EuRBPDB

Description

Ensembl ID: ENSG00000102189 (Gene tree)
Gene ID: 8411
Gene Symbol: EEA1
Alias: ZFYVE2
Full Name: early endosome antigen 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 158,695 bases
Position: chr12:92,770,637-92,929,331
Accession: 3185
RBP type: non-canonical RBP
Summary: (Early Endosome Antigen 1) is a Protein Coding gene. Diseases associated with EEA1 include Subacute Cutaneous Lupus Erythematosus and Cat-Scratch Disease. Among its related pathways are Phagosome and Endocytosis. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and 1-phosphatidylinositol binding.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000547833	EEA1-203	661	-	-	- (aa)	-	-
ENST00000418984	EEA1-202	2542	-	ENSP00000394312	40 (aa)	-	F8WE79
ENST00000322349	EEA1-201	9875	XM_011538814	ENSP00000317955	1411 (aa)	XP_011537116	Q15075
ENST00000553019	EEA1-205	558	-	ENSP00000449682	43 (aa)	-	F8VUZ7
ENST00000549790	EEA1-204	542	-	ENSP00000446785	42 (aa)	-	F8W119

Gene Model

Pathways

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000102189	rs10507017	12	92771160	?	Exploratory eye movement dysfunction in schizophrenia (responsive search score)	26242244	[3.72-8.7] unit decrease	6.212	EFO_0007700
ENSG00000102189	rs10507017	12	92771160	?	Exploratory eye movement dysfunction in schizophrenia (number of eye fixations)	26242244	[10.51-24.33] unit decrease	17.42	EFO_0007700
ENSG00000102189	rs140957346	12	92855755	?	Western dietary pattern	28644415			EFO_0008111
ENSG00000102189	rs10859383	12	92813675	?	General cognitive ability	29844566	z-score decrease	5.005	EFO_0004337
ENSG00000102189	rs17790352	12	92782429	A	Intelligence	29942086	z-score increase	5.694	EFO_0004337
ENSG00000102189	rs116987964	12	92892438	?	DNA methylation variation (age effect)	30348214			GO_0006306
ENSG00000102189	rs10745624	12	92882421	?	Neuroticism	30595370			EFO_0007660

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0005515	protein binding	9697774.10491193.10506127.11870209.14613930.16314522.16902405.24029230.29568061.	IPI	Function
GO:0005516	calmodulin binding	11741531.	NAS	Function
GO:0005545	1-phosphatidylinositol binding	11256955.	IDA	Function
GO:0005737	cytoplasm	7768953.	TAS	Component
GO:0005769	early endosome	11741531.12536145.15229288.15792797.15880641.16542649.18388320.18767904.19535332.22719997.25327288.	IDA	Component
GO:0005829	cytosol	7768953.	IDA	Component
GO:0005969	serine-pyruvate aminotransferase complex	-	IEA	Component
GO:0006897	endocytosis	21081650.	IMP	Process
GO:0006906	vesicle fusion	9697774.	IMP	Process
GO:0008270	zinc ion binding	11741531.	TAS	Function
GO:0016020	membrane	7768953.	TAS	Component
GO:0016189	synaptic vesicle to endosome fusion	11741531.	TAS	Process
GO:0019897	extrinsic component of plasma membrane	7768953.	IDA	Component
GO:0030742	GTP-dependent protein binding	10491193.	IDA	Function
GO:0031901	early endosome membrane	-	IEA	Component
GO:0039694	viral RNA genome replication	19376974.	IMP	Process
GO:0042803	protein homodimerization activity	11741531.	IDA	Function
GO:0044308	axonal spine	-	IEA	Component
GO:0045022	early endosome to late endosome transport	7768953.	NAS	Process
GO:0055037	recycling endosome	-	IEA	Component
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0098793	presynapse	-	IEA	Component