EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000103248 (Gene tree)
Gene ID: 64779
Gene Symbol: MTHFSD
Alias: FLJ12998
Full Name: methenyltetrahydrofolate synthetase domain containing
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 25,060 bases
Position: chr16:86,530,176-86,555,235
Accession: 25778
RBP type: canonical RBP
Summary: (Methenyltetrahydrofolate Synthetase Domain Containing) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000438761	RRM_1	PF00076.22	5.6e-07	1	1
ENSP00000444003	RRM_1	PF00076.22	1e-06	1	1
ENSP00000370612	RRM_1	PF00076.22	1e-06	1	1
ENSP00000489295	RRM_1	PF00076.22	1.1e-06	1	1
ENSP00000354152	RRM_1	PF00076.22	1.1e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26525917	MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.	Brain	2016 Jan	MacNair L	doi: 10.1093/brain/awv308
29797367	Copy number variations of MTHFSD gene across pig breeds and its association with litter size traits in Chinese indigenous Xiang pig.	J Anim Physiol Anim Nutr (Berl)	2018 May 24	Ran XQ	doi: 10.1111/jpn.12922

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000565482	MTHFSD-212	581	-	ENSP00000457794	89 (aa)	-	H3BUU0
ENST00000566050	MTHFSD-213	1270	-	ENSP00000456910	84 (aa)	-	H3BSW8
ENST00000566469	MTHFSD-214	824	-	ENSP00000455940	233 (aa)	-	H3BQU0
ENST00000568798	MTHFSD-217	560	-	ENSP00000455262	106 (aa)	-	H3BPD2
ENST00000625049	MTHFSD-219	3623	-	-	- (aa)	-	-
ENST00000567539	MTHFSD-215	556	-	ENSP00000454593	56 (aa)	-	H3BMX6
ENST00000568037	MTHFSD-216	845	-	ENSP00000480673	152 (aa)	-	A0A087WX22
ENST00000360900	MTHFSD-201	3013	XM_017023571	ENSP00000354152	383 (aa)	XP_016879060	Q2M296
ENST00000562096	MTHFSD-208	691	-	-	- (aa)	-	-
ENST00000561522	MTHFSD-205	543	-	ENSP00000454429	16 (aa)	-	H3BML0
ENST00000561848	MTHFSD-206	571	-	-	- (aa)	-	-
ENST00000562994	MTHFSD-210	565	-	ENSP00000456628	18 (aa)	-	H3BSB5
ENST00000543303	MTHFSD-203	1207	XM_005256101	ENSP00000444003	382 (aa)	XP_005256158	Q2M296
ENST00000561989	MTHFSD-207	508	-	ENSP00000455208	112 (aa)	-	H3BP93
ENST00000381214	MTHFSD-202	1210	XM_011523282	ENSP00000370612	383 (aa)	XP_011521584	Q2M296
ENST00000546093	MTHFSD-204	2451	XM_005256105	ENSP00000438761	220 (aa)	XP_005256162	F5H0M7
ENST00000564364	MTHFSD-211	493	-	ENSP00000458104	112 (aa)	-	H3BVG2
ENST00000569000	MTHFSD-218	573	-	ENSP00000454807	174 (aa)	-	H3BNE5
ENST00000634347	MTHFSD-220	1207	-	ENSP00000489295	382 (aa)	-	Q2M296
ENST00000562940	MTHFSD-209	1142	XM_011523284	ENSP00000456652	223 (aa)	XP_011521586	H3BSD1

Gene Model

Click here to download ENSG00000103248's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000103248	Platelet Function Tests	6.3300000E-006	-
ENSG00000103248	Platelet Function Tests	5.9300000E-006	-
ENSG00000103248	Platelet Function Tests	1.6561500E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000103248	rs3866634	16	86534323	G	Plasma parathyroid hormone levels	30134803	[0.18-0.46] unit increase	0.32	EFO_0004752
ENSG00000103248	rs6539952	16	86545617	A	FEV1	30804560	[0.012-0.022] unit decrease	0.017	EFO_0004314
ENSG00000103248	rs6539952	16	86545617	A	Lung function (FEV1/FVC)	30804560	[0.011-0.021] unit decrease	0.0159	EFO_0004713
ENSG00000103248	rs6539952	16	86545617	?	Lung function (FEV1/FVC)	30595370			EFO_0004713

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000103248's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000103248	MTHFSD	100	91.964	ENSAMEG00000018265	MTHFSD	93	80.000	Ailuropoda_melanoleuca
ENSG00000103248	MTHFSD	86	74.611	ENSAPLG00000011022	MTHFSD	100	62.360	Anas_platyrhynchos
ENSG00000103248	MTHFSD	100	97.753	ENSANAG00000006858	MTHFSD	100	92.287	Aotus_nancymaae
ENSG00000103248	MTHFSD	100	95.506	ENSBTAG00000012446	MTHFSD	94	76.053	Bos_taurus
ENSG00000103248	MTHFSD	100	96.629	ENSCJAG00000017146	MTHFSD	100	92.167	Callithrix_jacchus
ENSG00000103248	MTHFSD	100	95.506	ENSCHIG00000010977	MTHFSD	94	76.053	Capra_hircus
ENSG00000103248	MTHFSD	100	96.629	ENSTSYG00000002088	MTHFSD	100	83.029	Carlito_syrichta
ENSG00000103248	MTHFSD	100	96.629	ENSCCAG00000023314	MTHFSD	100	91.099	Cebus_capucinus
ENSG00000103248	MTHFSD	100	98.214	ENSCATG00000029682	MTHFSD	100	94.517	Cercocebus_atys
ENSG00000103248	MTHFSD	100	98.876	ENSCSAG00000003139	MTHFSD	96	94.987	Chlorocebus_sabaeus
ENSG00000103248	MTHFSD	100	79.775	ENSCPBG00000023581	MTHFSD	90	63.544	Chrysemys_picta_bellii
ENSG00000103248	MTHFSD	100	98.214	ENSCANG00000041133	MTHFSD	100	94.517	Colobus_angolensis_palliatus
ENSG00000103248	MTHFSD	100	95.506	ENSEASG00005013838	MTHFSD	94	79.474	Equus_asinus_asinus
ENSG00000103248	MTHFSD	99	61.468	ENSEEUG00000000162	MTHFSD	90	63.529	Erinaceus_europaeus
ENSG00000103248	MTHFSD	100	92.135	ENSFCAG00000023656	MTHFSD	99	77.895	Felis_catus
ENSG00000103248	MTHFSD	99	73.874	ENSFALG00000006657	MTHFSD	96	63.969	Ficedula_albicollis
ENSG00000103248	MTHFSD	100	80.899	ENSGAGG00000009305	MTHFSD	98	63.684	Gopherus_agassizii
ENSG00000103248	MTHFSD	100	100.000	ENSGGOG00000014557	MTHFSD	100	99.217	Gorilla_gorilla
ENSG00000103248	MTHFSD	97	74.405	ENSIPUG00000006695	mthfsd	93	52.880	Ictalurus_punctatus
ENSG00000103248	MTHFSD	99	72.523	ENSLOCG00000001066	mthfsd	95	55.556	Lepisosteus_oculatus
ENSG00000103248	MTHFSD	100	98.214	ENSMFAG00000044698	MTHFSD	100	94.256	Macaca_fascicularis
ENSG00000103248	MTHFSD	100	91.364	ENSMMUG00000019500	MTHFSD	100	91.364	Macaca_mulatta
ENSG00000103248	MTHFSD	100	98.214	ENSMNEG00000035992	MTHFSD	100	93.473	Macaca_nemestrina
ENSG00000103248	MTHFSD	100	97.753	ENSMLEG00000034717	MTHFSD	100	93.899	Mandrillus_leucophaeus
ENSG00000103248	MTHFSD	99	75.676	ENSMGAG00000007290	MTHFSD	92	64.156	Meleagris_gallopavo
ENSG00000103248	MTHFSD	94	86.076	ENSMICG00000035837	MTHFSD	100	72.987	Microcebus_murinus
ENSG00000103248	MTHFSD	96	86.916	ENSMOCG00000004916	Mthfsd	99	73.753	Microtus_ochrogaster
ENSG00000103248	MTHFSD	100	84.270	ENSMODG00000004537	MTHFSD	100	67.368	Monodelphis_domestica
ENSG00000103248	MTHFSD	96	85.047	MGP_CAROLIEiJ_G0031644	Mthfsd	100	74.931	Mus_caroli
ENSG00000103248	MTHFSD	100	86.517	MGP_PahariEiJ_G0023242	Mthfsd	99	74.278	Mus_pahari
ENSG00000103248	MTHFSD	100	93.258	ENSMPUG00000008611	MTHFSD	94	78.571	Mustela_putorius_furo
ENSG00000103248	MTHFSD	100	88.496	ENSMLUG00000017129	MTHFSD	96	78.249	Myotis_lucifugus
ENSG00000103248	MTHFSD	100	100.000	ENSNLEG00000035790	MTHFSD	100	96.345	Nomascus_leucogenys
ENSG00000103248	MTHFSD	100	83.146	ENSMEUG00000011642	MTHFSD	100	67.282	Notamacropus_eugenii
ENSG00000103248	MTHFSD	100	86.517	ENSOANG00000003740	MTHFSD	96	70.027	Ornithorhynchus_anatinus
ENSG00000103248	MTHFSD	98	90.000	ENSOGAG00000011905	MTHFSD	98	82.493	Otolemur_garnettii
ENSG00000103248	MTHFSD	100	95.506	ENSOARG00000011579	MTHFSD	94	76.579	Ovis_aries
ENSG00000103248	MTHFSD	100	100.000	ENSPPAG00000040098	MTHFSD	100	97.650	Pan_paniscus
ENSG00000103248	MTHFSD	100	93.258	ENSPPRG00000023220	MTHFSD	99	78.158	Panthera_pardus
ENSG00000103248	MTHFSD	100	100.000	ENSPTRG00000008440	MTHFSD	100	97.911	Pan_troglodytes
ENSG00000103248	MTHFSD	100	98.214	ENSPANG00000021729	MTHFSD	100	95.561	Papio_anubis
ENSG00000103248	MTHFSD	100	81.250	ENSPSIG00000009774	MTHFSD	97	65.714	Pelodiscus_sinensis
ENSG00000103248	MTHFSD	98	70.115	ENSPMGG00000000017	mthfsd	90	55.065	Periophthalmus_magnuspinnatus
ENSG00000103248	MTHFSD	100	95.506	ENSPCOG00000026655	MTHFSD	100	82.723	Propithecus_coquereli
ENSG00000103248	MTHFSD	100	94.382	ENSPVAG00000007545	MTHFSD	100	69.110	Pteropus_vampyrus
ENSG00000103248	MTHFSD	100	98.876	ENSRBIG00000043280	MTHFSD	100	94.256	Rhinopithecus_bieti
ENSG00000103248	MTHFSD	100	98.214	ENSRROG00000045411	MTHFSD	100	93.734	Rhinopithecus_roxellana
ENSG00000103248	MTHFSD	100	96.629	ENSSBOG00000033851	MTHFSD	100	91.885	Saimiri_boliviensis_boliviensis
ENSG00000103248	MTHFSD	100	82.222	ENSSHAG00000013081	MTHFSD	99	68.684	Sarcophilus_harrisii
ENSG00000103248	MTHFSD	100	78.652	ENSSPUG00000007833	MTHFSD	93	77.679	Sphenodon_punctatus
ENSG00000103248	MTHFSD	100	87.500	ENSSSCG00000002660	MTHFSD	94	75.989	Sus_scrofa
ENSG00000103248	MTHFSD	100	96.629	ENSUMAG00000007740	MTHFSD	97	80.609	Ursus_maritimus
ENSG00000103248	MTHFSD	100	93.258	ENSVPAG00000000971	MTHFSD	99	59.626	Vicugna_pacos

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component