EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000103005 (Gene tree)
Gene ID: 79650
Gene Symbol: USB1
Alias: FLJ13154|HVSL1|Mpn1|C16orf57
Full Name: U6 snRNA biogenesis phosphodiesterase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 22,078 bases
Position: chr16:57,999,546-58,021,623
Accession: 25792
RBP type: canonical RBP
Summary: This gene encodes a protein with several conserved domains, however, its exact function is not known. Mutations in this gene are associated with poikiloderma with neutropenia (PN), which shows phenotypic overlap with Rothmund-Thomson syndrome (RTS) caused by mutations in the RECQL4 gene. It is believed that this gene product interacts with RECQL4 protein via SMAD4 proteins, explaining the partial clinical overlap between PN and RTS. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000219281	HVSL	PF09749.9	1.6e-62	1	1
ENSP00000454928	HVSL	PF09749.9	3.8e-60	1	1
ENSP00000446143	HVSL	PF09749.9	8.6e-51	1	2
ENSP00000446143	HVSL	PF09749.9	8.6e-51	2	2
ENSP00000457322	HVSL	PF09749.9	2.4e-42	1	1
ENSP00000454692	HVSL	PF09749.9	5.7e-28	1	1
ENSP00000409792	HVSL	PF09749.9	9.5e-28	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28887445	Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities.	Nat Commun	2017 Sep 8	Didychuk AL	doi: 10.1038/s41467-017-00484-w.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000569252	USB1-215	573	-	-	- (aa)	-	-
ENST00000219281	USB1-201	2282	-	ENSP00000219281	265 (aa)	-	Q9BQ65
ENST00000565151	USB1-210	886	-	-	- (aa)	-	-
ENST00000563149	USB1-207	1751	-	ENSP00000454692	163 (aa)	-	H3BN52
ENST00000624720	USB1-216	2895	-	-	- (aa)	-	-
ENST00000568848	USB1-214	548	-	-	- (aa)	-	-
ENST00000564387	USB1-209	558	-	ENSP00000457302	95 (aa)	-	H3BTS1
ENST00000562534	USB1-206	562	-	-	- (aa)	-	-
ENST00000561743	USB1-205	1135	-	ENSP00000454928	214 (aa)	-	H3BNM8
ENST00000561568	USB1-204	671	-	ENSP00000457322	182 (aa)	-	H3BTT8
ENST00000565662	USB1-211	719	-	-	- (aa)	-	-
ENST00000566082	USB1-212	3888	-	-	- (aa)	-	-
ENST00000566292	USB1-213	575	-	-	- (aa)	-	-
ENST00000539737	USB1-203	1212	-	ENSP00000446143	247 (aa)	-	Q9BQ65
ENST00000423271	USB1-202	1217	-	ENSP00000409792	186 (aa)	-	Q9BQ65
ENST00000563207	USB1-208	464	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000103005's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000103005's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000103005	USB1	100	53.271	ENSAPOG00000011942	usb1	83	51.073	Acanthochromis_polyacanthus
ENSG00000103005	USB1	100	86.449	ENSAMEG00000017205	USB1	100	81.784	Ailuropoda_melanoleuca
ENSG00000103005	USB1	100	54.206	ENSACIG00000012234	usb1	82	53.125	Amphilophus_citrinellus
ENSG00000103005	USB1	100	54.206	ENSAOCG00000014831	usb1	80	53.304	Amphiprion_ocellaris
ENSG00000103005	USB1	100	54.673	ENSAPEG00000000296	usb1	80	53.744	Amphiprion_percula
ENSG00000103005	USB1	100	53.738	ENSATEG00000009348	usb1	82	51.948	Anabas_testudineus
ENSG00000103005	USB1	95	71.569	ENSAPLG00000002756	USB1	100	69.469	Anas_platyrhynchos
ENSG00000103005	USB1	98	65.550	ENSACAG00000015481	USB1	100	64.192	Anolis_carolinensis
ENSG00000103005	USB1	100	95.094	ENSANAG00000035640	USB1	100	95.094	Aotus_nancymaae
ENSG00000103005	USB1	100	54.206	ENSACLG00000020586	usb1	80	53.540	Astatotilapia_calliptera
ENSG00000103005	USB1	99	51.643	ENSAMXG00000040146	usb1	74	51.121	Astyanax_mexicanus
ENSG00000103005	USB1	100	85.514	ENSBTAG00000015758	USB1	100	83.774	Bos_taurus
ENSG00000103005	USB1	100	95.849	ENSCJAG00000011733	USB1	100	95.849	Callithrix_jacchus
ENSG00000103005	USB1	99	86.854	ENSCAFG00000008556	USB1	73	79.412	Canis_familiaris
ENSG00000103005	USB1	99	86.854	ENSCAFG00020009263	USB1	99	78.755	Canis_lupus_dingo
ENSG00000103005	USB1	100	84.579	ENSCHIG00000024290	USB1	100	83.019	Capra_hircus
ENSG00000103005	USB1	100	91.589	ENSTSYG00000006997	USB1	100	89.811	Carlito_syrichta
ENSG00000103005	USB1	100	70.093	ENSCAPG00000009057	USB1	100	72.430	Cavia_aperea
ENSG00000103005	USB1	100	85.981	ENSCPOG00000014325	USB1	100	82.090	Cavia_porcellus
ENSG00000103005	USB1	100	96.262	ENSCCAG00000022132	USB1	100	96.226	Cebus_capucinus
ENSG00000103005	USB1	100	96.729	ENSCATG00000032174	USB1	100	95.849	Cercocebus_atys
ENSG00000103005	USB1	82	85.795	ENSCLAG00000007363	USB1	100	85.795	Chinchilla_lanigera
ENSG00000103005	USB1	100	96.729	ENSCSAG00000004783	USB1	100	96.604	Chlorocebus_sabaeus
ENSG00000103005	USB1	100	67.290	ENSCPBG00000026943	USB1	100	61.151	Chrysemys_picta_bellii
ENSG00000103005	USB1	98	30.531	ENSCING00000011490	-	82	30.531	Ciona_intestinalis
ENSG00000103005	USB1	93	30.918	ENSCSAVG00000000894	-	82	30.263	Ciona_savignyi
ENSG00000103005	USB1	100	97.196	ENSCANG00000037135	USB1	100	95.849	Colobus_angolensis_palliatus
ENSG00000103005	USB1	100	88.318	ENSCGRG00001011243	USB1	100	83.582	Cricetulus_griseus_chok1gshd
ENSG00000103005	USB1	100	88.318	ENSCGRG00000013252	USB1	100	83.582	Cricetulus_griseus_crigri
ENSG00000103005	USB1	100	51.869	ENSCSEG00000013881	usb1	84	49.785	Cynoglossus_semilaevis
ENSG00000103005	USB1	95	51.961	ENSCVAG00000009252	usb1	97	50.000	Cyprinodon_variegatus
ENSG00000103005	USB1	100	50.467	ENSDARG00000003841	usb1	81	50.446	Danio_rerio
ENSG00000103005	USB1	100	86.916	ENSDORG00000001888	Usb1	100	83.019	Dipodomys_ordii
ENSG00000103005	USB1	95	39.524	FBgn0037713	CG16790	78	39.524	Drosophila_melanogaster
ENSG00000103005	USB1	97	75.706	ENSETEG00000019682	USB1	100	70.412	Echinops_telfairi
ENSG00000103005	USB1	99	50.704	ENSEBUG00000005889	usb1	78	50.901	Eptatretus_burgeri
ENSG00000103005	USB1	100	88.318	ENSEASG00005005484	USB1	100	85.660	Equus_asinus_asinus
ENSG00000103005	USB1	100	88.785	ENSECAG00000019493	USB1	91	86.038	Equus_caballus
ENSG00000103005	USB1	82	76.705	ENSEEUG00000000154	USB1	100	59.245	Erinaceus_europaeus
ENSG00000103005	USB1	100	49.302	ENSELUG00000010974	usb1	88	47.755	Esox_lucius
ENSG00000103005	USB1	100	88.785	ENSFCAG00000002693	USB1	100	84.644	Felis_catus
ENSG00000103005	USB1	99	68.396	ENSFALG00000006876	USB1	99	61.624	Ficedula_albicollis
ENSG00000103005	USB1	100	87.850	ENSFDAG00000010052	USB1	100	84.270	Fukomys_damarensis
ENSG00000103005	USB1	86	51.266	ENSFHEG00000012334	usb1	78	52.551	Fundulus_heteroclitus
ENSG00000103005	USB1	100	51.869	ENSGMOG00000004228	usb1	99	51.570	Gadus_morhua
ENSG00000103005	USB1	95	69.608	ENSGALG00000035604	USB1	89	66.814	Gallus_gallus
ENSG00000103005	USB1	100	53.023	ENSGAFG00000021890	usb1	87	50.206	Gambusia_affinis
ENSG00000103005	USB1	100	52.804	ENSGACG00000003257	usb1	81	51.770	Gasterosteus_aculeatus
ENSG00000103005	USB1	100	65.888	ENSGAGG00000022572	USB1	100	61.538	Gopherus_agassizii
ENSG00000103005	USB1	100	98.491	ENSGGOG00000017147	USB1	100	98.491	Gorilla_gorilla
ENSG00000103005	USB1	100	54.673	ENSHBUG00000009823	usb1	81	54.185	Haplochromis_burtoni
ENSG00000103005	USB1	100	87.383	ENSHGLG00000016078	USB1	98	85.019	Heterocephalus_glaber_female
ENSG00000103005	USB1	100	87.383	ENSHGLG00100005562	USB1	98	85.019	Heterocephalus_glaber_male
ENSG00000103005	USB1	99	55.399	ENSHCOG00000015633	usb1	86	54.709	Hippocampus_comes
ENSG00000103005	USB1	100	54.673	ENSIPUG00000008601	usb1	78	54.464	Ictalurus_punctatus
ENSG00000103005	USB1	100	87.850	ENSSTOG00000007548	USB1	100	83.516	Ictidomys_tridecemlineatus
ENSG00000103005	USB1	100	88.785	ENSJJAG00000021859	Usb1	100	85.019	Jaculus_jaculus
ENSG00000103005	USB1	100	53.271	ENSKMAG00000007200	usb1	80	52.423	Kryptolebias_marmoratus
ENSG00000103005	USB1	88	52.381	ENSLBEG00000008452	usb1	64	52.632	Labrus_bergylta
ENSG00000103005	USB1	86	59.893	ENSLACG00000000105	USB1	72	59.330	Latimeria_chalumnae
ENSG00000103005	USB1	100	55.607	ENSLOCG00000000465	usb1	85	54.357	Lepisosteus_oculatus
ENSG00000103005	USB1	100	66.822	ENSLAFG00000002267	USB1	100	65.556	Loxodonta_africana
ENSG00000103005	USB1	100	96.729	ENSMFAG00000003926	USB1	100	96.226	Macaca_fascicularis
ENSG00000103005	USB1	100	96.729	ENSMMUG00000022669	USB1	100	96.226	Macaca_mulatta
ENSG00000103005	USB1	100	96.262	ENSMNEG00000042487	USB1	100	95.849	Macaca_nemestrina
ENSG00000103005	USB1	100	96.729	ENSMLEG00000028756	USB1	100	96.226	Mandrillus_leucophaeus
ENSG00000103005	USB1	100	53.738	ENSMAMG00000015092	usb1	83	51.502	Mastacembelus_armatus
ENSG00000103005	USB1	100	54.206	ENSMZEG00005010008	usb1	80	53.540	Maylandia_zebra
ENSG00000103005	USB1	100	87.850	ENSMAUG00000007832	Usb1	100	84.270	Mesocricetus_auratus
ENSG00000103005	USB1	100	90.187	ENSMICG00000004900	USB1	100	89.811	Microcebus_murinus
ENSG00000103005	USB1	100	86.449	ENSMOCG00000022647	Usb1	100	83.146	Microtus_ochrogaster
ENSG00000103005	USB1	100	53.738	ENSMMOG00000000490	usb1	88	52.193	Mola_mola
ENSG00000103005	USB1	100	73.364	ENSMODG00000014067	USB1	100	66.791	Monodelphis_domestica
ENSG00000103005	USB1	100	52.804	ENSMALG00000005930	usb1	80	52.423	Monopterus_albus
ENSG00000103005	USB1	100	84.112	MGP_CAROLIEiJ_G0031421	Usb1	100	81.416	Mus_caroli
ENSG00000103005	USB1	100	84.579	ENSMUSG00000031792	Usb1	100	82.301	Mus_musculus
ENSG00000103005	USB1	100	84.579	MGP_PahariEiJ_G0023019	Usb1	100	82.906	Mus_pahari
ENSG00000103005	USB1	100	83.645	MGP_SPRETEiJ_G0032540	Usb1	100	79.775	Mus_spretus
ENSG00000103005	USB1	100	83.645	ENSMPUG00000004684	USB1	96	80.669	Mustela_putorius_furo
ENSG00000103005	USB1	100	87.383	ENSMLUG00000007400	USB1	100	87.013	Myotis_lucifugus
ENSG00000103005	USB1	100	89.252	ENSNGAG00000009703	Usb1	100	82.528	Nannospalax_galili
ENSG00000103005	USB1	100	52.804	ENSNBRG00000008747	usb1	99	53.465	Neolamprologus_brichardi
ENSG00000103005	USB1	100	97.312	ENSNLEG00000003340	USB1	100	98.000	Nomascus_leucogenys
ENSG00000103005	USB1	91	58.065	ENSMEUG00000003328	-	100	58.710	Notamacropus_eugenii
ENSG00000103005	USB1	70	87.879	ENSOPRG00000011803	USB1	72	87.879	Ochotona_princeps
ENSG00000103005	USB1	100	85.047	ENSODEG00000016214	USB1	100	81.273	Octodon_degus
ENSG00000103005	USB1	100	54.206	ENSONIG00000011063	usb1	81	53.744	Oreochromis_niloticus
ENSG00000103005	USB1	97	74.038	ENSOANG00000012118	USB1	94	73.778	Ornithorhynchus_anatinus
ENSG00000103005	USB1	100	51.869	ENSORLG00000012479	usb1	83	50.439	Oryzias_latipes
ENSG00000103005	USB1	100	52.804	ENSORLG00020018671	usb1	99	48.148	Oryzias_latipes_hni
ENSG00000103005	USB1	100	52.336	ENSORLG00015009679	usb1	84	50.877	Oryzias_latipes_hsok
ENSG00000103005	USB1	100	51.402	ENSOMEG00000012930	usb1	82	50.000	Oryzias_melastigma
ENSG00000103005	USB1	100	89.069	ENSOGAG00000003273	USB1	100	89.069	Otolemur_garnettii
ENSG00000103005	USB1	100	85.047	ENSOARG00000001107	USB1	93	83.128	Ovis_aries
ENSG00000103005	USB1	100	98.868	ENSPPAG00000042137	USB1	100	98.868	Pan_paniscus
ENSG00000103005	USB1	100	88.785	ENSPPRG00000024797	USB1	100	84.644	Panthera_pardus
ENSG00000103005	USB1	100	88.318	ENSPTIG00000007506	USB1	100	84.644	Panthera_tigris_altaica
ENSG00000103005	USB1	100	99.065	ENSPTRG00000008172	USB1	100	99.065	Pan_troglodytes
ENSG00000103005	USB1	100	96.729	ENSPANG00000025138	USB1	100	96.226	Papio_anubis
ENSG00000103005	USB1	99	55.399	ENSPKIG00000015109	usb1	76	55.111	Paramormyrops_kingsleyae
ENSG00000103005	USB1	100	51.389	ENSPSIG00000004305	USB1	100	53.097	Pelodiscus_sinensis
ENSG00000103005	USB1	99	51.174	ENSPMGG00000017725	usb1	85	52.018	Periophthalmus_magnuspinnatus
ENSG00000103005	USB1	100	86.449	ENSPEMG00000016183	Usb1	100	79.412	Peromyscus_maniculatus_bairdii
ENSG00000103005	USB1	100	50.463	ENSPMAG00000000462	usb1	100	49.367	Petromyzon_marinus
ENSG00000103005	USB1	98	53.110	ENSPFOG00000011130	usb1	82	51.754	Poecilia_formosa
ENSG00000103005	USB1	100	52.558	ENSPLAG00000009820	usb1	82	51.754	Poecilia_latipinna
ENSG00000103005	USB1	98	53.110	ENSPMEG00000006402	usb1	82	51.754	Poecilia_mexicana
ENSG00000103005	USB1	86	50.633	ENSPREG00000001047	usb1	79	53.061	Poecilia_reticulata
ENSG00000103005	USB1	95	94.048	ENSPPYG00000007401	USB1	100	94.048	Pongo_abelii
ENSG00000103005	USB1	100	91.589	ENSPCOG00000022612	USB1	100	90.566	Propithecus_coquereli
ENSG00000103005	USB1	100	83.178	ENSPVAG00000004613	USB1	100	79.623	Pteropus_vampyrus
ENSG00000103005	USB1	100	54.673	ENSPNYG00000022262	usb1	81	54.185	Pundamilia_nyererei
ENSG00000103005	USB1	100	50.935	ENSPNAG00000011736	usb1	76	51.339	Pygocentrus_nattereri
ENSG00000103005	USB1	100	85.047	ENSRNOG00000013216	Usb1	100	82.772	Rattus_norvegicus
ENSG00000103005	USB1	100	97.196	ENSRBIG00000044466	USB1	100	97.196	Rhinopithecus_bieti
ENSG00000103005	USB1	100	97.196	ENSRROG00000029211	USB1	100	96.604	Rhinopithecus_roxellana
ENSG00000103005	USB1	100	95.794	ENSSBOG00000029362	USB1	100	94.340	Saimiri_boliviensis_boliviensis
ENSG00000103005	USB1	100	72.897	ENSSHAG00000006993	USB1	94	71.308	Sarcophilus_harrisii
ENSG00000103005	USB1	99	56.808	ENSSFOG00015023663	usb1	75	55.042	Scleropages_formosus
ENSG00000103005	USB1	100	51.754	ENSSMAG00000015834	usb1	83	50.202	Scophthalmus_maximus
ENSG00000103005	USB1	100	55.140	ENSSDUG00000002949	usb1	83	54.464	Seriola_dumerili
ENSG00000103005	USB1	100	55.140	ENSSLDG00000014174	usb1	80	53.982	Seriola_lalandi_dorsalis
ENSG00000103005	USB1	100	68.692	ENSSPUG00000006741	USB1	100	68.692	Sphenodon_punctatus
ENSG00000103005	USB1	100	51.869	ENSSPAG00000007484	usb1	80	51.542	Stegastes_partitus
ENSG00000103005	USB1	100	87.850	ENSSSCG00000002807	USB1	100	81.413	Sus_scrofa
ENSG00000103005	USB1	99	69.340	ENSTGUG00000004792	USB1	87	68.018	Taeniopygia_guttata
ENSG00000103005	USB1	100	51.869	ENSTRUG00000021069	usb1	86	50.215	Takifugu_rubripes
ENSG00000103005	USB1	100	48.598	ENSTNIG00000000626	usb1	83	48.214	Tetraodon_nigroviridis
ENSG00000103005	USB1	100	59.813	ENSTBEG00000001507	USB1	100	61.638	Tupaia_belangeri
ENSG00000103005	USB1	100	85.981	ENSUAMG00000016823	USB1	100	82.528	Ursus_americanus
ENSG00000103005	USB1	100	85.981	ENSUMAG00000021369	USB1	100	85.981	Ursus_maritimus
ENSG00000103005	USB1	62	83.929	ENSVPAG00000009834	-	59	84.167	Vicugna_pacos
ENSG00000103005	USB1	99	87.324	ENSVVUG00000023700	USB1	93	84.232	Vulpes_vulpes
ENSG00000103005	USB1	95	57.635	ENSXETG00000013795	usb1	94	54.237	Xenopus_tropicalis
ENSG00000103005	USB1	100	53.023	ENSXMAG00000024687	usb1	67	52.193	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000175	3'-5'-exoribonuclease activity	21873635.	IBA	Function
GO:0000175	3'-5'-exoribonuclease activity	23190533.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	22899009.	IDA	Component
GO:0008380	RNA splicing	22899009.	IMP	Process
GO:0034477	U6 snRNA 3'-end processing	21873635.	IBA	Process
GO:0034477	U6 snRNA 3'-end processing	22899009.	IMP	Process
GO:0045171	intercellular bridge	-	IDA	Component
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	-	IEA	Process
GO:1990838	poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends	-	IEA	Function