EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000103342 (Gene tree)
Gene ID: 2935
Gene Symbol: GSPT1
Alias: GST1|ETF3A|eRF3a
Full Name: G1 to S phase transition 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 48,535 bases
Position: chr16:11,868,128-11,916,662
Accession: 4621
RBP type: canonical RBP
Summary: (G1 To S Phase Transition 1) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and mRNA surveillance pathway. Gene Ontology (GO) annotations related to this gene include GTPase activity. An important paralog of this gene is GSPT2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000408399	PAM2	PF07145.15	8.3e-06	1	1
ENSP00000398131	PAM2	PF07145.15	8.3e-06	1	1
ENSP00000399539	GTP_EFTU	PF00009.27	4e-46	1	1
ENSP00000454351	GTP_EFTU	PF00009.27	4e-46	1	1
ENSP00000456057	GTP_EFTU	PF00009.27	4.6e-46	1	1
ENSP00000408399	GTP_EFTU	PF00009.27	7.4e-46	1	1
ENSP00000398131	GTP_EFTU	PF00009.27	7.4e-46	1	1
ENSP00000456897	GTP_EFTU	PF00009.27	5.7e-22	1	1
ENSP00000456057	GTP_EFTU_D2	PF03144.25	9.1e-08	1	1
ENSP00000399539	GTP_EFTU_D2	PF03144.25	9.8e-08	1	1
ENSP00000454351	GTP_EFTU_D2	PF03144.25	9.8e-08	1	1
ENSP00000408399	GTP_EFTU_D2	PF03144.25	1.6e-07	1	1
ENSP00000398131	GTP_EFTU_D2	PF03144.25	1.6e-07	1	1
ENSP00000399539	GTP_EFTU_D3	PF03143.17	2.3e-31	1	1
ENSP00000454351	GTP_EFTU_D3	PF03143.17	2.3e-31	1	1
ENSP00000408399	GTP_EFTU_D3	PF03143.17	4.5e-31	1	1
ENSP00000398131	GTP_EFTU_D3	PF03143.17	4.5e-31	1	1
ENSP00000456057	GTP_EFTU_D3	PF03143.17	9.8e-19	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000562794	GSPT1-205	501	-	-	- (aa)	-	-
ENST00000563468	GSPT1-206	1962	-	ENSP00000454351	499 (aa)	-	P15170
ENST00000439887	GSPT1-203	2509	-	ENSP00000408399	636 (aa)	-	P15170
ENST00000562169	GSPT1-204	466	-	ENSP00000454538	94 (aa)	-	H3BMT9
ENST00000564790	GSPT1-207	491	-	-	- (aa)	-	-
ENST00000568849	GSPT1-210	790	-	ENSP00000456897	199 (aa)	-	H3BSV8
ENST00000565267	GSPT1-208	1864	-	ENSP00000456057	475 (aa)	-	H3BR35
ENST00000567631	GSPT1-209	678	-	-	- (aa)	-	-
ENST00000434724	GSPT1-202	7105	-	ENSP00000398131	637 (aa)	-	P15170
ENST00000420576	GSPT1-201	1603	-	ENSP00000399539	499 (aa)	-	P15170

Gene Model

Click here to download ENSG00000103342's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000103342	Diabetes Mellitus	5.7370000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000103342	rs1029285	16	11893261	?	Age at menopause	30595370			EFO_0004704

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000103342's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000103342	GSPT1	86	37.330	ENSG00000101210	EEF1A2	98	53.020
ENSG00000103342	GSPT1	86	38.462	ENSG00000156508	EEF1A1	99	52.083
ENSG00000103342	GSPT1	100	93.788	ENSG00000189369	GSPT2	99	87.279
ENSG00000103342	GSPT1	85	42.991	ENSG00000112339	HBS1L	95	42.683

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000103342	GSPT1	87	92.874	ENSAPOG00000004594	-	99	83.730	Acanthochromis_polyacanthus
ENSG00000103342	GSPT1	100	85.010	ENSAPOG00000002524	gspt1l	99	75.080	Acanthochromis_polyacanthus
ENSG00000103342	GSPT1	100	98.406	ENSAMEG00000009589	GSPT1	100	97.901	Ailuropoda_melanoleuca
ENSG00000103342	GSPT1	99	86.895	ENSACIG00000007028	-	100	86.895	Amphilophus_citrinellus
ENSG00000103342	GSPT1	87	87.586	ENSACIG00000006643	GSPT1	99	82.626	Amphilophus_citrinellus
ENSG00000103342	GSPT1	88	92.255	ENSAOCG00000020972	-	99	75.040	Amphiprion_ocellaris
ENSG00000103342	GSPT1	100	85.207	ENSAOCG00000016342	gspt1l	100	85.132	Amphiprion_ocellaris
ENSG00000103342	GSPT1	100	87.377	ENSAPEG00000010261	gspt1l	99	75.241	Amphiprion_percula
ENSG00000103342	GSPT1	88	85.682	ENSAPEG00000003359	-	99	80.159	Amphiprion_percula
ENSG00000103342	GSPT1	89	92.099	ENSATEG00000009194	GSPT1	99	74.882	Anabas_testudineus
ENSG00000103342	GSPT1	100	85.996	ENSATEG00000007769	gspt1l	99	75.080	Anabas_testudineus
ENSG00000103342	GSPT1	100	94.611	ENSACAG00000003979	GSPT1	99	93.499	Anolis_carolinensis
ENSG00000103342	GSPT1	87	95.181	ENSANAG00000036504	GSPT1	91	82.700	Aotus_nancymaae
ENSG00000103342	GSPT1	100	86.706	ENSACLG00000011643	gspt1l	99	76.786	Astatotilapia_calliptera
ENSG00000103342	GSPT1	89	92.081	ENSACLG00000017598	-	90	85.156	Astatotilapia_calliptera
ENSG00000103342	GSPT1	100	87.251	ENSAMXG00000008638	gspt1	89	87.251	Astyanax_mexicanus
ENSG00000103342	GSPT1	99	84.940	ENSAMXG00000002781	gspt1l	81	79.049	Astyanax_mexicanus
ENSG00000103342	GSPT1	100	98.998	ENSBTAG00000003577	GSPT1	100	96.406	Bos_taurus
ENSG00000103342	GSPT1	100	99.198	ENSCJAG00000018191	GSPT1	100	97.192	Callithrix_jacchus
ENSG00000103342	GSPT1	100	98.196	ENSCAFG00000018856	GSPT1	100	97.701	Canis_familiaris
ENSG00000103342	GSPT1	99	96.559	ENSCAFG00020024250	GSPT1	93	96.800	Canis_lupus_dingo
ENSG00000103342	GSPT1	100	98.798	ENSCHIG00000009274	GSPT1	100	96.256	Capra_hircus
ENSG00000103342	GSPT1	100	99.599	ENSTSYG00000013812	-	100	99.042	Carlito_syrichta
ENSG00000103342	GSPT1	100	81.633	ENSTSYG00000036050	-	95	76.421	Carlito_syrichta
ENSG00000103342	GSPT1	100	72.345	ENSCAPG00000014454	GSPT1	97	80.051	Cavia_aperea
ENSG00000103342	GSPT1	100	97.194	ENSCPOG00000009381	GSPT1	90	97.233	Cavia_porcellus
ENSG00000103342	GSPT1	99	88.710	ENSCCAG00000036663	-	97	86.355	Cebus_capucinus
ENSG00000103342	GSPT1	87	95.181	ENSCCAG00000035152	-	85	92.424	Cebus_capucinus
ENSG00000103342	GSPT1	100	94.844	ENSCATG00000025774	GSPT1	100	94.844	Cercocebus_atys
ENSG00000103342	GSPT1	100	97.595	ENSCLAG00000011772	GSPT1	99	97.561	Chinchilla_lanigera
ENSG00000103342	GSPT1	100	99.800	ENSCSAG00000008244	GSPT1	100	98.905	Chlorocebus_sabaeus
ENSG00000103342	GSPT1	100	74.749	ENSCHOG00000003850	GSPT1	85	71.220	Choloepus_hoffmanni
ENSG00000103342	GSPT1	100	96.994	ENSCPBG00000020430	GSPT1	94	95.969	Chrysemys_picta_bellii
ENSG00000103342	GSPT1	91	66.887	ENSCSAVG00000010206	-	99	58.803	Ciona_savignyi
ENSG00000103342	GSPT1	99	83.404	ENSCANG00000035684	GSPT1	100	83.404	Colobus_angolensis_palliatus
ENSG00000103342	GSPT1	100	98.196	ENSCGRG00001009583	Gspt1	99	98.374	Cricetulus_griseus_chok1gshd
ENSG00000103342	GSPT1	100	98.196	ENSCGRG00000002048	Gspt1	100	98.196	Cricetulus_griseus_crigri
ENSG00000103342	GSPT1	89	91.196	ENSCSEG00000019708	GSPT1	89	84.540	Cynoglossus_semilaevis
ENSG00000103342	GSPT1	99	67.530	ENSCVAG00000016392	-	99	60.892	Cyprinodon_variegatus
ENSG00000103342	GSPT1	86	93.443	ENSCVAG00000000869	GSPT1	99	75.358	Cyprinodon_variegatus
ENSG00000103342	GSPT1	100	87.251	ENSDARG00000031048	gspt1	89	87.251	Danio_rerio
ENSG00000103342	GSPT1	99	85.542	ENSDARG00000098627	gspt1l	99	75.201	Danio_rerio
ENSG00000103342	GSPT1	100	98.798	ENSDNOG00000004608	GSPT1	100	98.798	Dasypus_novemcinctus
ENSG00000103342	GSPT1	100	97.595	ENSDORG00000025038	Gspt1	100	97.595	Dipodomys_ordii
ENSG00000103342	GSPT1	100	97.395	ENSETEG00000018249	GSPT1	97	93.528	Echinops_telfairi
ENSG00000103342	GSPT1	100	98.798	ENSEASG00005011497	GSPT1	100	95.031	Equus_asinus_asinus
ENSG00000103342	GSPT1	97	98.969	ENSECAG00000021195	GSPT1	100	98.969	Equus_caballus
ENSG00000103342	GSPT1	99	92.893	ENSEEUG00000008851	GSPT1	97	86.156	Erinaceus_europaeus
ENSG00000103342	GSPT1	99	87.324	ENSELUG00000023492	gspt1l	99	75.645	Esox_lucius
ENSG00000103342	GSPT1	99	82.759	ENSELUG00000019323	-	88	85.928	Esox_lucius
ENSG00000103342	GSPT1	100	98.798	ENSFCAG00000022281	GSPT1	100	96.100	Felis_catus
ENSG00000103342	GSPT1	100	96.794	ENSFALG00000003880	GSPT1	85	95.577	Ficedula_albicollis
ENSG00000103342	GSPT1	100	97.194	ENSFDAG00000008253	GSPT1	100	96.731	Fukomys_damarensis
ENSG00000103342	GSPT1	99	86.895	ENSFHEG00000009090	gspt1l	88	87.500	Fundulus_heteroclitus
ENSG00000103342	GSPT1	99	82.192	ENSGMOG00000013056	GSPT1	99	73.228	Gadus_morhua
ENSG00000103342	GSPT1	86	83.636	ENSGMOG00000009933	-	77	83.636	Gadus_morhua
ENSG00000103342	GSPT1	100	96.192	ENSGALG00000039500	GSPT2	98	88.436	Gallus_gallus
ENSG00000103342	GSPT1	100	86.706	ENSGAFG00000005676	gspt1l	89	87.677	Gambusia_affinis
ENSG00000103342	GSPT1	89	86.456	ENSGAFG00000020793	-	99	82.281	Gambusia_affinis
ENSG00000103342	GSPT1	100	83.953	ENSGACG00000004324	gspt1l	97	77.217	Gasterosteus_aculeatus
ENSG00000103342	GSPT1	86	91.803	ENSGACG00000004490	-	99	75.345	Gasterosteus_aculeatus
ENSG00000103342	GSPT1	100	96.994	ENSGAGG00000016315	GSPT1	98	89.593	Gopherus_agassizii
ENSG00000103342	GSPT1	100	100.000	ENSGGOG00000004071	GSPT1	100	98.901	Gorilla_gorilla
ENSG00000103342	GSPT1	89	92.081	ENSHBUG00000001538	GSPT1	90	85.156	Haplochromis_burtoni
ENSG00000103342	GSPT1	86	92.575	ENSHBUG00000006257	gspt1l	99	92.575	Haplochromis_burtoni
ENSG00000103342	GSPT1	100	96.994	ENSHGLG00000010520	-	99	96.951	Heterocephalus_glaber_female
ENSG00000103342	GSPT1	100	86.373	ENSHGLG00000012034	-	99	84.740	Heterocephalus_glaber_female
ENSG00000103342	GSPT1	100	84.569	ENSHGLG00100010030	-	99	83.219	Heterocephalus_glaber_male
ENSG00000103342	GSPT1	100	96.994	ENSHGLG00100015621	-	100	96.538	Heterocephalus_glaber_male
ENSG00000103342	GSPT1	100	85.236	ENSHCOG00000016899	gspt1l	99	74.799	Hippocampus_comes
ENSG00000103342	GSPT1	100	80.784	ENSHCOG00000015286	GSPT1	99	72.337	Hippocampus_comes
ENSG00000103342	GSPT1	100	86.083	ENSIPUG00000001655	Gspt1	99	86.355	Ictalurus_punctatus
ENSG00000103342	GSPT1	99	85.312	ENSIPUG00000011358	Gspt1	99	74.392	Ictalurus_punctatus
ENSG00000103342	GSPT1	100	98.597	ENSSTOG00000015406	GSPT1	100	98.597	Ictidomys_tridecemlineatus
ENSG00000103342	GSPT1	100	98.397	ENSJJAG00000015530	Gspt1	100	95.761	Jaculus_jaculus
ENSG00000103342	GSPT1	99	86.895	ENSKMAG00000006311	-	88	86.694	Kryptolebias_marmoratus
ENSG00000103342	GSPT1	89	91.629	ENSKMAG00000021919	GSPT1	99	74.801	Kryptolebias_marmoratus
ENSG00000103342	GSPT1	89	91.422	ENSLBEG00000001128	GSPT1	89	84.241	Labrus_bergylta
ENSG00000103342	GSPT1	99	86.263	ENSLBEG00000006458	gspt1l	99	74.392	Labrus_bergylta
ENSG00000103342	GSPT1	100	75.800	ENSLACG00000001700	GSPT1	98	75.197	Latimeria_chalumnae
ENSG00000103342	GSPT1	100	89.264	ENSLOCG00000007431	gspt1	99	79.288	Lepisosteus_oculatus
ENSG00000103342	GSPT1	100	98.998	ENSLAFG00000032278	GSPT1	100	96.622	Loxodonta_africana
ENSG00000103342	GSPT1	100	99.800	ENSMFAG00000037675	GSPT1	100	99.060	Macaca_fascicularis
ENSG00000103342	GSPT1	100	99.800	ENSMMUG00000023178	GSPT1	100	99.800	Macaca_mulatta
ENSG00000103342	GSPT1	100	99.800	ENSMNEG00000032993	GSPT1	100	99.800	Macaca_nemestrina
ENSG00000103342	GSPT1	100	99.800	ENSMLEG00000028669	GSPT1	100	99.807	Mandrillus_leucophaeus
ENSG00000103342	GSPT1	100	86.588	ENSMAMG00000002821	gspt1l	99	75.563	Mastacembelus_armatus
ENSG00000103342	GSPT1	88	91.800	ENSMAMG00000004326	GSPT1	99	74.724	Mastacembelus_armatus
ENSG00000103342	GSPT1	100	86.706	ENSMZEG00005022024	gspt1l	99	76.786	Maylandia_zebra
ENSG00000103342	GSPT1	88	92.273	ENSMZEG00005007132	-	90	84.375	Maylandia_zebra
ENSG00000103342	GSPT1	100	95.792	ENSMGAG00000000878	GSPT1	99	94.423	Meleagris_gallopavo
ENSG00000103342	GSPT1	95	95.767	ENSMAUG00000000551	Gspt1	100	93.501	Mesocricetus_auratus
ENSG00000103342	GSPT1	100	99.198	ENSMICG00000014137	GSPT1	100	96.875	Microcebus_murinus
ENSG00000103342	GSPT1	100	97.996	ENSMOCG00000019604	Gspt1	97	92.834	Microtus_ochrogaster
ENSG00000103342	GSPT1	88	92.045	ENSMMOG00000003725	GSPT1	99	87.295	Mola_mola
ENSG00000103342	GSPT1	100	84.752	ENSMMOG00000009646	gspt1l	93	92.148	Mola_mola
ENSG00000103342	GSPT1	100	98.196	ENSMODG00000004728	-	100	93.174	Monodelphis_domestica
ENSG00000103342	GSPT1	100	83.034	ENSMODG00000023082	-	99	83.654	Monodelphis_domestica
ENSG00000103342	GSPT1	99	85.800	ENSMALG00000003550	-	99	73.591	Monopterus_albus
ENSG00000103342	GSPT1	89	91.403	ENSMALG00000009500	GSPT1	99	74.682	Monopterus_albus
ENSG00000103342	GSPT1	100	98.397	MGP_CAROLIEiJ_G0020458	Gspt1	100	97.980	Mus_caroli
ENSG00000103342	GSPT1	100	98.597	ENSMUSG00000062203	Gspt1	99	98.990	Mus_musculus
ENSG00000103342	GSPT1	100	97.996	MGP_PahariEiJ_G0016165	Gspt1	100	98.990	Mus_pahari
ENSG00000103342	GSPT1	100	98.597	MGP_SPRETEiJ_G0021353	Gspt1	100	98.990	Mus_spretus
ENSG00000103342	GSPT1	100	97.421	ENSMPUG00000014504	GSPT1	100	96.964	Mustela_putorius_furo
ENSG00000103342	GSPT1	99	98.580	ENSMLUG00000000792	GSPT1	100	97.701	Myotis_lucifugus
ENSG00000103342	GSPT1	100	97.996	ENSNGAG00000023220	Gspt1	97	95.285	Nannospalax_galili
ENSG00000103342	GSPT1	89	92.081	ENSNBRG00000002803	GSPT1	99	75.238	Neolamprologus_brichardi
ENSG00000103342	GSPT1	100	100.000	ENSNLEG00000010199	GSPT1	100	100.000	Nomascus_leucogenys
ENSG00000103342	GSPT1	95	63.684	ENSMEUG00000006697	-	83	75.424	Notamacropus_eugenii
ENSG00000103342	GSPT1	96	78.495	ENSMEUG00000015169	-	82	73.860	Notamacropus_eugenii
ENSG00000103342	GSPT1	94	97.859	ENSOPRG00000014219	GSPT1	87	86.645	Ochotona_princeps
ENSG00000103342	GSPT1	84	94.048	ENSODEG00000011524	-	99	84.149	Octodon_degus
ENSG00000103342	GSPT1	99	96.774	ENSODEG00000002248	-	100	96.774	Octodon_degus
ENSG00000103342	GSPT1	100	86.905	ENSONIG00000003456	gspt1l	99	76.175	Oreochromis_niloticus
ENSG00000103342	GSPT1	89	92.081	ENSONIG00000019754	-	99	75.238	Oreochromis_niloticus
ENSG00000103342	GSPT1	95	80.220	ENSOANG00000013811	-	96	71.707	Ornithorhynchus_anatinus
ENSG00000103342	GSPT1	77	98.177	ENSOANG00000009409	GSPT1	100	98.177	Ornithorhynchus_anatinus
ENSG00000103342	GSPT1	100	98.597	ENSOCUG00000004759	GSPT1	100	96.256	Oryctolagus_cuniculus
ENSG00000103342	GSPT1	86	92.272	ENSORLG00000002867	-	99	74.485	Oryzias_latipes
ENSG00000103342	GSPT1	99	86.004	ENSORLG00000026597	gspt1l	89	87.221	Oryzias_latipes
ENSG00000103342	GSPT1	86	92.506	ENSORLG00020006749	-	99	74.326	Oryzias_latipes_hni
ENSG00000103342	GSPT1	99	86.004	ENSORLG00020016364	gspt1l	89	87.221	Oryzias_latipes_hni
ENSG00000103342	GSPT1	99	85.801	ENSORLG00015008971	gspt1l	97	84.932	Oryzias_latipes_hsok
ENSG00000103342	GSPT1	86	92.272	ENSORLG00015005515	-	99	82.937	Oryzias_latipes_hsok
ENSG00000103342	GSPT1	86	93.208	ENSOMEG00000008108	-	97	84.064	Oryzias_melastigma
ENSG00000103342	GSPT1	99	85.859	ENSOMEG00000002739	gspt1l	89	85.000	Oryzias_melastigma
ENSG00000103342	GSPT1	100	97.426	ENSOGAG00000007083	GSPT1	100	94.219	Otolemur_garnettii
ENSG00000103342	GSPT1	100	98.798	ENSOARG00000007088	GSPT1	100	95.944	Ovis_aries
ENSG00000103342	GSPT1	67	98.438	ENSPPAG00000028454	-	84	99.187	Pan_paniscus
ENSG00000103342	GSPT1	100	98.798	ENSPPRG00000005042	GSPT1	100	98.798	Panthera_pardus
ENSG00000103342	GSPT1	100	98.798	ENSPTIG00000020265	GSPT1	100	98.798	Panthera_tigris_altaica
ENSG00000103342	GSPT1	100	97.796	ENSPTRG00000007779	-	98	97.692	Pan_troglodytes
ENSG00000103342	GSPT1	100	99.800	ENSPANG00000007630	GSPT1	100	98.906	Papio_anubis
ENSG00000103342	GSPT1	100	86.706	ENSPKIG00000022644	gspt1	99	75.767	Paramormyrops_kingsleyae
ENSG00000103342	GSPT1	88	75.410	ENSPKIG00000020492	gspt1l	55	83.801	Paramormyrops_kingsleyae
ENSG00000103342	GSPT1	100	96.794	ENSPSIG00000008275	GSPT1	99	95.769	Pelodiscus_sinensis
ENSG00000103342	GSPT1	86	89.461	ENSPMGG00000022247	GSPT1	96	76.329	Periophthalmus_magnuspinnatus
ENSG00000103342	GSPT1	99	83.065	ENSPMGG00000003007	gspt1l	99	84.073	Periophthalmus_magnuspinnatus
ENSG00000103342	GSPT1	100	98.597	ENSPEMG00000012896	Gspt1	100	94.984	Peromyscus_maniculatus_bairdii
ENSG00000103342	GSPT1	100	85.000	ENSPCIG00000005432	-	97	80.844	Phascolarctos_cinereus
ENSG00000103342	GSPT1	100	93.186	ENSPCIG00000007435	-	98	86.720	Phascolarctos_cinereus
ENSG00000103342	GSPT1	99	98.377	ENSPCIG00000026776	-	100	96.082	Phascolarctos_cinereus
ENSG00000103342	GSPT1	100	86.508	ENSPFOG00000016035	gspt1l	99	76.337	Poecilia_formosa
ENSG00000103342	GSPT1	86	92.974	ENSPFOG00000005224	-	99	75.399	Poecilia_formosa
ENSG00000103342	GSPT1	71	92.373	ENSPLAG00000001492	-	95	72.973	Poecilia_latipinna
ENSG00000103342	GSPT1	98	64.372	ENSPLAG00000007443	GSPT1	99	64.549	Poecilia_latipinna
ENSG00000103342	GSPT1	100	86.508	ENSPMEG00000022359	gspt1l	88	87.475	Poecilia_mexicana
ENSG00000103342	GSPT1	86	92.974	ENSPMEG00000007020	-	97	83.469	Poecilia_mexicana
ENSG00000103342	GSPT1	97	86.008	ENSPREG00000008023	gspt1l	78	86.214	Poecilia_reticulata
ENSG00000103342	GSPT1	89	91.648	ENSPREG00000016668	-	99	86.667	Poecilia_reticulata
ENSG00000103342	GSPT1	100	100.000	ENSPPYG00000007114	GSPT1	93	99.216	Pongo_abelii
ENSG00000103342	GSPT1	98	87.984	ENSPCAG00000011379	GSPT1	86	83.225	Procavia_capensis
ENSG00000103342	GSPT1	100	99.599	ENSPCOG00000013204	GSPT1	100	96.890	Propithecus_coquereli
ENSG00000103342	GSPT1	100	99.198	ENSPVAG00000005009	GSPT1	90	96.890	Pteropus_vampyrus
ENSG00000103342	GSPT1	100	86.706	ENSPNYG00000010474	gspt1l	99	76.786	Pundamilia_nyererei
ENSG00000103342	GSPT1	89	92.081	ENSPNYG00000002903	-	99	87.324	Pundamilia_nyererei
ENSG00000103342	GSPT1	100	86.588	ENSPNAG00000011819	gspt1	89	87.251	Pygocentrus_nattereri
ENSG00000103342	GSPT1	100	85.545	ENSPNAG00000002605	gspt1l	95	78.830	Pygocentrus_nattereri
ENSG00000103342	GSPT1	100	98.400	ENSRNOG00000046271	LOC100911685	100	95.305	Rattus_norvegicus
ENSG00000103342	GSPT1	100	99.800	ENSRBIG00000039784	GSPT1	100	99.422	Rhinopithecus_bieti
ENSG00000103342	GSPT1	100	99.800	ENSRROG00000031350	GSPT1	100	99.800	Rhinopithecus_roxellana
ENSG00000103342	GSPT1	100	99.198	ENSSBOG00000017761	GSPT1	100	99.229	Saimiri_boliviensis_boliviensis
ENSG00000103342	GSPT1	100	98.200	ENSSHAG00000005908	-	100	97.697	Sarcophilus_harrisii
ENSG00000103342	GSPT1	100	89.703	ENSSHAG00000002700	-	97	82.034	Sarcophilus_harrisii
ENSG00000103342	GSPT1	99	86.263	ENSSFOG00015014731	-	87	86.869	Scleropages_formosus
ENSG00000103342	GSPT1	100	88.822	ENSSFOG00015011277	gspt1	88	88.822	Scleropages_formosus
ENSG00000103342	GSPT1	89	91.176	ENSSMAG00000007886	GSPT1	99	73.975	Scophthalmus_maximus
ENSG00000103342	GSPT1	99	85.341	ENSSMAG00000014782	gspt1l	99	75.723	Scophthalmus_maximus
ENSG00000103342	GSPT1	86	93.039	ENSSDUG00000008404	GSPT1	99	75.000	Seriola_dumerili
ENSG00000103342	GSPT1	100	85.119	ENSSDUG00000016908	gspt1l	88	86.869	Seriola_dumerili
ENSG00000103342	GSPT1	100	85.516	ENSSLDG00000009000	gspt1l	88	87.273	Seriola_lalandi_dorsalis
ENSG00000103342	GSPT1	86	93.039	ENSSLDG00000008363	GSPT1	99	75.159	Seriola_lalandi_dorsalis
ENSG00000103342	GSPT1	94	91.489	ENSSARG00000013461	-	67	86.588	Sorex_araneus
ENSG00000103342	GSPT1	78	90.104	ENSSPUG00000007536	GSPT1	67	90.104	Sphenodon_punctatus
ENSG00000103342	GSPT1	61	71.930	ENSSPUG00000007551	-	85	56.373	Sphenodon_punctatus
ENSG00000103342	GSPT1	88	92.027	ENSSPAG00000004622	-	99	74.881	Stegastes_partitus
ENSG00000103342	GSPT1	99	86.145	ENSSPAG00000011542	gspt1l	96	84.538	Stegastes_partitus
ENSG00000103342	GSPT1	87	92.644	ENSSPAG00000009785	-	99	85.516	Stegastes_partitus
ENSG00000103342	GSPT1	100	98.597	ENSSSCG00000021118	GSPT1	100	96.412	Sus_scrofa
ENSG00000103342	GSPT1	100	96.794	ENSTGUG00000005103	GSPT1	99	95.577	Taeniopygia_guttata
ENSG00000103342	GSPT1	81	91.111	ENSTRUG00000016971	-	100	91.111	Takifugu_rubripes
ENSG00000103342	GSPT1	99	82.869	ENSTRUG00000012645	gspt1l	99	72.419	Takifugu_rubripes
ENSG00000103342	GSPT1	89	90.315	ENSTNIG00000012926	GSPT1	99	72.419	Tetraodon_nigroviridis
ENSG00000103342	GSPT1	99	83.400	ENSTNIG00000010212	gspt1l	100	83.400	Tetraodon_nigroviridis
ENSG00000103342	GSPT1	94	95.767	ENSTBEG00000008873	-	58	97.333	Tupaia_belangeri
ENSG00000103342	GSPT1	100	98.998	ENSTTRG00000011630	GSPT1	87	94.146	Tursiops_truncatus
ENSG00000103342	GSPT1	100	96.794	ENSUAMG00000004460	GSPT1	100	96.794	Ursus_americanus
ENSG00000103342	GSPT1	100	98.998	ENSUMAG00000004033	GSPT1	100	99.010	Ursus_maritimus
ENSG00000103342	GSPT1	100	98.998	ENSVPAG00000006903	GSPT1	84	98.842	Vicugna_pacos
ENSG00000103342	GSPT1	100	98.196	ENSVVUG00000018198	GSPT1	96	97.889	Vulpes_vulpes
ENSG00000103342	GSPT1	100	86.400	ENSXETG00000005540	gspt1	98	81.086	Xenopus_tropicalis
ENSG00000103342	GSPT1	99	83.936	ENSXCOG00000003084	-	98	85.010	Xiphophorus_couchianus
ENSG00000103342	GSPT1	98	83.096	ENSXCOG00000016099	gspt1l	99	83.096	Xiphophorus_couchianus
ENSG00000103342	GSPT1	100	86.905	ENSXMAG00000007284	gspt1l	88	87.677	Xiphophorus_maculatus
ENSG00000103342	GSPT1	89	91.648	ENSXMAG00000022050	-	99	75.358	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000082	G1/S transition of mitotic cell cycle	2511002.	TAS	Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	15326224.	TAS	Process
GO:0002184	cytoplasmic translational termination	21873635.	IBA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003747	translation release factor activity	21873635.	IBA	Function
GO:0003747	translation release factor activity	15326224.	IMP	Function
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0003924	GTPase activity	15326224.	TAS	Function
GO:0005515	protein binding	9620853.9712840.12489690.17577209.18256688.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005829	cytosol	-	TAS	Component
GO:0006412	translation	21873635.	IBA	Process
GO:0006479	protein methylation	18539146.	IDA	Process
GO:0018444	translation release factor complex	21873635.	IBA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26503584	Identification of four new susceptibility loci for testicular germ cell tumour.	Nat Commun	2015 Oct 27	Litchfield K	doi: 10.1038/ncomms9690.
19424636	eRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer development.	Oncol Rep	2009 Jun	Malta-Vacas J	-
22101789	GGCn polymorphism of eRF3a/GSPT1 gene and breast cancer susceptibility.	Med Oncol	2012 Sep	Miri M	doi: 10.1007/s12032-011-0111-x
15987717	Polyglycine expansions in eRF3/GSPT1 are associated with gastric cancer susceptibility.	Carcinogenesis	2005 Dec	Brito M	-
19963113	Differential expression of GSPT1 GGCn alleles in cancer.	Cancer Genet Cytogenet	2009 Dec	Malta-Vacas J	doi: 10.1016/j.cancergencyto.2009.08.010.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr16	11873111	3'Flank	novel		0.27
BLCA	chr16	11886541	Missense_Mutation	NA	H257Y	0.26
BLCA	chr16	11873130	Missense_Mutation	novel	E497Q	0.06
BLCA	chr16	11915906	Intron	rs760329757		0.07
BRCA	chr16	11873034	3'Flank	novel		0.08
BRCA	chr16	11896693	Missense_Mutation	novel	D39Y	0.1
BRCA	chr16	11894951	Splice_Region	novel		0.29
BRCA	chr16	11886562	Missense_Mutation	NA	F250L	0.17
BRCA	chr16	11915547	Intron	NA		0.54
BRCA	chr16	11891110	Missense_Mutation	NA	T105M	0.27
BRCA	chr16	11883035	Missense_Mutation	NA	L332F	0.18
BRCA	chr16	11877481	Missense_Mutation	NA	E372Q	0.25
CESC	chr16	11872955	3'Flank	novel		0.21
CESC	chr16	11872796	3'Flank	novel		0.2
CESC	chr16	11886873	Nonsense_Mutation	novel	R201delinsTYE*	0.06
CESC	chr16	11896742	Silent	novel	E22E	0.36
CESC	chr16	11877487	Missense_Mutation	NA	E370K	0.52
COAD	chr16	11885230	Missense_Mutation	rs200641745	N295S	0.43
COAD	chr16	11886923	Silent	NA	S184S	0.09
COAD	chr16	11886583	Missense_Mutation	NA	P243S	0.17
COAD	chr16	11887682	Missense_Mutation	rs767004325	R144H	0.03
DLBC	chr16	11915526	Intron	novel		0.22
GBM	chr16	11876135	Missense_Mutation	novel	Y410C	0.15	PAM2
GBM	chr16	11872963	3'Flank	novel		0.5
GBM	chr16	11886821	Silent	novel	L218L	0.03
HNSC	chr16	11875842	Missense_Mutation	novel	R456C	0.31	PAM2
HNSC	chr16	11887571	Missense_Mutation	novel	L181R	0.12
HNSC	chr16	11915898	Intron	novel		0.11
KIRC	chr16	11877544	Missense_Mutation	NA	V351I	0.27
KIRP	chr16	11886518	Silent	novel	L264L	0.23
LAML	chr16	11887656	Missense_Mutation	novel	H153Y	0.23
LGG	chr16	11887731	Frame_Shift_Ins	novel	*D128Rfs11**	0.26
LGG	chr16	11887644	Missense_Mutation	novel	L157I	0.08
LIHC	chr16	11887621	Silent	novel	S164S	0.41
LIHC	chr16	11898003	5'UTR	novel		0.28
LIHC	chr16	11897876	Splice_Site	novel		0.34
LUAD	chr16	11916065	5'UTR	novel		0.16
LUAD	chr16	11916051	5'UTR	novel		0.14
LUAD	chr16	11915862	Intron	novel		0.25
LUAD	chr16	11916072	5'UTR	novel		0.5
LUAD	chr16	11915910	Intron	rs753594316		0.19
LUSC	chr16	11915710	Intron	novel		1
LUSC	chr16	11876146	Silent	novel	I406I	0.05
LUSC	chr16	11916068	5'UTR	novel		0.65
LUSC	chr16	11885256	Silent	rs773228071	P286P	0.37
OV	chr16	11887584	Missense_Mutation	novel	D177H	0.04
OV	chr16	11897854	Missense_Mutation	NA	L3R	0.27
OV	chr16	11896610	Silent	NA	P66P	0.2
PAAD	chr16	11873159	Missense_Mutation	novel	A487V	0.15
PAAD	chr16	11896727	Silent	novel	I27I	0.24
READ	chr16	11891064	Splice_Region	novel	T120T	0.27
READ	chr16	11896637	Silent	novel	I57I	0.18
READ	chr16	11877575	Silent	rs377596394	N340N	0.15
SARC	chr16	11915824	Intron	novel		0.52
SKCM	chr16	11896636	Missense_Mutation	novel	P58S	0.42
SKCM	chr16	11896637	Silent	novel	I57I	0.42
SKCM	chr16	11875904	Missense_Mutation	NA	K435T	0.16	PAM2
SKCM	chr16	11886475	Missense_Mutation	NA	Y279N	0.32
SKCM	chr16	11916050	5'UTR	novel		0.35
SKCM	chr16	11896604	Silent	novel	G68G	0.36
SKCM	chr16	11876152	Silent	NA	S404S	0.27
SKCM	chr16	11916045	5'UTR	novel		0.3
SKCM	chr16	11916047	5'UTR	novel		0.34
SKCM	chr16	11873154	Missense_Mutation	NA	G489R	0.35
SKCM	chr16	11885183	Missense_Mutation	novel	K311E	0.4
STAD	chr16	11875903	Frame_Shift_Del	novel	*K435Nfs23**	0.22	PAM2
STAD	chr16	11876121	Frame_Shift_Del	novel	*V413Yfs6**	0.09	PAM2
STAD	chr16	11915870	Intron	novel		0.19
STAD	chr16	11885266	Missense_Mutation	NA	P283L	0.31
TGCT	chr16	11896682	Silent	novel	P42P	0.34
THCA	chr16	11915921	Intron	rs760668891		0.2
UCEC	chr16	11886593	Silent	NA	E239E	0.27
UCEC	chr16	11887611	Missense_Mutation	novel	N168Y	0.14
UCEC	chr16	11876129	Missense_Mutation	novel	A412V	0.32	PAM2
UCEC	chr16	11887666	Silent	rs201942282	T149T	0.45
UCEC	chr16	11887679	Missense_Mutation	NA	A145V	0.17
UCEC	chr16	11873091	3'Flank	novel		0.04
UCEC	chr16	11891099	Missense_Mutation	novel	Y109H	0.05
UCEC	chr16	11896732	Missense_Mutation	NA	E26K	0.39
UCEC	chr16	11897885	Splice_Region	novel		0.41
UCEC	chr16	11891105	Missense_Mutation	NA	E107Q	0.29
UCEC	chr16	11872766	3'Flank	novel		0.2
UCEC	chr16	11886491	Silent	rs773760465	S273S	0.33
UCEC	chr16	11891123	Missense_Mutation	novel	V101I	0.23
UCEC	chr16	11872820	3'Flank	novel		0.3
UCEC	chr16	11891109	Silent	novel	T105T	0.31
UCEC	chr16	11872759	3'Flank	novel		0.5
UCEC	chr16	11886604	Nonsense_Mutation	novel	E236*	0.31
UCEC	chr16	11872670	3'Flank	novel		0.5
UCEC	chr16	11885203	Missense_Mutation	NA	L304P	0.25
UCEC	chr16	11877551	Silent	novel	S348S	0.42
UCEC	chr16	11872696	3'Flank	novel		0.23
UCEC	chr16	11872739	3'Flank	novel		0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.1111	0.23475

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0011	Kaplan-Meier Survival Analysis
SARC	0.014	Kaplan-Meier Survival Analysis
MESO	0.0002	Kaplan-Meier Survival Analysis
SKCM	0.03	Kaplan-Meier Survival Analysis
COAD	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.0031	Kaplan-Meier Survival Analysis
READ	0.00021	Kaplan-Meier Survival Analysis
LIHC	0.0054	Kaplan-Meier Survival Analysis
UVM	0.025	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742