EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000102699 (Gene tree)
Gene ID: 143
Gene Symbol: PARP4
Alias: VAULT3|p193|VPARP|VWA5C|ADPRTL1
Full Name: poly(ADP-ribose) polymerase family member 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 92,068 bases
Position: chr13:24,420,926-24,512,993
Accession: 271
RBP type: canonical RBP
Summary: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000371419	PARP	PF00644.20	2e-38	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000480576	PARP4-202	380	-	-	- (aa)	-	-
ENST00000484989	PARP4-203	808	-	-	- (aa)	-	-
ENST00000381989	PARP4-201	5474	XM_011534931	ENSP00000371419	1724 (aa)	XP_011533233	Q9UKK3

Gene Model

Click here to download ENSG00000102699's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03410	Base excision repair	KEGG
hsa04210	Apoptosis	KEGG
hsa04217	Necroptosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000102699	Parkinson Disease	1.032521E-6	17052657
ENSG00000102699	Platelet Function Tests	2.1889300E-005	-
ENSG00000102699	Platelet Function Tests	1.7369900E-005	-
ENSG00000102699	Death, Sudden, Cardiac	7E-7	21658281

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000102699	rs9581094	13	24508492	?	Sudden cardiac arrest	21658281	[1.38-2.10]	1.7	EFO_0004278
ENSG00000102699	rs9578751	13	24500352	?	Idiopathic intracranial hypertension	29608535			EFO_1001132

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000102699's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000102699	PARP4	70	45.689	ENSAPOG00000020678	parp4	93	45.850	Acanthochromis_polyacanthus
ENSG00000102699	PARP4	100	71.059	ENSAMEG00000017377	PARP4	100	81.713	Ailuropoda_melanoleuca
ENSG00000102699	PARP4	79	46.078	ENSACIG00000021890	parp4	100	46.078	Amphilophus_citrinellus
ENSG00000102699	PARP4	78	45.968	ENSAPEG00000014531	parp4	64	45.968	Amphiprion_percula
ENSG00000102699	PARP4	70	47.368	ENSATEG00000023758	parp4	81	47.368	Anabas_testudineus
ENSG00000102699	PARP4	71	58.381	ENSAPLG00000005053	PARP4	99	61.275	Anas_platyrhynchos
ENSG00000102699	PARP4	78	54.894	ENSACAG00000001725	PARP4	75	54.894	Anolis_carolinensis
ENSG00000102699	PARP4	100	87.072	ENSANAG00000021254	PARP4	100	87.072	Aotus_nancymaae
ENSG00000102699	PARP4	78	45.491	ENSACLG00000009783	parp4	72	45.491	Astatotilapia_calliptera
ENSG00000102699	PARP4	80	47.087	ENSAMXG00000016657	parp4	78	47.087	Astyanax_mexicanus
ENSG00000102699	PARP4	94	71.159	ENSBTAG00000025400	PARP4	92	73.319	Bos_taurus
ENSG00000102699	PARP4	100	87.014	ENSCJAG00000004452	PARP4	100	87.014	Callithrix_jacchus
ENSG00000102699	PARP4	99	68.995	ENSCAFG00000007375	PARP4	99	75.518	Canis_familiaris
ENSG00000102699	PARP4	99	68.345	ENSCAFG00020002104	PARP4	99	82.114	Canis_lupus_dingo
ENSG00000102699	PARP4	100	66.025	ENSCHIG00000016066	PARP4	100	66.704	Capra_hircus
ENSG00000102699	PARP4	91	83.782	ENSTSYG00000014701	PARP4	100	70.122	Carlito_syrichta
ENSG00000102699	PARP4	99	66.820	ENSCPOG00000014672	PARP4	99	66.514	Cavia_porcellus
ENSG00000102699	PARP4	100	86.682	ENSCCAG00000032863	PARP4	100	86.856	Cebus_capucinus
ENSG00000102699	PARP4	100	88.406	ENSCATG00000035770	PARP4	100	88.406	Cercocebus_atys
ENSG00000102699	PARP4	100	91.763	ENSCSAG00000018004	PARP4	100	91.763	Chlorocebus_sabaeus
ENSG00000102699	PARP4	53	80.233	ENSCHOG00000006882	-	75	80.233	Choloepus_hoffmanni
ENSG00000102699	PARP4	79	61.644	ENSCPBG00000020893	PARP4	94	65.101	Chrysemys_picta_bellii
ENSG00000102699	PARP4	99	87.861	ENSCANG00000014573	PARP4	99	87.977	Colobus_angolensis_palliatus
ENSG00000102699	PARP4	80	79.967	ENSCGRG00001021886	Parp4	100	66.198	Cricetulus_griseus_chok1gshd
ENSG00000102699	PARP4	80	79.967	ENSCGRG00000011944	Parp4	100	65.460	Cricetulus_griseus_crigri
ENSG00000102699	PARP4	79	45.068	ENSCSEG00000004631	parp4	83	45.133	Cynoglossus_semilaevis
ENSG00000102699	PARP4	73	49.016	ENSCVAG00000010227	parp4	99	49.326	Cyprinodon_variegatus
ENSG00000102699	PARP4	80	46.369	ENSDARG00000069934	parp4	77	46.608	Danio_rerio
ENSG00000102699	PARP4	98	75.776	ENSDNOG00000037733	PARP4	77	75.776	Dasypus_novemcinctus
ENSG00000102699	PARP4	79	78.082	ENSDORG00000029090	Parp4	98	78.082	Dipodomys_ordii
ENSG00000102699	PARP4	99	71.098	ENSEASG00005000229	PARP4	97	81.818	Equus_asinus_asinus
ENSG00000102699	PARP4	99	71.346	ENSECAG00000009458	PARP4	99	71.027	Equus_caballus
ENSG00000102699	PARP4	79	47.368	ENSELUG00000005711	parp4	81	46.051	Esox_lucius
ENSG00000102699	PARP4	100	71.216	ENSFCAG00000031561	PARP4	100	71.036	Felis_catus
ENSG00000102699	PARP4	100	69.283	ENSFDAG00000010439	PARP4	100	69.396	Fukomys_damarensis
ENSG00000102699	PARP4	70	46.359	ENSFHEG00000021894	parp4	95	46.440	Fundulus_heteroclitus
ENSG00000102699	PARP4	65	53.933	ENSGMOG00000001674	parp4	72	53.933	Gadus_morhua
ENSG00000102699	PARP4	78	60.145	ENSGALG00000034473	PARP4	85	60.145	Gallus_gallus
ENSG00000102699	PARP4	78	44.963	ENSGACG00000008521	parp4	99	38.561	Gasterosteus_aculeatus
ENSG00000102699	PARP4	76	62.047	ENSGAGG00000006063	PARP4	77	62.047	Gopherus_agassizii
ENSG00000102699	PARP4	96	96.149	ENSGGOG00000002940	PARP4	97	96.149	Gorilla_gorilla
ENSG00000102699	PARP4	61	51.387	ENSHBUG00000018539	parp4	99	51.577	Haplochromis_burtoni
ENSG00000102699	PARP4	100	68.195	ENSHGLG00000008309	PARP4	100	68.195	Heterocephalus_glaber_female
ENSG00000102699	PARP4	100	68.195	ENSHGLG00100012331	PARP4	100	68.195	Heterocephalus_glaber_male
ENSG00000102699	PARP4	79	42.707	ENSHCOG00000017842	parp4	77	42.707	Hippocampus_comes
ENSG00000102699	PARP4	79	46.940	ENSIPUG00000003181	parp4	83	46.822	Ictalurus_punctatus
ENSG00000102699	PARP4	84	70.580	ENSSTOG00000027869	PARP4	100	70.513	Ictidomys_tridecemlineatus
ENSG00000102699	PARP4	59	50.294	ENSKMAG00000018334	parp4	96	50.294	Kryptolebias_marmoratus
ENSG00000102699	PARP4	79	46.853	ENSLBEG00000013362	parp4	72	46.853	Labrus_bergylta
ENSG00000102699	PARP4	99	45.289	ENSLACG00000005075	-	99	45.304	Latimeria_chalumnae
ENSG00000102699	PARP4	99	42.123	ENSLOCG00000010789	parp4	99	42.042	Lepisosteus_oculatus
ENSG00000102699	PARP4	71	80.474	ENSLAFG00000002022	-	100	81.843	Loxodonta_africana
ENSG00000102699	PARP4	100	91.531	ENSMMUG00000012297	PARP4	100	91.531	Macaca_mulatta
ENSG00000102699	PARP4	91	89.827	ENSMNEG00000044999	PARP4	100	89.827	Macaca_nemestrina
ENSG00000102699	PARP4	100	92.111	ENSMLEG00000041053	PARP4	100	92.111	Mandrillus_leucophaeus
ENSG00000102699	PARP4	72	43.881	ENSMAMG00000020871	parp4	94	43.881	Mastacembelus_armatus
ENSG00000102699	PARP4	75	45.650	ENSMZEG00005014412	parp4	72	45.491	Maylandia_zebra
ENSG00000102699	PARP4	81	57.649	ENSMGAG00000015136	PARP4	85	59.420	Meleagris_gallopavo
ENSG00000102699	PARP4	81	76.918	ENSMICG00000028028	PARP4	92	77.005	Microcebus_murinus
ENSG00000102699	PARP4	100	64.814	ENSMOCG00000016582	Parp4	100	64.563	Microtus_ochrogaster
ENSG00000102699	PARP4	76	43.333	ENSMMOG00000019397	parp4	98	43.333	Mola_mola
ENSG00000102699	PARP4	80	67.671	ENSMODG00000007894	PARP4	73	67.671	Monodelphis_domestica
ENSG00000102699	PARP4	60	45.455	ENSMALG00000004027	parp4	98	45.455	Monopterus_albus
ENSG00000102699	PARP4	82	76.404	MGP_CAROLIEiJ_G0019339	-	80	70.238	Mus_caroli
ENSG00000102699	PARP4	84	77.265	ENSMUSG00000054509	Parp4	75	75.273	Mus_musculus
ENSG00000102699	PARP4	83	76.886	MGP_PahariEiJ_G0030357	Parp4	78	76.886	Mus_pahari
ENSG00000102699	PARP4	92	74.359	MGP_SPRETEiJ_G0020230	Parp4	83	69.851	Mus_spretus
ENSG00000102699	PARP4	90	69.123	ENSMPUG00000013318	PARP4	99	69.172	Mustela_putorius_furo
ENSG00000102699	PARP4	100	71.182	ENSMLUG00000003797	PARP4	100	71.182	Myotis_lucifugus
ENSG00000102699	PARP4	94	73.680	ENSNGAG00000018396	Parp4	100	65.646	Nannospalax_galili
ENSG00000102699	PARP4	59	86.441	ENSMEUG00000015644	-	87	86.441	Notamacropus_eugenii
ENSG00000102699	PARP4	99	40.561	ENSONIG00000010261	parp4	99	40.561	Oreochromis_niloticus
ENSG00000102699	PARP4	88	75.742	ENSOCUG00000014529	PARP4	99	66.318	Oryctolagus_cuniculus
ENSG00000102699	PARP4	56	50.206	ENSORLG00000018162	parp4	87	50.103	Oryzias_latipes
ENSG00000102699	PARP4	56	51.703	ENSORLG00020011392	parp4	87	51.703	Oryzias_latipes_hni
ENSG00000102699	PARP4	71	46.769	ENSORLG00015007534	parp4	96	46.769	Oryzias_latipes_hsok
ENSG00000102699	PARP4	81	49.186	ENSOMEG00000012305	parp4	95	49.502	Oryzias_melastigma
ENSG00000102699	PARP4	95	82.817	ENSOGAG00000016230	PARP4	100	72.842	Otolemur_garnettii
ENSG00000102699	PARP4	98	70.523	ENSOARG00000014415	PARP4	100	66.534	Ovis_aries
ENSG00000102699	PARP4	100	97.680	ENSPPAG00000024134	PARP4	100	97.680	Pan_paniscus
ENSG00000102699	PARP4	100	71.273	ENSPPRG00000009047	PARP4	100	71.191	Panthera_pardus
ENSG00000102699	PARP4	100	98.086	ENSPTRG00000005711	PARP4	100	98.086	Pan_troglodytes
ENSG00000102699	PARP4	100	91.652	ENSPANG00000006504	PARP4	100	91.652	Papio_anubis
ENSG00000102699	PARP4	94	54.235	ENSPSIG00000014196	PARP4	100	46.414	Pelodiscus_sinensis
ENSG00000102699	PARP4	65	48.410	ENSPMGG00000007212	parp4	92	48.265	Periophthalmus_magnuspinnatus
ENSG00000102699	PARP4	80	78.612	ENSPEMG00000012639	Parp4	75	78.612	Peromyscus_maniculatus_bairdii
ENSG00000102699	PARP4	55	40.406	ENSPMAG00000008938	-	99	40.406	Petromyzon_marinus
ENSG00000102699	PARP4	73	69.014	ENSPCIG00000017800	-	99	69.014	Phascolarctos_cinereus
ENSG00000102699	PARP4	81	45.433	ENSPFOG00000002081	parp4	99	46.353	Poecilia_formosa
ENSG00000102699	PARP4	61	48.394	ENSPLAG00000019059	parp4	91	48.394	Poecilia_latipinna
ENSG00000102699	PARP4	57	50.554	ENSPLAG00000021665	parp4	90	48.718	Poecilia_latipinna
ENSG00000102699	PARP4	57	49.252	ENSPMEG00000017006	parp4	90	48.110	Poecilia_mexicana
ENSG00000102699	PARP4	61	48.187	ENSPMEG00000016931	-	91	48.187	Poecilia_mexicana
ENSG00000102699	PARP4	80	87.179	ENSPCOG00000022852	PARP4	92	87.179	Propithecus_coquereli
ENSG00000102699	PARP4	97	66.295	ENSPVAG00000016461	PARP4	100	66.765	Pteropus_vampyrus
ENSG00000102699	PARP4	75	45.411	ENSPNYG00000015691	parp4	69	45.411	Pundamilia_nyererei
ENSG00000102699	PARP4	56	52.160	ENSPNAG00000019054	parp4	64	52.160	Pygocentrus_nattereri
ENSG00000102699	PARP4	100	90.562	ENSRBIG00000040334	PARP4	100	90.793	Rhinopithecus_bieti
ENSG00000102699	PARP4	100	89.114	ENSRROG00000040417	PARP4	100	89.230	Rhinopithecus_roxellana
ENSG00000102699	PARP4	64	50.763	ENSSDUG00000014635	parp4	88	50.763	Seriola_dumerili
ENSG00000102699	PARP4	70	46.227	ENSSLDG00000022915	parp4	72	46.209	Seriola_lalandi_dorsalis
ENSG00000102699	PARP4	66	48.333	ENSSPAG00000010424	parp4	89	48.333	Stegastes_partitus
ENSG00000102699	PARP4	91	71.041	ENSSSCG00000022957	PARP4	92	70.220	Sus_scrofa
ENSG00000102699	PARP4	79	46.732	ENSTNIG00000015654	parp4	99	46.204	Tetraodon_nigroviridis
ENSG00000102699	PARP4	61	78.626	ENSUAMG00000027134	-	96	76.953	Ursus_americanus
ENSG00000102699	PARP4	100	70.098	ENSUMAG00000013978	PARP4	100	69.810	Ursus_maritimus
ENSG00000102699	PARP4	93	77.273	ENSVVUG00000006363	PARP4	99	77.273	Vulpes_vulpes
ENSG00000102699	PARP4	71	49.758	ENSXETG00000002639	-	97	49.360	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	10100603.	TAS	Function
GO:0003950	NAD+ ADP-ribosyltransferase activity	10477748.	IDA	Function
GO:0003950	NAD+ ADP-ribosyltransferase activity	10644454.	NAS	Function
GO:0005515	protein binding	15169895.22190034.	IPI	Function
GO:0005634	nucleus	10644454.	NAS	Component
GO:0005737	cytoplasm	10477748.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005876	spindle microtubule	10477748.	IDA	Component
GO:0006281	DNA repair	12101391.	NAS	Process
GO:0006464	cellular protein modification process	10477748.	IDA	Process
GO:0006471	protein ADP-ribosylation	10644454.	NAS	Process
GO:0006954	inflammatory response	12123754.	IMP	Process
GO:0006974	cellular response to DNA damage stimulus	10477748.	NAS	Process
GO:0008219	cell death	12140175.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019899	enzyme binding	15169895.	IDA	Function
GO:0042493	response to drug	11291045.	NAS	Process
GO:0051972	regulation of telomerase activity	15169895.	IDA	Process
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:1990404	protein ADP-ribosylase activity	25043379.	IDA	Function
GO:1990904	ribonucleoprotein complex	11479319.	NAS	Component