye Res	2016 May	Guimaraes-Souza EM	doi: 10.1016/j.exer.2015.11.025
26663181	microRNAs and Fragile X Syndrome.	Adv Exp Med Biol	2015	Lin SL	doi: 10.1007/978-3-319-22671-2_7.
26637167	Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish.	PLoS Genet	2015 Dec 4	Shamay-Ramot A	doi: 10.1371/journal.pgen.1005702
26571124	Regulation of Heart Rate in Drosophila via Fragile X Mental Retardation Protein.	PLoS One	2015 Nov 16	Novak SM	doi: 10.1371/journal.pone.0142836
26586091	Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity.	Nat Commun	2015 Nov 20	Zhang P	doi: 10.1038/ncomms9888.
26516618	Persistent astrocyte activation in the fragile X mouse cerebellum.	Brain Behav	2015 Sep 25	Pacey LK	doi: 10.1002/brb3.400
26412477	Fragile X mental retardation protein interactions with a G quadruplex structure in the 3'-untranslated region of NR2B mRNA.	Mol Biosyst	2015 Dec	Stefanovic S	doi: 10.1039/c5mb00423c.
26350240	Dysregulation and restoration of translational homeostasis in fragile X syndrome.	Nat Rev Neurosci	2015 Oct	Richter JD	doi: 10.1038/nrn4001
26250109	The FMRP/GRK4 mRNA interaction uncovers a new mode of binding of the Fragile X mental retardation protein in cerebellum.	Nucleic Acids Res	2015 Sep 30	Maurin T	doi: 10.1093/nar/gkv801
27378784	Identification of consensus binding sites clarifies FMRP binding determinants.	Nucleic Acids Res	2016 Aug 19	Anderson BR	doi: 10.1093/nar/gkw593
26065250	[Chromatin changes caused by CGG repeat expansion in fmr1 gene].	Mol Biol (Mosk)	2015 Mar-Apr	Yudkin DV	-
26048669	Opposite Dysregulation of Fragile-X Mental Retardation Protein and Heteronuclear Ribonucleoprotein C Protein Associates with Enhanced APP Translation in Alzheimer Disease.	Mol Neurobiol	2016 Jul	Borreca A	doi: 10.1007/s12035-015-9229-8
26051932	Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms.	Cell Rep	2015 Jun 16	Guo W	doi: 10.1016/j.celrep.2015.05.013
26020477	GABAB receptor upregulates fragile X mental retardation protein expression in neurons.	Sci Rep	2015 May 28	Zhang W	doi: 10.1038/srep10468.
25962042	Fragile X family members have important and non-overlapping functions.	Biomol Concepts	2011 Oct 1	Winograd C	doi: 10.1515/BMC.2011.033.
25948262	Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome.	J Neurosci	2015 May 6	Ifrim MF	doi: 10.1523/JNEUROSCI.2802-14.2015.
25908854	The Drosophila fragile X mental retardation protein participates in the piRNA pathway.	J Cell Sci	2015 Jun 1	Bozzetti MP	doi: 10.1242/jcs.161810
25917509	Fragile X mental retardation protein regulates olfactory sensitivity but not odorant discrimination.	Chem Senses	2015 Jun	Schilit Nitenson A	doi: 10.1093/chemse/bjv019
25849048	Quantitative profiling of brain lipid raft proteome in a mouse model of fragile X syndrome.	PLoS One	2015 Apr 7	Kalinowska M	doi: 10.1371/journal.pone.0121464
25820841	R-Baclofen Reverses a Social Behavior Deficit and Elevated Protein Synthesis in a Mouse Model of Fragile X Syndrome.	Int J Neuropsychopharmacol	2015 Mar 28	Qin M	doi: 10.1093/ijnp/pyv034.
28424484	The tandem Agenet domain of fragile X mental retardation protein interacts with FUS.	Sci Rep	2017 Apr 19	He Q	doi: 10.1038/s41598-017-01175-8.
27829268	Altered Translational Control of Fragile X Mental Retardation Protein on Myelin Proteins in Neuropsychiatric Disorders.	Biomol Ther (Seoul)	2017 May 1	Jeon SJ	doi: 10.4062/biomolther.2016.042.
28509881	dFmr1 Plays Roles in Small RNA Pathways of Drosophila melanogaster.	Int J Mol Sci	2017 May 16	Specchia V	doi: 10.3390/ijms18051066.
27860518	Molecular dynamics of FMRP and other RNA-binding proteins in MEG-01 differentiation: the role of mRNP complexes in non-neuronal development.	Biochem Cell Biol	2016 Dec	McCoy M	-
28575444	Intrinsically disordered RGG/RG domains mediate degenerate specificity in RNA binding.	Nucleic Acids Res	2017 Jul 27	Ozdilek BA	doi: 10.1093/nar/gkx460.
28612854	Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5'-UTR.	Mol Biosyst	2017 Jul 25	McAninch DS	doi: 10.1039/c7mb00070g.
28685837	Proteomic analyses of nucleus laminaris identified candidate targets of the fragile X mental retardation protein.	J Comp Neurol	2017 Oct 15	Sakano H	doi: 10.1002/cne.24281
28203608	Modeling Fragile X syndrome in neurogenesis: An unexpected phenotype and a novel tool for future therapies.	Neurogenesis (Austin)	2017 Jan 31	Bardoni B	doi: 10.1080/23262133.2016.1270384
28882193	Fragile X mental retardation protein regulates skeletal muscle stem cell activity by regulating the stability of Myf5 mRNA.	Skelet Muscle	2017 Sep 7	Fujita R	doi: 10.1186/s13395-017-0136-8.
28887386	Fragile X Mental Retardation Protein Restricts Small Dye Iontophoresis Entry into Central Neurons.	J Neurosci	2017 Oct 11	Kennedy T	doi: 10.1523/JNEUROSCI.0723-17.2017
25844398	FMRP regulates neurogenesis in vivo in Xenopus laevis tadpoles.	eNeuro	2015 Jan-Feb	Faulkner RL	-
28943283	STEP inhibition reverses behavioral, electrophysiologic, and synaptic abnormalities in Fmr1 KO mice.	Neuropharmacology	2018 Jan	Chatterjee M	doi: 10.1016/j.neuropharm.2017.09.026
29104533	Cell Type-Specific mRNA Dysregulation in Hippocampal CA1 Pyramidal Neurons of the Fragile X Syndrome Mouse Model.	Front Mol Neurosci	2017 Oct 20	Ceolin L	doi: 10.3389/fnmol.2017.00340
29114039	Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis.	Sci Signal	2017 Nov 7	Dear ML	doi: 10.1126/scisignal.aan3181.
29163124	The Search for an Effective Therapy to Treat Fragile X Syndrome: Dream or Reality?	Front Synaptic Neurosci	2017 Nov 6	Castagnola S	doi: 10.3389/fnsyn.2017.00015
29203851	Dynamic landscape of the local translation at activated synapses.	Mol Psychiatry	2018 Jan	Khlebodarova TM	doi: 10.1038/mp.2017.245
29212015	Opposing Post-transcriptional Control of InR by FMRP and LIN-28 Adjusts Stem Cell-Based Tissue Growth.	Cell Rep	2017 Dec 5	Luhur A	doi: 10.1016/j.celrep.2017.11.039.
29292077	Proteomic Profiling of Brain and Testis Reveals the Diverse Changes in Ribosomal Proteins in fmr1 Knockout Mice.	Neuroscience	2018 Feb 10	Xu B	doi: 10.1016/j.neuroscience.2017.12.023
29380377	Imbalance of synaptic actin dynamics as a key to fragile X syndrome?	J Physiol	2018 Jul	Michaelsen-Preusse K	doi: 10.1113/JP275571
29668986	HITS-CLIP in various brain areas reveals new targets and new modalities of RNA binding by fragile X mental retardation protein.	Nucleic Acids Res	2018 Jul 6	Maurin T	doi: 10.1093/nar/gky267.
29704597	Modelling fragile X syndrome in the laboratory setting: A behavioral perspective.	Behav Brain Res	2018 Sep 17	Melancia F	doi: 10.1016/j.bbr.2018.04.042
30107516	Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets.	Hum Mol Genet	2018 Nov 15	Zhang F	doi: 10.1093/hmg/ddy292.
30131676	The Intracellular Cleavage Product of the NG2 Proteoglycan Modulates Translation and Cell-Cycle Kinetics via Effects on mTORC1/FMRP Signaling.	Front Cell Neurosci	2018 Aug 7	Nayak T	doi: 10.3389/fncel.2018.00231
30137253	Involvement of Phosphodiesterase 2A Activity in the Pathophysiology of Fragile X Syndrome.	Cereb Cortex	2018 Aug 23	Maurin T	doi: 10.1093/cercor/bhy192
30151344	Regulation of Adult Neurogenesis by the Fragile X Family of RNA Binding Proteins.	Brain Plast	2018 Aug 10	Patzlaff NE	doi: 10.3233/BPL-170061.
30240639	Fragile X mental retardation protein regulates accumulation of the active zone protein Munc18-1 in presynapses via local translation in axons during synaptogenesis.	Neurosci Res	2019 Sep	Parvin S	doi: 10.1016/j.neures.2018.09.013
30319351	New Insights Into the Role of Cav2 Protein Family in Calcium Flux Deregulation in Fmr1-KO Neurons.	Front Mol Neurosci	2018 Sep 27	Castagnola S	doi: 10.3389/fnmol.2018.00342
27597551	Fragile X syndrome: Are signaling lipids the missing culprits?	Biochimie	2016 Nov	Tabet R	doi: 10.1016/j.biochi.2016.09.002
30373821	Regulatory discrimination of mRNAs by FMRP controls mouse adult neural stem cell differentiation.	Proc Natl Acad Sci U S A	2018 Nov 27	Liu B	doi: 10.1073/pnas.1809588115
30686771	The translational regulator FMRP controls lipid and glucose metabolism in mice and humans.	Mol Metab	2019 Mar	Leboucher A	doi: 10.1016/j.molmet.2019.01.002
30742117	Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice.	Nat Neurosci	2019 Mar	Shen M	doi: 10.1038/s41593-019-0338-y
30759772	Pharmacological Reactivation of the Silenced FMR1 Gene as a Targeted Therapeutic Approach for Fragile X Syndrome.	Brain Sci	2019 Feb 12	Kumari D	doi: 10.3390/brainsci9020039.
30877790	Deletion of the KH1 Domain of Fmr1 Leads to Transcriptional Alterations and Attentional Deficits in Rats.	Cereb Cortex	2019 May 1	Golden CEM	doi: 10.1093/cercor/bhz029.
30893603	Widespread Alterations in Translation Elongation in the Brain of Juvenile Fmr1 Knockout Mice.	Cell Rep	2019 Mar 19	Das Sharma S	doi: 10.1016/j.celrep.2019.02.086.
30905341	Handling FMRP and its molecular partners: Structural insights into Fragile X Syndrome.	Prog Biophys Mol Biol	2019 Jan	D'Annessa I	doi: 10.1016/j.pbiomolbio.2018.07.001
30940719	Reward-Related Expectations Trigger Dendritic Spine Plasticity in the Mouse Ventrolateral Orbitofrontal Cortex.	J Neurosci	2019 Jun 5	Whyte AJ	doi: 10.1523/JNEUROSCI.2031-18.2019
31035599	Molecular Biomarkers in Fragile X Syndrome.	Brain Sci	2019 Apr 27	Zafarullah M	doi: 10.3390/brainsci9050096.
31118285	Kinase pathway inhibition restores PSD95 induction in neurons lacking fragile X mental retardation protein.	Proc Natl Acad Sci U S A	2019 Jun 11	Yang Y	doi: 10.1073/pnas.1812056116
31191246	Structural and Functional Abnormalities in the Olfactory System of Fragile X Syndrome Models.	Front Mol Neurosci	2019 May 28	Bodaleo F	doi: 10.3389/fnmol.2019.00135
31241016	New Targeted Treatments in Fragile X Syndrome.	Curr Pediatr Rev	2019 Jun 25	Protic D	doi: 10.2174/1573396315666190625110748
31280136	Generation of a FMR1 homozygous knockout human embryonic stem cell line (WAe009-A-16) by CRISPR/Cas9 editing.	Stem Cell Res	2019 Jun 28	Giri S	doi: 10.1016/j.scr.2019.101494
31291981	NMDAR mediated translation at the synapse is regulated by MOV10 and FMRP.	Mol Brain	2019 Jul 10	Kute PM	doi: 10.1186/s13041-019-0473-0.
23264567	Neurodegenerative diseases: quantitative predictions of protein-RNA interactions.	RNA	2013 Feb	Cirillo D	doi: 10.1261/rna.034777.112
18805096	The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.	Cell	2008 Sep 19	Napoli I	doi: 10.1016/j.cell.2008.07.031.
15282548	Visualization of RNA-protein interactions in living cells: FMRP and IMP1 interact on mRNAs.	EMBO J	2004 Aug 18	Rackham O	-
30982501	Neuronal function and dysfunction of CYFIP2: from actin dynamics to early infantile epileptic encephalopathy.	BMB Rep	2019 May	Zhang Y	-
19396385	Fragile X mental retardation protein recognition of G quadruplex structure per se is sufficient for high affinity binding to RNA.	Mol Biosyst	2008 Dec	Bole M	doi: 10.1039/b812537f
17652158	The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly.	J Cell Sci	2007 Aug 15	Baguet A	-
22072660	Local RNA translation at the synapse and in disease.	J Neurosci	2011 Nov 9	Liu-Yesucevitz L	doi: 10.1523/JNEUROSCI.4105-11.2011.
22017584	Molecular mechanisms of fragile X syndrome: a twenty-year perspective.	Annu Rev Pathol	2012	Santoro MR	doi: 10.1146/annurev-pathol-011811-132457
21733196	CGGBP1 regulates cell cycle in cancer cells.	BMC Mol Biol	2011 Jul 7	Singh U	doi: 10.1186/1471-2199-12-28.
28826631	Multifarious Functions of the Fragile X Mental Retardation Protein.	Trends Genet	2017 Oct	Davis JK	doi: 10.1016/j.tig.2017.07.008

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000370470	FMR1-203	1774	-	ENSP00000359501	590 (aa)	-	Q06787
ENST00000370471	FMR1-204	4125	-	ENSP00000359502	537 (aa)	-	Q06787
ENST00000463120	FMR1-209	470	-	ENSP00000480886	119 (aa)	-	A0A087WXC0
ENST00000370475	FMR1-205	4308	-	ENSP00000359506	632 (aa)	-	Q06787
ENST00000218200	FMR1-201	4333	-	ENSP00000218200	611 (aa)	-	Q06787
ENST00000370477	FMR1-206	3437	-	ENSP00000359508	582 (aa)	-	A8MQB8
ENST00000440235	FMR1-208	4271	-	ENSP00000413764	586 (aa)	-	Q06787
ENST00000611273	FMR1-214	564	-	-	- (aa)	-	-
ENST00000475038	FMR1-210	571	-	ENSP00000480450	102 (aa)	-	A0A087WWR6
ENST00000616614	FMR1-216	1409	-	ENSP00000480513	76 (aa)	-	A0A087WWU4
ENST00000334557	FMR1-202	1295	-	ENSP00000355115	297 (aa)	-	Q8IXW7
ENST00000492846	FMR1-212	815	-	-	- (aa)	-	-
ENST00000643620	FMR1-221	1439	-	-	- (aa)	-	-
ENST00000439526	FMR1-207	3699	-	ENSP00000395923	592 (aa)	-	G3V0J0
ENST00000620828	FMR1-217	4830	-	-	- (aa)	-	-
ENST00000621453	FMR1-219	1864	-	ENSP00000479528	544 (aa)	-	R9WNI0
ENST00000495717	FMR1-213	776	-	ENSP00000481474	252 (aa)	-	A0A087WY29
ENST00000616382	FMR1-215	1648	-	ENSP00000481058	419 (aa)	-	A0A087WXI3
ENST00000478848	FMR1-211	541	-	-	- (aa)	-	-
ENST00000621987	FMR1-220	1352	-	ENSP00000477839	297 (aa)	-	Q8IXW7
ENST00000621447	FMR1-218	1832	-	ENSP00000484324	31 (aa)	-	A0A087X1M7

Gene Model

Click here to download ENSG00000102081's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000102081	Mental Competency	8.31966961407637E-5	17903295
ENSG00000102081	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	2E-8	22808956

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000102081's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000102081	FMR1	95	79.381	ENSG00000114416	FXR1	95	77.465
ENSG00000102081	FMR1	98	71.478	ENSG00000129245	FXR2	99	71.795

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000102081	FMR1	99	70.748	ENSAPOG00000017058	fxr1	68	66.242	Acanthochromis_polyacanthus
ENSG00000102081	FMR1	99	86.395	ENSAPOG00000006422	fmr1	99	65.997	Acanthochromis_polyacanthus
ENSG00000102081	FMR1	99	68.707	ENSAPOG00000003062	fxr2	80	62.128	Acanthochromis_polyacanthus
ENSG00000102081	FMR1	95	74.227	ENSAMEG00000016775	FXR2	66	70.219	Ailuropoda_melanoleuca
ENSG00000102081	FMR1	99	98.980	ENSAMEG00000014996	FMR1	100	96.994	Ailuropoda_melanoleuca
ENSG00000102081	FMR1	95	79.381	ENSAMEG00000012185	FXR1	67	72.812	Ailuropoda_melanoleuca
ENSG00000102081	FMR1	99	69.728	ENSACIG00000023354	fxr1	79	69.760	Amphilophus_citrinellus
ENSG00000102081	FMR1	95	72.165	ENSACIG00000021149	fxr2	70	66.508	Amphilophus_citrinellus
ENSG00000102081	FMR1	96	88.776	ENSACIG00000022552	fmr1	99	85.231	Amphilophus_citrinellus
ENSG00000102081	FMR1	99	86.395	ENSAOCG00000008025	fmr1	99	86.025	Amphiprion_ocellaris
ENSG00000102081	FMR1	95	73.196	ENSAOCG00000022178	fxr1	76	68.536	Amphiprion_ocellaris
ENSG00000102081	FMR1	99	68.707	ENSAOCG00000007975	fxr2	78	62.851	Amphiprion_ocellaris
ENSG00000102081	FMR1	99	70.748	ENSAPEG00000014981	fxr1	78	63.340	Amphiprion_percula
ENSG00000102081	FMR1	99	86.395	ENSAPEG00000015355	fmr1	99	65.842	Amphiprion_percula
ENSG00000102081	FMR1	99	68.707	ENSAPEG00000017208	fxr2	79	62.635	Amphiprion_percula
ENSG00000102081	FMR1	96	88.776	ENSATEG00000017772	fmr1	99	65.271	Anabas_testudineus
ENSG00000102081	FMR1	99	68.707	ENSATEG00000019423	fxr2	69	65.227	Anabas_testudineus
ENSG00000102081	FMR1	99	70.408	ENSATEG00000022488	fxr1	70	70.359	Anabas_testudineus
ENSG00000102081	FMR1	95	78.351	ENSAPLG00000010032	FXR1	68	72.136	Anas_platyrhynchos
ENSG00000102081	FMR1	96	96.939	ENSAPLG00000003811	FMR1	100	81.531	Anas_platyrhynchos
ENSG00000102081	FMR1	71	62.963	ENSACAG00000000561	-	77	36.653	Anolis_carolinensis
ENSG00000102081	FMR1	95	76.289	ENSACAG00000003918	FXR1	67	70.337	Anolis_carolinensis
ENSG00000102081	FMR1	95	76.289	ENSACAG00000023870	-	82	72.121	Anolis_carolinensis
ENSG00000102081	FMR1	96	97.959	ENSACAG00000007899	FMR1	100	84.491	Anolis_carolinensis
ENSG00000102081	FMR1	95	79.381	ENSANAG00000026001	FXR1	80	73.952	Aotus_nancymaae
ENSG00000102081	FMR1	100	98.316	ENSANAG00000026715	FMR1	100	98.316	Aotus_nancymaae
ENSG00000102081	FMR1	98	71.478	ENSANAG00000023710	FXR2	67	71.601	Aotus_nancymaae
ENSG00000102081	FMR1	99	69.388	ENSACLG00000010657	fxr2	70	64.756	Astatotilapia_calliptera
ENSG00000102081	FMR1	96	87.755	ENSACLG00000021559	fmr1	99	65.109	Astatotilapia_calliptera
ENSG00000102081	FMR1	99	70.408	ENSACLG00000025812	fxr1	68	65.672	Astatotilapia_calliptera
ENSG00000102081	FMR1	99	69.048	ENSAMXG00000001357	fxr1	71	69.162	Astyanax_mexicanus
ENSG00000102081	FMR1	99	70.068	ENSAMXG00000003585	fxr2	68	65.870	Astyanax_mexicanus
ENSG00000102081	FMR1	96	86.735	ENSAMXG00000000371	fmr1	99	81.493	Astyanax_mexicanus
ENSG00000102081	FMR1	98	71.478	ENSBTAG00000005462	FXR2	70	71.601	Bos_taurus
ENSG00000102081	FMR1	100	97.222	ENSBTAG00000012552	FMR1	100	96.399	Bos_taurus
ENSG00000102081	FMR1	95	79.381	ENSBTAG00000016457	FXR1	80	73.952	Bos_taurus
ENSG00000102081	FMR1	95	79.381	ENSCJAG00000012802	FXR1	80	73.952	Callithrix_jacchus
ENSG00000102081	FMR1	98	71.478	ENSCJAG00000015063	FXR2	67	71.601	Callithrix_jacchus
ENSG00000102081	FMR1	100	98.576	ENSCJAG00000003925	FMR1	100	98.576	Callithrix_jacchus
ENSG00000102081	FMR1	99	98.980	ENSCAFG00000019085	FMR1	100	94.778	Canis_familiaris
ENSG00000102081	FMR1	98	71.478	ENSCAFG00000016685	FXR2	67	71.601	Canis_familiaris
ENSG00000102081	FMR1	95	79.381	ENSCAFG00000011582	FXR1	80	73.952	Canis_familiaris
ENSG00000102081	FMR1	100	98.319	ENSCAFG00020024366	FMR1	99	97.849	Canis_lupus_dingo
ENSG00000102081	FMR1	95	79.381	ENSCAFG00020023527	FXR1	70	73.952	Canis_lupus_dingo
ENSG00000102081	FMR1	98	71.478	ENSCAFG00020007819	FXR2	67	71.601	Canis_lupus_dingo
ENSG00000102081	FMR1	98	71.478	ENSCHIG00000004007	FXR2	67	71.601	Capra_hircus
ENSG00000102081	FMR1	95	79.381	ENSCHIG00000017202	FXR1	70	73.952	Capra_hircus
ENSG00000102081	FMR1	99	97.959	ENSCHIG00000000198	FMR1	100	96.519	Capra_hircus
ENSG00000102081	FMR1	95	74.227	ENSTSYG00000004564	FXR2	67	71.299	Carlito_syrichta
ENSG00000102081	FMR1	95	78.351	ENSTSYG00000001610	FXR1	80	73.653	Carlito_syrichta
ENSG00000102081	FMR1	99	99.010	ENSTSYG00000014392	FMR1	99	97.500	Carlito_syrichta
ENSG00000102081	FMR1	95	74.227	ENSCAPG00000006378	FXR2	68	69.419	Cavia_aperea
ENSG00000102081	FMR1	100	94.958	ENSCAPG00000008575	FMR1	98	88.550	Cavia_aperea
ENSG00000102081	FMR1	88	70.385	ENSCAPG00000007992	FXR1	81	67.273	Cavia_aperea
ENSG00000102081	FMR1	96	98.980	ENSCPOG00000003723	FMR1	100	97.747	Cavia_porcellus
ENSG00000102081	FMR1	95	79.381	ENSCPOG00000010418	FXR1	81	73.952	Cavia_porcellus
ENSG00000102081	FMR1	98	71.478	ENSCPOG00000023303	FXR2	67	71.601	Cavia_porcellus
ENSG00000102081	FMR1	99	72.449	ENSCCAG00000025006	FXR1	76	72.388	Cebus_capucinus
ENSG00000102081	FMR1	100	98.527	ENSCCAG00000021737	FMR1	100	98.527	Cebus_capucinus
ENSG00000102081	FMR1	95	74.227	ENSCCAG00000013516	FXR2	65	67.372	Cebus_capucinus
ENSG00000102081	FMR1	95	79.381	ENSCATG00000040925	FXR1	81	73.016	Cercocebus_atys
ENSG00000102081	FMR1	100	98.892	ENSCATG00000038319	FMR1	100	98.903	Cercocebus_atys
ENSG00000102081	FMR1	98	71.478	ENSCATG00000039859	FXR2	67	71.601	Cercocebus_atys
ENSG00000102081	FMR1	97	98.276	ENSCLAG00000001233	FMR1	100	97.747	Chinchilla_lanigera
ENSG00000102081	FMR1	95	79.381	ENSCLAG00000014182	FXR1	81	73.952	Chinchilla_lanigera
ENSG00000102081	FMR1	98	71.478	ENSCLAG00000007322	FXR2	67	71.601	Chinchilla_lanigera
ENSG00000102081	FMR1	98	71.478	ENSCSAG00000011386	FXR2	67	71.601	Chlorocebus_sabaeus
ENSG00000102081	FMR1	100	98.854	ENSCSAG00000007281	FMR1	100	98.854	Chlorocebus_sabaeus
ENSG00000102081	FMR1	95	79.381	ENSCSAG00000013179	FXR1	67	73.952	Chlorocebus_sabaeus
ENSG00000102081	FMR1	100	94.958	ENSCHOG00000006340	-	81	100.000	Choloepus_hoffmanni
ENSG00000102081	FMR1	95	55.808	ENSCHOG00000013177	-	62	61.514	Choloepus_hoffmanni
ENSG00000102081	FMR1	69	78.571	ENSCHOG00000012877	FXR1	65	73.632	Choloepus_hoffmanni
ENSG00000102081	FMR1	95	78.351	ENSCPBG00000000223	FXR1	71	71.861	Chrysemys_picta_bellii
ENSG00000102081	FMR1	99	95.918	ENSCPBG00000020840	FMR1	100	94.910	Chrysemys_picta_bellii
ENSG00000102081	FMR1	95	77.320	ENSCPBG00000004747	FXR2	50	62.881	Chrysemys_picta_bellii
ENSG00000102081	FMR1	96	57.143	ENSCING00000008519	-	99	44.031	Ciona_intestinalis
ENSG00000102081	FMR1	96	56.122	ENSCSAVG00000007423	-	93	52.632	Ciona_savignyi
ENSG00000102081	FMR1	98	71.478	ENSCANG00000039094	FXR2	67	71.601	Colobus_angolensis_palliatus
ENSG00000102081	FMR1	95	79.381	ENSCANG00000028959	FXR1	76	68.563	Colobus_angolensis_palliatus
ENSG00000102081	FMR1	100	98.892	ENSCANG00000033482	FMR1	100	98.892	Colobus_angolensis_palliatus
ENSG00000102081	FMR1	95	78.351	ENSCGRG00001024795	Fxr1	81	73.653	Cricetulus_griseus_chok1gshd
ENSG00000102081	FMR1	99	98.980	ENSCGRG00001012567	Fmr1	100	97.475	Cricetulus_griseus_chok1gshd
ENSG00000102081	FMR1	98	71.478	ENSCGRG00001000488	Fxr2	67	71.601	Cricetulus_griseus_chok1gshd
ENSG00000102081	FMR1	100	95.798	ENSCGRG00000005009	Fmr1	99	96.440	Cricetulus_griseus_crigri
ENSG00000102081	FMR1	95	74.227	ENSCGRG00000012580	Fxr2	67	70.662	Cricetulus_griseus_crigri
ENSG00000102081	FMR1	95	78.351	ENSCGRG00000000624	Fxr1	69	72.642	Cricetulus_griseus_crigri
ENSG00000102081	FMR1	99	71.429	ENSCSEG00000001597	fxr1	69	69.452	Cynoglossus_semilaevis
ENSG00000102081	FMR1	96	84.694	ENSCSEG00000016308	fmr1	99	81.329	Cynoglossus_semilaevis
ENSG00000102081	FMR1	99	68.707	ENSCSEG00000013667	fxr2	68	64.579	Cynoglossus_semilaevis
ENSG00000102081	FMR1	99	70.408	ENSCVAG00000000711	fxr1	67	68.588	Cyprinodon_variegatus
ENSG00000102081	FMR1	95	71.134	ENSCVAG00000008490	fxr2	78	64.651	Cyprinodon_variegatus
ENSG00000102081	FMR1	96	86.735	ENSCVAG00000011644	fmr1	99	78.547	Cyprinodon_variegatus
ENSG00000102081	FMR1	96	84.694	ENSDARG00000037433	fmr1	99	80.299	Danio_rerio
ENSG00000102081	FMR1	99	67.347	ENSDARG00000022968	fxr1	74	67.665	Danio_rerio
ENSG00000102081	FMR1	99	69.388	ENSDARG00000016260	fxr2	79	64.502	Danio_rerio
ENSG00000102081	FMR1	95	79.381	ENSDNOG00000019065	-	76	73.494	Dasypus_novemcinctus
ENSG00000102081	FMR1	100	97.872	ENSDNOG00000019486	FMR1	100	97.872	Dasypus_novemcinctus
ENSG00000102081	FMR1	98	71.478	ENSDNOG00000001047	FXR2	67	71.601	Dasypus_novemcinctus
ENSG00000102081	FMR1	91	54.839	ENSDNOG00000032775	-	66	46.753	Dasypus_novemcinctus
ENSG00000102081	FMR1	95	74.227	ENSDORG00000014232	Fxr2	67	70.662	Dipodomys_ordii
ENSG00000102081	FMR1	95	79.381	ENSDORG00000005853	Fxr1	77	73.333	Dipodomys_ordii
ENSG00000102081	FMR1	100	97.479	ENSDORG00000012501	Fmr1	100	96.970	Dipodomys_ordii
ENSG00000102081	FMR1	95	57.576	FBgn0028734	Fmr1	81	49.495	Drosophila_melanogaster
ENSG00000102081	FMR1	95	74.227	ENSETEG00000018613	FXR2	65	70.347	Echinops_telfairi
ENSG00000102081	FMR1	95	78.351	ENSETEG00000006891	FXR1	75	72.840	Echinops_telfairi
ENSG00000102081	FMR1	99	97.959	ENSETEG00000006061	FMR1	90	92.706	Echinops_telfairi
ENSG00000102081	FMR1	95	59.794	ENSEBUG00000008785	fmr1	74	62.249	Eptatretus_burgeri
ENSG00000102081	FMR1	99	70.748	ENSEBUG00000005529	fxr1	69	70.359	Eptatretus_burgeri
ENSG00000102081	FMR1	95	79.381	ENSEASG00005016818	FXR1	67	73.653	Equus_asinus_asinus
ENSG00000102081	FMR1	100	98.319	ENSEASG00005014017	FMR1	100	92.827	Equus_asinus_asinus
ENSG00000102081	FMR1	98	71.478	ENSEASG00005019301	FXR2	67	71.601	Equus_asinus_asinus
ENSG00000102081	FMR1	95	79.381	ENSECAG00000007560	FXR1	80	73.653	Equus_caballus
ENSG00000102081	FMR1	98	71.478	ENSECAG00000007051	FXR2	67	71.601	Equus_caballus
ENSG00000102081	FMR1	100	97.872	ENSECAG00000032767	FMR1	100	97.872	Equus_caballus
ENSG00000102081	FMR1	95	78.351	ENSEEUG00000006823	FXR1	70	73.653	Erinaceus_europaeus
ENSG00000102081	FMR1	95	74.227	ENSEEUG00000013410	FXR2	65	65.443	Erinaceus_europaeus
ENSG00000102081	FMR1	100	94.118	ENSEEUG00000015366	FMR1	87	96.498	Erinaceus_europaeus
ENSG00000102081	FMR1	95	72.165	ENSELUG00000023014	fxr2	69	63.907	Esox_lucius
ENSG00000102081	FMR1	96	88.776	ENSELUG00000013325	fmr1	91	81.361	Esox_lucius
ENSG00000102081	FMR1	99	68.707	ENSELUG00000012917	fxr1	79	66.246	Esox_lucius
ENSG00000102081	FMR1	99	98.980	ENSFCAG00000007228	FMR1	100	97.709	Felis_catus
ENSG00000102081	FMR1	98	71.478	ENSFCAG00000009620	FXR2	67	71.601	Felis_catus
ENSG00000102081	FMR1	95	79.381	ENSFCAG00000022259	FXR1	68	70.347	Felis_catus
ENSG00000102081	FMR1	95	77.320	ENSFALG00000008301	FXR1	64	72.240	Ficedula_albicollis
ENSG00000102081	FMR1	99	95.238	ENSFALG00000012085	FMR1	100	94.311	Ficedula_albicollis
ENSG00000102081	FMR1	100	95.798	ENSFDAG00000017613	FMR1	100	97.073	Fukomys_damarensis
ENSG00000102081	FMR1	95	79.381	ENSFDAG00000019934	FXR1	81	73.684	Fukomys_damarensis
ENSG00000102081	FMR1	95	74.227	ENSFDAG00000013401	FXR2	67	71.299	Fukomys_damarensis
ENSG00000102081	FMR1	99	69.048	ENSFHEG00000023088	fxr2	66	69.103	Fundulus_heteroclitus
ENSG00000102081	FMR1	96	88.776	ENSFHEG00000000636	fmr1	99	65.116	Fundulus_heteroclitus
ENSG00000102081	FMR1	82	72.619	ENSFHEG00000003734	-	86	76.000	Fundulus_heteroclitus
ENSG00000102081	FMR1	99	68.027	ENSGMOG00000011293	fxr2	69	59.052	Gadus_morhua
ENSG00000102081	FMR1	96	87.755	ENSGMOG00000006141	fmr1	98	81.138	Gadus_morhua
ENSG00000102081	FMR1	95	73.196	ENSGMOG00000000446	fxr1	65	69.274	Gadus_morhua
ENSG00000102081	FMR1	95	78.351	ENSGALG00000008864	FXR1	75	73.653	Gallus_gallus
ENSG00000102081	FMR1	99	95.238	ENSGALG00000009177	FMR1	100	94.311	Gallus_gallus
ENSG00000102081	FMR1	96	87.755	ENSGAFG00000015494	fmr1	82	68.237	Gambusia_affinis
ENSG00000102081	FMR1	99	69.048	ENSGAFG00000001957	fxr2	70	63.866	Gambusia_affinis
ENSG00000102081	FMR1	99	69.388	ENSGAFG00000010906	fxr1	68	69.162	Gambusia_affinis
ENSG00000102081	FMR1	95	73.196	ENSGACG00000006052	fxr1	71	65.106	Gasterosteus_aculeatus
ENSG00000102081	FMR1	96	87.755	ENSGACG00000018742	fmr1	99	65.528	Gasterosteus_aculeatus
ENSG00000102081	FMR1	95	72.165	ENSGACG00000019983	fxr2	68	64.208	Gasterosteus_aculeatus
ENSG00000102081	FMR1	96	96.939	ENSGAGG00000024559	FMR1	98	93.789	Gopherus_agassizii
ENSG00000102081	FMR1	95	78.351	ENSGAGG00000025290	FXR1	69	69.792	Gopherus_agassizii
ENSG00000102081	FMR1	98	71.478	ENSGGOG00000024357	FXR2	67	71.601	Gorilla_gorilla
ENSG00000102081	FMR1	95	79.381	ENSGGOG00000009957	-	80	73.952	Gorilla_gorilla
ENSG00000102081	FMR1	99	99.010	ENSGGOG00000010373	FMR1	100	99.615	Gorilla_gorilla
ENSG00000102081	FMR1	96	87.755	ENSHBUG00000012534	fmr1	99	82.934	Haplochromis_burtoni
ENSG00000102081	FMR1	99	70.068	ENSHBUG00000004901	fxr1	68	65.672	Haplochromis_burtoni
ENSG00000102081	FMR1	99	69.388	ENSHBUG00000009073	fxr2	70	64.756	Haplochromis_burtoni
ENSG00000102081	FMR1	100	97.218	ENSHGLG00000000576	FMR1	100	97.218	Heterocephalus_glaber_female
ENSG00000102081	FMR1	98	71.478	ENSHGLG00000012247	FXR2	67	71.601	Heterocephalus_glaber_female
ENSG00000102081	FMR1	95	79.381	ENSHGLG00000018814	FXR1	81	74.251	Heterocephalus_glaber_female
ENSG00000102081	FMR1	95	79.381	ENSHGLG00100017463	FXR1	80	74.251	Heterocephalus_glaber_male
ENSG00000102081	FMR1	98	70.205	ENSHGLG00100018506	FXR2	67	70.482	Heterocephalus_glaber_male
ENSG00000102081	FMR1	96	98.980	ENSHGLG00100008323	FMR1	100	96.911	Heterocephalus_glaber_male
ENSG00000102081	FMR1	95	73.196	ENSHCOG00000010273	fxr1	94	69.091	Hippocampus_comes
ENSG00000102081	FMR1	95	73.196	ENSHCOG00000010337	fxr1	83	61.426	Hippocampus_comes
ENSG00000102081	FMR1	96	87.755	ENSHCOG00000004757	fmr1	99	64.638	Hippocampus_comes
ENSG00000102081	FMR1	95	67.616	ENSHCOG00000010198	FXR1	100	67.616	Hippocampus_comes
ENSG00000102081	FMR1	99	67.347	ENSHCOG00000010418	fxr2	68	65.476	Hippocampus_comes
ENSG00000102081	FMR1	99	69.388	ENSIPUG00000022953	fxr2	74	66.168	Ictalurus_punctatus
ENSG00000102081	FMR1	96	88.776	ENSIPUG00000014418	fmr1-b	99	81.982	Ictalurus_punctatus
ENSG00000102081	FMR1	99	69.728	ENSIPUG00000024597	fxr1	72	70.060	Ictalurus_punctatus
ENSG00000102081	FMR1	100	97.872	ENSSTOG00000003260	FMR1	100	97.872	Ictidomys_tridecemlineatus
ENSG00000102081	FMR1	98	71.478	ENSSTOG00000005657	FXR2	67	71.601	Ictidomys_tridecemlineatus
ENSG00000102081	FMR1	95	79.381	ENSSTOG00000010612	FXR1	81	73.952	Ictidomys_tridecemlineatus
ENSG00000102081	FMR1	98	71.478	ENSJJAG00000016434	Fxr2	67	71.601	Jaculus_jaculus
ENSG00000102081	FMR1	99	96.939	ENSJJAG00000008538	-	97	96.939	Jaculus_jaculus
ENSG00000102081	FMR1	95	78.351	ENSJJAG00000019175	Fxr1	76	69.076	Jaculus_jaculus
ENSG00000102081	FMR1	96	88.776	ENSKMAG00000006554	fmr1	91	80.467	Kryptolebias_marmoratus
ENSG00000102081	FMR1	99	69.388	ENSKMAG00000014569	fxr2	69	65.659	Kryptolebias_marmoratus
ENSG00000102081	FMR1	99	70.068	ENSKMAG00000004687	fxr1	66	70.181	Kryptolebias_marmoratus
ENSG00000102081	FMR1	95	74.227	ENSLBEG00000015038	fxr1	75	59.459	Labrus_bergylta
ENSG00000102081	FMR1	96	86.735	ENSLBEG00000014381	fmr1	99	79.573	Labrus_bergylta
ENSG00000102081	FMR1	95	74.227	ENSLBEG00000011791	-	80	66.453	Labrus_bergylta
ENSG00000102081	FMR1	95	72.165	ENSLBEG00000000923	fxr2	77	64.783	Labrus_bergylta
ENSG00000102081	FMR1	99	71.429	ENSLACG00000011290	FXR1	71	71.557	Latimeria_chalumnae
ENSG00000102081	FMR1	95	94.845	ENSLACG00000005358	FMR1	100	69.640	Latimeria_chalumnae
ENSG00000102081	FMR1	95	76.289	ENSLACG00000006238	FXR2	69	71.333	Latimeria_chalumnae
ENSG00000102081	FMR1	96	45.499	ENSLOCG00000013240	fxr2	67	44.540	Lepisosteus_oculatus
ENSG00000102081	FMR1	99	71.429	ENSLOCG00000000589	fxr1	68	71.257	Lepisosteus_oculatus
ENSG00000102081	FMR1	96	88.776	ENSLOCG00000015397	fmr1	99	71.635	Lepisosteus_oculatus
ENSG00000102081	FMR1	95	79.381	ENSLAFG00000001908	FXR1	79	74.349	Loxodonta_africana
ENSG00000102081	FMR1	100	96.639	ENSLAFG00000013592	FMR1	100	97.735	Loxodonta_africana
ENSG00000102081	FMR1	95	73.196	ENSLAFG00000001114	FXR2	67	70.347	Loxodonta_africana
ENSG00000102081	FMR1	95	79.381	ENSMFAG00000040264	FXR1	80	73.952	Macaca_fascicularis
ENSG00000102081	FMR1	100	98.892	ENSMFAG00000000241	FMR1	100	98.892	Macaca_fascicularis
ENSG00000102081	FMR1	98	71.478	ENSMFAG00000043282	FXR2	67	71.601	Macaca_fascicularis
ENSG00000102081	FMR1	95	79.381	ENSMMUG00000012105	FXR1	92	72.180	Macaca_mulatta
ENSG00000102081	FMR1	98	71.478	ENSMMUG00000013510	FXR2	67	71.601	Macaca_mulatta
ENSG00000102081	FMR1	100	98.892	ENSMMUG00000015814	FMR1	100	98.892	Macaca_mulatta
ENSG00000102081	FMR1	98	71.478	ENSMNEG00000031195	FXR2	67	71.601	Macaca_nemestrina
ENSG00000102081	FMR1	95	79.381	ENSMNEG00000031733	FXR1	80	73.952	Macaca_nemestrina
ENSG00000102081	FMR1	100	98.892	ENSMNEG00000024342	FMR1	100	98.892	Macaca_nemestrina
ENSG00000102081	FMR1	95	79.381	ENSMLEG00000041270	FXR1	80	73.952	Mandrillus_leucophaeus
ENSG00000102081	FMR1	100	98.892	ENSMLEG00000035664	FMR1	100	98.892	Mandrillus_leucophaeus
ENSG00000102081	FMR1	98	71.478	ENSMLEG00000034764	FXR2	68	71.601	Mandrillus_leucophaeus
ENSG00000102081	FMR1	95	76.289	ENSMAMG00000012607	fxr1	70	67.597	Mastacembelus_armatus
ENSG00000102081	FMR1	99	68.707	ENSMAMG00000004616	fxr2	69	65.548	Mastacembelus_armatus
ENSG00000102081	FMR1	96	89.796	ENSMAMG00000000787	fmr1	99	65.224	Mastacembelus_armatus
ENSG00000102081	FMR1	99	70.748	ENSMZEG00005015679	fxr1	68	66.167	Maylandia_zebra
ENSG00000102081	FMR1	96	87.755	ENSMZEG00005005455	fmr1	99	65.109	Maylandia_zebra
ENSG00000102081	FMR1	99	69.388	ENSMZEG00005028541	fxr2	69	67.033	Maylandia_zebra
ENSG00000102081	FMR1	95	72.165	ENSMZEG00005007512	FXR2	89	65.848	Maylandia_zebra
ENSG00000102081	FMR1	96	96.939	ENSMGAG00000008270	FMR1	100	93.711	Meleagris_gallopavo
ENSG00000102081	FMR1	95	78.351	ENSMGAG00000009602	FXR1	70	72.555	Meleagris_gallopavo
ENSG00000102081	FMR1	98	71.478	ENSMAUG00000002021	Fxr2	67	71.601	Mesocricetus_auratus
ENSG00000102081	FMR1	95	78.351	ENSMAUG00000001188	Fxr1	81	73.653	Mesocricetus_auratus
ENSG00000102081	FMR1	96	98.980	ENSMAUG00000000336	-	92	98.837	Mesocricetus_auratus
ENSG00000102081	FMR1	100	96.639	ENSMAUG00000005814	Fmr1	94	97.659	Mesocricetus_auratus
ENSG00000102081	FMR1	100	98.653	ENSMICG00000000838	FMR1	100	98.653	Microcebus_murinus
ENSG00000102081	FMR1	95	79.381	ENSMICG00000048978	-	66	72.910	Microcebus_murinus
ENSG00000102081	FMR1	98	71.478	ENSMICG00000014799	FXR2	67	71.601	Microcebus_murinus
ENSG00000102081	FMR1	91	78.495	ENSMICG00000033163	-	79	62.651	Microcebus_murinus
ENSG00000102081	FMR1	98	71.478	ENSMOCG00000019049	Fxr2	67	71.601	Microtus_ochrogaster
ENSG00000102081	FMR1	100	97.306	ENSMOCG00000005190	Fmr1	100	97.306	Microtus_ochrogaster
ENSG00000102081	FMR1	95	78.351	ENSMOCG00000017707	Fxr1	80	72.871	Microtus_ochrogaster
ENSG00000102081	FMR1	96	89.796	ENSMMOG00000010038	fmr1	96	86.159	Mola_mola
ENSG00000102081	FMR1	95	71.429	ENSMMOG00000012192	fxr2	60	67.436	Mola_mola
ENSG00000102081	FMR1	99	70.408	ENSMMOG00000001546	fxr1	81	66.091	Mola_mola
ENSG00000102081	FMR1	95	80.412	ENSMODG00000021294	FXR1	67	71.685	Monodelphis_domestica
ENSG00000102081	FMR1	95	74.227	ENSMODG00000007179	FXR2	63	68.675	Monodelphis_domestica
ENSG00000102081	FMR1	99	94.898	ENSMODG00000005550	FMR1	100	89.082	Monodelphis_domestica
ENSG00000102081	FMR1	96	90.816	ENSMALG00000012587	fmr1	99	86.111	Monopterus_albus
ENSG00000102081	FMR1	99	68.367	ENSMALG00000003105	fxr2	79	64.430	Monopterus_albus
ENSG00000102081	FMR1	95	76.289	ENSMALG00000019947	fxr1	68	70.606	Monopterus_albus
ENSG00000102081	FMR1	95	75.258	MGP_CAROLIEiJ_G0016578	Fxr2	67	71.903	Mus_caroli
ENSG00000102081	FMR1	99	98.639	MGP_CAROLIEiJ_G0033121	Fmr1	100	97.466	Mus_caroli
ENSG00000102081	FMR1	95	78.351	MGP_CAROLIEiJ_G0024927	Fxr1	70	73.653	Mus_caroli
ENSG00000102081	FMR1	99	98.639	ENSMUSG00000000838	Fmr1	100	97.466	Mus_musculus
ENSG00000102081	FMR1	95	74.227	ENSMUSG00000018765	Fxr2	67	71.299	Mus_musculus
ENSG00000102081	FMR1	95	78.351	ENSMUSG00000027680	Fxr1	81	73.653	Mus_musculus
ENSG00000102081	FMR1	98	71.478	MGP_PahariEiJ_G0017709	Fxr2	67	71.601	Mus_pahari
ENSG00000102081	FMR1	99	98.639	MGP_PahariEiJ_G0031663	Fmr1	100	97.128	Mus_pahari
ENSG00000102081	FMR1	95	78.351	MGP_PahariEiJ_G0026371	Fxr1	85	71.053	Mus_pahari
ENSG00000102081	FMR1	95	74.227	MGP_SPRETEiJ_G0017414	Fxr2	67	71.299	Mus_spretus
ENSG00000102081	FMR1	95	78.351	MGP_SPRETEiJ_G0025861	Fxr1	71	73.653	Mus_spretus
ENSG00000102081	FMR1	99	98.639	MGP_SPRETEiJ_G0034275	Fmr1	100	97.466	Mus_spretus
ENSG00000102081	FMR1	99	98.980	ENSMPUG00000011485	FMR1	100	94.937	Mustela_putorius_furo
ENSG00000102081	FMR1	95	79.381	ENSMPUG00000002333	FXR1	67	73.952	Mustela_putorius_furo
ENSG00000102081	FMR1	95	74.227	ENSMPUG00000009051	FXR2	64	71.299	Mustela_putorius_furo
ENSG00000102081	FMR1	99	98.299	ENSMLUG00000000587	FMR1	100	96.840	Myotis_lucifugus
ENSG00000102081	FMR1	95	79.381	ENSMLUG00000006840	FXR1	67	72.956	Myotis_lucifugus
ENSG00000102081	FMR1	98	71.478	ENSMLUG00000003438	FXR2	66	71.601	Myotis_lucifugus
ENSG00000102081	FMR1	98	71.478	ENSNGAG00000016236	Fxr2	67	71.601	Nannospalax_galili
ENSG00000102081	FMR1	100	96.639	ENSNGAG00000020908	Fmr1	99	96.278	Nannospalax_galili
ENSG00000102081	FMR1	95	78.351	ENSNGAG00000021726	Fxr1	80	72.871	Nannospalax_galili
ENSG00000102081	FMR1	99	69.388	ENSNBRG00000012358	fxr2	70	64.756	Neolamprologus_brichardi
ENSG00000102081	FMR1	99	70.068	ENSNBRG00000021072	fxr1	77	67.919	Neolamprologus_brichardi
ENSG00000102081	FMR1	96	87.755	ENSNBRG00000022213	fmr1	99	82.635	Neolamprologus_brichardi
ENSG00000102081	FMR1	100	99.324	ENSNLEG00000013269	FMR1	100	99.324	Nomascus_leucogenys
ENSG00000102081	FMR1	98	71.478	ENSNLEG00000009662	FXR2	70	71.601	Nomascus_leucogenys
ENSG00000102081	FMR1	95	65.979	ENSNLEG00000031391	-	72	61.847	Nomascus_leucogenys
ENSG00000102081	FMR1	95	79.381	ENSNLEG00000005928	FXR1	80	73.186	Nomascus_leucogenys
ENSG00000102081	FMR1	81	97.590	ENSMEUG00000014280	-	69	96.970	Notamacropus_eugenii
ENSG00000102081	FMR1	82	98.810	ENSOPRG00000012759	-	64	94.340	Ochotona_princeps
ENSG00000102081	FMR1	95	74.227	ENSOPRG00000017108	FXR2	65	70.347	Ochotona_princeps
ENSG00000102081	FMR1	95	76.289	ENSOPRG00000009223	FXR1	69	65.931	Ochotona_princeps
ENSG00000102081	FMR1	95	79.381	ENSODEG00000001069	-	68	73.731	Octodon_degus
ENSG00000102081	FMR1	95	79.381	ENSODEG00000006177	-	69	72.388	Octodon_degus
ENSG00000102081	FMR1	100	95.798	ENSODEG00000008377	FMR1	100	97.705	Octodon_degus
ENSG00000102081	FMR1	95	74.227	ENSODEG00000017803	FXR2	67	68.278	Octodon_degus
ENSG00000102081	FMR1	93	63.158	ENSODEG00000000998	-	63	42.641	Octodon_degus
ENSG00000102081	FMR1	99	69.388	ENSONIG00000018373	fxr2	70	64.756	Oreochromis_niloticus
ENSG00000102081	FMR1	99	70.068	ENSONIG00000003740	fxr1	71	65.739	Oreochromis_niloticus
ENSG00000102081	FMR1	99	85.374	ENSONIG00000015823	fmr1	99	67.192	Oreochromis_niloticus
ENSG00000102081	FMR1	95	73.196	ENSOANG00000005646	-	52	69.858	Ornithorhynchus_anatinus
ENSG00000102081	FMR1	95	80.412	ENSOANG00000011045	FXR1	65	68.633	Ornithorhynchus_anatinus
ENSG00000102081	FMR1	96	96.939	ENSOANG00000001097	FMR1	99	86.120	Ornithorhynchus_anatinus
ENSG00000102081	FMR1	100	97.943	ENSOCUG00000014621	FMR1	100	97.943	Oryctolagus_cuniculus
ENSG00000102081	FMR1	95	74.227	ENSOCUG00000010393	FXR2	68	70.440	Oryctolagus_cuniculus
ENSG00000102081	FMR1	95	79.381	ENSOCUG00000023518	FXR1	58	73.952	Oryctolagus_cuniculus
ENSG00000102081	FMR1	99	85.714	ENSORLG00000009094	fmr1	99	66.038	Oryzias_latipes
ENSG00000102081	FMR1	99	68.707	ENSORLG00000011787	fxr1	68	68.563	Oryzias_latipes
ENSG00000102081	FMR1	99	68.707	ENSORLG00000011571	fxr2	69	68.770	Oryzias_latipes
ENSG00000102081	FMR1	99	85.374	ENSORLG00020020254	fmr1	99	65.571	Oryzias_latipes_hni
ENSG00000102081	FMR1	99	68.707	ENSORLG00020012552	fxr2	69	68.770	Oryzias_latipes_hni
ENSG00000102081	FMR1	99	68.707	ENSORLG00020005318	fxr1	71	68.563	Oryzias_latipes_hni
ENSG00000102081	FMR1	99	68.707	ENSORLG00015013785	fxr2	69	68.770	Oryzias_latipes_hsok
ENSG00000102081	FMR1	99	68.707	ENSORLG00015003151	fxr1	71	68.563	Oryzias_latipes_hsok
ENSG00000102081	FMR1	99	85.714	ENSORLG00015015300	fmr1	99	65.934	Oryzias_latipes_hsok
ENSG00000102081	FMR1	99	85.374	ENSOMEG00000017281	fmr1	98	85.494	Oryzias_melastigma
ENSG00000102081	FMR1	95	74.227	ENSOMEG00000011753	fxr1	77	66.467	Oryzias_melastigma
ENSG00000102081	FMR1	95	70.103	ENSOMEG00000005986	fxr2	75	65.569	Oryzias_melastigma
ENSG00000102081	FMR1	98	71.478	ENSOGAG00000008146	FXR2	67	71.601	Otolemur_garnettii
ENSG00000102081	FMR1	95	79.381	ENSOGAG00000008751	FXR1	70	73.952	Otolemur_garnettii
ENSG00000102081	FMR1	99	98.639	ENSOGAG00000013061	FMR1	100	97.152	Otolemur_garnettii
ENSG00000102081	FMR1	98	71.478	ENSOARG00000014984	FXR2	67	71.601	Ovis_aries
ENSG00000102081	FMR1	99	97.959	ENSOARG00000009673	FMR1	100	96.519	Ovis_aries
ENSG00000102081	FMR1	95	79.381	ENSOARG00000020674	FXR1	70	73.952	Ovis_aries
ENSG00000102081	FMR1	95	79.381	ENSPPAG00000037630	-	80	73.952	Pan_paniscus
ENSG00000102081	FMR1	95	74.227	ENSPPAG00000029387	FXR2	67	68.278	Pan_paniscus
ENSG00000102081	FMR1	100	99.663	ENSPPAG00000041836	FMR1	100	99.663	Pan_paniscus
ENSG00000102081	FMR1	99	98.980	ENSPPRG00000018962	FMR1	100	97.709	Panthera_pardus
ENSG00000102081	FMR1	95	79.381	ENSPPRG00000004943	FXR1	80	73.952	Panthera_pardus
ENSG00000102081	FMR1	94	56.107	ENSPPRG00000015847	-	97	60.985	Panthera_pardus
ENSG00000102081	FMR1	98	71.478	ENSPPRG00000009200	-	67	71.601	Panthera_pardus
ENSG00000102081	FMR1	100	96.639	ENSPTIG00000019115	FMR1	99	96.071	Panthera_tigris_altaica
ENSG00000102081	FMR1	95	74.227	ENSPTIG00000007284	FXR2	63	70.662	Panthera_tigris_altaica
ENSG00000102081	FMR1	95	79.381	ENSPTIG00000019748	FXR1	80	73.952	Panthera_tigris_altaica
ENSG00000102081	FMR1	98	71.478	ENSPTRG00000008698	FXR2	67	71.601	Pan_troglodytes
ENSG00000102081	FMR1	95	79.381	ENSPTRG00000015656	-	80	73.952	Pan_troglodytes
ENSG00000102081	FMR1	100	99.842	ENSPTRG00000022349	FMR1	100	99.842	Pan_troglodytes
ENSG00000102081	FMR1	99	99.010	ENSPANG00000018447	FMR1	100	98.571	Papio_anubis
ENSG00000102081	FMR1	98	71.478	ENSPANG00000024057	FXR2	67	71.601	Papio_anubis
ENSG00000102081	FMR1	95	79.381	ENSPANG00000011899	FXR1	82	72.274	Papio_anubis
ENSG00000102081	FMR1	99	63.265	ENSPKIG00000014091	FXR1	71	60.870	Paramormyrops_kingsleyae
ENSG00000102081	FMR1	96	85.714	ENSPKIG00000001628	fmr1	99	81.571	Paramormyrops_kingsleyae
ENSG00000102081	FMR1	99	68.707	ENSPKIG00000002030	fxr1	70	67.245	Paramormyrops_kingsleyae
ENSG00000102081	FMR1	99	68.367	ENSPKIG00000025286	fxr2	68	69.697	Paramormyrops_kingsleyae
ENSG00000102081	FMR1	95	78.351	ENSPSIG00000007616	FXR1	65	72.555	Pelodiscus_sinensis
ENSG00000102081	FMR1	95	77.320	ENSPSIG00000008173	FXR2	68	70.588	Pelodiscus_sinensis
ENSG00000102081	FMR1	96	97.959	ENSPSIG00000009079	FMR1	100	91.212	Pelodiscus_sinensis
ENSG00000102081	FMR1	96	87.755	ENSPMGG00000013391	fmr1	93	82.335	Periophthalmus_magnuspinnatus
ENSG00000102081	FMR1	95	75.258	ENSPMGG00000014074	fxr1	78	65.438	Periophthalmus_magnuspinnatus
ENSG00000102081	FMR1	95	72.165	ENSPMGG00000005453	fxr2	68	59.091	Periophthalmus_magnuspinnatus
ENSG00000102081	FMR1	99	98.980	ENSPEMG00000017439	Fmr1	100	97.475	Peromyscus_maniculatus_bairdii
ENSG00000102081	FMR1	95	78.351	ENSPEMG00000012962	Fxr1	80	72.871	Peromyscus_maniculatus_bairdii
ENSG00000102081	FMR1	98	71.478	ENSPEMG00000019239	Fxr2	68	71.601	Peromyscus_maniculatus_bairdii
ENSG00000102081	FMR1	99	68.367	ENSPMAG00000002849	-	76	68.263	Petromyzon_marinus
ENSG00000102081	FMR1	95	75.258	ENSPMAG00000007610	-	68	70.312	Petromyzon_marinus
ENSG00000102081	FMR1	95	80.412	ENSPCIG00000026314	FXR1	67	73.952	Phascolarctos_cinereus
ENSG00000102081	FMR1	99	95.238	ENSPCIG00000022498	FMR1	100	94.311	Phascolarctos_cinereus
ENSG00000102081	FMR1	95	74.227	ENSPCIG00000028979	FXR2	67	70.997	Phascolarctos_cinereus
ENSG00000102081	FMR1	99	69.728	ENSPFOG00000006858	fxr2	69	70.359	Poecilia_formosa
ENSG00000102081	FMR1	99	70.408	ENSPFOG00000014691	fxr1	68	70.359	Poecilia_formosa
ENSG00000102081	FMR1	99	85.374	ENSPFOG00000004138	fmr1	99	65.984	Poecilia_formosa
ENSG00000102081	FMR1	99	70.068	ENSPLAG00000023193	fxr1	71	70.060	Poecilia_latipinna
ENSG00000102081	FMR1	99	69.728	ENSPLAG00000006074	fxr2	70	64.482	Poecilia_latipinna
ENSG00000102081	FMR1	99	85.374	ENSPLAG00000005126	fmr1	99	65.271	Poecilia_latipinna
ENSG00000102081	FMR1	99	85.374	ENSPMEG00000003164	fmr1	99	65.480	Poecilia_mexicana
ENSG00000102081	FMR1	99	70.068	ENSPMEG00000019092	fxr1	83	70.060	Poecilia_mexicana
ENSG00000102081	FMR1	99	69.728	ENSPMEG00000024257	fxr2	70	64.482	Poecilia_mexicana
ENSG00000102081	FMR1	99	68.367	ENSPREG00000022738	fxr1	80	65.011	Poecilia_reticulata
ENSG00000102081	FMR1	84	86.047	ENSPREG00000014149	fmr1	99	56.064	Poecilia_reticulata
ENSG00000102081	FMR1	73	82.488	ENSPREG00000003249	fmr1	86	77.542	Poecilia_reticulata
ENSG00000102081	FMR1	99	69.388	ENSPREG00000002076	fxr2	69	70.060	Poecilia_reticulata
ENSG00000102081	FMR1	98	62.543	ENSPPYG00000007930	FXR2	62	63.746	Pongo_abelii
ENSG00000102081	FMR1	95	79.381	ENSPPYG00000014327	FXR1	70	73.952	Pongo_abelii
ENSG00000102081	FMR1	99	99.660	ENSPPYG00000020797	FMR1	96	94.588	Pongo_abelii
ENSG00000102081	FMR1	99	98.980	ENSPCAG00000011936	FMR1	100	96.677	Procavia_capensis
ENSG00000102081	FMR1	95	73.196	ENSPCAG00000013184	FXR2	78	65.559	Procavia_capensis
ENSG00000102081	FMR1	100	98.653	ENSPCOG00000028651	FMR1	100	98.200	Propithecus_coquereli
ENSG00000102081	FMR1	95	74.227	ENSPCOG00000024603	FXR2	67	71.299	Propithecus_coquereli
ENSG00000102081	FMR1	95	79.381	ENSPCOG00000020057	FXR1	80	73.885	Propithecus_coquereli
ENSG00000102081	FMR1	99	98.639	ENSPVAG00000013386	FMR1	100	91.139	Pteropus_vampyrus
ENSG00000102081	FMR1	98	71.478	ENSPVAG00000016306	FXR2	64	71.601	Pteropus_vampyrus
ENSG00000102081	FMR1	99	66.327	ENSPVAG00000002823	FXR1	76	67.066	Pteropus_vampyrus
ENSG00000102081	FMR1	99	70.408	ENSPNYG00000014047	fxr1	71	65.672	Pundamilia_nyererei
ENSG00000102081	FMR1	99	69.388	ENSPNYG00000018583	fxr2	68	65.227	Pundamilia_nyererei
ENSG00000102081	FMR1	96	87.755	ENSPNYG00000000045	fmr1	99	76.558	Pundamilia_nyererei
ENSG00000102081	FMR1	99	68.367	ENSPNAG00000021229	fxr1	68	68.263	Pygocentrus_nattereri
ENSG00000102081	FMR1	96	86.735	ENSPNAG00000006251	fmr1	99	81.737	Pygocentrus_nattereri
ENSG00000102081	FMR1	99	70.408	ENSPNAG00000013032	fxr2	68	65.652	Pygocentrus_nattereri
ENSG00000102081	FMR1	95	78.351	ENSRNOG00000051480	Fxr1	81	73.780	Rattus_norvegicus
ENSG00000102081	FMR1	95	74.227	ENSRNOG00000011876	Fxr2	67	71.299	Rattus_norvegicus
ENSG00000102081	FMR1	99	98.639	ENSRNOG00000057464	Fmr1	100	97.079	Rattus_norvegicus
ENSG00000102081	FMR1	95	79.381	ENSRBIG00000036968	FXR1	84	73.952	Rhinopithecus_bieti
ENSG00000102081	FMR1	99	98.305	ENSRBIG00000028998	FMR1	100	80.997	Rhinopithecus_bieti
ENSG00000102081	FMR1	98	71.478	ENSRBIG00000034647	FXR2	67	71.601	Rhinopithecus_bieti
ENSG00000102081	FMR1	99	99.010	ENSRROG00000044396	FMR1	100	97.692	Rhinopithecus_roxellana
ENSG00000102081	FMR1	95	79.381	ENSRROG00000034524	FXR1	80	73.952	Rhinopithecus_roxellana
ENSG00000102081	FMR1	98	71.478	ENSRROG00000035470	FXR2	67	71.601	Rhinopithecus_roxellana
ENSG00000102081	FMR1	95	79.381	ENSSBOG00000033567	FXR1	80	73.186	Saimiri_boliviensis_boliviensis
ENSG00000102081	FMR1	95	74.227	ENSSBOG00000031395	FXR2	68	71.646	Saimiri_boliviensis_boliviensis
ENSG00000102081	FMR1	100	98.200	ENSSBOG00000026623	FMR1	100	98.200	Saimiri_boliviensis_boliviensis
ENSG00000102081	FMR1	95	74.227	ENSSHAG00000015678	FXR2	67	70.997	Sarcophilus_harrisii
ENSG00000102081	FMR1	95	80.412	ENSSHAG00000018625	FXR1	66	71.239	Sarcophilus_harrisii
ENSG00000102081	FMR1	99	95.578	ENSSHAG00000012940	FMR1	100	87.893	Sarcophilus_harrisii
ENSG00000102081	FMR1	95	70.103	ENSSFOG00015013518	FXR1	74	63.772	Scleropages_formosus
ENSG00000102081	FMR1	96	88.776	ENSSFOG00015004051	fmr1	99	85.417	Scleropages_formosus
ENSG00000102081	FMR1	99	71.429	ENSSFOG00015008103	fxr1	70	69.631	Scleropages_formosus
ENSG00000102081	FMR1	99	70.068	ENSSFOG00015016623	fxr2	77	70.659	Scleropages_formosus
ENSG00000102081	FMR1	95	72.165	ENSSMAG00000013659	fxr2	69	65.569	Scophthalmus_maximus
ENSG00000102081	FMR1	99	83.673	ENSSMAG00000013698	fmr1	86	76.404	Scophthalmus_maximus
ENSG00000102081	FMR1	99	67.905	ENSSMAG00000019240	fxr1	77	67.456	Scophthalmus_maximus
ENSG00000102081	FMR1	95	72.165	ENSSDUG00000018392	fxr2	68	64.579	Seriola_dumerili
ENSG00000102081	FMR1	96	88.776	ENSSDUG00000013947	fmr1	82	78.755	Seriola_dumerili
ENSG00000102081	FMR1	99	71.088	ENSSDUG00000016557	fxr1	70	66.525	Seriola_dumerili
ENSG00000102081	FMR1	95	72.165	ENSSLDG00000017119	fxr2	68	64.579	Seriola_lalandi_dorsalis
ENSG00000102081	FMR1	95	74.227	ENSSLDG00000018386	fxr1	78	65.745	Seriola_lalandi_dorsalis
ENSG00000102081	FMR1	96	88.776	ENSSLDG00000022042	fmr1	99	80.556	Seriola_lalandi_dorsalis
ENSG00000102081	FMR1	93	56.679	ENSSARG00000011976	FXR1	63	58.675	Sorex_araneus
ENSG00000102081	FMR1	98	55.670	ENSSARG00000006113	FXR2	64	57.704	Sorex_araneus
ENSG00000102081	FMR1	96	97.959	ENSSARG00000003475	FMR1	100	90.407	Sorex_araneus
ENSG00000102081	FMR1	96	95.918	ENSSPUG00000014177	FMR1	100	93.354	Sphenodon_punctatus
ENSG00000102081	FMR1	95	77.320	ENSSPUG00000014501	FXR1	76	71.721	Sphenodon_punctatus
ENSG00000102081	FMR1	96	89.796	ENSSPAG00000005758	fmr1	99	64.832	Stegastes_partitus
ENSG00000102081	FMR1	95	72.165	ENSSPAG00000007975	fxr2	77	63.877	Stegastes_partitus
ENSG00000102081	FMR1	99	69.728	ENSSPAG00000010538	fxr1	77	66.567	Stegastes_partitus
ENSG00000102081	FMR1	98	71.478	ENSSSCG00000017953	FXR2	68	71.601	Sus_scrofa
ENSG00000102081	FMR1	100	97.709	ENSSSCG00000012727	FMR1	100	97.709	Sus_scrofa
ENSG00000102081	FMR1	95	78.351	ENSSSCG00000011769	FXR1	80	73.653	Sus_scrofa
ENSG00000102081	FMR1	96	96.939	ENSTGUG00000004735	FMR1	100	83.045	Taeniopygia_guttata
ENSG00000102081	FMR1	95	77.320	ENSTGUG00000010560	FXR1	67	72.555	Taeniopygia_guttata
ENSG00000102081	FMR1	95	73.196	ENSTRUG00000003486	fxr1	71	63.383	Takifugu_rubripes
ENSG00000102081	FMR1	99	68.027	ENSTRUG00000010696	fxr2	68	62.527	Takifugu_rubripes
ENSG00000102081	FMR1	99	74.830	ENSTRUG00000005362	fmr1	98	74.312	Takifugu_rubripes
ENSG00000102081	FMR1	87	38.202	ENSTNIG00000006816	-	85	36.364	Tetraodon_nigroviridis
ENSG00000102081	FMR1	99	75.510	ENSTNIG00000010121	fmr1	80	75.535	Tetraodon_nigroviridis
ENSG00000102081	FMR1	99	68.367	ENSTNIG00000005118	fxr2	79	68.563	Tetraodon_nigroviridis
ENSG00000102081	FMR1	95	73.196	ENSTNIG00000003790	fxr1	70	65.502	Tetraodon_nigroviridis
ENSG00000102081	FMR1	100	95.798	ENSTBEG00000003253	FMR1	100	83.389	Tupaia_belangeri
ENSG00000102081	FMR1	82	75.000	ENSTBEG00000002514	FXR2	65	62.461	Tupaia_belangeri
ENSG00000102081	FMR1	95	79.381	ENSTTRG00000014698	FXR1	70	73.353	Tursiops_truncatus
ENSG00000102081	FMR1	98	71.478	ENSTTRG00000010231	FXR2	65	71.601	Tursiops_truncatus
ENSG00000102081	FMR1	96	98.980	ENSTTRG00000000613	FMR1	100	96.817	Tursiops_truncatus
ENSG00000102081	FMR1	98	71.478	ENSUAMG00000001330	FXR2	85	66.972	Ursus_americanus
ENSG00000102081	FMR1	95	79.381	ENSUAMG00000006833	FXR1	65	73.494	Ursus_americanus
ENSG00000102081	FMR1	99	98.980	ENSUAMG00000013787	FMR1	99	97.373	Ursus_americanus
ENSG00000102081	FMR1	100	94.958	ENSUMAG00000009869	FMR1	99	94.502	Ursus_maritimus
ENSG00000102081	FMR1	95	74.227	ENSUMAG00000016725	FXR2	67	69.637	Ursus_maritimus
ENSG00000102081	FMR1	95	79.381	ENSUMAG00000007061	FXR1	65	73.494	Ursus_maritimus
ENSG00000102081	FMR1	82	75.000	ENSVPAG00000000147	FXR2	59	62.346	Vicugna_pacos
ENSG00000102081	FMR1	96	98.980	ENSVPAG00000008700	FMR1	100	96.748	Vicugna_pacos
ENSG00000102081	FMR1	95	79.381	ENSVPAG00000003384	FXR1	69	73.186	Vicugna_pacos
ENSG00000102081	FMR1	95	79.381	ENSVVUG00000006660	FXR1	70	73.952	Vulpes_vulpes
ENSG00000102081	FMR1	100	95.798	ENSVVUG00000000753	FMR1	99	97.574	Vulpes_vulpes
ENSG00000102081	FMR1	98	71.478	ENSVVUG00000027916	FXR2	50	71.601	Vulpes_vulpes
ENSG00000102081	FMR1	95	76.289	ENSXETG00000019441	fxr1	71	71.557	Xenopus_tropicalis
ENSG00000102081	FMR1	99	92.857	ENSXETG00000019647	fmr1	100	91.617	Xenopus_tropicalis
ENSG00000102081	FMR1	99	85.374	ENSXCOG00000013342	fmr1	96	83.832	Xiphophorus_couchianus
ENSG00000102081	FMR1	98	70.297	ENSXCOG00000005798	fxr2	94	67.606	Xiphophorus_couchianus
ENSG00000102081	FMR1	95	73.196	ENSXCOG00000008158	fxr1	71	56.587	Xiphophorus_couchianus
ENSG00000102081	FMR1	99	69.048	ENSXMAG00000011669	fxr2	70	64.076	Xiphophorus_maculatus
ENSG00000102081	FMR1	96	87.755	ENSXMAG00000000827	fmr1	99	64.907	Xiphophorus_maculatus
ENSG00000102081	FMR1	99	70.408	ENSXMAG00000000666	fxr1	71	66.237	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	18653529.	IDA	Process
GO:0000775	chromosome, centromeric region	-	IEA	Component
GO:0001934	positive regulation of protein phosphorylation	21873635.	IBA	Process
GO:0002092	positive regulation of receptor internalization	25561520.	IDA	Process
GO:0002151	G-quadruplex RNA binding	18653529.25464849.	IDA	Function
GO:0003682	chromatin binding	-	ISS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	15381419.	IDA	Function
GO:0003723	RNA binding	10496225.25225333.	IMP	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0003729	mRNA binding	11157796.18936162.25561520.	IDA	Function
GO:0003730	mRNA 3'-UTR binding	21873635.	IBA	Function
GO:0003730	mRNA 3'-UTR binding	17417632.	IDA	Function
GO:0005515	protein binding	7489725.10556305.11157796.11438699.12837692.15380484.15381419.16407062.16571602.18093976.18936162.21771594.24514761.24658146.25225333.25464849.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	18936162.	IDA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005654	nucleoplasm	16571602.	IDA	Component
GO:0005694	chromosome	-	ISS	Component
GO:0005730	nucleolus	16571602.24658146.	IDA	Component
GO:0005730	nucleolus	16407062.	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	9659908.15381419.16571602.18936162.	IDA	Component
GO:0005737	cytoplasm	16407062.	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005844	polysome	21873635.	IBA	Component
GO:0005844	polysome	9659908.19097999.25464849.25561520.	IDA	Component
GO:0005844	polysome	-	ISS	Component
GO:0005845	mRNA cap binding complex	-	ISS	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0006974	cellular response to DNA damage stimulus	24813610.	IDA	Process
GO:0007215	glutamate receptor signaling pathway	-	ISS	Process
GO:0007417	central nervous system development	21873635.	IBA	Process
GO:0008017	microtubule binding	-	ISS	Function
GO:0008089	anterograde axonal transport	21873635.	IBA	Process
GO:0008266	poly(U) RNA binding	7688265.8156595.	IDA	Function
GO:0008380	RNA splicing	-	IEA	Process
GO:0010369	chromocenter	-	ISS	Component
GO:0010494	cytoplasmic stress granule	-	IEA	Component
GO:0014069	postsynaptic density	21873635.	IBA	Component
GO:0014069	postsynaptic density	-	ISS	Component
GO:0015030	Cajal body	-	IEA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0017148	negative regulation of translation	21873635.	IBA	Process
GO:0019034	viral replication complex	24514761.	IDA	Component
GO:0019897	extrinsic component of plasma membrane	-	ISS	Component
GO:0030054	cell junction	-	IEA	Component
GO:0030371	translation repressor activity	11157796.	IDA	Function
GO:0030424	axon	21873635.	IBA	Component
GO:0030424	axon	-	ISS	Component
GO:0030425	dendrite	-	ISS	Component
GO:0030426	growth cone	21873635.	IBA	Component
GO:0030426	growth cone	15380484.	IDA	Component
GO:0031047	gene silencing by RNA	-	IEA	Process
GO:0031369	translation initiation factor binding	24658146.	IPI	Function
GO:0032433	filopodium tip	-	ISS	Component
GO:0032797	SMN complex	18093976.	IDA	Component
GO:0033129	positive regulation of histone phosphorylation	24813610.	IDA	Process
GO:0033592	RNA strand annealing activity	17057366.	IDA	Function
GO:0034046	poly(G) binding	7688265.	IDA	Function
GO:0034644	cellular response to UV	-	ISS	Process
GO:0035064	methylated histone binding	24813610.	IDA	Function
GO:0035197	siRNA binding	17057366.	IDA	Function
GO:0035198	miRNA binding	17057366.	IDA	Function
GO:0035613	RNA stem-loop binding	15805463.19166269.	IDA	Function
GO:0035770	ribonucleoprotein granule	21873635.	IBA	Component
GO:0036464	cytoplasmic ribonucleoprotein granule	21873635.	IBA	Component
GO:0036464	cytoplasmic ribonucleoprotein granule	15121898.15380484.18093976.	IDA	Component
GO:0042734	presynaptic membrane	-	IEA	Component
GO:0042788	polysomal ribosome	12837692.	TAS	Component
GO:0042802	identical protein binding	11157796.	IDA	Function
GO:0042802	identical protein binding	17850748.21446998.	IPI	Function
GO:0042803	protein homodimerization activity	21873635.	IBA	Function
GO:0042803	protein homodimerization activity	7489725.	IDA	Function
GO:0042995	cell projection	15380484.	IDA	Component
GO:0043005	neuron projection	18093976.	IDA	Component
GO:0043022	ribosome binding	24658146.	IPI	Function
GO:0043025	neuronal cell body	21873635.	IBA	Component
GO:0043197	dendritic spine	21873635.	IBA	Component
GO:0043197	dendritic spine	-	ISS	Component
GO:0043204	perikaryon	15380484.18093976.	IDA	Component
GO:0043204	perikaryon	-	ISS	Component
GO:0043488	regulation of mRNA stability	21873635.	IBA	Process
GO:0043488	regulation of mRNA stability	-	ISS	Process
GO:0043679	axon terminus	-	ISS	Component
GO:0044325	ion channel binding	25561520.	IPI	Function
GO:0044326	dendritic spine neck	21873635.	IBA	Component
GO:0044830	modulation by host of viral RNA genome replication	24514761.	IMP	Process
GO:0045182	translation regulator activity	21873635.	IBA	Function
GO:0045202	synapse	-	ISS	Component
GO:0045211	postsynaptic membrane	-	IEA	Component
GO:0045727	positive regulation of translation	21873635.	IBA	Process
GO:0045727	positive regulation of translation	19097999.19166269.	IDA	Process
GO:0045947	negative regulation of translational initiation	-	ISS	Process
GO:0046928	regulation of neurotransmitter secretion	-	ISS	Process
GO:0046982	protein heterodimerization activity	7489725.	IDA	Function
GO:0048027	mRNA 5'-UTR binding	19166269.	IDA	Function
GO:0048471	perinuclear region of cytoplasm	24658146.	IDA	Component
GO:0048814	regulation of dendrite morphogenesis	21873635.	IBA	Process
GO:0051028	mRNA transport	-	ISS	Process
GO:0051489	regulation of filopodium assembly	21873635.	IBA	Process
GO:0051489	regulation of filopodium assembly	16631377.	IDA	Process
GO:0051491	positive regulation of filopodium assembly	-	ISS	Process
GO:0060964	regulation of gene silencing by miRNA	25464849.	IMP	Process
GO:0060998	regulation of dendritic spine development	21873635.	IBA	Process
GO:0060998	regulation of dendritic spine development	16631377.	IDA	Process
GO:0060999	positive regulation of dendritic spine development	-	ISS	Process
GO:0070840	dynein complex binding	-	ISS	Function
GO:0071598	neuronal ribonucleoprotein granule	21873635.	IBA	Component
GO:0071598	neuronal ribonucleoprotein granule	-	ISS	Component
GO:0072711	cellular response to hydroxyurea	-	ISS	Process
GO:0097386	glial cell projection	-	ISS	Component
GO:0098586	cellular response to virus	24514761.	IDA	Process
GO:0098793	presynapse	21873635.	IBA	Component
GO:0098793	presynapse	-	ISS	Component
GO:0098794	postsynapse	-	ISS	Component
GO:0098908	regulation of neuronal action potential	25561520.	IDA	Process
GO:0099578	regulation of translation at postsynapse, modulating synaptic transmission	21873635.	IBA	Process
GO:1900453	negative regulation of long-term synaptic depression	-	ISS	Process
GO:1901254	positive regulation of intracellular transport of viral material	24514761.	IMP	Process
GO:1901386	negative regulation of voltage-gated calcium channel activity	-	ISS	Process
GO:1901800	positive regulation of proteasomal protein catabolic process	-	ISS	Process
GO:1902373	negative regulation of mRNA catabolic process	25225333.	IMP	Process
GO:1902416	positive regulation of mRNA binding	25464849.	IDA	Process
GO:1902737	dendritic filopodium	21873635.	IBA	Component
GO:1902737	dendritic filopodium	-	ISS	Component
GO:1904115	axon cytoplasm	-	IEA	Component
GO:1905244	regulation of modification of synaptic structure	21873635.	IBA	Process
GO:1990124	messenger ribonucleoprotein complex	25225333.	IDA	Component
GO:1990812	growth cone filopodium	-	ISS	Component
GO:1990825	sequence-specific mRNA binding	12927206.23235829.	IDA	Function
GO:1990904	ribonucleoprotein complex	9659908.19097999.	IDA	Component
GO:2000301	negative regulation of synaptic vesicle exocytosis	-	ISS	Process
GO:2000637	positive regulation of gene silencing by miRNA	17057366.	IDA	Process
GO:2000766	negative regulation of cytoplasmic translation	-	ISS	Process
GO:2001022	positive regulation of response to DNA damage stimulus	21873635.	IBA	Process
GO:2001022	positive regulation of response to DNA damage stimulus	24813610.	IDA	Process