EuRBPDB

Description

Ensembl ID: ENSG00000102900 (Gene tree)
Gene ID: 9688
Gene Symbol: NUP93
Alias: KIAA0095
Full Name: nucleoporin 93
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 120,182 bases
Position: chr16:56,730,105-56,850,286
Accession: 28958
RBP type: non-canonical RBP
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30087672	Host Factor Nucleoporin 93 Is Involved in the Nuclear Export of Influenza Virus RNA.	Front Microbiol	2018 Jul 24	Furusawa Y	doi: 10.3389/fmicb.2018.01675

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000566315	NUP93-211	589	-	ENSP00000456264	151 (aa)	-	H3BRI8
ENST00000569842	NUP93-220	2834	-	ENSP00000458101	880 (aa)	-	H3BVG0
ENST00000569863	NUP93-221	630	-	ENSP00000454587	125 (aa)	-	H3BMX0
ENST00000566678	NUP93-212	442	-	ENSP00000454935	132 (aa)	-	H3BNN5
ENST00000563465	NUP93-206	458	-	-	- (aa)	-	-
ENST00000564278	NUP93-209	588	-	-	- (aa)	-	-
ENST00000564887	NUP93-210	2875	-	ENSP00000458039	696 (aa)	-	Q8N1F7
ENST00000308159	NUP93-201	2741	XM_005256263	ENSP00000310668	819 (aa)	XP_005256320	Q8N1F7
ENST00000569322	NUP93-218	410	-	ENSP00000457907	84 (aa)	-	H3BV15
ENST00000568656	NUP93-217	592	-	ENSP00000454285	178 (aa)	-	H3BM93
ENST00000563437	NUP93-205	762	-	-	- (aa)	-	-
ENST00000563858	NUP93-208	797	-	ENSP00000455230	229 (aa)	-	H3BPA9
ENST00000567081	NUP93-214	315	-	ENSP00000455181	16 (aa)	-	H3BP72
ENST00000563486	NUP93-207	635	-	ENSP00000456196	140 (aa)	-	H3BRD9
ENST00000567641	NUP93-215	604	-	ENSP00000455210	156 (aa)	-	H3BP95
ENST00000562496	NUP93-203	583	-	ENSP00000457902	136 (aa)	-	H3BV11
ENST00000566727	NUP93-213	563	-	-	- (aa)	-	-
ENST00000568283	NUP93-216	584	-	ENSP00000454844	40 (aa)	-	H3BNG7
ENST00000563405	NUP93-204	477	-	ENSP00000458078	117 (aa)	-	H3BVE2
ENST00000569595	NUP93-219	590	-	-	- (aa)	-	-
ENST00000542526	NUP93-202	8257	-	ENSP00000440235	696 (aa)	-	Q8N1F7

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000102900	Body Mass Index	4.50357007770509E-5	17903300
ENSG00000102900	Body Weight	7.49497633821469E-5	17903300
ENSG00000102900	Body Mass Index	1.39911514573609E-5	17903300
ENSG00000102900	Body Weight	6.17556487216985E-5	17903300
ENSG00000102900	Body Weight	1.09252979116435E-5	17903300
ENSG00000102900	Body Weight	5.05650024283257E-5	17903300
ENSG00000102900	Body Weight	1.794793731184E-5	17903300
ENSG00000102900	Body Weight	3.21046024019152E-5	17903300
ENSG00000102900	Body Weight	9.42253851003642E-5	17903300
ENSG00000102900	Cholesterol, HDL	9.1020000E-005	-
ENSG00000102900	Platelet Function Tests	9.5700000E-009	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000102900	rs118070237	16	56795510	?	Potassium levels	29403010	[0.061-0.114] unit decrease novel	0.0877	EFO_0009283
ENSG00000102900	rs77780456	16	56815202	?	High density lipoprotein cholesterol levels	29403010	[0.14-0.2] unit increase novel	0.17	EFO_0004612
ENSG00000102900	rs79600951	16	56800342	G	HDL cholesterol	28270201	[0.1-0.18] mg/dl decrease	0.14015938	EFO_0004612
ENSG00000102900	rs6499854	16	56846930	?	Age at loss of ambulation in Duchenne muscular dystrophy	30014611			Orphanet_98896\|EFO_0008336
ENSG00000102900	rs10852553	16	56791754	G	High density lipoprotein cholesterol levels	29507422	unit decrease	0.056	EFO_0004612
ENSG00000102900	rs10852553	16	56791754	G	High density lipoprotein cholesterol levels	29507422	unit decrease	0.048	EFO_0004612
ENSG00000102900	rs16962399	16	56812892	C	High density lipoprotein cholesterol levels	29507422	unit increase	0.077	EFO_0004612
ENSG00000102900	rs16962399	16	56812892	C	High density lipoprotein cholesterol levels	29507422	unit increase	0.067	EFO_0004612

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000102900	NUP93	94	42.254	FBgn0038274	Nup93-2	99	36.242	Drosophila_melanogaster
ENSG00000102900	NUP93	100	100.000	ENSMUSG00000032939	Nup93	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	26878725.	IPI	Function
GO:0005635	nuclear envelope	26878725.	IDA	Component
GO:0005635	nuclear envelope	-	TAS	Component
GO:0005643	nuclear pore	21873635.	IBA	Component
GO:0005643	nuclear pore	12802065.15229283.	IDA	Component
GO:0006110	regulation of glycolytic process	-	TAS	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0006409	tRNA export from nucleus	-	TAS	Process
GO:0006606	protein import into nucleus	21873635.	IBA	Process
GO:0006998	nuclear envelope organization	26878725.	IDA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	TAS	Process
GO:0016925	protein sumoylation	-	TAS	Process
GO:0016973	poly(A)+ mRNA export from nucleus	21873635.	IBA	Process
GO:0017056	structural constituent of nuclear pore	21873635.	IBA	Function
GO:0017056	structural constituent of nuclear pore	15229283.	IMP	Function
GO:0019083	viral transcription	-	TAS	Process
GO:0031965	nuclear membrane	15229283.	IDA	Component
GO:0034399	nuclear periphery	15229283.	IDA	Component
GO:0043657	host cell	-	IEA	Component
GO:0051292	nuclear pore complex assembly	26878725.	IDA	Process
GO:0051292	nuclear pore complex assembly	15229283.	IMP	Process
GO:0060391	positive regulation of SMAD protein signal transduction	26878725.	IDA	Process
GO:0060395	SMAD protein signal transduction	26878725.	IDA	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process
GO:0072001	renal system development	-	ISS	Process
GO:0075733	intracellular transport of virus	-	TAS	Process
GO:1900034	regulation of cellular response to heat	-	TAS	Process