EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000102738 (Gene tree)
Gene ID: 10240
Gene Symbol: MRPS31
Alias: IMOGN38
Full Name: mitochondrial ribosomal protein S31
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 42,089 bases
Position: chr13:40,729,135-40,771,223
Accession: 16632
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000315397	MRP-S31	PF15433.6	1.1e-111	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000435009	MRPS31-202	588	-	-	- (aa)	-	-
ENST00000498078	MRPS31-204	782	-	-	- (aa)	-	-
ENST00000461675	MRPS31-203	507	-	-	- (aa)	-	-
ENST00000323563	MRPS31-201	1462	-	ENSP00000315397	395 (aa)	-	Q92665

Gene Model

Click here to download ENSG00000102738's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000102738's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000102738	MRPS31	80	42.216	ENSAPOG00000001691	mrps31	84	42.216	Acanthochromis_polyacanthus
ENSG00000102738	MRPS31	100	75.819	ENSAMEG00000011719	MRPS31	100	75.819	Ailuropoda_melanoleuca
ENSG00000102738	MRPS31	83	40.503	ENSACIG00000000954	mrps31	98	40.503	Amphilophus_citrinellus
ENSG00000102738	MRPS31	79	44.713	ENSAOCG00000015793	mrps31	83	44.713	Amphiprion_ocellaris
ENSG00000102738	MRPS31	79	43.505	ENSAPEG00000002580	mrps31	83	43.505	Amphiprion_percula
ENSG00000102738	MRPS31	84	40.870	ENSATEG00000015311	mrps31	80	40.870	Anabas_testudineus
ENSG00000102738	MRPS31	89	47.425	ENSAPLG00000004031	MRPS31	95	47.425	Anas_platyrhynchos
ENSG00000102738	MRPS31	81	47.561	ENSACAG00000016639	MRPS31	95	47.774	Anolis_carolinensis
ENSG00000102738	MRPS31	100	86.146	ENSANAG00000028614	MRPS31	92	86.146	Aotus_nancymaae
ENSG00000102738	MRPS31	81	43.027	ENSACLG00000014414	mrps31	77	43.363	Astatotilapia_calliptera
ENSG00000102738	MRPS31	100	72.953	ENSBTAG00000015522	MRPS31	100	72.953	Bos_taurus
ENSG00000102738	MRPS31	100	86.582	ENSCJAG00000017805	MRPS31	100	86.582	Callithrix_jacchus
ENSG00000102738	MRPS31	100	72.544	ENSCAFG00000005961	MRPS31	100	74.352	Canis_familiaris
ENSG00000102738	MRPS31	87	75.793	ENSCAFG00020021258	MRPS31	99	75.793	Canis_lupus_dingo
ENSG00000102738	MRPS31	100	73.552	ENSCHIG00000012457	MRPS31	100	73.552	Capra_hircus
ENSG00000102738	MRPS31	55	62.963	ENSCAPG00000013597	-	99	62.963	Cavia_aperea
ENSG00000102738	MRPS31	100	67.677	ENSCPOG00000003332	MRPS31	100	67.677	Cavia_porcellus
ENSG00000102738	MRPS31	100	87.121	ENSCCAG00000033771	MRPS31	100	87.121	Cebus_capucinus
ENSG00000102738	MRPS31	100	87.657	ENSCATG00000030049	MRPS31	100	87.657	Cercocebus_atys
ENSG00000102738	MRPS31	100	69.192	ENSCLAG00000003239	MRPS31	100	69.192	Chinchilla_lanigera
ENSG00000102738	MRPS31	100	79.302	ENSCSAG00000017841	MRPS31	100	78.055	Chlorocebus_sabaeus
ENSG00000102738	MRPS31	95	70.370	ENSCHOG00000008470	MRPS31	98	70.635	Choloepus_hoffmanni
ENSG00000102738	MRPS31	84	51.585	ENSCPBG00000000676	MRPS31	89	52.586	Chrysemys_picta_bellii
ENSG00000102738	MRPS31	100	90.380	ENSCANG00000035831	MRPS31	100	90.380	Colobus_angolensis_palliatus
ENSG00000102738	MRPS31	99	65.823	ENSCGRG00001014160	Mrps31	99	65.823	Cricetulus_griseus_chok1gshd
ENSG00000102738	MRPS31	99	65.823	ENSCGRG00000013513	Mrps31	99	65.823	Cricetulus_griseus_crigri
ENSG00000102738	MRPS31	75	38.111	ENSCSEG00000007168	mrps31	90	38.111	Cynoglossus_semilaevis
ENSG00000102738	MRPS31	81	42.478	ENSCVAG00000000787	mrps31	84	42.478	Cyprinodon_variegatus
ENSG00000102738	MRPS31	75	48.860	ENSDARG00000057855	mrps31	71	49.201	Danio_rerio
ENSG00000102738	MRPS31	100	72.544	ENSDNOG00000048890	MRPS31	100	72.544	Dasypus_novemcinctus
ENSG00000102738	MRPS31	62	76.735	ENSDORG00000003839	-	99	76.735	Dipodomys_ordii
ENSG00000102738	MRPS31	61	34.545	FBgn0036557	mRpS31	65	35.714	Drosophila_melanogaster
ENSG00000102738	MRPS31	95	79.101	ENSEASG00005013786	MRPS31	100	78.338	Equus_asinus_asinus
ENSG00000102738	MRPS31	100	79.345	ENSECAG00000003600	MRPS31	100	79.345	Equus_caballus
ENSG00000102738	MRPS31	100	43.216	ENSEEUG00000010474	-	100	43.216	Erinaceus_europaeus
ENSG00000102738	MRPS31	81	43.235	ENSELUG00000014713	mrps31	59	43.235	Esox_lucius
ENSG00000102738	MRPS31	100	76.203	ENSFCAG00000025278	MRPS31	100	76.203	Felis_catus
ENSG00000102738	MRPS31	87	48.588	ENSFALG00000008596	MRPS31	82	48.588	Ficedula_albicollis
ENSG00000102738	MRPS31	100	67.254	ENSFDAG00000007092	MRPS31	100	67.254	Fukomys_damarensis
ENSG00000102738	MRPS31	76	44.762	ENSFHEG00000003180	mrps31	81	44.268	Fundulus_heteroclitus
ENSG00000102738	MRPS31	92	46.966	ENSGALG00000017033	MRPS31	84	46.966	Gallus_gallus
ENSG00000102738	MRPS31	83	41.420	ENSGAFG00000004758	mrps31	79	41.420	Gambusia_affinis
ENSG00000102738	MRPS31	84	52.161	ENSGAGG00000023778	MRPS31	86	52.161	Gopherus_agassizii
ENSG00000102738	MRPS31	100	96.203	ENSGGOG00000006468	MRPS31	100	96.203	Gorilla_gorilla
ENSG00000102738	MRPS31	81	43.323	ENSHBUG00000023744	mrps31	77	43.323	Haplochromis_burtoni
ENSG00000102738	MRPS31	100	70.529	ENSHGLG00000006949	MRPS31	89	70.529	Heterocephalus_glaber_female
ENSG00000102738	MRPS31	100	70.529	ENSHGLG00100014909	MRPS31	89	70.529	Heterocephalus_glaber_male
ENSG00000102738	MRPS31	76	43.730	ENSHCOG00000004654	mrps31	90	43.730	Hippocampus_comes
ENSG00000102738	MRPS31	77	43.302	ENSIPUG00000021226	MRPS31	71	43.302	Ictalurus_punctatus
ENSG00000102738	MRPS31	100	63.544	ENSSTOG00000000986	MRPS31	100	63.544	Ictidomys_tridecemlineatus
ENSG00000102738	MRPS31	100	60.506	ENSJJAG00000016398	Mrps31	100	60.759	Jaculus_jaculus
ENSG00000102738	MRPS31	83	40.237	ENSKMAG00000008273	mrps31	89	40.237	Kryptolebias_marmoratus
ENSG00000102738	MRPS31	81	40.964	ENSLBEG00000025368	mrps31	81	41.566	Labrus_bergylta
ENSG00000102738	MRPS31	85	44.475	ENSLACG00000009463	MRPS31	97	44.475	Latimeria_chalumnae
ENSG00000102738	MRPS31	85	46.398	ENSLOCG00000008798	mrps31	97	46.398	Lepisosteus_oculatus
ENSG00000102738	MRPS31	100	73.165	ENSLAFG00000014360	MRPS31	100	73.165	Loxodonta_africana
ENSG00000102738	MRPS31	100	89.873	ENSMFAG00000003515	MRPS31	100	89.873	Macaca_fascicularis
ENSG00000102738	MRPS31	100	89.367	ENSMMUG00000001899	MRPS31	100	89.367	Macaca_mulatta
ENSG00000102738	MRPS31	100	86.869	ENSMNEG00000031161	MRPS31	100	86.869	Macaca_nemestrina
ENSG00000102738	MRPS31	100	87.406	ENSMLEG00000031037	MRPS31	100	87.406	Mandrillus_leucophaeus
ENSG00000102738	MRPS31	76	45.048	ENSMAMG00000015718	mrps31	76	45.048	Mastacembelus_armatus
ENSG00000102738	MRPS31	81	42.730	ENSMZEG00005016376	mrps31	77	43.068	Maylandia_zebra
ENSG00000102738	MRPS31	85	45.559	ENSMGAG00000015040	MRPS31	98	47.977	Meleagris_gallopavo
ENSG00000102738	MRPS31	99	57.614	ENSMAUG00000000659	Mrps31	99	57.614	Mesocricetus_auratus
ENSG00000102738	MRPS31	100	79.494	ENSMICG00000006449	MRPS31	100	79.494	Microcebus_murinus
ENSG00000102738	MRPS31	100	65.063	ENSMOCG00000004060	Mrps31	100	65.063	Microtus_ochrogaster
ENSG00000102738	MRPS31	76	46.835	ENSMMOG00000016475	mrps31	78	46.835	Mola_mola
ENSG00000102738	MRPS31	100	56.328	ENSMODG00000010347	MRPS31	100	56.328	Monodelphis_domestica
ENSG00000102738	MRPS31	76	45.631	ENSMALG00000017802	mrps31	76	45.631	Monopterus_albus
ENSG00000102738	MRPS31	99	64.975	ENSMUSG00000031533	Mrps31	99	64.975	Mus_musculus
ENSG00000102738	MRPS31	99	65.736	MGP_PahariEiJ_G0021364	Mrps31	99	65.736	Mus_pahari
ENSG00000102738	MRPS31	99	64.467	MGP_SPRETEiJ_G0032012	Mrps31	99	64.467	Mus_spretus
ENSG00000102738	MRPS31	100	78.338	ENSMLUG00000008416	MRPS31	100	78.338	Myotis_lucifugus
ENSG00000102738	MRPS31	99	71.320	ENSNGAG00000014071	Mrps31	99	71.320	Nannospalax_galili
ENSG00000102738	MRPS31	81	42.136	ENSNBRG00000020362	mrps31	90	41.840	Neolamprologus_brichardi
ENSG00000102738	MRPS31	100	75.063	ENSNLEG00000032608	-	100	74.307	Nomascus_leucogenys
ENSG00000102738	MRPS31	100	97.468	ENSNLEG00000001164	MRPS31	100	97.468	Nomascus_leucogenys
ENSG00000102738	MRPS31	100	70.633	ENSOPRG00000014606	MRPS31	100	70.633	Ochotona_princeps
ENSG00000102738	MRPS31	55	62.500	ENSODEG00000000752	-	99	62.500	Octodon_degus
ENSG00000102738	MRPS31	84	44.248	ENSONIG00000005438	mrps31	99	44.248	Oreochromis_niloticus
ENSG00000102738	MRPS31	87	58.989	ENSOANG00000015515	MRPS31	99	58.659	Ornithorhynchus_anatinus
ENSG00000102738	MRPS31	67	63.060	ENSOCUG00000021467	-	98	63.060	Oryctolagus_cuniculus
ENSG00000102738	MRPS31	77	46.875	ENSORLG00000007732	mrps31	85	46.875	Oryzias_latipes
ENSG00000102738	MRPS31	76	45.768	ENSORLG00020003824	mrps31	79	45.768	Oryzias_latipes_hni
ENSG00000102738	MRPS31	80	45.133	ENSORLG00015009102	mrps31	87	45.133	Oryzias_latipes_hsok
ENSG00000102738	MRPS31	75	43.175	ENSOMEG00000002621	mrps31	81	43.175	Oryzias_melastigma
ENSG00000102738	MRPS31	83	72.783	ENSOGAG00000026515	-	99	72.783	Otolemur_garnettii
ENSG00000102738	MRPS31	99	79.188	ENSOGAG00000024374	-	99	79.188	Otolemur_garnettii
ENSG00000102738	MRPS31	100	73.552	ENSOARG00000009534	MRPS31	100	73.552	Ovis_aries
ENSG00000102738	MRPS31	100	98.481	ENSPPAG00000031430	MRPS31	100	98.481	Pan_paniscus
ENSG00000102738	MRPS31	100	76.456	ENSPPRG00000023214	MRPS31	100	76.456	Panthera_pardus
ENSG00000102738	MRPS31	100	76.456	ENSPTIG00000011300	MRPS31	100	76.456	Panthera_tigris_altaica
ENSG00000102738	MRPS31	100	98.987	ENSPTRG00000005808	MRPS31	100	98.987	Pan_troglodytes
ENSG00000102738	MRPS31	100	90.633	ENSPANG00000012316	MRPS31	100	90.633	Papio_anubis
ENSG00000102738	MRPS31	85	42.033	ENSPKIG00000001361	mrps31	83	41.622	Paramormyrops_kingsleyae
ENSG00000102738	MRPS31	84	51.585	ENSPSIG00000004039	MRPS31	93	51.585	Pelodiscus_sinensis
ENSG00000102738	MRPS31	76	44.620	ENSPMGG00000003183	mrps31	77	44.620	Periophthalmus_magnuspinnatus
ENSG00000102738	MRPS31	99	65.063	ENSPEMG00000000766	Mrps31	99	65.063	Peromyscus_maniculatus_bairdii
ENSG00000102738	MRPS31	100	54.342	ENSPCIG00000023173	MRPS31	100	54.950	Phascolarctos_cinereus
ENSG00000102738	MRPS31	83	41.593	ENSPFOG00000008723	mrps31	78	41.246	Poecilia_formosa
ENSG00000102738	MRPS31	83	41.246	ENSPLAG00000015987	mrps31	78	41.246	Poecilia_latipinna
ENSG00000102738	MRPS31	83	42.478	ENSPMEG00000009296	mrps31	91	42.478	Poecilia_mexicana
ENSG00000102738	MRPS31	83	41.742	ENSPREG00000022750	mrps31	92	44.805	Poecilia_reticulata
ENSG00000102738	MRPS31	100	94.684	ENSPPYG00000005306	MRPS31	100	94.684	Pongo_abelii
ENSG00000102738	MRPS31	69	85.787	ENSPCOG00000020462	MRPS31	100	85.787	Propithecus_coquereli
ENSG00000102738	MRPS31	84	74.757	ENSPVAG00000012044	MRPS31	88	74.757	Pteropus_vampyrus
ENSG00000102738	MRPS31	72	50.167	ENSPNAG00000001402	mrps31	62	50.000	Pygocentrus_nattereri
ENSG00000102738	MRPS31	99	64.975	ENSRNOG00000011839	Mrps31	99	64.975	Rattus_norvegicus
ENSG00000102738	MRPS31	100	85.063	ENSRBIG00000034673	MRPS31	100	85.063	Rhinopithecus_bieti
ENSG00000102738	MRPS31	100	89.169	ENSRROG00000040313	MRPS31	100	89.169	Rhinopithecus_roxellana
ENSG00000102738	MRPS31	100	78.228	ENSSBOG00000034159	MRPS31	100	78.228	Saimiri_boliviensis_boliviensis
ENSG00000102738	MRPS31	100	55.257	ENSSHAG00000007140	-	99	59.375	Sarcophilus_harrisii
ENSG00000102738	MRPS31	79	43.038	ENSSFOG00015022620	mrps31	79	43.038	Scleropages_formosus
ENSG00000102738	MRPS31	82	39.077	ENSSMAG00000014484	mrps31	83	39.077	Scophthalmus_maximus
ENSG00000102738	MRPS31	81	44.214	ENSSDUG00000010247	mrps31	83	44.214	Seriola_dumerili
ENSG00000102738	MRPS31	81	44.179	ENSSLDG00000020714	mrps31	91	44.179	Seriola_lalandi_dorsalis
ENSG00000102738	MRPS31	87	69.298	ENSSARG00000004428	MRPS31	99	69.298	Sorex_araneus
ENSG00000102738	MRPS31	85	52.326	ENSSPUG00000015717	MRPS31	85	52.326	Sphenodon_punctatus
ENSG00000102738	MRPS31	81	42.899	ENSSPAG00000001984	mrps31	85	42.899	Stegastes_partitus
ENSG00000102738	MRPS31	100	74.242	ENSSSCG00000009372	MRPS31	100	74.242	Sus_scrofa
ENSG00000102738	MRPS31	84	41.908	ENSTRUG00000016490	mrps31	81	41.880	Takifugu_rubripes
ENSG00000102738	MRPS31	78	45.679	ENSTNIG00000011759	mrps31	99	45.679	Tetraodon_nigroviridis
ENSG00000102738	MRPS31	82	91.870	ENSTBEG00000012018	-	81	91.870	Tupaia_belangeri
ENSG00000102738	MRPS31	87	80.523	ENSTTRG00000012556	MRPS31	100	80.523	Tursiops_truncatus
ENSG00000102738	MRPS31	81	75.078	ENSUAMG00000021714	MRPS31	79	75.078	Ursus_americanus
ENSG00000102738	MRPS31	100	76.071	ENSUMAG00000019427	MRPS31	100	76.071	Ursus_maritimus
ENSG00000102738	MRPS31	100	80.253	ENSVPAG00000004619	MRPS31	100	80.253	Vicugna_pacos
ENSG00000102738	MRPS31	100	72.796	ENSVVUG00000026751	MRPS31	72	72.796	Vulpes_vulpes
ENSG00000102738	MRPS31	87	49.020	ENSXETG00000020699	mrps31	100	49.020	Xenopus_tropicalis
ENSG00000102738	MRPS31	83	41.543	ENSXCOG00000006828	mrps31	92	41.543	Xiphophorus_couchianus
ENSG00000102738	MRPS31	83	41.246	ENSXMAG00000012165	mrps31	87	41.246	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003735	structural constituent of ribosome	-	IEA	Function
GO:0005515	protein binding	21988832.	IPI	Function
GO:0005730	nucleolus	-	IDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005763	mitochondrial small ribosomal subunit	21873635.	IBA	Component
GO:0019904	protein domain specific binding	11984006.	IPI	Function
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process