EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000103356 (Gene tree)
Gene ID: 124454
Gene Symbol: EARS2
Alias: KIAA1970|MSE1
Full Name: glutamyl-tRNA synthetase 2, mitochondrial
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 35,719 bases
Position: chr16:23,522,013-23,557,731
Accession: 29419
RBP type: canonical RBP
Summary: This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000457107	tRNA-synt_1c	PF00749.21	3.1e-87	1	1
ENSP00000395196	tRNA-synt_1c	PF00749.21	3.4e-87	1	1
ENSP00000456467	tRNA-synt_1c	PF00749.21	3.4e-87	1	1
ENSP00000456218	tRNA-synt_1c	PF00749.21	3.7e-87	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
15078106	The tRNA-interacting factor p43 associates with mammalian arginyl-tRNA synthetase but does not modify its tRNA aminoacylation properties.	Biochemistry	2004 Apr 20	Guigou L	-
15667228	Role of Arc1p in the modulation of yeast glutamyl-tRNA synthetase activity.	Biochemistry	2005 Feb 1	Graindorge JS	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000565344	EARS2-216	550	-	-	- (aa)	-	-
ENST00000562402	EARS2-203	580	-	-	- (aa)	-	-
ENST00000564776	EARS2-213	290	-	-	- (aa)	-	-
ENST00000449606	EARS2-201	3961	-	ENSP00000395196	523 (aa)	-	Q5JPH6
ENST00000564997	EARS2-215	572	-	ENSP00000455875	79 (aa)	-	H3BQP8
ENST00000564668	EARS2-211	627	-	ENSP00000455789	99 (aa)	-	H3BQI0
ENST00000563499	EARS2-208	556	-	ENSP00000458604	112 (aa)	-	I3L166
ENST00000563232	EARS2-206	1709	-	ENSP00000456218	534 (aa)	-	Q5JPH6
ENST00000562799	EARS2-205	559	-	-	- (aa)	-	-
ENST00000564987	EARS2-214	2870	-	-	- (aa)	-	-
ENST00000564759	EARS2-212	599	-	-	- (aa)	-	-
ENST00000562581	EARS2-204	533	-	ENSP00000455519	54 (aa)	-	H3BPY3
ENST00000566017	EARS2-217	539	-	-	- (aa)	-	-
ENST00000563459	EARS2-207	3840	XM_011545738	ENSP00000456467	523 (aa)	XP_011544040	Q5JPH6
ENST00000564501	EARS2-210	2027	-	ENSP00000457107	506 (aa)	-	H3BTB7
ENST00000561859	EARS2-202	518	-	-	- (aa)	-	-
ENST00000564461	EARS2-209	675	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000103356's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00860	Porphyrin and chlorophyll metabolism	KEGG
hsa00970	Aminoacyl-tRNA biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000103356's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000103356	EARS2	93	63.918	ENSAPOG00000003634	zgc:153247	89	63.918	Acanthochromis_polyacanthus
ENSG00000103356	EARS2	100	87.380	ENSAMEG00000014339	EARS2	97	88.189	Ailuropoda_melanoleuca
ENSG00000103356	EARS2	92	62.607	ENSACIG00000023608	zgc:153247	89	62.607	Amphilophus_citrinellus
ENSG00000103356	EARS2	93	64.330	ENSAOCG00000012957	zgc:153247	89	64.330	Amphiprion_ocellaris
ENSG00000103356	EARS2	93	64.330	ENSAPEG00000010160	zgc:153247	89	64.330	Amphiprion_percula
ENSG00000103356	EARS2	95	63.052	ENSATEG00000005214	zgc:153247	92	63.052	Anabas_testudineus
ENSG00000103356	EARS2	56	75.000	ENSACAG00000011852	EARS2	100	75.000	Anolis_carolinensis
ENSG00000103356	EARS2	100	91.969	ENSANAG00000005585	EARS2	100	91.969	Aotus_nancymaae
ENSG00000103356	EARS2	93	64.742	ENSACLG00000005434	zgc:153247	89	64.742	Astatotilapia_calliptera
ENSG00000103356	EARS2	93	59.631	ENSAMXG00000010705	zgc:153247	92	59.631	Astyanax_mexicanus
ENSG00000103356	EARS2	100	86.424	ENSBTAG00000045593	EARS2	96	87.598	Bos_taurus
ENSG00000103356	EARS2	92	38.351	WBGene00001338	ears-2	97	38.351	Caenorhabditis_elegans
ENSG00000103356	EARS2	100	92.292	ENSCJAG00000020611	EARS2	100	92.292	Callithrix_jacchus
ENSG00000103356	EARS2	100	85.878	ENSCAFG00000017673	EARS2	98	86.497	Canis_familiaris
ENSG00000103356	EARS2	100	86.233	ENSCAFG00020021370	EARS2	98	86.863	Canis_lupus_dingo
ENSG00000103356	EARS2	100	86.042	ENSCHIG00000022512	EARS2	95	87.008	Capra_hircus
ENSG00000103356	EARS2	99	89.464	ENSTSYG00000013319	EARS2	99	89.464	Carlito_syrichta
ENSG00000103356	EARS2	87	75.510	ENSCAPG00000015400	EARS2	92	75.724	Cavia_aperea
ENSG00000103356	EARS2	100	85.851	ENSCPOG00000006866	EARS2	97	87.723	Cavia_porcellus
ENSG00000103356	EARS2	100	93.281	ENSCCAG00000027770	EARS2	100	93.281	Cebus_capucinus
ENSG00000103356	EARS2	100	94.455	ENSCATG00000007725	EARS2	100	94.455	Cercocebus_atys
ENSG00000103356	EARS2	100	85.468	ENSCLAG00000010779	EARS2	97	86.811	Chinchilla_lanigera
ENSG00000103356	EARS2	100	94.646	ENSCSAG00000006802	EARS2	100	94.646	Chlorocebus_sabaeus
ENSG00000103356	EARS2	91	70.378	ENSCHOG00000000416	EARS2	100	70.378	Choloepus_hoffmanni
ENSG00000103356	EARS2	94	69.450	ENSCPBG00000002203	EARS2	94	69.450	Chrysemys_picta_bellii
ENSG00000103356	EARS2	93	44.882	ENSCING00000002621	-	93	44.882	Ciona_intestinalis
ENSG00000103356	EARS2	93	42.944	ENSCSAVG00000009646	-	99	42.944	Ciona_savignyi
ENSG00000103356	EARS2	97	95.285	ENSCANG00000025933	EARS2	97	95.285	Colobus_angolensis_palliatus
ENSG00000103356	EARS2	100	84.130	ENSCGRG00001008031	Ears2	96	84.872	Cricetulus_griseus_chok1gshd
ENSG00000103356	EARS2	100	84.130	ENSCGRG00000017645	Ears2	96	84.872	Cricetulus_griseus_crigri
ENSG00000103356	EARS2	94	50.304	ENSCSEG00000020916	zgc:153247	94	50.304	Cynoglossus_semilaevis
ENSG00000103356	EARS2	97	62.327	ENSCVAG00000014815	zgc:153247	92	62.327	Cyprinodon_variegatus
ENSG00000103356	EARS2	93	60.206	ENSDARG00000103099	EARS2	96	60.206	Danio_rerio
ENSG00000103356	EARS2	98	82.549	ENSDNOG00000042899	EARS2	100	82.027	Dasypus_novemcinctus
ENSG00000103356	EARS2	100	85.468	ENSDORG00000001402	Ears2	97	86.614	Dipodomys_ordii
ENSG00000103356	EARS2	93	48.185	FBgn0036629	GluRS-m	95	48.185	Drosophila_melanogaster
ENSG00000103356	EARS2	69	86.164	ENSETEG00000013495	-	67	90.909	Echinops_telfairi
ENSG00000103356	EARS2	90	47.253	ENSEBUG00000004342	zgc:153247	95	46.652	Eptatretus_burgeri
ENSG00000103356	EARS2	100	87.380	ENSEASG00005017631	EARS2	98	87.843	Equus_asinus_asinus
ENSG00000103356	EARS2	100	87.763	ENSECAG00000014955	EARS2	98	88.235	Equus_caballus
ENSG00000103356	EARS2	97	83.104	ENSEEUG00000002443	EARS2	97	83.104	Erinaceus_europaeus
ENSG00000103356	EARS2	93	59.267	ENSELUG00000020736	zgc:153247	84	59.267	Esox_lucius
ENSG00000103356	EARS2	100	87.572	ENSFCAG00000005178	EARS2	98	88.039	Felis_catus
ENSG00000103356	EARS2	93	67.695	ENSFALG00000003828	EARS2	96	67.695	Ficedula_albicollis
ENSG00000103356	EARS2	92	86.335	ENSFDAG00000010868	EARS2	96	86.335	Fukomys_damarensis
ENSG00000103356	EARS2	98	60.687	ENSFHEG00000013890	zgc:153247	98	60.944	Fundulus_heteroclitus
ENSG00000103356	EARS2	92	64.389	ENSGMOG00000017453	zgc:153247	99	64.389	Gadus_morhua
ENSG00000103356	EARS2	94	68.826	ENSGALG00000006122	EARS2	98	68.826	Gallus_gallus
ENSG00000103356	EARS2	93	64.536	ENSGAFG00000011088	zgc:153247	89	64.536	Gambusia_affinis
ENSG00000103356	EARS2	97	60.980	ENSGACG00000019531	zgc:153247	94	62.603	Gasterosteus_aculeatus
ENSG00000103356	EARS2	96	67.723	ENSGAGG00000009428	EARS2	96	67.723	Gopherus_agassizii
ENSG00000103356	EARS2	88	97.222	ENSGGOG00000007365	-	100	97.222	Gorilla_gorilla
ENSG00000103356	EARS2	93	64.536	ENSHBUG00000006503	zgc:153247	89	64.536	Haplochromis_burtoni
ENSG00000103356	EARS2	100	85.277	ENSHGLG00000018646	EARS2	97	86.220	Heterocephalus_glaber_female
ENSG00000103356	EARS2	100	83.174	ENSHGLG00100012460	EARS2	96	86.939	Heterocephalus_glaber_male
ENSG00000103356	EARS2	95	64.056	ENSHCOG00000020966	zgc:153247	91	64.056	Hippocampus_comes
ENSG00000103356	EARS2	93	57.906	ENSIPUG00000013399	ears2	84	57.906	Ictalurus_punctatus
ENSG00000103356	EARS2	100	87.954	ENSSTOG00000023825	EARS2	98	88.824	Ictidomys_tridecemlineatus
ENSG00000103356	EARS2	100	84.321	ENSJJAG00000008606	Ears2	97	86.139	Jaculus_jaculus
ENSG00000103356	EARS2	93	62.887	ENSKMAG00000009867	zgc:153247	89	62.887	Kryptolebias_marmoratus
ENSG00000103356	EARS2	93	62.474	ENSLBEG00000009775	zgc:153247	92	62.474	Labrus_bergylta
ENSG00000103356	EARS2	98	65.184	ENSLACG00000000935	EARS2	89	67.006	Latimeria_chalumnae
ENSG00000103356	EARS2	99	62.619	ENSLOCG00000004065	zgc:153247	86	65.914	Lepisosteus_oculatus
ENSG00000103356	EARS2	100	86.424	ENSLAFG00000001027	EARS2	97	87.795	Loxodonta_africana
ENSG00000103356	EARS2	100	94.264	ENSMFAG00000045825	EARS2	100	94.264	Macaca_fascicularis
ENSG00000103356	EARS2	98	94.153	ENSMMUG00000020525	EARS2	96	94.153	Macaca_mulatta
ENSG00000103356	EARS2	100	94.073	ENSMNEG00000028490	EARS2	100	94.073	Macaca_nemestrina
ENSG00000103356	EARS2	100	94.837	ENSMLEG00000031859	EARS2	100	94.837	Mandrillus_leucophaeus
ENSG00000103356	EARS2	93	65.773	ENSMAMG00000006541	zgc:153247	92	65.773	Mastacembelus_armatus
ENSG00000103356	EARS2	93	64.536	ENSMZEG00005013831	zgc:153247	89	64.536	Maylandia_zebra
ENSG00000103356	EARS2	91	67.992	ENSMGAG00000006567	EARS2	92	67.635	Meleagris_gallopavo
ENSG00000103356	EARS2	81	84.434	ENSMAUG00000012883	Ears2	99	84.434	Mesocricetus_auratus
ENSG00000103356	EARS2	100	88.337	ENSMICG00000007745	EARS2	98	88.337	Microcebus_murinus
ENSG00000103356	EARS2	100	83.748	ENSMOCG00000012928	Ears2	97	84.872	Microtus_ochrogaster
ENSG00000103356	EARS2	93	59.588	ENSMMOG00000011306	zgc:153247	95	59.588	Mola_mola
ENSG00000103356	EARS2	57	66.667	ENSMODG00000011839	-	100	66.667	Monodelphis_domestica
ENSG00000103356	EARS2	100	76.571	ENSMODG00000006745	-	93	79.508	Monodelphis_domestica
ENSG00000103356	EARS2	93	63.299	ENSMALG00000009275	zgc:153247	89	63.299	Monopterus_albus
ENSG00000103356	EARS2	100	84.895	MGP_CAROLIEiJ_G0030414	Ears2	97	85.996	Mus_caroli
ENSG00000103356	EARS2	100	85.086	ENSMUSG00000030871	Ears2	97	86.193	Mus_musculus
ENSG00000103356	EARS2	100	85.086	MGP_PahariEiJ_G0013624	Ears2	97	86.193	Mus_pahari
ENSG00000103356	EARS2	100	85.086	MGP_SPRETEiJ_G0031528	Ears2	97	86.193	Mus_spretus
ENSG00000103356	EARS2	100	86.616	ENSMPUG00000012116	EARS2	97	87.402	Mustela_putorius_furo
ENSG00000103356	EARS2	100	85.086	ENSMLUG00000012120	EARS2	98	85.490	Myotis_lucifugus
ENSG00000103356	EARS2	100	85.086	ENSNGAG00000004141	Ears2	98	85.855	Nannospalax_galili
ENSG00000103356	EARS2	93	63.711	ENSNBRG00000007510	zgc:153247	89	63.711	Neolamprologus_brichardi
ENSG00000103356	EARS2	96	88.462	ENSNLEG00000012054	-	85	97.465	Nomascus_leucogenys
ENSG00000103356	EARS2	80	81.390	ENSMEUG00000015505	EARS2	100	81.390	Notamacropus_eugenii
ENSG00000103356	EARS2	100	85.086	ENSOPRG00000011980	EARS2	98	86.391	Ochotona_princeps
ENSG00000103356	EARS2	100	83.174	ENSODEG00000014346	EARS2	97	84.449	Octodon_degus
ENSG00000103356	EARS2	93	64.330	ENSONIG00000003867	zgc:153247	95	64.330	Oreochromis_niloticus
ENSG00000103356	EARS2	86	73.165	ENSOANG00000009665	EARS2	92	73.165	Ornithorhynchus_anatinus
ENSG00000103356	EARS2	96	86.853	ENSOCUG00000008434	EARS2	96	86.853	Oryctolagus_cuniculus
ENSG00000103356	EARS2	93	61.864	ENSORLG00000010051	zgc:153247	98	62.156	Oryzias_latipes
ENSG00000103356	EARS2	95	61.694	ENSORLG00020009785	zgc:153247	99	61.694	Oryzias_latipes_hni
ENSG00000103356	EARS2	96	62.425	ENSORLG00015009164	zgc:153247	91	62.425	Oryzias_latipes_hsok
ENSG00000103356	EARS2	93	64.536	ENSOMEG00000018724	zgc:153247	89	64.536	Oryzias_melastigma
ENSG00000103356	EARS2	100	87.763	ENSOGAG00000001074	EARS2	100	87.763	Otolemur_garnettii
ENSG00000103356	EARS2	100	86.233	ENSOARG00000017122	EARS2	95	87.402	Ovis_aries
ENSG00000103356	EARS2	100	99.044	ENSPPAG00000028179	EARS2	100	99.044	Pan_paniscus
ENSG00000103356	EARS2	100	87.572	ENSPPRG00000022131	EARS2	98	88.039	Panthera_pardus
ENSG00000103356	EARS2	100	87.763	ENSPTIG00000020509	EARS2	98	88.235	Panthera_tigris_altaica
ENSG00000103356	EARS2	100	99.044	ENSPTRG00000007887	EARS2	100	99.044	Pan_troglodytes
ENSG00000103356	EARS2	100	94.646	ENSPANG00000015102	EARS2	100	94.646	Papio_anubis
ENSG00000103356	EARS2	93	62.140	ENSPKIG00000002340	zgc:153247	88	62.140	Paramormyrops_kingsleyae
ENSG00000103356	EARS2	93	66.053	ENSPSIG00000006509	EARS2	100	66.667	Pelodiscus_sinensis
ENSG00000103356	EARS2	93	62.500	ENSPMGG00000020747	zgc:153247	88	62.500	Periophthalmus_magnuspinnatus
ENSG00000103356	EARS2	100	84.704	ENSPEMG00000010930	Ears2	97	85.462	Peromyscus_maniculatus_bairdii
ENSG00000103356	EARS2	93	79.098	ENSPCIG00000026595	-	62	79.098	Phascolarctos_cinereus
ENSG00000103356	EARS2	93	64.124	ENSPFOG00000013117	zgc:153247	89	64.124	Poecilia_formosa
ENSG00000103356	EARS2	93	64.124	ENSPLAG00000006366	zgc:153247	89	64.124	Poecilia_latipinna
ENSG00000103356	EARS2	93	64.330	ENSPMEG00000007681	zgc:153247	87	64.330	Poecilia_mexicana
ENSG00000103356	EARS2	93	63.918	ENSPREG00000013860	zgc:153247	90	63.918	Poecilia_reticulata
ENSG00000103356	EARS2	100	98.279	ENSPPYG00000007190	EARS2	100	98.279	Pongo_abelii
ENSG00000103356	EARS2	99	79.310	ENSPCAG00000010280	EARS2	99	79.310	Procavia_capensis
ENSG00000103356	EARS2	100	88.337	ENSPCOG00000022897	EARS2	100	88.337	Propithecus_coquereli
ENSG00000103356	EARS2	97	83.071	ENSPVAG00000008432	EARS2	100	82.792	Pteropus_vampyrus
ENSG00000103356	EARS2	93	64.536	ENSPNYG00000007588	zgc:153247	89	64.536	Pundamilia_nyererei
ENSG00000103356	EARS2	95	53.427	ENSPNAG00000001508	zgc:153247	98	56.823	Pygocentrus_nattereri
ENSG00000103356	EARS2	100	84.895	ENSRNOG00000025353	Ears2	97	86.220	Rattus_norvegicus
ENSG00000103356	EARS2	100	94.837	ENSRBIG00000024034	EARS2	100	94.837	Rhinopithecus_bieti
ENSG00000103356	EARS2	100	94.455	ENSRROG00000033969	EARS2	100	94.455	Rhinopithecus_roxellana
ENSG00000103356	EARS2	92	36.546	YOL033W	MSE1	90	36.327	Saccharomyces_cerevisiae
ENSG00000103356	EARS2	100	91.969	ENSSBOG00000030889	EARS2	100	91.969	Saimiri_boliviensis_boliviensis
ENSG00000103356	EARS2	91	78.197	ENSSHAG00000006329	EARS2	100	78.197	Sarcophilus_harrisii
ENSG00000103356	EARS2	91	55.042	ENSSFOG00015019361	zgc:153247	99	55.042	Scleropages_formosus
ENSG00000103356	EARS2	93	65.567	ENSSMAG00000021255	zgc:153247	90	65.567	Scophthalmus_maximus
ENSG00000103356	EARS2	93	65.567	ENSSDUG00000014030	zgc:153247	90	65.567	Seriola_dumerili
ENSG00000103356	EARS2	92	64.530	ENSSLDG00000007194	zgc:153247	92	64.530	Seriola_lalandi_dorsalis
ENSG00000103356	EARS2	100	69.025	ENSSARG00000002939	EARS2	98	69.625	Sorex_araneus
ENSG00000103356	EARS2	97	68.279	ENSSPUG00000010271	EARS2	98	68.279	Sphenodon_punctatus
ENSG00000103356	EARS2	93	64.124	ENSSPAG00000011636	zgc:153247	89	64.124	Stegastes_partitus
ENSG00000103356	EARS2	100	85.851	ENSSSCG00000010797	EARS2	100	87.209	Sus_scrofa
ENSG00000103356	EARS2	92	67.360	ENSTGUG00000006015	EARS2	100	67.360	Taeniopygia_guttata
ENSG00000103356	EARS2	93	58.557	ENSTRUG00000015357	zgc:153247	92	58.557	Takifugu_rubripes
ENSG00000103356	EARS2	93	62.268	ENSTNIG00000008248	zgc:153247	93	62.268	Tetraodon_nigroviridis
ENSG00000103356	EARS2	100	77.438	ENSTBEG00000006202	EARS2	98	78.193	Tupaia_belangeri
ENSG00000103356	EARS2	100	87.572	ENSTTRG00000005252	EARS2	98	88.235	Tursiops_truncatus
ENSG00000103356	EARS2	96	73.077	ENSUAMG00000016907	-	90	78.431	Ursus_americanus
ENSG00000103356	EARS2	98	87.475	ENSUMAG00000008941	EARS2	97	81.421	Ursus_maritimus
ENSG00000103356	EARS2	100	86.042	ENSVVUG00000006049	EARS2	98	86.667	Vulpes_vulpes
ENSG00000103356	EARS2	96	63.473	ENSXETG00000012433	ears2	96	63.473	Xenopus_tropicalis
ENSG00000103356	EARS2	93	64.124	ENSXCOG00000015986	zgc:153247	89	64.124	Xiphophorus_couchianus
ENSG00000103356	EARS2	93	63.918	ENSXMAG00000014857	zgc:153247	89	63.918	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	-	IEA	Function
GO:0004818	glutamate-tRNA ligase activity	21873635.	IBA	Function
GO:0004818	glutamate-tRNA ligase activity	19805282.	IDA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005739	mitochondrion	19805282.	IDA	Component
GO:0005759	mitochondrial matrix	-	IEA	Component
GO:0006424	glutamyl-tRNA aminoacylation	21873635.	IBA	Process
GO:0006424	glutamyl-tRNA aminoacylation	19805282.	IDA	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0050561	glutamate-tRNA(Gln) ligase activity	19805282.	IDA	Function
GO:0070127	tRNA aminoacylation for mitochondrial protein translation	19805282.	IDA	Process