EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000103671 (Gene tree)
Gene ID: 9325
Gene Symbol: TRIP4
Alias: HsT17391|ZC2HC5|ASC-1
Full Name: thyroid hormone receptor interactor 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 67,556 bases
Position: chr15:64,387,748-64,455,303
Accession: 12310
RBP type: canonical RBP
Summary: This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000261884	ASCH	PF04266.14	3.3e-19	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000561265	TRIP4-212	1039	-	-	- (aa)	-	-
ENST00000560567	TRIP4-210	1536	-	ENSP00000453106	368 (aa)	-	H0YL91
ENST00000559833	TRIP4-208	636	-	-	- (aa)	-	-
ENST00000557834	TRIP4-202	586	-	-	- (aa)	-	-
ENST00000560475	TRIP4-209	521	-	ENSP00000454558	61 (aa)	-	H3BMU9
ENST00000558820	TRIP4-205	847	-	ENSP00000452675	43 (aa)	-	H0YK63
ENST00000558442	TRIP4-204	362	-	-	- (aa)	-	-
ENST00000559565	TRIP4-206	761	-	-	- (aa)	-	-
ENST00000560920	TRIP4-211	565	-	ENSP00000453276	126 (aa)	-	H0YLN7
ENST00000559777	TRIP4-207	425	-	-	- (aa)	-	-
ENST00000261884	TRIP4-201	2045	-	ENSP00000261884	581 (aa)	-	Q15650
ENST00000558162	TRIP4-203	558	-	ENSP00000452764	111 (aa)	-	H0YKD9

Gene Model

Click here to download ENSG00000103671's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000103671	Alzheimer Disease	4E-7	24162737

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000103671	rs74615166	15	64433291	C	Alzheimer's disease (late onset)	24162737	[1.17-1.42]	1.29	EFO_0000249
ENSG00000103671	rs72741332	15	64452591	?	Menarche (age at onset)	30595370			EFO_0004703

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000103671's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000103671	TRIP4	95	46.858	ENSAPOG00000023326	trip4	97	46.454	Acanthochromis_polyacanthus
ENSG00000103671	TRIP4	100	91.050	ENSAMEG00000002591	TRIP4	100	91.050	Ailuropoda_melanoleuca
ENSG00000103671	TRIP4	95	55.018	ENSACIG00000010577	trip4	98	55.018	Amphilophus_citrinellus
ENSG00000103671	TRIP4	92	59.942	ENSAOCG00000000395	trip4	96	54.674	Amphiprion_ocellaris
ENSG00000103671	TRIP4	97	57.886	ENSAPEG00000003621	trip4	99	58.579	Amphiprion_percula
ENSG00000103671	TRIP4	98	58.966	ENSATEG00000019577	trip4	99	59.483	Anabas_testudineus
ENSG00000103671	TRIP4	98	70.984	ENSAPLG00000004612	TRIP4	99	70.984	Anas_platyrhynchos
ENSG00000103671	TRIP4	98	69.151	ENSACAG00000007077	TRIP4	90	69.151	Anolis_carolinensis
ENSG00000103671	TRIP4	100	97.418	ENSANAG00000027612	TRIP4	100	97.418	Aotus_nancymaae
ENSG00000103671	TRIP4	98	60.622	ENSACLG00000013819	trip4	99	61.391	Astatotilapia_calliptera
ENSG00000103671	TRIP4	97	60.315	ENSAMXG00000007270	trip4	99	60.664	Astyanax_mexicanus
ENSG00000103671	TRIP4	99	87.952	ENSBTAG00000014493	TRIP4	99	87.952	Bos_taurus
ENSG00000103671	TRIP4	100	97.246	ENSCJAG00000005107	TRIP4	100	97.246	Callithrix_jacchus
ENSG00000103671	TRIP4	100	90.534	ENSCAFG00000017091	TRIP4	100	90.534	Canis_familiaris
ENSG00000103671	TRIP4	100	90.534	ENSCAFG00020008960	TRIP4	100	90.534	Canis_lupus_dingo
ENSG00000103671	TRIP4	97	87.722	ENSCHIG00000023818	TRIP4	98	87.722	Capra_hircus
ENSG00000103671	TRIP4	100	94.836	ENSTSYG00000007185	TRIP4	100	94.836	Carlito_syrichta
ENSG00000103671	TRIP4	70	85.714	ENSCAPG00000017624	TRIP4	89	85.714	Cavia_aperea
ENSG00000103671	TRIP4	100	88.640	ENSCPOG00000006483	TRIP4	100	88.640	Cavia_porcellus
ENSG00000103671	TRIP4	100	90.017	ENSCCAG00000026483	TRIP4	100	90.017	Cebus_capucinus
ENSG00000103671	TRIP4	100	98.967	ENSCATG00000041144	TRIP4	100	98.967	Cercocebus_atys
ENSG00000103671	TRIP4	100	90.361	ENSCLAG00000006872	TRIP4	100	90.361	Chinchilla_lanigera
ENSG00000103671	TRIP4	100	99.139	ENSCSAG00000012499	TRIP4	100	99.139	Chlorocebus_sabaeus
ENSG00000103671	TRIP4	82	78.788	ENSCHOG00000010776	TRIP4	82	78.788	Choloepus_hoffmanni
ENSG00000103671	TRIP4	97	69.718	ENSCPBG00000006093	TRIP4	99	69.542	Chrysemys_picta_bellii
ENSG00000103671	TRIP4	60	44.776	ENSCING00000020094	-	98	50.345	Ciona_intestinalis
ENSG00000103671	TRIP4	98	41.709	ENSCSAVG00000005293	-	99	41.709	Ciona_savignyi
ENSG00000103671	TRIP4	100	95.869	ENSCANG00000033593	TRIP4	100	95.869	Colobus_angolensis_palliatus
ENSG00000103671	TRIP4	100	90.189	ENSCGRG00001021158	Trip4	100	90.189	Cricetulus_griseus_chok1gshd
ENSG00000103671	TRIP4	91	87.143	ENSCGRG00000002340	Trip4	100	87.143	Cricetulus_griseus_crigri
ENSG00000103671	TRIP4	97	58.448	ENSCSEG00000009015	trip4	98	58.448	Cynoglossus_semilaevis
ENSG00000103671	TRIP4	97	56.201	ENSCVAG00000021094	-	90	57.714	Cyprinodon_variegatus
ENSG00000103671	TRIP4	97	56.201	ENSCVAG00000020984	trip4	99	57.303	Cyprinodon_variegatus
ENSG00000103671	TRIP4	97	57.996	ENSDARG00000098074	trip4	99	58.772	Danio_rerio
ENSG00000103671	TRIP4	100	89.845	ENSDNOG00000008654	TRIP4	100	89.845	Dasypus_novemcinctus
ENSG00000103671	TRIP4	100	90.361	ENSDORG00000014914	Trip4	100	90.361	Dipodomys_ordii
ENSG00000103671	TRIP4	74	39.450	FBgn0031115	CG11710	80	39.450	Drosophila_melanogaster
ENSG00000103671	TRIP4	100	84.812	ENSETEG00000001597	TRIP4	100	84.812	Echinops_telfairi
ENSG00000103671	TRIP4	98	47.759	ENSEBUG00000009039	trip4	99	48.359	Eptatretus_burgeri
ENSG00000103671	TRIP4	100	91.222	ENSEASG00005006538	TRIP4	100	91.222	Equus_asinus_asinus
ENSG00000103671	TRIP4	94	90.778	ENSECAG00000024689	TRIP4	99	88.419	Equus_caballus
ENSG00000103671	TRIP4	80	85.864	ENSEEUG00000007741	TRIP4	80	85.864	Erinaceus_europaeus
ENSG00000103671	TRIP4	98	55.613	ENSELUG00000022449	trip4	99	55.613	Esox_lucius
ENSG00000103671	TRIP4	100	91.394	ENSFCAG00000010618	TRIP4	100	91.394	Felis_catus
ENSG00000103671	TRIP4	98	68.858	ENSFALG00000009816	TRIP4	99	69.031	Ficedula_albicollis
ENSG00000103671	TRIP4	100	90.706	ENSFDAG00000017051	TRIP4	100	90.706	Fukomys_damarensis
ENSG00000103671	TRIP4	97	59.862	ENSFHEG00000015795	trip4	99	59.862	Fundulus_heteroclitus
ENSG00000103671	TRIP4	97	57.886	ENSGMOG00000008455	trip4	99	57.886	Gadus_morhua
ENSG00000103671	TRIP4	100	70.017	ENSGALG00000030672	TRIP4	99	70.017	Gallus_gallus
ENSG00000103671	TRIP4	97	58.966	ENSGAFG00000003491	trip4	99	58.966	Gambusia_affinis
ENSG00000103671	TRIP4	98	56.897	ENSGACG00000016986	trip4	99	56.757	Gasterosteus_aculeatus
ENSG00000103671	TRIP4	81	70.711	ENSGAGG00000003671	TRIP4	85	70.711	Gopherus_agassizii
ENSG00000103671	TRIP4	100	99.828	ENSGGOG00000022608	TRIP4	100	99.828	Gorilla_gorilla
ENSG00000103671	TRIP4	98	60.794	ENSHBUG00000021071	trip4	99	61.391	Haplochromis_burtoni
ENSG00000103671	TRIP4	100	90.706	ENSHGLG00000009286	TRIP4	100	90.706	Heterocephalus_glaber_female
ENSG00000103671	TRIP4	100	90.189	ENSHGLG00100017760	TRIP4	100	90.189	Heterocephalus_glaber_male
ENSG00000103671	TRIP4	97	57.340	ENSHCOG00000017904	trip4	98	57.858	Hippocampus_comes
ENSG00000103671	TRIP4	98	59.445	ENSIPUG00000013205	trip4	99	59.965	Ictalurus_punctatus
ENSG00000103671	TRIP4	100	93.804	ENSSTOG00000014228	TRIP4	100	93.804	Ictidomys_tridecemlineatus
ENSG00000103671	TRIP4	97	81.996	ENSJJAG00000001629	Trip4	99	81.996	Jaculus_jaculus
ENSG00000103671	TRIP4	97	61.538	ENSKMAG00000001297	trip4	99	61.538	Kryptolebias_marmoratus
ENSG00000103671	TRIP4	97	59.272	ENSLBEG00000018354	trip4	99	59.792	Labrus_bergylta
ENSG00000103671	TRIP4	99	64.028	ENSLACG00000014856	TRIP4	99	64.028	Latimeria_chalumnae
ENSG00000103671	TRIP4	98	61.847	ENSLOCG00000014993	trip4	99	61.847	Lepisosteus_oculatus
ENSG00000103671	TRIP4	100	88.468	ENSLAFG00000017612	TRIP4	100	88.468	Loxodonta_africana
ENSG00000103671	TRIP4	100	98.967	ENSMFAG00000036568	TRIP4	100	98.967	Macaca_fascicularis
ENSG00000103671	TRIP4	100	98.967	ENSMMUG00000009882	TRIP4	100	98.967	Macaca_mulatta
ENSG00000103671	TRIP4	100	99.139	ENSMNEG00000033592	TRIP4	100	99.139	Macaca_nemestrina
ENSG00000103671	TRIP4	100	98.967	ENSMLEG00000027911	TRIP4	100	98.967	Mandrillus_leucophaeus
ENSG00000103671	TRIP4	97	58.232	ENSMAMG00000013374	trip4	99	58.232	Mastacembelus_armatus
ENSG00000103671	TRIP4	98	60.794	ENSMZEG00005013450	trip4	99	61.391	Maylandia_zebra
ENSG00000103671	TRIP4	100	95.525	ENSMICG00000008679	TRIP4	100	95.525	Microcebus_murinus
ENSG00000103671	TRIP4	100	89.845	ENSMOCG00000012669	Trip4	100	89.845	Microtus_ochrogaster
ENSG00000103671	TRIP4	95	58.929	ENSMMOG00000002315	trip4	98	59.464	Mola_mola
ENSG00000103671	TRIP4	100	77.835	ENSMODG00000010743	TRIP4	91	77.835	Monodelphis_domestica
ENSG00000103671	TRIP4	100	89.157	MGP_CAROLIEiJ_G0032370	Trip4	100	89.157	Mus_caroli
ENSG00000103671	TRIP4	100	88.640	ENSMUSG00000032386	Trip4	100	88.640	Mus_musculus
ENSG00000103671	TRIP4	100	88.468	MGP_PahariEiJ_G0015235	Trip4	100	88.468	Mus_pahari
ENSG00000103671	TRIP4	100	88.985	MGP_SPRETEiJ_G0033509	Trip4	100	88.985	Mus_spretus
ENSG00000103671	TRIP4	100	90.878	ENSMPUG00000000568	TRIP4	100	90.878	Mustela_putorius_furo
ENSG00000103671	TRIP4	95	89.636	ENSMLUG00000013367	TRIP4	100	89.636	Myotis_lucifugus
ENSG00000103671	TRIP4	100	91.252	ENSNGAG00000019566	Trip4	100	91.252	Nannospalax_galili
ENSG00000103671	TRIP4	96	59.965	ENSNBRG00000020663	trip4	97	60.847	Neolamprologus_brichardi
ENSG00000103671	TRIP4	100	98.967	ENSNLEG00000012455	TRIP4	100	98.967	Nomascus_leucogenys
ENSG00000103671	TRIP4	74	78.049	ENSMEUG00000005886	TRIP4	86	72.000	Notamacropus_eugenii
ENSG00000103671	TRIP4	100	83.477	ENSOPRG00000009512	TRIP4	100	83.477	Ochotona_princeps
ENSG00000103671	TRIP4	100	89.329	ENSODEG00000016494	TRIP4	100	89.329	Octodon_degus
ENSG00000103671	TRIP4	92	62.209	ENSONIG00000005703	trip4	98	59.810	Oreochromis_niloticus
ENSG00000103671	TRIP4	98	78.284	ENSOANG00000013357	TRIP4	99	76.780	Ornithorhynchus_anatinus
ENSG00000103671	TRIP4	100	92.255	ENSOCUG00000002322	TRIP4	100	92.255	Oryctolagus_cuniculus
ENSG00000103671	TRIP4	97	57.340	ENSORLG00000001710	trip4	99	57.858	Oryzias_latipes
ENSG00000103671	TRIP4	97	57.831	ENSORLG00020022346	trip4	99	58.348	Oryzias_latipes_hni
ENSG00000103671	TRIP4	97	58.549	ENSORLG00015022509	trip4	99	59.067	Oryzias_latipes_hsok
ENSG00000103671	TRIP4	97	59.826	ENSOMEG00000007655	trip4	99	60.348	Oryzias_melastigma
ENSG00000103671	TRIP4	100	84.906	ENSOGAG00000012427	TRIP4	100	84.906	Otolemur_garnettii
ENSG00000103671	TRIP4	99	88.124	ENSOARG00000020739	TRIP4	99	88.124	Ovis_aries
ENSG00000103671	TRIP4	100	99.828	ENSPPAG00000017953	TRIP4	100	99.828	Pan_paniscus
ENSG00000103671	TRIP4	100	91.222	ENSPPRG00000013668	TRIP4	100	91.222	Panthera_pardus
ENSG00000103671	TRIP4	100	91.222	ENSPTIG00000014502	TRIP4	100	91.222	Panthera_tigris_altaica
ENSG00000103671	TRIP4	100	90.878	ENSPTRG00000007160	TRIP4	100	90.878	Pan_troglodytes
ENSG00000103671	TRIP4	100	99.139	ENSPANG00000016750	TRIP4	100	99.139	Papio_anubis
ENSG00000103671	TRIP4	92	58.213	ENSPKIG00000009253	trip4	99	57.414	Paramormyrops_kingsleyae
ENSG00000103671	TRIP4	98	59.028	ENSPKIG00000022978	-	99	59.028	Paramormyrops_kingsleyae
ENSG00000103671	TRIP4	94	70.450	ENSPSIG00000012082	TRIP4	98	70.450	Pelodiscus_sinensis
ENSG00000103671	TRIP4	98	54.355	ENSPMGG00000019015	trip4	98	54.704	Periophthalmus_magnuspinnatus
ENSG00000103671	TRIP4	100	87.091	ENSPEMG00000012446	Trip4	100	87.091	Peromyscus_maniculatus_bairdii
ENSG00000103671	TRIP4	99	77.990	ENSPCIG00000029450	TRIP4	95	77.835	Phascolarctos_cinereus
ENSG00000103671	TRIP4	97	58.681	ENSPFOG00000014732	trip4	99	58.681	Poecilia_formosa
ENSG00000103671	TRIP4	97	58.681	ENSPLAG00000013794	trip4	99	58.681	Poecilia_latipinna
ENSG00000103671	TRIP4	99	58.377	ENSPMEG00000001331	trip4	99	58.854	Poecilia_mexicana
ENSG00000103671	TRIP4	97	57.812	ENSPREG00000006576	trip4	99	57.812	Poecilia_reticulata
ENSG00000103671	TRIP4	100	99.139	ENSPPYG00000006550	TRIP4	100	99.139	Pongo_abelii
ENSG00000103671	TRIP4	98	77.895	ENSPCAG00000016310	TRIP4	100	77.625	Procavia_capensis
ENSG00000103671	TRIP4	97	99.219	ENSPCOG00000013484	TRIP4	100	77.625	Propithecus_coquereli
ENSG00000103671	TRIP4	95	90.517	ENSPVAG00000016613	TRIP4	100	79.249	Pteropus_vampyrus
ENSG00000103671	TRIP4	98	57.565	ENSPNYG00000011318	trip4	98	57.739	Pundamilia_nyererei
ENSG00000103671	TRIP4	98	59.298	ENSPNAG00000020884	trip4	99	59.825	Pygocentrus_nattereri
ENSG00000103671	TRIP4	100	88.640	ENSRNOG00000016121	Trip4	100	88.640	Rattus_norvegicus
ENSG00000103671	TRIP4	88	99.265	ENSRBIG00000038027	TRIP4	100	99.265	Rhinopithecus_bieti
ENSG00000103671	TRIP4	100	99.484	ENSRROG00000030525	TRIP4	100	99.484	Rhinopithecus_roxellana
ENSG00000103671	TRIP4	100	85.370	ENSSBOG00000020516	TRIP4	100	85.370	Saimiri_boliviensis_boliviensis
ENSG00000103671	TRIP4	94	78.832	ENSSHAG00000000040	TRIP4	100	78.832	Sarcophilus_harrisii
ENSG00000103671	TRIP4	98	59.123	ENSSFOG00015000143	trip4	98	59.860	Scleropages_formosus
ENSG00000103671	TRIP4	97	58.885	ENSSMAG00000010539	trip4	99	58.885	Scophthalmus_maximus
ENSG00000103671	TRIP4	97	58.448	ENSSDUG00000000225	trip4	99	59.310	Seriola_dumerili
ENSG00000103671	TRIP4	97	58.793	ENSSLDG00000000215	trip4	99	59.310	Seriola_lalandi_dorsalis
ENSG00000103671	TRIP4	83	88.473	ENSSARG00000003710	TRIP4	83	88.473	Sorex_araneus
ENSG00000103671	TRIP4	96	62.903	ENSSPUG00000004511	TRIP4	98	64.043	Sphenodon_punctatus
ENSG00000103671	TRIP4	97	59.585	ENSSPAG00000008520	trip4	99	59.585	Stegastes_partitus
ENSG00000103671	TRIP4	100	89.501	ENSSSCG00000004552	TRIP4	90	89.501	Sus_scrofa
ENSG00000103671	TRIP4	98	69.580	ENSTGUG00000004673	TRIP4	100	69.580	Taeniopygia_guttata
ENSG00000103671	TRIP4	97	57.216	ENSTRUG00000016488	trip4	99	57.732	Takifugu_rubripes
ENSG00000103671	TRIP4	99	58.020	ENSTNIG00000009582	trip4	99	58.020	Tetraodon_nigroviridis
ENSG00000103671	TRIP4	94	93.248	ENSTBEG00000015881	TRIP4	100	93.248	Tupaia_belangeri
ENSG00000103671	TRIP4	94	87.032	ENSTTRG00000009674	TRIP4	89	90.625	Tursiops_truncatus
ENSG00000103671	TRIP4	100	90.361	ENSUMAG00000012640	TRIP4	100	90.361	Ursus_maritimus
ENSG00000103671	TRIP4	100	86.059	ENSVPAG00000010808	TRIP4	100	86.059	Vicugna_pacos
ENSG00000103671	TRIP4	100	91.222	ENSVVUG00000013776	TRIP4	100	91.222	Vulpes_vulpes
ENSG00000103671	TRIP4	97	59.790	ENSXETG00000010649	trip4	97	59.790	Xenopus_tropicalis
ENSG00000103671	TRIP4	97	58.681	ENSXMAG00000000526	trip4	99	59.375	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002020	protease binding	25219498.	IPI	Function
GO:0003713	transcription coactivator activity	21873635.	IBA	Function
GO:0003713	transcription coactivator activity	25219498.	IMP	Function
GO:0005515	protein binding	25219498.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	10454579.12077347.25219498.26924529.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	10454579.	IDA	Component
GO:0005813	centrosome	20873783.	IDA	Component
GO:0005829	cytosol	-	IEA	Component
GO:0006355	regulation of transcription, DNA-templated	12077347.	IDA	Process
GO:0006355	regulation of transcription, DNA-templated	26924529.	IMP	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0016604	nuclear body	-	IDA	Component
GO:0016922	nuclear receptor binding	10454579.	IDA	Function
GO:0019901	protein kinase binding	20873783.	IPI	Function
GO:0030331	estrogen receptor binding	25219498.	IPI	Function
GO:0030520	intracellular estrogen receptor signaling pathway	25219498.	IDA	Process
GO:0031594	neuromuscular junction	26924529.	IMP	Component
GO:0032991	protein-containing complex	20873783.	IDA	Component
GO:0035035	histone acetyltransferase binding	25219498.	IPI	Function
GO:0044389	ubiquitin-like protein ligase binding	25219498.	IPI	Function
GO:0045661	regulation of myoblast differentiation	-	ISS	Process
GO:0045893	positive regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0045893	positive regulation of transcription, DNA-templated	25219498.	IMP	Process
GO:0099053	activating signal cointegrator 1 complex	12077347.	IDA	Component
GO:1901998	toxin transport	-	IEA	Process