EuRBPDB

Description

Ensembl ID: ENSG00000102753 (Gene tree)
Gene ID: 3839
Gene Symbol: KPNA3
Alias: SRP1gamma|SRP4|hSRP1|IPOA4
Full Name: karyopherin subunit alpha 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 93,615 bases
Position: chr13:49,699,307-49,792,921
Accession: 6396
RBP type: non-canonical RBP
Summary: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000436760	KPNA3-202	588	-	ENSP00000393869	91 (aa)	-	H0Y4S9
ENST00000261667	KPNA3-201	4474	XM_017020561	ENSP00000261667	521 (aa)	XP_016876050	O00505

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000102753	C-Reactive Protein	1.41165567021928E-6	17903293
ENSG00000102753	Dermatitis, Atopic	9E-6	25574825
ENSG00000102753	Psoriasis	9E-6	25574825
ENSG00000102753	Body Composition	8E-6	23251661
ENSG00000102753	Menopause	9E-8	22267201

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000102753	rs9535307	13	49717706	A	Obesity-related traits	23251661	[NR] kg/y increase	0.03	EFO_0005106
ENSG00000102753	rs3736830	13	49732085	G	Menopause (age at onset)	22267201	[0.11-0.25] years decrease	0.18	EFO_0004704
ENSG00000102753	rs3736830	13	49732085	?	Inflammatory skin disease	25574825			EFO_0000274\|EFO_0000676
ENSG00000102753	rs56255891	13	49764020	?	General cognitive ability	29844566	z-score increase	4.53	EFO_0004337
ENSG00000102753	rs9535333	13	49766727	?	Lung function (FEV1/FVC)	30595370			EFO_0004713

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000102753	KPNA3	96	62.089	WBGene00002074	ima-3	99	62.089	Caenorhabditis_elegans
ENSG00000102753	KPNA3	99	67.892	FBgn0027338	Kap-alpha3	99	67.954	Drosophila_melanogaster
ENSG00000102753	KPNA3	99	43.478	FBgn0267727	Pen	96	46.535	Drosophila_melanogaster
ENSG00000102753	KPNA3	95	48.337	ENSG00000025800	KPNA6	95	48.337	Homo_sapiens
ENSG00000102753	KPNA3	95	48.350	ENSG00000114030	KPNA1	99	48.308	Homo_sapiens
ENSG00000102753	KPNA3	98	46.893	YNL189W	SRP1	97	46.893	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	10523667.15057270.16189514.19412186.19447967.21516116.21988832.25416956.25910212.26382858.26496610.	IPI	Function
GO:0005643	nuclear pore	9154134.	TAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006607	NLS-bearing protein import into nucleus	9435235.	TAS	Process
GO:0008022	protein C-terminus binding	-	IEA	Function
GO:0008139	nuclear localization sequence binding	9435235.	TAS	Function
GO:0008565	protein transporter activity	-	IEA	Function
GO:0019054	modulation by virus of host process	-	TAS	Process
GO:0043657	host cell	-	IEA	Component
GO:0046718	viral entry into host cell	-	IEA	Process
GO:0061608	nuclear import signal receptor activity	-	IEA	Function
GO:0065003	protein-containing complex assembly	9435235.	TAS	Process
GO:0075732	viral penetration into host nucleus	-	IEA	Process