EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000103495 (Gene tree)
Gene ID: 4150
Gene Symbol: MAZ
Alias: ZF87|Pur-1|Zif87|ZNF801
Full Name: MYC associated zinc finger protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 5,101 bases
Position: chr16:29,806,083-29,811,183
Accession: 6914
RBP type: canonical RBP
Summary: (MYC Associated Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is VEZF1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000219782	zf-C2H2	PF00096.26	2.8e-25	1	2
ENSP00000219782	zf-C2H2	PF00096.26	2.8e-25	2	2
ENSP00000443956	zf-C2H2	PF00096.26	1.6e-19	1	2
ENSP00000443956	zf-C2H2	PF00096.26	1.6e-19	2	2
ENSP00000313362	zf-C2H2	PF00096.26	2.4e-19	1	2
ENSP00000313362	zf-C2H2	PF00096.26	2.4e-19	2	2
ENSP00000460057	zf-C2H2	PF00096.26	1e-17	1	4
ENSP00000460057	zf-C2H2	PF00096.26	1e-17	2	4
ENSP00000460057	zf-C2H2	PF00096.26	1e-17	3	4
ENSP00000460057	zf-C2H2	PF00096.26	1e-17	4	4
ENSP00000480440	zf-C2H2	PF00096.26	1.1e-17	1	3
ENSP00000480440	zf-C2H2	PF00096.26	1.1e-17	2	3
ENSP00000480440	zf-C2H2	PF00096.26	1.1e-17	3	3
ENSP00000455794	zf-C2H2	PF00096.26	7.3e-11	1	2
ENSP00000455794	zf-C2H2	PF00096.26	7.3e-11	2	2
ENSP00000461630	zf-C2H2	PF00096.26	9.9e-06	1	1
ENSP00000458201	zf-C2H2	PF00096.26	2.3e-05	1	1
ENSP00000219782	zf-met	PF12874.7	3.1e-08	1	1
ENSP00000458201	zf-met	PF12874.7	2.7e-07	1	2
ENSP00000458201	zf-met	PF12874.7	2.7e-07	2	2
ENSP00000461630	zf-met	PF12874.7	2.1e-06	1	2
ENSP00000461630	zf-met	PF12874.7	2.1e-06	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22198906	Loss-of-function thrombospondin-1 mutations in familial pulmonary hypertension.	Am J Physiol Lung Cell Mol Physiol	2012 Mar 15	Maloney JP	doi: 10.1152/ajplung.00282.2011

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000616501	MAZ-216	991	-	ENSP00000480440	252 (aa)	-	A0A087WWR2
ENST00000568544	MAZ-214	1464	-	ENSP00000455473	78 (aa)	-	H3BPU3
ENST00000568411	MAZ-213	599	-	ENSP00000455794	196 (aa)	-	H3BQI4
ENST00000545521	MAZ-203	2333	-	ENSP00000443956	454 (aa)	-	P56270
ENST00000322945	MAZ-202	2532	-	ENSP00000313362	477 (aa)	-	P56270
ENST00000567444	MAZ-211	635	-	ENSP00000460057	202 (aa)	-	I3L2Z5
ENST00000562557	MAZ-206	475	-	ENSP00000461630	78 (aa)	-	I3L4Y2
ENST00000561855	MAZ-204	672	-	ENSP00000456179	84 (aa)	-	H3BRC5
ENST00000568282	MAZ-212	1593	-	ENSP00000458201	94 (aa)	-	I3L0M3
ENST00000562337	MAZ-205	1574	-	ENSP00000455726	172 (aa)	-	P56270
ENST00000563012	MAZ-207	646	-	ENSP00000455913	152 (aa)	-	H3BQS2
ENST00000219782	MAZ-201	2698	XM_006721047	ENSP00000219782	493 (aa)	XP_006721110	P56270
ENST00000566906	MAZ-210	1455	-	ENSP00000461174	184 (aa)	-	I3L4D3
ENST00000565777	MAZ-209	1313	-	-	- (aa)	-	-
ENST00000563402	MAZ-208	1461	-	ENSP00000457310	186 (aa)	-	H3BTS8
ENST00000569978	MAZ-215	567	-	ENSP00000460877	53 (aa)	-	I3L411

Gene Model

Click here to download ENSG00000103495's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000103495	Multiple Sclerosis	5E-7	27386562

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000103495	rs34286592	16	29809159	T	Multiple sclerosis	27386562	[1.09-1.23]	1.16	EFO_0003885

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000103495's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000103495	MAZ	80	38.298	ENSG00000169957	ZNF768	57	37.662

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000103495	MAZ	100	85.897	ENSANAG00000037536	-	100	88.542	Aotus_nancymaae
ENSG00000103495	MAZ	100	100.000	ENSANAG00000036195	-	100	93.927	Aotus_nancymaae
ENSG00000103495	MAZ	100	100.000	ENSBTAG00000052323	MAZ	100	99.394	Bos_taurus
ENSG00000103495	MAZ	100	100.000	ENSCJAG00000007189	MAZ	100	99.798	Callithrix_jacchus
ENSG00000103495	MAZ	100	100.000	ENSCAFG00000016964	MAZ	100	97.902	Canis_familiaris
ENSG00000103495	MAZ	100	100.000	ENSCAFG00020017751	MAZ	100	99.192	Canis_lupus_dingo
ENSG00000103495	MAZ	100	100.000	ENSCHIG00000020711	MAZ	100	99.394	Capra_hircus
ENSG00000103495	MAZ	100	100.000	ENSTSYG00000026702	-	100	100.000	Carlito_syrichta
ENSG00000103495	MAZ	100	100.000	ENSCAPG00000006391	-	100	100.000	Cavia_aperea
ENSG00000103495	MAZ	100	100.000	ENSCCAG00000037524	MAZ	100	100.000	Cebus_capucinus
ENSG00000103495	MAZ	100	100.000	ENSCATG00000033033	MAZ	100	100.000	Cercocebus_atys
ENSG00000103495	MAZ	100	100.000	ENSCLAG00000010257	-	100	100.000	Chinchilla_lanigera
ENSG00000103495	MAZ	100	98.936	ENSCSAG00000006110	MAZ	100	99.628	Chlorocebus_sabaeus
ENSG00000103495	MAZ	96	84.000	ENSCPBG00000012768	-	93	74.444	Chrysemys_picta_bellii
ENSG00000103495	MAZ	100	98.936	ENSCANG00000035162	MAZ	100	99.621	Colobus_angolensis_palliatus
ENSG00000103495	MAZ	100	100.000	ENSCGRG00001008879	Maz	100	98.174	Cricetulus_griseus_chok1gshd
ENSG00000103495	MAZ	100	100.000	ENSCGRG00000014850	-	100	99.526	Cricetulus_griseus_crigri
ENSG00000103495	MAZ	76	78.431	ENSCVAG00000015597	si:ch211-166g5.4	52	78.947	Cyprinodon_variegatus
ENSG00000103495	MAZ	96	60.526	ENSDARG00000063555	si:ch211-166g5.4	86	77.778	Danio_rerio
ENSG00000103495	MAZ	100	100.000	ENSEASG00005013172	MAZ	100	98.990	Equus_asinus_asinus
ENSG00000103495	MAZ	100	100.000	ENSECAG00000024341	MAZ	100	98.990	Equus_caballus
ENSG00000103495	MAZ	76	77.778	ENSELUG00000022514	si:ch211-166g5.4	77	77.419	Esox_lucius
ENSG00000103495	MAZ	100	100.000	ENSFCAG00000014146	MAZ	100	99.192	Felis_catus
ENSG00000103495	MAZ	71	98.507	ENSFDAG00000010852	-	100	74.408	Fukomys_damarensis
ENSG00000103495	MAZ	82	80.714	ENSFHEG00000000918	MAZ	91	80.714	Fundulus_heteroclitus
ENSG00000103495	MAZ	96	69.737	ENSGALG00000049721	-	64	69.737	Gallus_gallus
ENSG00000103495	MAZ	76	79.085	ENSGAFG00000000293	si:ch211-166g5.4	57	79.605	Gambusia_affinis
ENSG00000103495	MAZ	82	72.989	ENSGACG00000014840	maza	89	67.257	Gasterosteus_aculeatus
ENSG00000103495	MAZ	96	84.000	ENSGAGG00000008124	MAZ	97	81.538	Gopherus_agassizii
ENSG00000103495	MAZ	100	100.000	ENSGGOG00000042750	-	100	100.000	Gorilla_gorilla
ENSG00000103495	MAZ	100	97.436	ENSHGLG00000011024	-	96	82.576	Heterocephalus_glaber_female
ENSG00000103495	MAZ	100	98.936	ENSHGLG00000018743	-	100	98.106	Heterocephalus_glaber_female
ENSG00000103495	MAZ	94	85.526	ENSHGLG00100017872	-	89	79.909	Heterocephalus_glaber_male
ENSG00000103495	MAZ	100	100.000	ENSSTOG00000027842	MAZ	100	99.242	Ictidomys_tridecemlineatus
ENSG00000103495	MAZ	100	100.000	ENSJJAG00000020922	-	100	98.864	Jaculus_jaculus
ENSG00000103495	MAZ	100	73.077	ENSLACG00000010161	MAZ	79	72.964	Latimeria_chalumnae
ENSG00000103495	MAZ	100	98.936	ENSMFAG00000040127	MAZ	100	99.621	Macaca_fascicularis
ENSG00000103495	MAZ	100	98.936	ENSMMUG00000019826	MAZ	98	83.641	Macaca_mulatta
ENSG00000103495	MAZ	100	98.936	ENSMNEG00000037329	MAZ	100	99.621	Macaca_nemestrina
ENSG00000103495	MAZ	100	98.936	ENSMLEG00000036147	-	100	98.936	Mandrillus_leucophaeus
ENSG00000103495	MAZ	76	79.739	ENSMAMG00000018743	-	72	80.263	Mastacembelus_armatus
ENSG00000103495	MAZ	100	100.000	ENSMAUG00000011903	Maz	100	96.901	Mesocricetus_auratus
ENSG00000103495	MAZ	100	100.000	ENSMICG00000030392	MAZ	100	99.594	Microcebus_murinus
ENSG00000103495	MAZ	100	100.000	ENSMOCG00000003611	Maz	100	97.912	Microtus_ochrogaster
ENSG00000103495	MAZ	100	100.000	ENSMUSG00000030678	Maz	100	98.377	Mus_musculus
ENSG00000103495	MAZ	100	100.000	MGP_PahariEiJ_G0013693	Maz	100	98.580	Mus_pahari
ENSG00000103495	MAZ	100	93.590	ENSMEUG00000009482	MAZ	99	76.171	Notamacropus_eugenii
ENSG00000103495	MAZ	100	100.000	ENSODEG00000014451	MAZ	100	99.242	Octodon_degus
ENSG00000103495	MAZ	78	94.937	ENSOANG00000004112	-	77	97.980	Ornithorhynchus_anatinus
ENSG00000103495	MAZ	100	100.000	ENSOARG00000005520	MAZ	99	93.231	Ovis_aries
ENSG00000103495	MAZ	100	100.000	ENSPPAG00000041571	-	76	97.561	Pan_paniscus
ENSG00000103495	MAZ	87	100.000	ENSPPRG00000011596	-	100	87.121	Panthera_pardus
ENSG00000103495	MAZ	100	100.000	ENSPPRG00000016750	-	100	94.929	Panthera_pardus
ENSG00000103495	MAZ	100	100.000	ENSPTIG00000007866	-	100	100.000	Panthera_tigris_altaica
ENSG00000103495	MAZ	100	100.000	ENSPTRG00000007968	MAZ	100	99.594	Pan_troglodytes
ENSG00000103495	MAZ	100	98.936	ENSPANG00000016381	-	100	99.621	Papio_anubis
ENSG00000103495	MAZ	78	79.114	ENSPKIG00000018202	-	80	70.183	Paramormyrops_kingsleyae
ENSG00000103495	MAZ	100	100.000	ENSPEMG00000008318	-	100	91.469	Peromyscus_maniculatus_bairdii
ENSG00000103495	MAZ	62	60.000	ENSPMAG00000004866	-	82	50.655	Petromyzon_marinus
ENSG00000103495	MAZ	85	72.414	ENSPFOG00000005397	si:ch211-166g5.4	52	79.605	Poecilia_formosa
ENSG00000103495	MAZ	76	80.132	ENSPLAG00000017219	si:ch211-166g5.4	77	80.667	Poecilia_latipinna
ENSG00000103495	MAZ	76	80.132	ENSPMEG00000017552	si:ch211-166g5.4	77	80.667	Poecilia_mexicana
ENSG00000103495	MAZ	86	71.676	ENSPREG00000023113	si:ch211-166g5.4	55	79.605	Poecilia_reticulata
ENSG00000103495	MAZ	100	100.000	ENSPPYG00000007260	-	100	100.000	Pongo_abelii
ENSG00000103495	MAZ	100	100.000	ENSPCOG00000022370	MAZ	100	99.594	Propithecus_coquereli
ENSG00000103495	MAZ	100	100.000	ENSPVAG00000017209	MAZ	79	100.000	Pteropus_vampyrus
ENSG00000103495	MAZ	85	71.930	ENSPNAG00000004042	si:ch211-166g5.4	85	67.532	Pygocentrus_nattereri
ENSG00000103495	MAZ	100	98.936	ENSRBIG00000001823	MAZ	100	99.621	Rhinopithecus_bieti
ENSG00000103495	MAZ	100	98.936	ENSRROG00000026952	MAZ	100	99.621	Rhinopithecus_roxellana
ENSG00000103495	MAZ	100	98.936	ENSSBOG00000020791	-	100	99.621	Saimiri_boliviensis_boliviensis
ENSG00000103495	MAZ	86	74.566	ENSSFOG00015021699	si:ch211-166g5.4	60	74.500	Scleropages_formosus
ENSG00000103495	MAZ	99	84.416	ENSSPUG00000010618	MAZ	100	69.604	Sphenodon_punctatus
ENSG00000103495	MAZ	100	100.000	ENSSSCG00000025321	MAZ	98	99.349	Sus_scrofa
ENSG00000103495	MAZ	100	100.000	ENSTTRG00000005420	MAZ	82	96.923	Tursiops_truncatus
ENSG00000103495	MAZ	100	100.000	ENSUAMG00000004622	MAZ	100	100.000	Ursus_americanus
ENSG00000103495	MAZ	100	100.000	ENSVVUG00000026097	MAZ	100	100.000	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	1502157.25487955.	IDA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	25487955.	IDA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	11527412.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	1502157.	IDA	Process
GO:0006369	termination of RNA polymerase II transcription	1502157.	IDA	Process
GO:0008284	positive regulation of cell proliferation	25487955.	IDA	Process
GO:0010628	positive regulation of gene expression	25487955.	IDA	Process
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	25487955.	IDA	Process
GO:0030335	positive regulation of cell migration	25487955.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	25487955.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051897	positive regulation of protein kinase B signaling	25487955.	IDA	Process
GO:2001234	negative regulation of apoptotic signaling pathway	25487955.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25487955	MiR-449a exerts tumor-suppressive functions in human glioblastoma by targeting Myc-associated zinc-finger protein.	Mol Oncol	2015 Mar	Yao Y	doi: 10.1016/j.molonc.2014.11.003
17902047	MAZ drives tumor-specific expression of PPAR gamma 1 in breast cancer cells.	Breast Cancer Res Treat	2008 Sep	Wang X	-
21665940	Control of VEGF expression in triple-negative breast carcinoma cells by suppression of SAF-1 transcription factor activity.	Mol Cancer Res	2011 Aug	Ray A	doi: 10.1158/1541-7786.MCR-10-0598
25449683	Induction of Ras by SAF-1/MAZ through a feed-forward loop promotes angiogenesis in breast cancer.	Cancer Med	2015 Feb	Ray A	doi: 10.1002/cam4.362
23609189	The prostate cancer-up-regulated Myc-associated zinc-finger protein (MAZ) modulates proliferation and metastasis through reciprocal regulation of androgen receptor.	Med Oncol	2013	Jiao L	doi: 10.1007/s12032-013-0570-3
28577976	Dual function of MAZ mediated by FOXF2 in basal-like breast cancer: Promotion of proliferation and suppression of progression.	Cancer Lett	2017 Aug 28	Yu ZH	doi: 10.1016/j.canlet.2017.05.020
29414775	The MAZ transcription factor is a downstream target of the oncoprotein Cyr61/CCN1 and promotes pancreatic cancer cell invasion via CRAF-ERK signaling.	J Biol Chem	2018 Mar 23	Maity G	doi: 10.1074/jbc.RA117.000333

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr16	29809568	Intron	novel		0.12
BLCA	chr16	29807385	Missense_Mutation	novel	K200N	0.24
BLCA	chr16	29807697	Silent	novel	E304E	0.19
BLCA	chr16	29807418	Silent	novel	I211I	0.32
BLCA	chr16	29807707	Nonsense_Mutation	novel	Q308*	0.38
BLCA	chr16	29808242	Silent	NA	L352L	0.23
BLCA	chr16	29807493	Silent	novel	L236L	0.29
BLCA	chr16	29806785	Missense_Mutation	novel	M28I	0.49
BLCA	chr16	29808254	Silent	novel	V356V	0.23
BLCA	chr16	29807751	Missense_Mutation	novel	M322I	0.1
BRCA	chr16	29808593	Silent	NA	T377T	0.52
BRCA	chr16	29807666	Missense_Mutation	novel	L294Q	0.11
BRCA	chr16	29810205	Nonsense_Mutation	NA	Q470*	0.39
BRCA	chr16	29809558	Intron	novel		0.19
BRCA	chr16	29810104	Missense_Mutation	rs746270470	A436V	0.67
BRCA	chr16	29808682	Missense_Mutation	NA	S407W	0.33
BRCA	chr16	29807849	Intron	NA		0.26
BRCA	chr16	29808242	Silent	NA	L352L	0.5
CESC	chr16	29808664	Frame_Shift_Del	novel	*L401Qfs21**	0.11
CESC	chr16	29810504	3'UTR	novel		0.35
CESC	chr16	29809646	Intron	novel		0.37
CESC	chr16	29810254	3'UTR	novel		0.31
CESC	chr16	29808569	Splice_Site	NA	X370_splice	0.3
CESC	chr16	29808670	Missense_Mutation	novel	S403W	0.48
CESC	chr16	29810503	3'UTR	rs760467318		0.35
COAD	chr16	29806879	Nonsense_Mutation	novel	Q60*	0.21	zf-C2H2
COAD	chr16	29807390	Missense_Mutation	novel	G202D	0.31
COAD	chr16	29806732	Missense_Mutation	NA	A11P	0.1
COAD	chr16	29809606	Intron	NA		0.26
COAD	chr16	29810120	Silent	rs370548510	A441A	0.31
COAD	chr16	29809602	Intron	rs765655408		0.1
COAD	chr16	29809685	Intron	rs769505112		0.38
COAD	chr16	29808663	Silent	rs1043766	L401L	0.19
DLBC	chr16	29807735	In_Frame_Del	novel	K317_D320delinsN	0.23
DLBC	chr16	29807437	Missense_Mutation	rs747608454	G218S	0.17
ESCA	chr16	29810247	3'UTR	rs571424053		0.24
ESCA	chr16	29810535	3'UTR	novel		0.15
ESCA	chr16	29810679	3'UTR	novel		0.55
GBM	chr16	29808207	Intron	novel		0.19
HNSC	chr16	29808744	Splice_Region	novel		0.18
HNSC	chr16	29808704	Missense_Mutation	novel	S414R	0.39
HNSC	chr16	29808146	Intron	novel		0.36
KIRP	chr16	29809674	Intron	novel		0.45
KIRP	chr16	29808295	Splice_Site	novel	X369_splice	0.3
LIHC	chr16	29808717	Missense_Mutation	NA	H419Y	0.48
LIHC	chr16	29807790	Frame_Shift_Del	novel	*K335Nfs67**	0.42
LUAD	chr16	29810143	Missense_Mutation	rs780618980	V449A	0.32
LUAD	chr16	29810144	Silent	rs549096750	V449V	0.32
LUAD	chr16	29807845	Intron	novel		0.45
LUAD	chr16	29810113	Missense_Mutation	NA	A439V	0.21
LUAD	chr16	29807558	Missense_Mutation	NA	A258V	0.44
LUAD	chr16	29810057	Intron	rs757068152		0.27
LUAD	chr16	29808627	Missense_Mutation	rs748661675	E389K	0.09
LUSC	chr16	29807585	Frame_Shift_Del	novel	*T268Rfs27**	0.75
LUSC	chr16	29807671	Nonsense_Mutation	NA	R296*	0.21
LUSC	chr16	29807331	Missense_Mutation	novel	K182N	0.17
LUSC	chr16	29808579	Missense_Mutation	novel	A373T	0.3
LUSC	chr16	29808256	Missense_Mutation	novel	R357T	0.31
LUSC	chr16	29807815	Nonsense_Mutation	NA	K344*	0.53
LUSC	chr16	29810071	Splice_Region	novel		0.26
LUSC	chr16	29807626	Missense_Mutation	novel	C281S	0.32
LUSC	chr16	29807690	Missense_Mutation	NA	S302L	0.15
OV	chr16	29809540	Intron	NA		0.44
PAAD	chr16	29807827	Missense_Mutation	novel	R348W	0.08
PRAD	chr16	29809627	Intron	NA		0.29
PRAD	chr16	29809685	Intron	rs769505112		0.41
READ	chr16	29810109	In_Frame_Del	rs780065474	A446_A448del	0.46
SARC	chr16	29808129	Intron	novel		0.36
SKCM	chr16	29810044	Intron	rs775675641		0.37
SKCM	chr16	29810076	Splice_Site	novel	X427_splice	0.1
SKCM	chr16	29808857	Intron	novel		0.79
SKCM	chr16	29807433	Silent	NA	K216K	0.43
SKCM	chr16	29810071	Splice_Region	novel		0.13
SKCM	chr16	29809577	Intron	NA		0.82
SKCM	chr16	29809610	Intron	novel		0.37
SKCM	chr16	29809611	Intron	rs369815478		0.37
SKCM	chr16	29807403	Silent	novel	R206R	0.41
STAD	chr16	29806733	Frame_Shift_Del	rs767720617	*F14Sfs15**	0.38
STAD	chr16	29806776	Silent	rs749236448	G25G	0.35
STAD	chr16	29806733	Frame_Shift_Del	rs767720617	*F14Sfs15**	0.37
STAD	chr16	29808722	Silent	rs374491337	V420V	0.38
STAD	chr16	29809696	Intron	rs34942081		0.41
STAD	chr16	29806823	Missense_Mutation	NA	P41R	0.13
STAD	chr16	29809696	Intron	rs34942081		0.42
STAD	chr16	29806766	Frame_Shift_Del	NA	*V24Wfs5**	0.48
STAD	chr16	29810120	Silent	novel	A441A	0.24
STAD	chr16	29807753	Missense_Mutation	novel	S323I	0.05
STAD	chr16	29807754	In_Frame_Ins	novel	S323_Y324insRSKIFSK	0.04
STAD	chr16	29810120	Silent	rs370548510	A441A	0.3
STAD	chr16	29807795	Missense_Mutation	NA	Y337C	0.08
STAD	chr16	29806733	Frame_Shift_Del	rs767720617	*F14Sfs15**	0.23
STAD	chr16	29806732	Frame_Shift_Ins	rs775841544	*F14Lfs34**	0.41
STAD	chr16	29807753	Missense_Mutation	rs768483206	S323N	0.26
STAD	chr16	29806730	Missense_Mutation	novel	L10P	0.36
THYM	chr16	29807713	Missense_Mutation	rs778060413	P310S	0.09
UCEC	chr16	29810690	3'UTR	novel		0.75
UCEC	chr16	29808603	Silent	novel	L381L	0.49
UCEC	chr16	29807612	Missense_Mutation	novel	R276L	0.23
UCEC	chr16	29809634	Intron	rs376051318		0.29
UCEC	chr16	29810101	Missense_Mutation	NA	A435V	0.27
UCEC	chr16	29810637	3'UTR	novel		0.35
UCEC	chr16	29808097	Intron	novel		0.35
UCEC	chr16	29808799	Intron	novel		0.36
UCEC	chr16	29810321	3'UTR	novel		0.39
UCEC	chr16	29808728	Silent	rs771873431	E422E	0.32
UCEC	chr16	29809684	Intron	NA		0.56
UCEC	chr16	29808532	Intron	novel		0.44
UCEC	chr16	29808724	Missense_Mutation	novel	C421Y	0.23
UCEC	chr16	29807471	Missense_Mutation	novel	T229I	0.5
UCEC	chr16	29809602	Intron	rs765655408		0.57
UCEC	chr16	29808610	Missense_Mutation	NA	A383V	0.47
UCEC	chr16	29808612	Missense_Mutation	NA	H384Y	0.37
UCEC	chr16	29808140	Intron	novel		0.08
UCEC	chr16	29808798	Intron	rs768501778		0.49
UCS	chr16	29810222	Missense_Mutation	novel	Q475H	0.71

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.0556	0.23475
LUAD	AMP	0.2461	0.20955

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0053	Kaplan-Meier Survival Analysis
STAD	0.015	Kaplan-Meier Survival Analysis
MESO	0.0092	Kaplan-Meier Survival Analysis
ACC	0.0012	Kaplan-Meier Survival Analysis
SKCM	0.00026	Kaplan-Meier Survival Analysis
PRAD	0.015	Kaplan-Meier Survival Analysis
KIRP	0.0027	Kaplan-Meier Survival Analysis
BLCA	0.01	Kaplan-Meier Survival Analysis
LIHC	0.0025	Kaplan-Meier Survival Analysis
THCA	0.0073	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742