EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000103657 (Gene tree)
Gene ID: 8925
Gene Symbol: HERC1
Alias: p532|p619
Full Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 225,332 bases
Position: chr15:63,608,618-63,833,949
Accession: 4867
RBP type: non-canonical RBP
Summary: This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000561400	HERC1-214	2215	-	ENSP00000453937	691 (aa)	-	H0YNB1
ENST00000561436	HERC1-215	551	-	-	- (aa)	-	-
ENST00000559886	HERC1-205	2462	-	-	- (aa)	-	-
ENST00000561348	HERC1-212	588	-	-	- (aa)	-	-
ENST00000561359	HERC1-213	551	-	ENSP00000453603	47 (aa)	-	H0YMH0
ENST00000560519	HERC1-209	591	-	-	- (aa)	-	-
ENST00000560983	HERC1-211	457	-	-	- (aa)	-	-
ENST00000560316	HERC1-207	577	-	ENSP00000453010	20 (aa)	-	H0YL07
ENST00000559715	HERC1-204	495	-	ENSP00000452654	165 (aa)	-	H0YK45
ENST00000558324	HERC1-202	828	-	ENSP00000453196	152 (aa)	-	H0YLG2
ENST00000560462	HERC1-208	647	-	ENSP00000452969	145 (aa)	-	H0YKW7
ENST00000443617	HERC1-201	15137	XM_017022699	ENSP00000390158	4861 (aa)	XP_016878188	Q15751
ENST00000559996	HERC1-206	443	-	-	- (aa)	-	-
ENST00000558532	HERC1-203	581	-	ENSP00000453086	153 (aa)	-	H0YL74
ENST00000560897	HERC1-210	539	-	ENSP00000452671	26 (aa)	-	H0YK60

Gene Model

Click here to download ENSG00000103657's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04120	Ubiquitin mediated proteolysis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000103657	Hypertension	1.2276459E-005	-
ENSG00000103657	Corneal Pachymetry	1E-6	21835309

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000103657	rs61740450	15	63729277	G	Glucagon levels in response to oral glucose tolerance test (120 minutes)	29093273	[0.033-0.083] unit decrease	0.058	EFO_0008463\|EFO_0004307
ENSG00000103657	rs74320127	15	63782903	G	Disease progression in age-related macular degeneration	29346644		1.71	EFO_0001365\|EFO_0008336
ENSG00000103657	rs74320127	15	63782903	G	Disease progression in age-related macular degeneration	29346644		1.71	EFO_0001365\|EFO_0008336
ENSG00000103657	rs7170477	15	63811578	A	Atrial fibrillation	30061737	[1.03-1.05]	1.04	EFO_0000275
ENSG00000103657	rs34366173	15	63706716	C	Reticulocyte fraction of red cells	27863252	[0.016-0.031] unit decrease	0.02358172	EFO_0007986
ENSG00000103657	rs11630290	15	63623587	C	Iris characteristics	21835309	[0.05-0.13] unit increase	0.09	EFO_0004731
ENSG00000103657	rs542221686	15	63660333	?	Heel bone mineral density	30048462	[0.021-0.035] unit decrease	0.0280907	EFO_0009270
ENSG00000103657	rs17186681	15	63696566	T	Neuroticism	30643256	[0.0067-0.0139] unit increase	0.010271766	EFO_0007660
ENSG00000103657	rs17186681	15	63696566	T	Depressive symptoms	30643256	[0.0043-0.0089] unit increase	0.006595448	EFO_0007006
ENSG00000103657	rs17186681	15	63696566	T	Well-being spectrum (multivariate analysis)	30643256	[0.0043-0.0088] unit increase	0.006561042	EFO_0007869
ENSG00000103657	rs17186681	15	63696566	T	Positive affect	30643256	[0.0051-0.0107] unit increase	0.007914303	EFO_0007869
ENSG00000103657	rs79503123	15	63719606	C	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.011-0.021] unit decrease	0.0161567	EFO_0006527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000103657's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004842	ubiquitin-protein transferase activity	-	IEA	Function
GO:0005086	ARF guanyl-nucleotide exchange factor activity	8861955.	TAS	Function
GO:0005737	cytoplasm	8861955.	TAS	Component
GO:0005794	Golgi apparatus	-	IEA	Component
GO:0005829	cytosol	-	IEA	Component
GO:0010507	negative regulation of autophagy	-	IEA	Process
GO:0016020	membrane	-	IEA	Component
GO:0016567	protein ubiquitination	-	IEA	Process
GO:0021702	cerebellar Purkinje cell differentiation	-	IEA	Process
GO:0031175	neuron projection development	-	IEA	Process
GO:0050885	neuromuscular process controlling balance	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr15	63624324	Missense_Mutation	novel	S4427G	0.38
BLCA	chr15	63615791	Nonsense_Mutation	NA	R4691*	0.3
BLCA	chr15	63664578	Missense_Mutation	novel	H2858Y	0.33
BLCA	chr15	63756549	Missense_Mutation	rs757806758	T474M	0.51
BLCA	chr15	63655930	Missense_Mutation	novel	V3299A	0.15
BLCA	chr15	63686472	Nonsense_Mutation	novel	E2038*	0.12
BLCA	chr15	63686473	Silent	novel	P2037P	0.12
BLCA	chr15	63616516	Missense_Mutation	NA	E4619K	0.3
BLCA	chr15	63655875	Silent	NA	L3317L	0.63
BLCA	chr15	63718670	Silent	NA	S1294S	0.23
BLCA	chr15	63775453	Silent	NA	L57L	0.32
BLCA	chr15	63649922	Missense_Mutation	novel	G3517E	0.2
BLCA	chr15	63656327	Missense_Mutation	novel	E3211Q	0.18
BLCA	chr15	63696152	Missense_Mutation	novel	G1698V	0.44
BLCA	chr15	63678000	Silent	NA	P2305P	0.41
BLCA	chr15	63630556	Silent	novel	I4292I	0.27
BLCA	chr15	63638525	Silent	novel	L3993L	0.21
BLCA	chr15	63747040	Missense_Mutation	novel	N800H	0.58
BLCA	chr15	63635987	Missense_Mutation	novel	A4130S	0.16
BLCA	chr15	63712829	Silent	rs371768176	S1510S	0.24
BLCA	chr15	63694496	Nonsense_Mutation	NA	Q1766*	0.51
BLCA	chr15	63677950	Missense_Mutation	NA	R2322P	0.27
BLCA	chr15	63775627	5'UTR	novel		0.27
BLCA	chr15	63634827	Missense_Mutation	NA	G4159E	0.39
BLCA	chr15	63638749	Missense_Mutation	NA	D3977H	0.05
BLCA	chr15	63638460	Missense_Mutation	novel	R4015I	0.18
BLCA	chr15	63712789	Missense_Mutation	novel	E1524K	0.3
BLCA	chr15	63623807	Missense_Mutation	NA	R4510Q	0.46
BLCA	chr15	63677858	Missense_Mutation	NA	E2353Q	0.19
BLCA	chr15	63692555	Frame_Shift_Ins	novel	*K1896Qfs55**	0.15
BLCA	chr15	63758324	Missense_Mutation	novel	D358N	0.15
BLCA	chr15	63774906	Missense_Mutation	novel	D240H	0.35
BLCA	chr15	63692413	Missense_Mutation	NA	S1943L	0.17
BLCA	chr15	63628755	Missense_Mutation	NA	K4343E	0.1
BLCA	chr15	63694312	Missense_Mutation	novel	G1827A	0.44
BLCA	chr15	63674812	Missense_Mutation	novel	S2459L	0.08
BLCA	chr15	63655796	Missense_Mutation	novel	D3344H	0.5
BLCA	chr15	63643411	Missense_Mutation	novel	S3775C	0.2
BLCA	chr15	63677884	Missense_Mutation	NA	S2344F	0.31
BLCA	chr15	63658568	Missense_Mutation	rs769687179	R3192K	0.24
BLCA	chr15	63725472	Nonsense_Mutation	NA	Q1130*	0.19
BLCA	chr15	63628800	Missense_Mutation	rs774606926	T4328A	0.28
BLCA	chr15	63640442	Missense_Mutation	novel	H3871Y	0.21
BRCA	chr15	63609250	Frame_Shift_Del	NA	*P4806Lfs10**	0.18
BRCA	chr15	63680128	Silent	NA	A2166A	0.22
BRCA	chr15	63642970	Nonsense_Mutation	NA	S3807*	0.34
BRCA	chr15	63661912	Missense_Mutation	NA	R3004H	0.09
BRCA	chr15	63666098	Missense_Mutation	NA	M2792I	0.46
BRCA	chr15	63638518	Splice_Site	novel	X3990_splice	0.06
BRCA	chr15	63616495	Missense_Mutation	rs368472341	V4626M	0.12
BRCA	chr15	63718641	Missense_Mutation	NA	R1304Q	0.41
BRCA	chr15	63669588	Missense_Mutation	novel	Q2719R	0.13
BRCA	chr15	63764096	Splice_Region	novel	E342E	0.07
BRCA	chr15	63775009	Silent	rs756210841	P205P	0.37
BRCA	chr15	63658570	Missense_Mutation	novel	M3191I	0.12
BRCA	chr15	63733017	Silent	novel	S925S	0.15
BRCA	chr15	63674390	Missense_Mutation	NA	V2600L	0.56
BRCA	chr15	63747813	Missense_Mutation	NA	E755D	0.53
BRCA	chr15	63655777	Missense_Mutation	NA	R3350T	0.26
BRCA	chr15	63775004	Nonsense_Mutation	novel	S207*	0.11
BRCA	chr15	63746970	Missense_Mutation	NA	R823Q	0.12
BRCA	chr15	63609067	3'UTR	novel		0.27
BRCA	chr15	63648140	Missense_Mutation	novel	D3603H	0.32
BRCA	chr15	63612309	Missense_Mutation	novel	R4781Q	0.07
BRCA	chr15	63645611	Silent	NA	V3650V	0.18
BRCA	chr15	63663007	Missense_Mutation	NA	E2960Q	0.25
BRCA	chr15	63727703	Missense_Mutation	NA	R1097K	0.28
BRCA	chr15	63725363	Missense_Mutation	NA	E1166V	0.21
BRCA	chr15	63615904	Missense_Mutation	NA	S4653Y	0.16
BRCA	chr15	63616600	Missense_Mutation	rs748693076	R4591C	0.17
BRCA	chr15	63640207	Missense_Mutation	rs774633591	S3949Y	0.13
BRCA	chr15	63712830	Missense_Mutation	rs757745102	S1510L	0.15
BRCA	chr15	63732938	Missense_Mutation	NA	L952V	0.38
BRCA	chr15	63672695	Splice_Site	NA	X2616_splice	0.29
BRCA	chr15	63725505	Missense_Mutation	NA	E1119K	0.31
BRCA	chr15	63712895	Frame_Shift_Del	NA	*S1489Vfs10**	0.27
BRCA	chr15	63626046	Frame_Shift_Del	novel	*R4402Pfs14**	0.1
BRCA	chr15	63678000	Silent	NA	P2305P	0.18
BRCA	chr15	63756588	Missense_Mutation	novel	S461L	0.08
BRCA	chr15	63636141	Frame_Shift_Del	novel	*F4079Lfs3**	0.04
BRCA	chr15	63694538	Missense_Mutation	novel	R1752C	0.04
BRCA	chr15	63758295	Missense_Mutation	NA	I367M	0.34
BRCA	chr15	63666436	Missense_Mutation	NA	P2748L	0.36
BRCA	chr15	63749748	Missense_Mutation	NA	S649L	0.17
BRCA	chr15	63645665	Missense_Mutation	novel	M3632I	0.1
BRCA	chr15	63723289	Missense_Mutation	NA	Y1212C	0.6
CESC	chr15	63775324	Silent	rs147377413	A100A	0.23
CESC	chr15	63672523	Missense_Mutation	rs375309992	P2673L	0.32
CESC	chr15	63713474	Missense_Mutation	NA	R1448W	0.28
CESC	chr15	63758324	Missense_Mutation	novel	D358N	0.44
CESC	chr15	63612364	Missense_Mutation	novel	E4763Q	0.37
CESC	chr15	63640271	Missense_Mutation	NA	E3928K	0.2
CESC	chr15	63608759	3'UTR	novel		0.21
CESC	chr15	63774805	Frame_Shift_Ins	novel	*A274Gfs24**	0.14
CESC	chr15	63640183	Missense_Mutation	novel	P3957H	0.53
CESC	chr15	63663127	Missense_Mutation	novel	A2920S	0.46
CESC	chr15	63686527	Silent	rs201690555	G2019G	0.33
CESC	chr15	63694003	Frame_Shift_Ins	novel	*V1879Sfs2**	0.39
CESC	chr15	63713543	Nonsense_Mutation	novel	R1425*	0.41
CESC	chr15	63729518	Silent	novel	C1000C	0.33
CESC	chr15	63775291	Silent	novel	Q111Q	0.43
CESC	chr15	63680751	In_Frame_Del	novel	R2083_G2084delinsS	0.27
CESC	chr15	63609104	Missense_Mutation	NA	E4855K	0.21
CESC	chr15	63624328	Splice_Site	NA	X4426_splice	0.31
CESC	chr15	63626035	Missense_Mutation	NA	D4409N	0.26
CESC	chr15	63746951	Silent	NA	L829L	0.12
CESC	chr15	63651321	Missense_Mutation	novel	S3493F	0.28
CESC	chr15	63616615	Missense_Mutation	novel	M4586L	0.53
CESC	chr15	63723308	Missense_Mutation	NA	E1206K	0.37
CESC	chr15	63640361	Nonsense_Mutation	novel	Q3898*	0.42
CESC	chr15	63654236	Silent	rs751994406	L3391L	0.36
CESC	chr15	63637611	Silent	novel	I4042I	0.09
CHOL	chr15	63727823	Missense_Mutation	novel	S1057L	0.32
COAD	chr15	63626056	Missense_Mutation	rs777743186	R4402W	0.33
COAD	chr15	63661794	Nonsense_Mutation	NA	Y3043*	0.38
COAD	chr15	63749713	Nonsense_Mutation	NA	E661*	0.42
COAD	chr15	63616639	Missense_Mutation	novel	Q4578E	0.39
COAD	chr15	63764179	Missense_Mutation	novel	D315Y	0.8
COAD	chr15	63652472	Missense_Mutation	rs373098342	V3454I	0.3
COAD	chr15	63654157	Nonsense_Mutation	novel	K3418*	0.29
COAD	chr15	63658579	Silent	novel	T3188T	0.24
COAD	chr15	63669627	Nonsense_Mutation	novel	S2706*	0.34
COAD	chr15	63698868	Missense_Mutation	novel	H1589N	0.24
COAD	chr15	63775137	Nonsense_Mutation	novel	R163*	0.32
COAD	chr15	63674951	Nonsense_Mutation	NA	R2413*	0.07
COAD	chr15	63774861	Missense_Mutation	novel	A255T	0.21
COAD	chr15	63693993	Missense_Mutation	NA	S1882N	0.31
COAD	chr15	63725354	Missense_Mutation	NA	T1169I	0.37
COAD	chr15	63663087	Missense_Mutation	novel	D2933G	0.29
COAD	chr15	63678096	In_Frame_Del	novel	K2273del	0.06
COAD	chr15	63686382	Missense_Mutation	novel	T2068A	0.42
COAD	chr15	63678017	Frame_Shift_Del	novel	*C2300Hfs14**	0.44
COAD	chr15	63694004	Frame_Shift_Del	NA	*V1879Lfs26**	0.37
COAD	chr15	63713372	Missense_Mutation	NA	G1482R	0.24
COAD	chr15	63723358	Splice_Region	rs777737824		0.21
COAD	chr15	63678206	Frame_Shift_Del	novel	M2237*	0.39
COAD	chr15	63752852	Intron	novel		0.37
COAD	chr15	63689690	Missense_Mutation	rs781450433	R1983C	0.09
COAD	chr15	63649864	Missense_Mutation	novel	E3536D	0.14
COAD	chr15	63775382	Missense_Mutation	novel	A81V	0.17
COAD	chr15	63643020	Silent	novel	G3790G	0.43
COAD	chr15	63729262	Missense_Mutation	NA	N1043S	0.1
COAD	chr15	63749474	Silent	NA	G704G	0.34
COAD	chr15	63756689	Silent	rs548577788	C427C	0.38
COAD	chr15	63666067	Missense_Mutation	novel	E2803K	0.29
COAD	chr15	63674933	Nonsense_Mutation	novel	R2419*	0.19
COAD	chr15	63661958	Missense_Mutation	rs774657002	V2989I	0.55
COAD	chr15	63754527	Missense_Mutation	novel	W584C	0.33
COAD	chr15	63674985	Silent	NA	G2401G	0.45
COAD	chr15	63694451	Missense_Mutation	rs779058478	V1781I	0.4
COAD	chr15	63609054	3'UTR	novel		0.08
COAD	chr15	63775308	Nonsense_Mutation	NA	R106*	0.79
COAD	chr15	63747790	Missense_Mutation	novel	S763Y	0.25
COAD	chr15	63774939	Missense_Mutation	novel	L229I	0.09
COAD	chr15	63672667	Missense_Mutation	novel	D2625G	0.36
COAD	chr15	63727669	Missense_Mutation	NA	Q1108H	0.2
COAD	chr15	63669535	Splice_Region	novel		0.4
COAD	chr15	63640296	Missense_Mutation	NA	W3919C	0.28
COAD	chr15	63643525	Missense_Mutation	NA	A3737V	0.38
COAD	chr15	63674667	Silent	NA	Q2507Q	0.34
COAD	chr15	63729559	Missense_Mutation	NA	E987K	0.33
COAD	chr15	63775137	Nonsense_Mutation	novel	R163*	0.27
COAD	chr15	63626106	Frame_Shift_Ins	rs772789325	*Q4385Pfs25**	0.22
COAD	chr15	63725320	Silent	rs374385019	D1180D	0.4
COAD	chr15	63626097	Missense_Mutation	rs755893599	A4388V	0.08
COAD	chr15	63645525	Missense_Mutation	rs143508709	R3679H	0.28
COAD	chr15	63630566	Missense_Mutation	novel	A4289V	0.18
COAD	chr15	63612254	Silent	NA	D4799D	0.19
COAD	chr15	63753085	Missense_Mutation	NA	G592D	0.16
COAD	chr15	63616658	Nonsense_Mutation	novel	C4571*	0.13
COAD	chr15	63640394	Frame_Shift_Ins	novel	*L3887Pfs44**	0.06
COAD	chr15	63674356	Missense_Mutation	NA	G2611V	0.25
COAD	chr15	63628728	Missense_Mutation	rs756796869	R4352C	0.52
COAD	chr15	63678341	Missense_Mutation	rs765707550	R2192C	0.14
COAD	chr15	63674442	Missense_Mutation	novel	R2582S	0.27
COAD	chr15	63725297	Missense_Mutation	novel	Q1188R	0.2
DLBC	chr15	63659760	Missense_Mutation	novel	M3134L	0.06
DLBC	chr15	63678338	Missense_Mutation	novel	G2193S	0.13
ESCA	chr15	63734762	Nonsense_Mutation	novel	Q870*	0.19
ESCA	chr15	63774701	Missense_Mutation	rs781379594	R308H	0.1
ESCA	chr15	63718585	Missense_Mutation	rs377537305	R1323W	0.19
ESCA	chr15	63713411	Missense_Mutation	novel	E1469K	0.29
ESCA	chr15	63734850	Splice_Site	novel	X841_splice	0.44
ESCA	chr15	63774702	Missense_Mutation	rs748144670	R308C	0.13
ESCA	chr15	63624269	Missense_Mutation	rs753722310	P4445L	0.06
ESCA	chr15	63713405	Nonsense_Mutation	novel	Q1471*	0.19
ESCA	chr15	63669686	Silent	novel	S2686S	0.39
ESCA	chr15	63674434	Missense_Mutation	novel	G2585E	0.32
GBM	chr15	63677926	Missense_Mutation	NA	R2330H	0.42
GBM	chr15	63655873	Missense_Mutation	NA	R3318Q	0.87
GBM	chr15	63626099	Silent	novel	G4387G	0.33
GBM	chr15	63725495	Missense_Mutation	novel	D1122G	0.5
GBM	chr15	63677926	Missense_Mutation	NA	R2330H	0.27
GBM	chr15	63609005	3'UTR	novel		0.35
GBM	chr15	63756622	Missense_Mutation	novel	T450S	0.04
GBM	chr15	63698733	Missense_Mutation	novel	A1634T	0.33
GBM	chr15	63774897	Missense_Mutation	novel	G243C	0.18
GBM	chr15	63656290	Missense_Mutation	rs759638200	R3223Q	0.17
GBM	chr15	63674481	Missense_Mutation	novel	H2569Q	0.08
GBM	chr15	63615894	In_Frame_Del	novel	G4656del	0.04
GBM	chr15	63733098	Silent	rs78998206	H898H	0.43
HNSC	chr15	63630563	Missense_Mutation	rs748059385	G4290E	0.26
HNSC	chr15	63612423	Missense_Mutation	novel	R4743Q	0.11
HNSC	chr15	63628815	Missense_Mutation	novel	L4323I	0.2
HNSC	chr15	63775062	Missense_Mutation	rs759975674	L188V	0.26
HNSC	chr15	63686483	Missense_Mutation	novel	S2034F	0.12
HNSC	chr15	63734728	Missense_Mutation	novel	G881V	0.34
HNSC	chr15	63666386	Missense_Mutation	novel	R2765W	0.26
HNSC	chr15	63775136	Missense_Mutation	rs375843350	R163L	0.23
HNSC	chr15	63694411	Missense_Mutation	novel	Q1794L	0.32
HNSC	chr15	63612280	Nonsense_Mutation	novel	Q4791*	0.18
HNSC	chr15	63649811	Missense_Mutation	rs766536918	R3554Q	0.23
HNSC	chr15	63672567	Frame_Shift_Ins	novel	*T2659Afs18**	0.09
HNSC	chr15	63612345	Missense_Mutation	rs759086324	R4769Q	0.12
HNSC	chr15	63636053	Missense_Mutation	novel	D4108Y	0.15
HNSC	chr15	63678062	Missense_Mutation	novel	R2285G	0.09
HNSC	chr15	63686405	Missense_Mutation	novel	Y2060C	0.35
HNSC	chr15	63718692	Missense_Mutation	novel	Y1287C	0.17
HNSC	chr15	63612415	Missense_Mutation	novel	E4746K	0.14
HNSC	chr15	63656180	Missense_Mutation	novel	I3260V	0.29
HNSC	chr15	63749445	Missense_Mutation	novel	G714V	0.35
HNSC	chr15	63658616	Missense_Mutation	novel	R3176T	0.17
HNSC	chr15	63658608	Missense_Mutation	novel	A3179T	0.27
HNSC	chr15	63674568	Missense_Mutation	novel	E2540D	0.34
HNSC	chr15	63651321	Missense_Mutation	novel	S3493F	0.27
KICH	chr15	63674510	Nonsense_Mutation	rs755228005	R2560*	0.41
KIRC	chr15	63694841	Silent	novel	V1725V	0.35
KIRC	chr15	63652513	Missense_Mutation	NA	K3440T	0.1
KIRC	chr15	63638477	Missense_Mutation	NA	Q4009H	0.18
KIRC	chr15	63623743	Silent	NA	T4531T	0.33
KIRC	chr15	63694060	In_Frame_Ins	novel	L1859_H1860insGTLHPN	0.05
KIRC	chr15	63663110	Frame_Shift_Ins	novel	*N2925Kfs3**	0.27
KIRC	chr15	63658717	Splice_Region	NA	G3142G	0.26
KIRC	chr15	63678025	Missense_Mutation	NA	R2297M	0.18
KIRC	chr15	63669630	Missense_Mutation	NA	S2705Y	0.1
KIRC	chr15	63663151	Missense_Mutation	NA	I2912V	0.04
KIRP	chr15	63755250	Nonsense_Mutation	novel	E537*	0.23
KIRP	chr15	63664590	Missense_Mutation	novel	D2854N	0.4
KIRP	chr15	63666133	Missense_Mutation	novel	D2781N	0.43
KIRP	chr15	63713497	Missense_Mutation	NA	A1440G	0.38
KIRP	chr15	63686462	Missense_Mutation	NA	Q2041R	0.43
KIRP	chr15	63661766	Missense_Mutation	NA	T3053P	0.37
KIRP	chr15	63626122	Missense_Mutation	novel	D4380H	0.34
KIRP	chr15	63732970	Missense_Mutation	novel	A941D	0.38
KIRP	chr15	63729265	Nonsense_Mutation	NA	W1042*	0.18
KIRP	chr15	63654288	Missense_Mutation	novel	C3374S	0.45
KIRP	chr15	63698979	Silent	novel	L1552L	0.42
LAML	chr15	63694807	Missense_Mutation	novel	E1737K	0.08
LAML	chr15	63623821	Silent	novel	L4505L	0.03
LAML	chr15	63754543	Missense_Mutation	novel	D579G	0.11
LGG	chr15	63643429	Missense_Mutation	novel	G3769E	0.95
LGG	chr15	63725412	Missense_Mutation	novel	G1150W	0.1
LGG	chr15	63677981	Nonsense_Mutation	novel	G2312*	0.36
LGG	chr15	63674413	Missense_Mutation	rs749237440	A2592V	0.23
LGG	chr15	63641535	Missense_Mutation	novel	P3848A	0.39
LGG	chr15	63612530	Silent	novel	S4707S	0.15
LGG	chr15	63630586	Silent	NA	P4282P	0.44
LGG	chr15	63636008	Missense_Mutation	novel	R4123W	0.35
LGG	chr15	63652425	Silent	rs369327928	V3469V	0.45
LGG	chr15	63654259	Missense_Mutation	rs753186773	R3384W	0.47
LGG	chr15	63656196	Silent	novel	S3254S	0.43
LGG	chr15	63664526	Missense_Mutation	rs767027749	A2875V	0.15
LGG	chr15	63749466	Missense_Mutation	novel	T707N	0.05
LGG	chr15	63609167	Missense_Mutation	NA	I4834V	0.23
LGG	chr15	63672652	Frame_Shift_Ins	novel	*A2630Efs19**	0.11
LGG	chr15	63672653	Missense_Mutation	novel	A2630T	0.11
LGG	chr15	63692555	Frame_Shift_Ins	novel	*K1896Qfs55**	0.14
LGG	chr15	63692557	In_Frame_Ins	novel	L1894_R1895insINTLRQ	0.14
LGG	chr15	63674968	Missense_Mutation	novel	G2407D	0.32
LGG	chr15	63680738	Silent	NA	T2088T	0.12
LGG	chr15	63753007	Missense_Mutation	rs200768642	K618R	0.06
LIHC	chr15	63678047	Missense_Mutation	NA	D2290Y	0.4
LIHC	chr15	63694349	Missense_Mutation	NA	S1815C	0.22
LIHC	chr15	63651369	Missense_Mutation	NA	A3477V	0.41
LIHC	chr15	63674995	Missense_Mutation	NA	Y2398F	0.31
LIHC	chr15	63756743	Missense_Mutation	novel	E409D	0.39
LIHC	chr15	63696258	Nonsense_Mutation	novel	R1663*	0.41
LIHC	chr15	63608994	3'UTR	novel		0.28
LIHC	chr15	63633886	Frame_Shift_Ins	novel	*L4219Tfs16**	0.27
LIHC	chr15	63640294	Missense_Mutation	NA	N3920S	0.08
LIHC	chr15	63729494	Splice_Region	novel		0.4
LIHC	chr15	63674587	Missense_Mutation	novel	I2534K	0.5
LIHC	chr15	63616588	Missense_Mutation	novel	P4595T	0.07
LIHC	chr15	63698921	Missense_Mutation	rs748628494	N1571S	0.18
LIHC	chr15	63623854	Silent	rs751845469	A4494A	0.33
LIHC	chr15	63686400	Silent	NA	L2062L	0.54
LIHC	chr15	63652518	Silent	novel	N3438N	0.35
LIHC	chr15	63677931	Silent	novel	T2328T	0.07
LIHC	chr15	63775564	Missense_Mutation	novel	W20C	0.46
LUAD	chr15	63753086	Splice_Site	NA	X592_splice	0.2
LUAD	chr15	63713484	Silent	novel	S1444S	0.21
LUAD	chr15	63725369	Missense_Mutation	rs531482851	P1164L	0.37
LUAD	chr15	63663076	Missense_Mutation	novel	E2937K	0.15
LUAD	chr15	63678275	Missense_Mutation	novel	E2214K	0.18
LUAD	chr15	63638448	Missense_Mutation	novel	V4019A	0.2
LUAD	chr15	63640418	Frame_Shift_Ins	novel	*V3879Rfs6**	0.07
LUAD	chr15	63640421	Frame_Shift_Del	novel	*Q3877Hfs4**	0.05
LUAD	chr15	63626055	Missense_Mutation	novel	R4402Q	0.28
LUAD	chr15	63640248	Missense_Mutation	novel	K3935N	0.08
LUAD	chr15	63674920	Missense_Mutation	novel	E2423V	0.09
LUAD	chr15	63698732	Missense_Mutation	NA	A1634E	0.15
LUAD	chr15	63775297	Silent	NA	V109V	0.36
LUAD	chr15	63623725	Missense_Mutation	novel	Q4537H	0.14
LUAD	chr15	63663166	Missense_Mutation	NA	S2907C	0.26
LUAD	chr15	63749778	Missense_Mutation	NA	G639D	0.71
LUAD	chr15	63654173	Missense_Mutation	NA	M3412I	0.12
LUAD	chr15	63716347	Missense_Mutation	novel	E1369K	0.06
LUAD	chr15	63678360	Missense_Mutation	novel	K2185N	0.18
LUAD	chr15	63775466	Missense_Mutation	novel	Q53L	0.44
LUAD	chr15	63664590	Missense_Mutation	NA	D2854H	0.31
LUAD	chr15	63696318	Nonsense_Mutation	NA	Q1643*	0.21
LUAD	chr15	63638499	Missense_Mutation	novel	W4002L	0.51
LUAD	chr15	63686376	Missense_Mutation	NA	G2070W	0.12
LUAD	chr15	63630492	Missense_Mutation	novel	A4314T	0.26
LUAD	chr15	63734771	Missense_Mutation	novel	L867V	0.41
LUAD	chr15	63775493	Missense_Mutation	rs570728689	N44S	0.36
LUAD	chr15	63694828	Missense_Mutation	NA	Q1730E	0.29
LUSC	chr15	63640276	Missense_Mutation	NA	W3926L	0.29
LUSC	chr15	63630577	Silent	novel	I4285I	0.38
LUSC	chr15	63718603	Nonsense_Mutation	NA	Q1317*	0.3
LUSC	chr15	63674677	Missense_Mutation	novel	R2504T	0.14
LUSC	chr15	63663125	Silent	rs373686089	A2920A	0.05
LUSC	chr15	63694828	Missense_Mutation	NA	Q1730E	0.15
LUSC	chr15	63696274	Missense_Mutation	novel	I1657M	0.16
LUSC	chr15	63674537	Missense_Mutation	novel	P2551S	0.14
LUSC	chr15	63652498	Frame_Shift_Ins	novel	*T3445Nfs6**	0.15
LUSC	chr15	63754516	Missense_Mutation	novel	G588A	0.07
LUSC	chr15	63754627	Missense_Mutation	NA	R551P	0.17
LUSC	chr15	63775544	Missense_Mutation	novel	S27C	0.14
LUSC	chr15	63734823	Silent	NA	G849G	0.48
LUSC	chr15	63775424	Missense_Mutation	novel	R67L	0.2
LUSC	chr15	63696137	Missense_Mutation	novel	L1703S	0.31
LUSC	chr15	63678149	Missense_Mutation	novel	K2256Q	0.29
LUSC	chr15	63734836	Missense_Mutation	novel	T845I	0.4
LUSC	chr15	63718792	Missense_Mutation	novel	G1283E	0.28
LUSC	chr15	63659841	Missense_Mutation	NA	R3107G	0.17
LUSC	chr15	63675020	Missense_Mutation	novel	A2390S	0.45
LUSC	chr15	63696257	Missense_Mutation	NA	R1663T	0.24
LUSC	chr15	63612395	Missense_Mutation	novel	Q4752H	0.17
LUSC	chr15	63729567	Missense_Mutation	NA	H984R	0.08
LUSC	chr15	63696291	Missense_Mutation	novel	E1652Q	0.16
LUSC	chr15	63718644	Missense_Mutation	novel	V1303A	0.39
LUSC	chr15	63756643	Nonsense_Mutation	rs774088719	Q443*	0.39
LUSC	chr15	63654231	Missense_Mutation	rs200318759	R3393H	0.09
LUSC	chr15	63648099	Missense_Mutation	novel	K3616N	0.23
LUSC	chr15	63636003	Silent	novel	R4124R	0.43
LUSC	chr15	63612383	Missense_Mutation	NA	W4756C	0.22
LUSC	chr15	63626096	Silent	rs752398916	A4388A	0.2
LUSC	chr15	63725336	Missense_Mutation	rs763817683	T1175M	0.1
LUSC	chr15	63659780	Missense_Mutation	novel	M3127T	0.14
LUSC	chr15	63696126	Missense_Mutation	novel	Q1707E	0.36
LUSC	chr15	63698942	Missense_Mutation	rs562272047	H1564R	0.16
LUSC	chr15	63756709	Missense_Mutation	novel	D421N	0.35
LUSC	chr15	63636101	Missense_Mutation	novel	G4092R	0.08
LUSC	chr15	63649737	Missense_Mutation	novel	Y3579H	0.39
LUSC	chr15	63649738	Silent	novel	C3578C	0.39
LUSC	chr15	63774955	Silent	NA	S223S	0.16
MESO	chr15	63775262	In_Frame_Del	novel	K120_Y121delinsN	0.3
OV	chr15	63753012	Missense_Mutation	NA	I616M	0.21
OV	chr15	63672534	Silent	NA	A2669A	0.44
OV	chr15	63658664	In_Frame_Del	NA	S3152_Q3160del	0.42
OV	chr15	63666119	Silent	rs746534415	I2785I	0.24
OV	chr15	63672516	Silent	NA	V2675V	0.19
OV	chr15	63648074	Missense_Mutation	NA	H3625Y	0.57
OV	chr15	63672595	Missense_Mutation	novel	S2649I	0.06
OV	chr15	63713627	Missense_Mutation	rs759913014	R1397C	0.54
OV	chr15	63674749	Frame_Shift_Ins	novel	*Q2480Lfs11**	0.07
OV	chr15	63713562	Silent	rs201470593	P1418P	0.2
OV	chr15	63674464	Missense_Mutation	novel	V2575D	0.05
OV	chr15	63659873	Nonsense_Mutation	NA	L3096*	0.62
PAAD	chr15	63615881	Missense_Mutation	novel	G4661C	0.05
PAAD	chr15	63624323	Missense_Mutation	novel	S4427N	0.15
PAAD	chr15	63628707	Missense_Mutation	rs2229746	T4359A	0.19
PAAD	chr15	63643043	Nonsense_Mutation	novel	Q3783*	0.18
PAAD	chr15	63675021	Silent	novel	T2389T	0.18
PAAD	chr15	63725306	Missense_Mutation	novel	D1185A	0.16
PAAD	chr15	63727761	Missense_Mutation	novel	A1078T	0.12
PAAD	chr15	63733097	Missense_Mutation	novel	V899I	0.18
PAAD	chr15	63758279	Missense_Mutation	novel	E373K	0.21
PAAD	chr15	63616561	Missense_Mutation	novel	V4604L	0.24
PAAD	chr15	63733028	Missense_Mutation	rs766581151	G922R	0.34
PRAD	chr15	63755309	Nonsense_Mutation	NA	S517*	0.21
PRAD	chr15	63755310	Missense_Mutation	NA	S517P	0.21
PRAD	chr15	63752933	Intron	novel		0.34
PRAD	chr15	63612549	Missense_Mutation	novel	A4701V	0.31
PRAD	chr15	63678205	Frame_Shift_Ins	novel	*M2237Nfs9**	0.5
PRAD	chr15	63692448	Silent	novel	E1931E	0.34
PRAD	chr15	63713415	Silent	novel	R1467R	0.36
READ	chr15	63645591	Missense_Mutation	rs374565654	S3657L	0.31
READ	chr15	63652508	Missense_Mutation	NA	L3442I	0.25
READ	chr15	63692450	Missense_Mutation	novel	E1931K	0.23
READ	chr15	63718641	Missense_Mutation	NA	R1304Q	0.32
READ	chr15	63749666	Silent	NA	H676H	0.15
READ	chr15	63756680	Silent	NA	G430G	0.18
READ	chr15	63661958	Missense_Mutation	rs774657002	V2989I	0.42
READ	chr15	63663042	Missense_Mutation	novel	T2948N	0.09
READ	chr15	63651278	Missense_Mutation	NA	K3507N	0.43
READ	chr15	63663147	Missense_Mutation	NA	S2913Y	0.4
READ	chr15	63674644	Missense_Mutation	NA	A2515V	0.33
READ	chr15	63692507	Missense_Mutation	NA	R1912C	0.35
READ	chr15	63638756	Silent	NA	N3974N	0.46
READ	chr15	63674799	Silent	rs374567563	I2463I	0.11
READ	chr15	63678047	Missense_Mutation	NA	D2290N	0.3
READ	chr15	63716418	Missense_Mutation	NA	R1345Q	0.22
READ	chr15	63729295	Missense_Mutation	rs775255598	R1032H	0.24
READ	chr15	63732930	Missense_Mutation	NA	F954L	0.35
SARC	chr15	63654231	Missense_Mutation	rs200318759	R3393H	0.09
SARC	chr15	63734791	Missense_Mutation	novel	R860Q	0.39
SARC	chr15	63749415	Missense_Mutation	NA	S724L	0.46
SARC	chr15	63665996	Frame_Shift_Del	novel	S2825*	0.3
SARC	chr15	63609080	3'UTR	novel		0.26
SARC	chr15	63663010	Missense_Mutation	novel	P2959S	0.31
SARC	chr15	63636119	Missense_Mutation	novel	T4086A	0.54
SKCM	chr15	63674474	Missense_Mutation	novel	K2572Q	0.36
SKCM	chr15	63678095	Missense_Mutation	novel	E2274K	0.46
SKCM	chr15	63645066	Missense_Mutation	rs780339168	R3704C	0.39
SKCM	chr15	63713650	Missense_Mutation	NA	F1389Y	0.5
SKCM	chr15	63658717	Splice_Region	novel	G3142G	0.5
SKCM	chr15	63616537	Missense_Mutation	novel	P4612S	0.38
SKCM	chr15	63675032	Nonsense_Mutation	rs767105101	R2386*	0.37
SKCM	chr15	63674709	Silent	novel	S2493S	0.24
SKCM	chr15	63660976	In_Frame_Del	novel	V3072_Y3073del	0.18
SKCM	chr15	63725328	Missense_Mutation	NA	F1178L	0.2
SKCM	chr15	63640235	Silent	NA	L3940L	0.2
SKCM	chr15	63727787	Missense_Mutation	NA	S1069F	0.43
SKCM	chr15	63638433	Missense_Mutation	novel	P4024L	0.29
SKCM	chr15	63665992	Missense_Mutation	rs760456325	P2828S	0.34
SKCM	chr15	63689678	Missense_Mutation	novel	L1987F	0.55
SKCM	chr15	63663011	Silent	NA	I2958I	0.1
SKCM	chr15	63674416	Missense_Mutation	NA	R2591Q	0.15
SKCM	chr15	63775332	Missense_Mutation	NA	P98S	0.46
SKCM	chr15	63658557	Missense_Mutation	NA	L3196F	0.88
SKCM	chr15	63718636	Missense_Mutation	novel	R1306C	0.43
SKCM	chr15	63749522	Silent	novel	A688A	0.31
SKCM	chr15	63755239	Missense_Mutation	NA	F540L	0.3
SKCM	chr15	63656291	Nonsense_Mutation	NA	R3223*	0.22
SKCM	chr15	63727817	Missense_Mutation	novel	A1059V	0.21
SKCM	chr15	63630471	Missense_Mutation	NA	G4321R	0.22
SKCM	chr15	63758344	Missense_Mutation	rs775881894	S351L	0.2
SKCM	chr15	63775294	Silent	NA	L110L	0.44
SKCM	chr15	63609050	3'UTR	novel		0.56
SKCM	chr15	63615829	Missense_Mutation	NA	S4678F	0.12
SKCM	chr15	63626124	Missense_Mutation	rs770061334	P4379L	0.15
SKCM	chr15	63661794	Silent	NA	Y3043Y	0.07
SKCM	chr15	63658706	Missense_Mutation	NA	S3146F	0.23
SKCM	chr15	63713477	Missense_Mutation	novel	H1447Y	0.42
SKCM	chr15	63713478	Silent	novel	I1446I	0.41
SKCM	chr15	63623743	Silent	novel	T4531T	0.11
SKCM	chr15	63663182	Silent	novel	Q2901Q	0.22
SKCM	chr15	63656303	Nonsense_Mutation	novel	R3219*	0.5
SKCM	chr15	63656304	Silent	novel	I3218I	0.5
SKCM	chr15	63680687	Silent	novel	T2105T	0.25
SKCM	chr15	63643035	Silent	NA	V3785V	0.42
SKCM	chr15	63612310	Nonsense_Mutation	NA	R4781*	0.43
SKCM	chr15	63666437	Missense_Mutation	NA	P2748S	0.44
SKCM	chr15	63612419	Silent	NA	Y4744Y	0.24
SKCM	chr15	63661889	Missense_Mutation	NA	R3012G	0.27
SKCM	chr15	63609050	3'UTR	novel		0.53
SKCM	chr15	63678136	Missense_Mutation	rs200084879	S2260L	0.46
SKCM	chr15	63615860	Missense_Mutation	novel	P4668S	0.36
SKCM	chr15	63678129	Missense_Mutation	NA	Q2262H	0.32
SKCM	chr15	63656291	Nonsense_Mutation	NA	R3223*	0.3
SKCM	chr15	63609260	Missense_Mutation	NA	D4803N	0.22
SKCM	chr15	63656291	Nonsense_Mutation	NA	R3223*	0.22
SKCM	chr15	63725499	Missense_Mutation	NA	I1121V	0.31
SKCM	chr15	63754544	Missense_Mutation	NA	D579N	0.44
SKCM	chr15	63674448	Silent	NA	I2580I	0.26
SKCM	chr15	63649855	Silent	novel	A3539A	0.3
SKCM	chr15	63643484	Frame_Shift_Del	novel	*R3751Gfs17**	0.29
SKCM	chr15	63672606	Silent	novel	S2645S	0.38
SKCM	chr15	63718882	Missense_Mutation	novel	T1253I	0.38
SKCM	chr15	63615861	Silent	rs760023312	I4667I	0.38
SKCM	chr15	63723317	Missense_Mutation	NA	G1203R	0.39
SKCM	chr15	63775194	Missense_Mutation	NA	H144Y	0.42
SKCM	chr15	63698832	Missense_Mutation	NA	G1601R	0.15
STAD	chr15	63612455	Missense_Mutation	NA	E4732D	0.16
STAD	chr15	63713368	Frame_Shift_Del	novel	*G1483Vfs4**	0.2
STAD	chr15	63775178	Missense_Mutation	rs769145958	R149H	0.14
STAD	chr15	63658634	Missense_Mutation	rs369547448	R3170H	0.36
STAD	chr15	63692450	Missense_Mutation	novel	E1931K	0.36
STAD	chr15	63659806	Silent	NA	S3118S	0.27
STAD	chr15	63692461	Missense_Mutation	novel	P1927Q	0.11
STAD	chr15	63674627	Missense_Mutation	novel	A2521T	0.2
STAD	chr15	63643438	Missense_Mutation	novel	G3766V	0.33
STAD	chr15	63674485	Missense_Mutation	NA	R2568Q	0.13
STAD	chr15	63764119	Missense_Mutation	NA	A335T	0.31
STAD	chr15	63674866	Missense_Mutation	rs371256403	R2441Q	0.35
STAD	chr15	63694150	Missense_Mutation	NA	A1830T	0.33
STAD	chr15	63718610	Missense_Mutation	NA	E1314D	0.29
STAD	chr15	63727813	Silent	NA	G1060G	0.26
STAD	chr15	63669655	Missense_Mutation	novel	R2697C	0.4
STAD	chr15	63674486	Nonsense_Mutation	novel	R2568*	0.34
STAD	chr15	63725319	Missense_Mutation	NA	G1181S	0.4
STAD	chr15	63729615	Missense_Mutation	novel	D968A	0.09
STAD	chr15	63612420	Missense_Mutation	NA	Y4744C	0.13
STAD	chr15	63658634	Missense_Mutation	rs369547448	R3170H	0.15
STAD	chr15	63675009	Silent	NA	L2393L	0.31
STAD	chr15	63658564	Silent	rs776848656	A3193A	0.32
STAD	chr15	63678009	Silent	NA	E2302E	0.08
STAD	chr15	63680544	Frame_Shift_Del	novel	*N2153Mfs7**	0.14
STAD	chr15	63692527	Missense_Mutation	NA	G1905V	0.29
STAD	chr15	63624231	Missense_Mutation	rs770067924	R4458C	0.24
STAD	chr15	63666056	Silent	novel	S2806S	0.29
STAD	chr15	63674486	Nonsense_Mutation	novel	R2568*	0.31
STAD	chr15	63678205	Frame_Shift_Ins	novel	*M2237Nfs9**	0.37
STAD	chr15	63725408	Missense_Mutation	rs371163845	R1151Q	0.25
STAD	chr15	63616599	Missense_Mutation	novel	R4591H	0.11
STAD	chr15	63674365	Missense_Mutation	NA	Q2608R	0.28
STAD	chr15	63677996	Silent	NA	L2307L	0.12
STAD	chr15	63674387	Frame_Shift_Ins	novel	*V2601Sfs15**	0.22
STAD	chr15	63612528	Nonsense_Mutation	NA	W4708*	0.29
STAD	chr15	63674844	Silent	rs754595820	D2448D	0.36
STAD	chr15	63725409	Missense_Mutation	rs771392135	R1151W	0.12
STAD	chr15	63775173	Missense_Mutation	rs544246854	R151W	0.28
STAD	chr15	63674506	Missense_Mutation	novel	A2561V	0.43
STAD	chr15	63698726	Splice_Site	NA	X1635_splice	0.2
STAD	chr15	63678235	Missense_Mutation	novel	D2227G	0.14
STAD	chr15	63775405	Silent	novel	D73D	0.21
STAD	chr15	63641588	Missense_Mutation	NA	A3830V	0.33
STAD	chr15	63630484	Frame_Shift_Del	NA	*S4317Afs9**	0.25
STAD	chr15	63616507	Missense_Mutation	NA	D4622N	0.1
STAD	chr15	63658682	Missense_Mutation	rs762686925	R3154K	0.08
STAD	chr15	63734799	Silent	NA	L857L	0.17
STAD	chr15	63692518	Frame_Shift_Del	novel	L1908*	0.21
STAD	chr15	63634777	Missense_Mutation	NA	L4176F	0.18
STAD	chr15	63612298	Missense_Mutation	NA	N4785D	0.29
STAD	chr15	63659841	Missense_Mutation	rs755553525	R3107C	0.18
STAD	chr15	63756591	Missense_Mutation	NA	V460A	0.14
STAD	chr15	63659846	Missense_Mutation	novel	D3105V	0.19
STAD	chr15	63652443	Silent	NA	S3463S	0.17
STAD	chr15	63655768	Missense_Mutation	rs758546456	Y3353C	0.29
STAD	chr15	63713467	Missense_Mutation	NA	A1450V	0.37
STAD	chr15	63651356	Silent	NA	L3481L	0.29
STAD	chr15	63659751	Missense_Mutation	novel	T3137A	0.35
TGCT	chr15	63643496	Missense_Mutation	rs375304469	I3747V	0.31
TGCT	chr15	63612345	Frame_Shift_Del	novel	*R4769Gfs19**	0.1
THCA	chr15	63609162	Frame_Shift_Del	novel	*N4835Kfs41**	0.47
THCA	chr15	63615861	Silent	rs760023312	I4667I	0.33
THYM	chr15	63774742	Frame_Shift_Del	novel	*S295Afs6**	0.12
THYM	chr15	63675038	Nonsense_Mutation	novel	R2384*	0.22
UCEC	chr15	63609105	Silent	novel	A4854A	0.11
UCEC	chr15	63628816	Splice_Site	NA	X4323_splice	0.12
UCEC	chr15	63690585	Silent	NA	L1965L	0.46
UCEC	chr15	63615791	Nonsense_Mutation	NA	R4691*	0.37
UCEC	chr15	63633858	Missense_Mutation	NA	S4228Y	0.21
UCEC	chr15	63658593	Missense_Mutation	NA	L3184I	0.42
UCEC	chr15	63694477	Frame_Shift_Del	novel	*L1772Wfs8**	0.29
UCEC	chr15	63713521	Missense_Mutation	novel	P1432L	0.08
UCEC	chr15	63674590	Missense_Mutation	NA	L2533P	0.32
UCEC	chr15	63680635	Missense_Mutation	NA	E2123K	0.12
UCEC	chr15	63694872	Missense_Mutation	novel	R1715I	0.19
UCEC	chr15	63723281	Missense_Mutation	rs748836788	R1215W	0.33
UCEC	chr15	63692507	Missense_Mutation	NA	R1912C	0.06
UCEC	chr15	63608631	3'UTR	novel		0.19
UCEC	chr15	63637621	Missense_Mutation	novel	T4039I	0.1
UCEC	chr15	63645578	Silent	novel	C3661C	0.13
UCEC	chr15	63649873	Nonsense_Mutation	novel	W3533*	0.07
UCEC	chr15	63654236	Silent	rs751994406	L3391L	0.41
UCEC	chr15	63663200	Silent	NA	G2895G	0.38
UCEC	chr15	63674799	Silent	rs374567563	I2463I	0.35
UCEC	chr15	63675053	Missense_Mutation	NA	P2379S	0.23
UCEC	chr15	63734728	Missense_Mutation	novel	G881E	0.34
UCEC	chr15	63754627	Missense_Mutation	NA	R551P	0.38
UCEC	chr15	63756492	Missense_Mutation	novel	G493E	0.23
UCEC	chr15	63654298	Missense_Mutation	novel	A3371T	0.68
UCEC	chr15	63615895	Missense_Mutation	NA	G4656V	0.35
UCEC	chr15	63698889	Missense_Mutation	novel	L1582F	0.06
UCEC	chr15	63718641	Missense_Mutation	NA	R1304Q	0.3
UCEC	chr15	63749697	Missense_Mutation	NA	R666K	0.21
UCEC	chr15	63630633	Missense_Mutation	NA	R4267C	0.17
UCEC	chr15	63648149	Nonsense_Mutation	novel	G3600*	0.59
UCEC	chr15	63652483	Missense_Mutation	novel	G3450D	0.28
UCEC	chr15	63658694	Missense_Mutation	novel	S3150N	0.09
UCEC	chr15	63749382	Missense_Mutation	novel	A735V	0.08
UCEC	chr15	63775555	Missense_Mutation	novel	E23D	0.39
UCEC	chr15	63694452	Silent	rs374580110	N1780N	0.43
UCEC	chr15	63775351	Missense_Mutation	NA	K91N	0.45
UCEC	chr15	63718652	Silent	novel	V1300V	0.45
UCEC	chr15	63747840	Silent	novel	H746H	0.36
UCEC	chr15	63774852	Nonsense_Mutation	rs756121133	R258*	0.11
UCEC	chr15	63734803	Missense_Mutation	novel	P856L	0.42
UCEC	chr15	63640200	Silent	rs375981726	T3951T	0.42
UCEC	chr15	63638776	Missense_Mutation	novel	D3968N	0.37
UCEC	chr15	63641632	Silent	rs777677825	V3815V	0.34
UCEC	chr15	63669554	Silent	novel	R2730R	0.31
UCEC	chr15	63677875	Missense_Mutation	novel	V2347D	0.39
UCEC	chr15	63718578	Missense_Mutation	novel	R1325I	0.22
UCEC	chr15	63758277	Missense_Mutation	novel	E373D	0.48
UCEC	chr15	63758278	Missense_Mutation	novel	E373A	0.31
UCEC	chr15	63660989	Missense_Mutation	novel	Q3069H	0.13
UCEC	chr15	63663204	Missense_Mutation	novel	A2894V	0.39
UCEC	chr15	63698851	Silent	novel	N1594N	0.35
UCEC	chr15	63635996	Missense_Mutation	novel	Q4127E	0.42
UCEC	chr15	63658565	Missense_Mutation	rs761525337	A3193V	0.29
UCEC	chr15	63712779	Missense_Mutation	NA	A1527V	0.4
UCEC	chr15	63774955	Silent	NA	S223S	0.37
UCEC	chr15	63775641	5'UTR	novel		0.36
UCEC	chr15	63729623	Missense_Mutation	novel	K965N	0.09
UCEC	chr15	63655805	Missense_Mutation	NA	L3341V	0.25
UCEC	chr15	63694110	Missense_Mutation	NA	D1843G	0.17
UCEC	chr15	63725492	Missense_Mutation	novel	P1123L	0.06
UCEC	chr15	63665943	Missense_Mutation	NA	E2844G	0.24
UCEC	chr15	63663126	Missense_Mutation	rs759461833	A2920V	0.2
UCEC	chr15	63654326	Splice_Site	NA	X3362_splice	0.1
UCEC	chr15	63630580	In_Frame_Ins	novel	Q4284_I4285insDL	0.06
UCEC	chr15	63712780	Missense_Mutation	rs748070202	A1527T	0.39
UCEC	chr15	63615913	Missense_Mutation	NA	P4650H	0.14
UCEC	chr15	63674788	Missense_Mutation	novel	S2467Y	0.13
UCEC	chr15	63672613	Missense_Mutation	rs756487485	T2643M	0.3
UCEC	chr15	63656090	Nonsense_Mutation	novel	Q3290*	0.53
UCEC	chr15	63612312	Missense_Mutation	NA	S4780F	0.24
UCEC	chr15	63686506	Silent	novel	E2026E	0.46
UCEC	chr15	63616618	Missense_Mutation	NA	L4585V	0.5
UCEC	chr15	63626048	Silent	NA	L4404L	0.37
UCEC	chr15	63628813	Splice_Region	rs745687811	L4323L	0.35
UCEC	chr15	63643505	Missense_Mutation	rs529584007	R3744W	0.49
UCEC	chr15	63677858	Nonsense_Mutation	NA	E2353*	0.45
UCEC	chr15	63716387	Silent	rs768732027	E1355E	0.46
UCEC	chr15	63746986	Nonsense_Mutation	NA	Q818*	0.13
UCEC	chr15	63678024	Missense_Mutation	NA	R2297S	0.41
UCEC	chr15	63678131	Nonsense_Mutation	novel	*Q2262Ifs8**	0.04
UCEC	chr15	63648196	Missense_Mutation	novel	S3584Y	0.18
UCEC	chr15	63608662	3'UTR	novel		0.25
UCEC	chr15	63666000	Nonsense_Mutation	novel	S2825*	0.46
UCEC	chr15	63672518	Missense_Mutation	novel	V2675M	0.36
UCEC	chr15	63698762	Missense_Mutation	novel	I1624T	0.3
UCEC	chr15	63698886	Missense_Mutation	novel	T1583A	0.28
UCEC	chr15	63628719	Missense_Mutation	novel	S4355G	0.3
UCEC	chr15	63712777	Splice_Region	novel	L1528L	0.21
UCEC	chr15	63713436	Missense_Mutation	novel	I1460M	0.28
UCEC	chr15	63609105	Silent	novel	A4854A	0.42
UCEC	chr15	63661888	Missense_Mutation	NA	R3012H	0.35
UCEC	chr15	63686378	Missense_Mutation	novel	S2069Y	0.3
UCEC	chr15	63754604	Missense_Mutation	novel	D559Y	0.3
UCEC	chr15	63638524	Nonsense_Mutation	novel	G3994*	0.19
UCEC	chr15	63713420	Nonsense_Mutation	novel	R1466*	0.54
UCEC	chr15	63609107	Missense_Mutation	novel	A4854T	0.3
UCEC	chr15	63630609	Missense_Mutation	rs371244791	R4275C	0.43
UCEC	chr15	63634845	Missense_Mutation	novel	G4153D	0.38
UCEC	chr15	63641510	Missense_Mutation	rs375549428	R3856Q	0.43
UCEC	chr15	63645556	Missense_Mutation	novel	P3669T	0.31
UCEC	chr15	63674413	Missense_Mutation	rs749237440	A2592V	0.35
UCEC	chr15	63674986	Missense_Mutation	novel	G2401D	0.46
UCEC	chr15	63698914	Silent	novel	S1573S	0.33
UCEC	chr15	63727755	Missense_Mutation	NA	P1080S	0.3
UCEC	chr15	63674950	Missense_Mutation	novel	R2413Q	0.42
UCEC	chr15	63677951	Missense_Mutation	novel	R2322W	0.43
UCEC	chr15	63678341	Missense_Mutation	rs765707550	R2192C	0.36
UCEC	chr15	63694894	Missense_Mutation	novel	D1708N	0.49
UCEC	chr15	63696211	Silent	novel	R1678R	0.48
UCEC	chr15	63716355	Missense_Mutation	novel	P1366Q	0.43
UCEC	chr15	63758254	Missense_Mutation	novel	S381I	0.14
UCEC	chr15	63713660	Splice_Site	novel	X1384_splice	0.12
UCEC	chr15	63640229	Missense_Mutation	NA	N3942D	0.15
UCEC	chr15	63651290	Silent	NA	G3503G	0.34
UCEC	chr15	63672612	Silent	rs753107374	T2643T	0.34
UCEC	chr15	63675059	Missense_Mutation	NA	P2377S	0.46
UCEC	chr15	63641542	Silent	NA	N3845N	0.08
UCEC	chr15	63694108	Silent	NA	L1844L	0.49
UCEC	chr15	63723338	Silent	NA	L1196L	0.08
UCEC	chr15	63608807	3'UTR	novel		0.31
UCEC	chr15	63641530	Silent	novel	C3849C	0.43
UCEC	chr15	63775635	5'UTR	novel		0.44
UCEC	chr15	63608877	3'UTR	rs561716616		0.26
UCEC	chr15	63609211	Frame_Shift_Del	novel	*P4819Rfs57**	0.11
UCEC	chr15	63674880	Silent	rs764066761	S2436S	0.36
UCEC	chr15	63729642	Frame_Shift_Ins	novel	*A959Dfs6**	0.06
UCEC	chr15	63729644	Nonsense_Mutation	novel	*Q958Hfs2**	0.04
UCEC	chr15	63692416	Missense_Mutation	novel	S1942Y	0.17
UCEC	chr15	63712774	Splice_Site	novel	X1528_splice	0.36
UCEC	chr15	63716418	Missense_Mutation	NA	R1345Q	0.28
UCEC	chr15	63756616	Missense_Mutation	NA	E452K	0.29
UCEC	chr15	63754575	Missense_Mutation	novel	C568W	0.53
UCEC	chr15	63674412	Silent	rs777515838	A2592A	0.32
UCEC	chr15	63678242	Nonsense_Mutation	NA	R2225*	0.38
UCEC	chr15	63680117	Missense_Mutation	novel	Y2170C	0.4
UCEC	chr15	63754597	Missense_Mutation	novel	S561N	0.38
UCEC	chr15	63775289	Missense_Mutation	rs754763662	R112H	0.37
UCEC	chr15	63609211	Missense_Mutation	rs756534965	P4819L	0.35
UCEC	chr15	63752852	Intron	novel		0.57
UCEC	chr15	63674649	Silent	rs369950378	L2513L	0.19
UCEC	chr15	63775289	Missense_Mutation	rs754763662	R112H	0.19
UCEC	chr15	63678131	Nonsense_Mutation	novel	*Q2262Ifs8**	0.05
UCEC	chr15	63645066	Missense_Mutation	rs780339168	R3704C	0.37
UCEC	chr15	63656291	Nonsense_Mutation	NA	R3223*	0.36
UCEC	chr15	63675108	Silent	novel	T2360T	0.38
UCEC	chr15	63752882	Intron	novel		0.34
UCEC	chr15	63659806	Silent	NA	S3118S	0.44
UCEC	chr15	63674526	Missense_Mutation	novel	H2554Q	0.16
UCEC	chr15	63622852	Missense_Mutation	novel	P4551T	0.22
UCEC	chr15	63634884	Missense_Mutation	novel	S4140Y	0.16
UCEC	chr15	63654236	Silent	rs751994406	L3391L	0.46
UCEC	chr15	63659752	Missense_Mutation	novel	E3136D	0.3
UCEC	chr15	63664490	Missense_Mutation	rs762861130	R2887H	0.35
UCEC	chr15	63674788	Missense_Mutation	novel	S2467F	0.34
UCEC	chr15	63712805	Missense_Mutation	novel	Q1518H	0.34
UCEC	chr15	63733144	Missense_Mutation	NA	R883I	0.26
UCEC	chr15	63746943	Nonsense_Mutation	novel	S832*	0.37
UCEC	chr15	63756710	Silent	novel	T420T	0.31
UCEC	chr15	63775111	Silent	rs377592300	A171A	0.29
UCEC	chr15	63696220	Silent	rs377147575	T1675T	0.34
UCEC	chr15	63727726	Silent	novel	L1089L	0.2
UCEC	chr15	63754636	Missense_Mutation	novel	S548N	0.39
UCEC	chr15	63677979	Silent	NA	G2312G	0.06
UCEC	chr15	63609075	3'UTR	novel		0.45
UCEC	chr15	63632747	Missense_Mutation	novel	A4253D	0.39
UCEC	chr15	63659806	Silent	NA	S3118S	0.42
UCEC	chr15	63666057	Missense_Mutation	rs764147265	S2806L	0.38
UCEC	chr15	63675052	Missense_Mutation	rs769370738	P2379L	0.46
UCEC	chr15	63694421	Missense_Mutation	novel	M1791V	0.5
UCEC	chr15	63698730	Missense_Mutation	novel	E1635K	0.12
UCEC	chr15	63643506	Silent	novel	L3743L	0.36
UCEC	chr15	63758251	Missense_Mutation	novel	S382N	0.1
UCEC	chr15	63626055	Missense_Mutation	rs369029117	R4402L	0.52
UCEC	chr15	63654258	Missense_Mutation	NA	R3384Q	0.04
UCEC	chr15	63753011	Missense_Mutation	novel	R617C	0.14
UCEC	chr15	63725335	Silent	novel	T1175T	0.44
UCEC	chr15	63725319	Missense_Mutation	NA	G1181S	0.29
UCEC	chr15	63624231	Missense_Mutation	rs770067924	R4458C	0.35
UCEC	chr15	63666008	Silent	rs777930748	G2822G	0.41
UCEC	chr15	63674486	Nonsense_Mutation	novel	R2568*	0.2
UCEC	chr15	63690592	Missense_Mutation	novel	E1962D	0.38
UCEC	chr15	63696221	Missense_Mutation	rs369910646	T1675M	0.27
UCEC	chr15	63727756	Silent	novel	R1079R	0.29
UCEC	chr15	63764098	Nonsense_Mutation	novel	E342*	0.37
UCEC	chr15	63678233	Missense_Mutation	novel	R2228S	0.3
UCEC	chr15	63666443	Missense_Mutation	rs769159645	T2746A	0.12
UCEC	chr15	63833888	5'UTR	novel		0.4
UCEC	chr15	63669538	Missense_Mutation	NA	A2736T	0.49
UCEC	chr15	63674668	Missense_Mutation	NA	Q2507R	0.15
UCEC	chr15	63729642	Frame_Shift_Ins	novel	*A959Dfs11**	0.07
UCEC	chr15	63680717	Nonsense_Mutation	NA	W2095*	0.23
UCEC	chr15	63686424	Missense_Mutation	novel	G2054S	0.48
UCEC	chr15	63729328	Missense_Mutation	novel	L1021P	0.3
UCEC	chr15	63775484	Missense_Mutation	novel	V47A	0.4
UCEC	chr15	63775066	Frame_Shift_Ins	novel	*S187Kfs13**	0.06
UCEC	chr15	63775067	Frame_Shift_Ins	novel	*L186Hfs13**	0.04
UCEC	chr15	63696217	Silent	novel	S1676S	0.14
UCEC	chr15	63648068	Splice_Site	novel	X3626_splice	0.39
UCEC	chr15	63698816	Missense_Mutation	novel	A1606V	0.39
UCEC	chr15	63674970	Missense_Mutation	novel	M2406I	0.39
UCEC	chr15	63675039	Silent	rs777341695	A2383A	0.2
UCEC	chr15	63640415	Missense_Mutation	NA	H3880N	0.46
UCEC	chr15	63774839	Missense_Mutation	rs781546007	R262Q	0.34
UCEC	chr15	63733033	Missense_Mutation	novel	G920D	0.44
UCEC	chr15	63718855	Frame_Shift_Ins	NA	*T1262Nfs4**	0.51
UCEC	chr15	63678131	Nonsense_Mutation	novel	*Q2262Ifs8**	0.08
UCEC	chr15	63727721	Missense_Mutation	NA	P1091H	0.47
UCEC	chr15	63764176	Missense_Mutation	NA	R316W	0.41
UCEC	chr15	63752877	Intron	novel		0.23
UCEC	chr15	63612345	Missense_Mutation	rs759086324	R4769Q	0.36
UCEC	chr15	63616654	Missense_Mutation	rs770964448	D4573N	0.38
UCEC	chr15	63623728	Silent	novel	C4536C	0.21
UCEC	chr15	63640378	Missense_Mutation	novel	V3892A	0.21
UCEC	chr15	63674486	Nonsense_Mutation	novel	R2568*	0.35
UCEC	chr15	63675022	Missense_Mutation	novel	T2389M	0.23
UCEC	chr15	63678357	Missense_Mutation	novel	I2186M	0.4
UCEC	chr15	63727735	Silent	novel	L1086L	0.17
UCEC	chr15	63752852	Intron	novel		0.22
UCEC	chr15	63755291	Missense_Mutation	novel	S523N	0.25
UCEC	chr15	63758294	Missense_Mutation	novel	V368I	0.23
UCEC	chr15	63774720	Missense_Mutation	rs773366677	I302V	0.19
UCEC	chr15	63674950	Frame_Shift_Ins	novel	*R2413Qfs28**	0.04
UCEC	chr15	63608878	3'UTR	novel		0.44
UCEC	chr15	63630578	Missense_Mutation	novel	I4285N	0.4
UCEC	chr15	63655923	Silent	novel	L3301L	0.46
UCEC	chr15	63664513	Silent	novel	R2879R	0.46
UCEC	chr15	63623823	Missense_Mutation	NA	L4505I	0.32
UCEC	chr15	63649835	Missense_Mutation	NA	S3546Y	0.26
UCEC	chr15	63674932	Missense_Mutation	rs376323982	R2419Q	0.32
UCEC	chr15	63678253	Missense_Mutation	rs781012109	R2221H	0.23
UCEC	chr15	63686402	Missense_Mutation	NA	G2061V	0.3
UCEC	chr15	63694364	Missense_Mutation	NA	A1810S	0.13
UCEC	chr15	63756655	Missense_Mutation	NA	D439Y	0.17
UCEC	chr15	63764133	Missense_Mutation	NA	C330Y	0.24
UCEC	chr15	63616579	Missense_Mutation	novel	L4598F	0.48
UCEC	chr15	63628736	Missense_Mutation	novel	S4349L	0.39
UCEC	chr15	63643411	Missense_Mutation	novel	S3775F	0.36
UCEC	chr15	63659814	Missense_Mutation	novel	P3116S	0.37
UCEC	chr15	63674423	Missense_Mutation	novel	L2589M	0.41
UCEC	chr15	63713579	Nonsense_Mutation	novel	R1413*	0.45
UCEC	chr15	63725347	Nonsense_Mutation	novel	Y1171*	0.41
UCEC	chr15	63674649	Silent	rs369950378	L2513L	0.33
UCEC	chr15	63680572	Missense_Mutation	novel	E2144K	0.26
UCEC	chr15	63698781	Missense_Mutation	novel	T1618A	0.39
UCEC	chr15	63712870	Missense_Mutation	rs773120855	R1497W	0.31
UCEC	chr15	63747779	Missense_Mutation	novel	R767G	0.31
UCEC	chr15	63775053	Missense_Mutation	rs761404083	D191N	0.39
UCS	chr15	63729295	Missense_Mutation	rs775255598	R1032H	0.21
UCS	chr15	63678032	Nonsense_Mutation	novel	Q2295*	0.39
UCS	chr15	63680778	Splice_Site	novel	X2076_splice	0.43

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KICH	AMP	0.303	0.21756
KIRP	DEL	0.0972	0.2062
LGG	AMP	0.0175	0.19963
PAAD	AMP	0.0598	0.20695
PAAD	DEL	0.1087	0.13216

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.0023	Kaplan-Meier Survival Analysis
HNSC	0.0013	Kaplan-Meier Survival Analysis
ESCA	0.049	Kaplan-Meier Survival Analysis
PAAD	0.002	Kaplan-Meier Survival Analysis
READ	0.016	Kaplan-Meier Survival Analysis
LGG	0.00022	Kaplan-Meier Survival Analysis
LUAD	0.00021	Kaplan-Meier Survival Analysis
OV	0.0029	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

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Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742