EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000103152 (Gene tree)
Gene ID: 4350
Gene Symbol: MPG
Alias: MDG
Full Name: N-methylpurine DNA glycosylase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 8,847 bases
Position: chr16:77,007-85,853
Accession: 7211
RBP type: non-canonical RBP
Summary: (N-Methylpurine DNA Glycosylase) is a Protein Coding gene. Among its related pathways are Recognition and association of DNA glycosylase with site containing an affected purine and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include damaged DNA binding and DNA-3-methyladenine glycosylase activity.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
14702295	The trp RNA-binding attenuation protein of Bacillus subtilis regulates translation of the tryptophan transport gene trpP (yhaG) by blocking ribosome binding.	J Bacteriol	2004 Jan	Yakhnin H	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000219431	MPG-201	1193	XM_024450282	ENSP00000219431	298 (aa)	XP_024306050	P29372
ENST00000475280	MPG-205	510	-	-	- (aa)	-	-
ENST00000356432	MPG-202	1205	-	ENSP00000348809	293 (aa)	-	P29372
ENST00000397817	MPG-203	1039	-	ENSP00000380918	281 (aa)	-	P29372
ENST00000436333	MPG-204	884	-	ENSP00000388097	251 (aa)	-	A2IDA3

Gene Model

Click here to download ENSG00000103152's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03410	Base excision repair	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000103152's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000103152	MPG	98	74.564	ENSMUSG00000020287	Mpg	74	80.800	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003684	damaged DNA binding	10854423.	TAS	Function
GO:0003905	alkylbase DNA N-glycosylase activity	21873635.	IBA	Function
GO:0005515	protein binding	18482256.25416956.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006284	base-excision repair	21873635.	IBA	Process
GO:0006307	DNA dealkylation involved in DNA repair	1645538.	TAS	Process
GO:0008725	DNA-3-methyladenine glycosylase activity	-	IEA	Function
GO:0019104	DNA N-glycosylase activity	-	TAS	Function
GO:0042645	mitochondrial nucleoid	-	IEA	Component
GO:0043916	DNA-7-methylguanine glycosylase activity	-	IEA	Function
GO:0045007	depurination	-	TAS	Process
GO:0052821	DNA-7-methyladenine glycosylase activity	-	IEA	Function
GO:0052822	DNA-3-methylguanine glycosylase activity	-	IEA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
30241046	PIG11 over-expression predicts good prognosis and induces HepG2 cell apoptosis via reactive oxygen species-dependent mitochondrial pathway.	Biomed Pharmacother	2018 Dec	Wang Y	doi: 10.1016/j.biopha.2018.09.062
17029639	Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition.	BMC Cancer	2006 Oct 9	Broderick P	-
22266085	Elevated N3-methylpurine-DNA glycosylase DNA repair activity is associated with lung cancer.	Mutat Res	2012 Apr 1	Crosbie PA	doi: 10.1016/j.mrfmmm.2012.01.001
25355292	Enzymatic MPG DNA repair assays for two different oxidative DNA lesions reveal associations with increased lung cancer risk.	Carcinogenesis	2014 Dec	Leitner-Dagan Y	doi: 10.1093/carcin/bgu214
23537643	Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins.	Biochem Biophys Res Commun	2013 Apr 19	Liang C	doi: 10.1016/j.bbrc.2013.02.126

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr16	85485	Missense_Mutation	novel	K202R	0.07
BLCA	chr16	83070	Missense_Mutation	novel	P112S	0.1
BLCA	chr16	85662	Missense_Mutation	rs774213821	R261Q	0.36
BRCA	chr16	83088	Nonsense_Mutation	rs199655862	R118*	0.09
BRCA	chr16	83163	Frame_Shift_Ins	NA	*R145Pfs88**	0.35
BRCA	chr16	79525	Missense_Mutation	NA	S47T	0.24
BRCA	chr16	85463	Nonsense_Mutation	NA	Q195*	0.12
BRCA	chr16	83186	Silent	NA	F150F	0.33
BRCA	chr16	83094	Missense_Mutation	rs2308313	R120C	0.12
CESC	chr16	79584	Frame_Shift_Ins	novel	*T67Nfs42**	0.15
CESC	chr16	85757	Missense_Mutation	novel	E293K	0.57
COAD	chr16	85640	Missense_Mutation	novel	P254S	0.32
COAD	chr16	79225	5'UTR	novel		0.19
COAD	chr16	79300	Frame_Shift_Del	NA	*A5Lfs4**	0.15
COAD	chr16	85405	Silent	rs751887856	D175D	0.37
COAD	chr16	79563	Missense_Mutation	rs61753368	R60C	0.33
COAD	chr16	79684	Missense_Mutation	novel	R100Q	0.08
COAD	chr16	85616	Missense_Mutation	novel	R246C	0.14
COAD	chr16	85520	Missense_Mutation	NA	L214F	0.25
ESCA	chr16	85446	Missense_Mutation	novel	G189D	0.54
ESCA	chr16	85511	Missense_Mutation	novel	D211N	0.2
GBM	chr16	83089	Missense_Mutation	rs201536549	R118Q	0.26
GBM	chr16	85671	Missense_Mutation	novel	V264A	0.26
HNSC	chr16	79269	5'UTR	novel		0.36
KIRC	chr16	83208	Missense_Mutation	rs562548652	V158M	0.38
KIRP	chr16	85676	Missense_Mutation	novel	H266N	0.67
LGG	chr16	83123	Silent	novel	G129G	0.35
LGG	chr16	83124	Missense_Mutation	novel	P130S	0.4
LIHC	chr16	79607	Missense_Mutation	novel	I74M	0.28
OV	chr16	85511	Missense_Mutation	NA	D211Y	0.97
OV	chr16	85507	Silent	NA	L209L	0.77
OV	chr16	83077	Missense_Mutation	novel	G114D	0.69
READ	chr16	83134	Missense_Mutation	novel	E133A	0.21
READ	chr16	79253	5'UTR	rs368196338		0.38
SKCM	chr16	79528	Missense_Mutation	NA	S48L	0.3
SKCM	chr16	85717	Silent	novel	V279V	0.42
SKCM	chr16	85718	Missense_Mutation	rs566736218	R280W	0.41
STAD	chr16	85494	Missense_Mutation	NA	A205D	0.43
STAD	chr16	79487	Silent	rs754765496	S34S	0.27
STAD	chr16	83170	Missense_Mutation	rs764172082	R145H	0.31
STAD	chr16	85515	Missense_Mutation	rs142373562	R212H	0.14
STAD	chr16	79491	Missense_Mutation	rs373341989	D36N	0.17
STAD	chr16	79444	Frame_Shift_Del	novel	*K21Rfs87**	0.18
STAD	chr16	79445	Missense_Mutation	novel	Q20H	0.18
UCEC	chr16	79692	Silent	NA	L103L	0.27
UCEC	chr16	85455	Missense_Mutation	novel	T192I	0.13
UCEC	chr16	79268	5'UTR	novel		0.31
UCEC	chr16	79666	Missense_Mutation	rs772837868	P94L	0.5
UCEC	chr16	83194	Missense_Mutation	novel	P153Q	0.22
UCEC	chr16	79305	Missense_Mutation	rs112187829	A5T	0.53
UCEC	chr16	79533	Missense_Mutation	rs112910924	D50N	0.38
UCEC	chr16	79306	Missense_Mutation	novel	A5D	0.51
UCEC	chr16	83089	Missense_Mutation	rs201536549	R118Q	0.25
UCEC	chr16	79305	Missense_Mutation	rs112187829	A5T	0.15
UCEC	chr16	79588	Missense_Mutation	rs761403424	P68L	0.1
UCEC	chr16	79497	Missense_Mutation	NA	A38T	0.11
UCEC	chr16	79434	Missense_Mutation	rs560374683	R17W	0.38
UCEC	chr16	85500	Missense_Mutation	rs759578895	R207H	0.41
UCEC	chr16	85717	Silent	novel	V279V	0.59
UCS	chr16	79448	Missense_Mutation	novel	K21N	0.25

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.5222	0.22898
CHOL	DEL	0.1111	0.23475
ESCA	DEL	0.288	0.012791
LUAD	DEL	0.1318	0.1886
UCS	DEL	0.5	0.13407

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.0078	Kaplan-Meier Survival Analysis
SARC	0.008	Kaplan-Meier Survival Analysis
MESO	0.037	Kaplan-Meier Survival Analysis
HNSC	0.042	Kaplan-Meier Survival Analysis
PAAD	0.037	Kaplan-Meier Survival Analysis
LAML	0.0054	Kaplan-Meier Survival Analysis
UCEC	0.00097	Kaplan-Meier Survival Analysis
LIHC	0.045	Kaplan-Meier Survival Analysis
THCA	0.035	Kaplan-Meier Survival Analysis
UVM	0.0002	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742