EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000102921 (Gene tree)
Gene ID: 9683
Gene Symbol: N4BP1
Alias: N
Full Name: NEDD4 binding protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 81,423 bases
Position: chr16:48,538,726-48,620,148
Accession: 29850
RBP type: canonical RBP
Summary: (NEDD4 Binding Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is NYNRIN.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000262384	RNase_Zc3h12a	PF11977.8	6.9e-54	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31133753	N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation.	Nat Microbiol	2019 May 27	Yamasoba D	doi: 10.1038/s41564-019-0460-3

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000569027	N4BP1-206	536	-	-	- (aa)	-	-
ENST00000564710	N4BP1-203	540	-	ENSP00000460667	142 (aa)	-	I3L3R7
ENST00000262384	N4BP1-201	7106	XM_011523482	ENSP00000262384	896 (aa)	XP_011521784	O75113
ENST00000565638	N4BP1-205	296	-	-	- (aa)	-	-
ENST00000565423	N4BP1-204	549	-	-	- (aa)	-	-
ENST00000564124	N4BP1-202	2485	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000102921's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000102921	Arthritis, Rheumatoid	6E-7	22491018
ENSG00000102921	Drug Resistance	6E-7	22491018

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000102921	rs6500395	16	48587491	?	Response to tocilizumab in rheumatoid arthritis	22491018	[NR] unit increase	2.2	EFO_0000685\|GO_0042493
ENSG00000102921	rs569868609	16	48619072	C	Sum eosinophil basophil counts	27863252	[0.017-0.032] unit decrease	0.02426945	EFO_0005090\|EFO_0004842
ENSG00000102921	rs569868609	16	48619072	C	Eosinophil counts	27863252	[0.018-0.033] unit decrease	0.02517495	EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000102921's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000102921	N4BP1	74	36.111	ENSG00000100441	KHNYN	91	40.800

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000102921	N4BP1	79	52.795	ENSAPOG00000019418	n4bp1	82	52.923	Acanthochromis_polyacanthus
ENSG00000102921	N4BP1	100	93.662	ENSAMEG00000010288	N4BP1	100	89.593	Ailuropoda_melanoleuca
ENSG00000102921	N4BP1	79	52.351	ENSACIG00000016386	n4bp1	74	51.497	Amphilophus_citrinellus
ENSG00000102921	N4BP1	74	55.238	ENSAOCG00000016073	n4bp1	79	53.309	Amphiprion_ocellaris
ENSG00000102921	N4BP1	80	49.855	ENSAPEG00000022641	n4bp1	76	53.309	Amphiprion_percula
ENSG00000102921	N4BP1	99	36.858	ENSATEG00000013553	n4bp1	96	37.410	Anabas_testudineus
ENSG00000102921	N4BP1	99	62.411	ENSAPLG00000012344	N4BP1	100	53.899	Anas_platyrhynchos
ENSG00000102921	N4BP1	100	49.569	ENSACAG00000006034	N4BP1	99	49.244	Anolis_carolinensis
ENSG00000102921	N4BP1	100	97.183	ENSANAG00000023220	N4BP1	100	95.556	Aotus_nancymaae
ENSG00000102921	N4BP1	93	46.212	ENSACLG00000014886	n4bp1	77	53.870	Astatotilapia_calliptera
ENSG00000102921	N4BP1	89	51.562	ENSAMXG00000029866	n4bp1	95	39.126	Astyanax_mexicanus
ENSG00000102921	N4BP1	100	91.549	ENSBTAG00000019938	N4BP1	100	89.075	Bos_taurus
ENSG00000102921	N4BP1	100	97.887	ENSCJAG00000012640	N4BP1	100	95.759	Callithrix_jacchus
ENSG00000102921	N4BP1	100	93.662	ENSCAFG00000010010	N4BP1	100	89.396	Canis_familiaris
ENSG00000102921	N4BP1	100	93.662	ENSCAFG00020000467	N4BP1	96	89.115	Canis_lupus_dingo
ENSG00000102921	N4BP1	100	90.845	ENSCHIG00000019641	N4BP1	100	88.629	Capra_hircus
ENSG00000102921	N4BP1	100	92.958	ENSTSYG00000025531	N4BP1	93	89.892	Carlito_syrichta
ENSG00000102921	N4BP1	92	75.061	ENSCAPG00000008630	N4BP1	100	75.303	Cavia_aperea
ENSG00000102921	N4BP1	100	83.803	ENSCPOG00000022635	N4BP1	100	80.379	Cavia_porcellus
ENSG00000102921	N4BP1	100	97.887	ENSCCAG00000013512	N4BP1	100	96.205	Cebus_capucinus
ENSG00000102921	N4BP1	100	98.592	ENSCATG00000036429	N4BP1	100	97.991	Cercocebus_atys
ENSG00000102921	N4BP1	100	88.732	ENSCLAG00000006600	N4BP1	100	84.356	Chinchilla_lanigera
ENSG00000102921	N4BP1	100	98.592	ENSCSAG00000005417	N4BP1	100	98.025	Chlorocebus_sabaeus
ENSG00000102921	N4BP1	100	93.662	ENSCHOG00000010107	N4BP1	86	82.725	Choloepus_hoffmanni
ENSG00000102921	N4BP1	98	63.830	ENSCPBG00000016004	N4BP1	99	54.526	Chrysemys_picta_bellii
ENSG00000102921	N4BP1	100	97.183	ENSCANG00000026516	N4BP1	100	97.711	Colobus_angolensis_palliatus
ENSG00000102921	N4BP1	100	86.620	ENSCGRG00001014095	N4bp1	100	82.851	Cricetulus_griseus_chok1gshd
ENSG00000102921	N4BP1	100	86.620	ENSCGRG00000001035	N4bp1	100	82.332	Cricetulus_griseus_crigri
ENSG00000102921	N4BP1	81	54.693	ENSCSEG00000021560	n4bp1	97	55.128	Cynoglossus_semilaevis
ENSG00000102921	N4BP1	78	52.288	ENSCVAG00000013900	n4bp1	80	53.074	Cyprinodon_variegatus
ENSG00000102921	N4BP1	99	38.847	ENSDARG00000057491	n4bp1	95	38.486	Danio_rerio
ENSG00000102921	N4BP1	100	87.014	ENSDNOG00000043012	N4BP1	100	87.014	Dasypus_novemcinctus
ENSG00000102921	N4BP1	100	87.324	ENSDORG00000002154	N4bp1	99	84.096	Dipodomys_ordii
ENSG00000102921	N4BP1	100	88.028	ENSETEG00000013845	N4BP1	94	80.720	Echinops_telfairi
ENSG00000102921	N4BP1	76	38.739	ENSEBUG00000003301	-	63	37.815	Eptatretus_burgeri
ENSG00000102921	N4BP1	100	92.958	ENSEASG00005014535	N4BP1	100	88.286	Equus_asinus_asinus
ENSG00000102921	N4BP1	100	92.254	ENSECAG00000024238	N4BP1	100	87.960	Equus_caballus
ENSG00000102921	N4BP1	74	91.803	ENSEEUG00000008071	N4BP1	70	92.424	Erinaceus_europaeus
ENSG00000102921	N4BP1	81	51.250	ENSELUG00000015239	n4bp1	95	38.654	Esox_lucius
ENSG00000102921	N4BP1	100	92.254	ENSFCAG00000025750	N4BP1	100	90.190	Felis_catus
ENSG00000102921	N4BP1	95	60.294	ENSFALG00000000101	N4BP1	98	52.406	Ficedula_albicollis
ENSG00000102921	N4BP1	100	87.324	ENSFDAG00000005284	N4BP1	99	84.958	Fukomys_damarensis
ENSG00000102921	N4BP1	69	52.744	ENSFHEG00000010345	n4bp1	88	52.870	Fundulus_heteroclitus
ENSG00000102921	N4BP1	99	39.633	ENSGMOG00000012940	n4bp1	91	53.247	Gadus_morhua
ENSG00000102921	N4BP1	100	53.312	ENSGALG00000003907	N4BP1	100	53.571	Gallus_gallus
ENSG00000102921	N4BP1	80	51.524	ENSGAFG00000015065	n4bp1	80	51.360	Gambusia_affinis
ENSG00000102921	N4BP1	82	48.485	ENSGACG00000002633	n4bp1	74	50.909	Gasterosteus_aculeatus
ENSG00000102921	N4BP1	96	65.468	ENSGAGG00000011327	N4BP1	100	53.837	Gopherus_agassizii
ENSG00000102921	N4BP1	100	99.442	ENSGGOG00000015565	N4BP1	100	99.442	Gorilla_gorilla
ENSG00000102921	N4BP1	79	52.174	ENSHBUG00000004798	n4bp1	96	38.147	Haplochromis_burtoni
ENSG00000102921	N4BP1	100	87.324	ENSHGLG00000019576	N4BP1	100	84.950	Heterocephalus_glaber_female
ENSG00000102921	N4BP1	100	87.324	ENSHGLG00100011563	N4BP1	100	83.501	Heterocephalus_glaber_male
ENSG00000102921	N4BP1	99	36.290	ENSHCOG00000011807	n4bp1	96	37.193	Hippocampus_comes
ENSG00000102921	N4BP1	99	39.173	ENSIPUG00000020354	n4bp1	76	54.777	Ictalurus_punctatus
ENSG00000102921	N4BP1	100	93.662	ENSSTOG00000006205	N4BP1	100	89.639	Ictidomys_tridecemlineatus
ENSG00000102921	N4BP1	100	85.915	ENSJJAG00000017340	N4bp1	100	83.147	Jaculus_jaculus
ENSG00000102921	N4BP1	74	55.238	ENSKMAG00000019562	n4bp1	84	45.283	Kryptolebias_marmoratus
ENSG00000102921	N4BP1	79	50.298	ENSLBEG00000018074	n4bp1	96	37.539	Labrus_bergylta
ENSG00000102921	N4BP1	97	55.797	ENSLACG00000014946	N4BP1	100	46.288	Latimeria_chalumnae
ENSG00000102921	N4BP1	74	61.905	ENSLOCG00000007525	n4bp1	61	75.000	Lepisosteus_oculatus
ENSG00000102921	N4BP1	100	91.549	ENSLAFG00000017688	N4BP1	100	83.852	Loxodonta_africana
ENSG00000102921	N4BP1	100	98.592	ENSMFAG00000025909	N4BP1	100	98.214	Macaca_fascicularis
ENSG00000102921	N4BP1	100	98.592	ENSMMUG00000018978	N4BP1	100	98.103	Macaca_mulatta
ENSG00000102921	N4BP1	100	98.592	ENSMNEG00000035504	N4BP1	100	98.326	Macaca_nemestrina
ENSG00000102921	N4BP1	100	98.592	ENSMLEG00000030992	N4BP1	100	97.831	Mandrillus_leucophaeus
ENSG00000102921	N4BP1	74	55.238	ENSMAMG00000016743	n4bp1	72	49.560	Mastacembelus_armatus
ENSG00000102921	N4BP1	93	46.212	ENSMZEG00005016117	n4bp1	77	53.870	Maylandia_zebra
ENSG00000102921	N4BP1	75	72.897	ENSMGAG00000005064	N4BP1	100	53.287	Meleagris_gallopavo
ENSG00000102921	N4BP1	100	87.324	ENSMAUG00000019066	N4bp1	98	81.280	Mesocricetus_auratus
ENSG00000102921	N4BP1	100	92.254	ENSMICG00000035077	N4BP1	100	90.848	Microcebus_murinus
ENSG00000102921	N4BP1	100	83.803	ENSMOCG00000016652	N4bp1	100	80.379	Microtus_ochrogaster
ENSG00000102921	N4BP1	83	48.907	ENSMMOG00000002611	n4bp1	71	55.844	Mola_mola
ENSG00000102921	N4BP1	100	72.028	ENSMODG00000012970	-	97	66.144	Monodelphis_domestica
ENSG00000102921	N4BP1	79	51.515	ENSMALG00000008228	n4bp1	84	51.652	Monopterus_albus
ENSG00000102921	N4BP1	100	81.362	MGP_CAROLIEiJ_G0031349	N4bp1	100	81.362	Mus_caroli
ENSG00000102921	N4BP1	100	81.138	ENSMUSG00000031652	N4bp1	100	81.138	Mus_musculus
ENSG00000102921	N4BP1	100	82.394	MGP_PahariEiJ_G0022950	N4bp1	100	81.585	Mus_pahari
ENSG00000102921	N4BP1	100	81.362	MGP_SPRETEiJ_G0032467	N4bp1	100	81.362	Mus_spretus
ENSG00000102921	N4BP1	100	92.958	ENSMPUG00000003034	N4BP1	100	89.519	Mustela_putorius_furo
ENSG00000102921	N4BP1	100	87.413	ENSNGAG00000013195	N4bp1	100	83.166	Nannospalax_galili
ENSG00000102921	N4BP1	93	46.212	ENSNBRG00000019593	n4bp1	88	33.066	Neolamprologus_brichardi
ENSG00000102921	N4BP1	100	97.183	ENSNLEG00000000653	N4BP1	99	97.586	Nomascus_leucogenys
ENSG00000102921	N4BP1	61	71.831	ENSMEUG00000006533	-	93	71.831	Notamacropus_eugenii
ENSG00000102921	N4BP1	100	85.211	ENSODEG00000009642	N4BP1	100	82.386	Octodon_degus
ENSG00000102921	N4BP1	92	48.855	ENSONIG00000007367	n4bp1	99	39.934	Oreochromis_niloticus
ENSG00000102921	N4BP1	99	61.421	ENSOANG00000000582	N4BP1	97	61.379	Ornithorhynchus_anatinus
ENSG00000102921	N4BP1	100	90.141	ENSOCUG00000012740	N4BP1	100	87.654	Oryctolagus_cuniculus
ENSG00000102921	N4BP1	99	36.972	ENSORLG00000027201	n4bp1	96	37.539	Oryzias_latipes
ENSG00000102921	N4BP1	99	36.925	ENSORLG00020017177	n4bp1	96	37.829	Oryzias_latipes_hni
ENSG00000102921	N4BP1	99	36.188	ENSORLG00015007443	n4bp1	96	37.422	Oryzias_latipes_hsok
ENSG00000102921	N4BP1	77	55.963	ENSOMEG00000014670	n4bp1	65	62.626	Oryzias_melastigma
ENSG00000102921	N4BP1	100	93.662	ENSOGAG00000012341	N4BP1	100	84.222	Otolemur_garnettii
ENSG00000102921	N4BP1	100	90.845	ENSOARG00000016957	N4BP1	100	87.709	Ovis_aries
ENSG00000102921	N4BP1	100	99.442	ENSPPAG00000034858	N4BP1	100	99.442	Pan_paniscus
ENSG00000102921	N4BP1	100	92.254	ENSPPRG00000014683	N4BP1	100	90.301	Panthera_pardus
ENSG00000102921	N4BP1	100	92.254	ENSPTIG00000013078	N4BP1	93	89.976	Panthera_tigris_altaica
ENSG00000102921	N4BP1	100	100.000	ENSPTRG00000008096	N4BP1	100	99.554	Pan_troglodytes
ENSG00000102921	N4BP1	100	98.592	ENSPANG00000007118	N4BP1	100	98.103	Papio_anubis
ENSG00000102921	N4BP1	100	61.806	ENSPSIG00000011341	N4BP1	100	52.431	Pelodiscus_sinensis
ENSG00000102921	N4BP1	77	54.902	ENSPMGG00000002201	n4bp1	72	54.902	Periophthalmus_magnuspinnatus
ENSG00000102921	N4BP1	100	85.915	ENSPEMG00000016429	N4bp1	100	83.012	Peromyscus_maniculatus_bairdii
ENSG00000102921	N4BP1	100	69.930	ENSPCIG00000021093	N4BP1	100	67.231	Phascolarctos_cinereus
ENSG00000102921	N4BP1	79	52.063	ENSPFOG00000003008	n4bp1	77	51.057	Poecilia_formosa
ENSG00000102921	N4BP1	79	52.063	ENSPLAG00000000581	n4bp1	77	51.057	Poecilia_latipinna
ENSG00000102921	N4BP1	74	56.190	ENSPMEG00000015027	n4bp1	71	51.057	Poecilia_mexicana
ENSG00000102921	N4BP1	79	51.829	ENSPREG00000018960	n4bp1	81	51.964	Poecilia_reticulata
ENSG00000102921	N4BP1	100	99.296	ENSPPYG00000007330	N4BP1	100	98.993	Pongo_abelii
ENSG00000102921	N4BP1	99	79.286	ENSPCAG00000003813	N4BP1	95	67.655	Procavia_capensis
ENSG00000102921	N4BP1	100	93.662	ENSPCOG00000026157	N4BP1	100	90.290	Propithecus_coquereli
ENSG00000102921	N4BP1	100	90.141	ENSPVAG00000003838	N4BP1	87	86.115	Pteropus_vampyrus
ENSG00000102921	N4BP1	73	55.340	ENSPNYG00000023298	n4bp1	96	37.727	Pundamilia_nyererei
ENSG00000102921	N4BP1	92	48.855	ENSPNAG00000015520	n4bp1	96	40.087	Pygocentrus_nattereri
ENSG00000102921	N4BP1	100	83.099	ENSRNOG00000015121	N4bp1	100	80.271	Rattus_norvegicus
ENSG00000102921	N4BP1	100	97.545	ENSRBIG00000035001	N4BP1	100	97.545	Rhinopithecus_bieti
ENSG00000102921	N4BP1	100	96.990	ENSRROG00000037371	N4BP1	100	97.531	Rhinopithecus_roxellana
ENSG00000102921	N4BP1	100	97.887	ENSSBOG00000019911	N4BP1	100	94.938	Saimiri_boliviensis_boliviensis
ENSG00000102921	N4BP1	100	69.930	ENSSHAG00000016460	N4BP1	99	68.724	Sarcophilus_harrisii
ENSG00000102921	N4BP1	74	54.286	ENSSMAG00000014235	n4bp1	69	52.469	Scophthalmus_maximus
ENSG00000102921	N4BP1	99	35.474	ENSSDUG00000021382	n4bp1	96	35.900	Seriola_dumerili
ENSG00000102921	N4BP1	92	47.328	ENSSLDG00000004993	n4bp1	96	38.453	Seriola_lalandi_dorsalis
ENSG00000102921	N4BP1	100	88.028	ENSSARG00000009865	N4BP1	100	86.988	Sorex_araneus
ENSG00000102921	N4BP1	87	67.742	ENSSPUG00000003001	N4BP1	98	53.105	Sphenodon_punctatus
ENSG00000102921	N4BP1	80	53.097	ENSSPAG00000009205	n4bp1	83	52.096	Stegastes_partitus
ENSG00000102921	N4BP1	100	90.141	ENSSSCG00000002841	N4BP1	100	89.632	Sus_scrofa
ENSG00000102921	N4BP1	95	59.559	ENSTGUG00000008647	N4BP1	99	52.909	Taeniopygia_guttata
ENSG00000102921	N4BP1	74	52.381	ENSTRUG00000003167	n4bp1	89	39.161	Takifugu_rubripes
ENSG00000102921	N4BP1	92	45.113	ENSTRUG00000000224	-	98	33.663	Takifugu_rubripes
ENSG00000102921	N4BP1	60	40.253	ENSTNIG00000002366	n4bp1	57	53.481	Tetraodon_nigroviridis
ENSG00000102921	N4BP1	100	92.254	ENSTBEG00000003709	N4BP1	95	82.478	Tupaia_belangeri
ENSG00000102921	N4BP1	100	93.662	ENSTTRG00000016111	N4BP1	100	87.244	Tursiops_truncatus
ENSG00000102921	N4BP1	100	92.958	ENSUAMG00000027463	N4BP1	96	89.755	Ursus_americanus
ENSG00000102921	N4BP1	100	92.254	ENSUMAG00000006688	N4BP1	100	89.642	Ursus_maritimus
ENSG00000102921	N4BP1	100	95.070	ENSVPAG00000000597	N4BP1	100	89.747	Vicugna_pacos
ENSG00000102921	N4BP1	100	93.662	ENSVVUG00000018051	N4BP1	89	89.967	Vulpes_vulpes
ENSG00000102921	N4BP1	85	60.177	ENSXETG00000025007	n4bp1	86	62.733	Xenopus_tropicalis
ENSG00000102921	N4BP1	74	57.143	ENSXCOG00000013559	n4bp1	80	50.311	Xiphophorus_couchianus
ENSG00000102921	N4BP1	79	51.863	ENSXMAG00000006141	n4bp1	71	52.000	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	17592138.21903422.	IPI	Function
GO:0005730	nucleolus	-	ISS	Component
GO:0016605	PML body	-	ISS	Component
GO:0031397	negative regulation of protein ubiquitination	-	ISS	Process
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	-	ISS	Process
GO:0034644	cellular response to UV	17592138.	IMP	Process