EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000103966 (Gene tree)
Gene ID: 30844
Gene Symbol: EHD4
Alias: PAST4
Full Name: EH domain containing 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 76,640 bases
Position: chr15:41,895,939-41,972,578
Accession: 3245
RBP type: canonical RBP
Summary: EHD4 (EH Domain Containing 4) is a Protein Coding gene. Among its related pathways are Endocytosis and Trk receptor signaling mediated by the MAPK pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and GTP binding. An important paralog of this gene is EHD3.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000220325	MMR_HSR1	PF01926.23	1e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000569223	EHD4-202	2032	-	-	- (aa)	-	-
ENST00000220325	EHD4-201	6416	-	ENSP00000220325	541 (aa)	-	Q9H223

Gene Model

Click here to download ENSG00000103966's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04144	Endocytosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000103966	Heart Rate	6.83820371251711E-6	17903306
ENSG00000103966	Lymphocyte Count	2.0590000E-005	-
ENSG00000103966	Neutrophils	5.2760000E-005	-
ENSG00000103966	Platelet Function Tests	2.1403900E-005	-
ENSG00000103966	Platelet Function Tests	1.6534600E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000103966	rs17739167	15	41942834	G	Monocyte count	27863252	[0.025-0.041] unit increase	0.03312018	EFO_0005091
ENSG00000103966	rs57556178	15	41950690	?	Monocyte count	29403010	[0.029-0.061] unit decrease novel	0.04488	EFO_0005091
ENSG00000103966	rs4924590	15	41941475	A	Lymphocyte percentage of white cells	27863252	[0.02-0.037] unit decrease	0.02847509	EFO_0007993
ENSG00000103966	rs12101888	15	41939155	T	Myeloid white cell count	27863252	[0.03-0.046] unit increase	0.03781998	EFO_0007988
ENSG00000103966	rs2250635	15	41969267	C	Myeloid white cell count	27863252	[0.04-0.063] unit decrease	0.0514926	EFO_0007988
ENSG00000103966	rs1704413	15	41972233	G	Platelet count	27863252	[0.023-0.046] unit decrease	0.03430164	EFO_0004309
ENSG00000103966	rs12101888	15	41939155	T	White blood cell count	27863252	[0.026-0.042] unit increase	0.033985	EFO_0004308
ENSG00000103966	rs12101888	15	41939155	T	Neutrophil count	27863252	[0.027-0.043] unit increase	0.03508634	EFO_0004833
ENSG00000103966	rs2250635	15	41969267	C	Neutrophil count	27863252	[0.035-0.057] unit decrease	0.0459773	EFO_0004833
ENSG00000103966	rs4924590	15	41941475	A	Granulocyte count	27863252	[0.028-0.044] unit increase	0.03594739	EFO_0007987
ENSG00000103966	rs2250635	15	41969267	C	Granulocyte count	27863252	[0.036-0.058] unit decrease	0.04691554	EFO_0007987
ENSG00000103966	rs2250635	15	41969267	C	Sum neutrophil eosinophil counts	27863252	[0.036-0.059] unit decrease	0.04748152	EFO_0004833\|EFO_0004842
ENSG00000103966	rs12101888	15	41939155	T	Sum neutrophil eosinophil counts	27863252	[0.028-0.044] unit increase	0.03573294	EFO_0004833\|EFO_0004842
ENSG00000103966	rs2250635	15	41969267	C	Sum basophil neutrophil counts	27863252	[0.034-0.057] unit decrease	0.0453847	EFO_0004833\|EFO_0005090
ENSG00000103966	rs4924590	15	41941475	A	Sum basophil neutrophil counts	27863252	[0.027-0.044] unit increase	0.03532786	EFO_0004833\|EFO_0005090
ENSG00000103966	rs11631075	15	41942975	G	Heel bone mineral density	30598549	[0.0085-0.0159] unit increase	0.0121872	EFO_0009270
ENSG00000103966	rs8035074	15	41947581	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000103966	rs72726027	15	41956628	?	White blood cell count	30595370			EFO_0004308
ENSG00000103966	rs1614170	15	41947207	?	Eosinophil counts	30595370			EFO_0004842
ENSG00000103966	rs11631075	15	41942975	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000103966's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000103966	EHD4	100	76.895	ENSAPOG00000004967	ehd4	86	76.895	Acanthochromis_polyacanthus
ENSG00000103966	EHD4	100	98.706	ENSAMEG00000016343	EHD4	100	98.706	Ailuropoda_melanoleuca
ENSG00000103966	EHD4	100	76.895	ENSAPEG00000013326	ehd4	99	76.895	Amphiprion_percula
ENSG00000103966	EHD4	100	77.634	ENSATEG00000015573	ehd4	99	77.634	Anabas_testudineus
ENSG00000103966	EHD4	99	90.706	ENSAPLG00000008924	EHD4	94	90.706	Anas_platyrhynchos
ENSG00000103966	EHD4	99	87.616	ENSACAG00000014864	EHD4	99	87.616	Anolis_carolinensis
ENSG00000103966	EHD4	100	98.706	ENSANAG00000033562	EHD4	100	98.706	Aotus_nancymaae
ENSG00000103966	EHD4	100	77.449	ENSACLG00000017182	ehd4	99	77.449	Astatotilapia_calliptera
ENSG00000103966	EHD4	100	79.852	ENSAMXG00000008348	ehd4	99	79.852	Astyanax_mexicanus
ENSG00000103966	EHD4	100	94.640	ENSBTAG00000006792	EHD4	100	94.640	Bos_taurus
ENSG00000103966	EHD4	100	98.891	ENSCJAG00000020657	EHD4	100	98.891	Callithrix_jacchus
ENSG00000103966	EHD4	100	98.521	ENSCAFG00000009869	EHD4	100	98.521	Canis_familiaris
ENSG00000103966	EHD4	100	98.521	ENSCAFG00020004728	EHD4	100	98.521	Canis_lupus_dingo
ENSG00000103966	EHD4	100	94.824	ENSCHIG00000025291	EHD4	100	94.824	Capra_hircus
ENSG00000103966	EHD4	100	98.521	ENSTSYG00000028107	EHD4	100	98.521	Carlito_syrichta
ENSG00000103966	EHD4	100	98.891	ENSCCAG00000030886	EHD4	100	98.891	Cebus_capucinus
ENSG00000103966	EHD4	100	99.445	ENSCATG00000034221	EHD4	100	99.445	Cercocebus_atys
ENSG00000103966	EHD4	100	99.445	ENSCSAG00000008190	EHD4	100	99.445	Chlorocebus_sabaeus
ENSG00000103966	EHD4	96	89.942	ENSCPBG00000011098	EHD4	99	89.942	Chrysemys_picta_bellii
ENSG00000103966	EHD4	98	63.080	ENSCING00000023326	-	99	63.080	Ciona_intestinalis
ENSG00000103966	EHD4	98	63.956	ENSCSAVG00000000028	-	98	63.956	Ciona_savignyi
ENSG00000103966	EHD4	100	97.227	ENSCGRG00001024863	Ehd4	100	97.227	Cricetulus_griseus_chok1gshd
ENSG00000103966	EHD4	95	97.476	ENSCGRG00000007631	Ehd4	99	97.476	Cricetulus_griseus_crigri
ENSG00000103966	EHD4	99	76.923	ENSCSEG00000011195	ehd4	78	77.052	Cynoglossus_semilaevis
ENSG00000103966	EHD4	100	76.710	ENSCVAG00000006962	ehd4	99	76.710	Cyprinodon_variegatus
ENSG00000103966	EHD4	100	76.895	ENSDARG00000054302	ehd4	88	76.895	Danio_rerio
ENSG00000103966	EHD4	100	97.597	ENSDNOG00000037551	EHD4	100	97.597	Dasypus_novemcinctus
ENSG00000103966	EHD4	99	98.327	ENSEASG00005015157	EHD4	100	98.327	Equus_asinus_asinus
ENSG00000103966	EHD4	99	98.327	ENSECAG00000017216	EHD4	100	98.327	Equus_caballus
ENSG00000103966	EHD4	100	97.412	ENSEEUG00000009114	EHD4	100	97.412	Erinaceus_europaeus
ENSG00000103966	EHD4	99	77.612	ENSELUG00000004390	ehd4	98	77.612	Esox_lucius
ENSG00000103966	EHD4	100	97.967	ENSFCAG00000040964	EHD4	100	97.967	Felis_catus
ENSG00000103966	EHD4	89	90.397	ENSFALG00000005954	EHD4	100	90.397	Ficedula_albicollis
ENSG00000103966	EHD4	89	96.033	ENSFDAG00000015044	EHD4	100	96.033	Fukomys_damarensis
ENSG00000103966	EHD4	100	90.221	ENSGALG00000008950	EHD4	100	90.406	Gallus_gallus
ENSG00000103966	EHD4	100	76.710	ENSGAFG00000007267	ehd4	99	76.866	Gambusia_affinis
ENSG00000103966	EHD4	99	89.219	ENSGAGG00000020474	EHD4	99	89.219	Gopherus_agassizii
ENSG00000103966	EHD4	100	99.445	ENSGGOG00000011817	EHD4	100	99.445	Gorilla_gorilla
ENSG00000103966	EHD4	100	77.449	ENSHBUG00000016153	ehd4	99	77.449	Haplochromis_burtoni
ENSG00000103966	EHD4	100	95.009	ENSHGLG00000016918	EHD4	100	95.009	Heterocephalus_glaber_female
ENSG00000103966	EHD4	99	76.306	ENSHCOG00000021219	ehd4	98	76.306	Hippocampus_comes
ENSG00000103966	EHD4	100	78.928	ENSIPUG00000018207	ehd4	99	78.928	Ictalurus_punctatus
ENSG00000103966	EHD4	100	97.967	ENSSTOG00000000719	EHD4	100	97.967	Ictidomys_tridecemlineatus
ENSG00000103966	EHD4	99	76.679	ENSLBEG00000020127	ehd4	98	76.679	Labrus_bergylta
ENSG00000103966	EHD4	99	81.564	ENSLACG00000017804	EHD4	91	81.564	Latimeria_chalumnae
ENSG00000103966	EHD4	99	79.702	ENSLOCG00000009774	ehd4	98	79.702	Lepisosteus_oculatus
ENSG00000103966	EHD4	100	99.445	ENSMFAG00000042599	EHD4	100	99.445	Macaca_fascicularis
ENSG00000103966	EHD4	100	99.445	ENSMMUG00000003846	EHD4	100	99.445	Macaca_mulatta
ENSG00000103966	EHD4	100	99.445	ENSMNEG00000031951	EHD4	100	99.445	Macaca_nemestrina
ENSG00000103966	EHD4	100	77.634	ENSMAMG00000000024	ehd4	99	77.634	Mastacembelus_armatus
ENSG00000103966	EHD4	100	77.449	ENSMZEG00005024022	ehd4	99	77.449	Maylandia_zebra
ENSG00000103966	EHD4	100	77.449	ENSMZEG00005004542	-	99	77.449	Maylandia_zebra
ENSG00000103966	EHD4	100	97.043	ENSMAUG00000020399	Ehd4	100	97.043	Mesocricetus_auratus
ENSG00000103966	EHD4	100	97.412	ENSMICG00000034027	EHD4	100	97.412	Microcebus_murinus
ENSG00000103966	EHD4	100	97.043	ENSMOCG00000010893	Ehd4	100	97.043	Microtus_ochrogaster
ENSG00000103966	EHD4	100	77.264	ENSMMOG00000013306	ehd4	99	77.264	Mola_mola
ENSG00000103966	EHD4	100	95.379	ENSMODG00000017946	EHD4	100	95.379	Monodelphis_domestica
ENSG00000103966	EHD4	100	76.895	ENSMALG00000005796	ehd4	99	76.895	Monopterus_albus
ENSG00000103966	EHD4	100	97.043	MGP_CAROLIEiJ_G0024161	Ehd4	100	97.043	Mus_caroli
ENSG00000103966	EHD4	100	97.043	ENSMUSG00000027293	Ehd4	100	97.043	Mus_musculus
ENSG00000103966	EHD4	100	96.673	MGP_PahariEiJ_G0025603	Ehd4	100	96.673	Mus_pahari
ENSG00000103966	EHD4	100	97.043	MGP_SPRETEiJ_G0025077	Ehd4	100	97.043	Mus_spretus
ENSG00000103966	EHD4	100	98.152	ENSMPUG00000009546	EHD4	100	98.152	Mustela_putorius_furo
ENSG00000103966	EHD4	100	96.488	ENSMLUG00000011689	EHD4	100	96.488	Myotis_lucifugus
ENSG00000103966	EHD4	100	97.782	ENSNGAG00000004194	Ehd4	100	97.782	Nannospalax_galili
ENSG00000103966	EHD4	100	77.264	ENSNBRG00000022623	ehd4	99	77.264	Neolamprologus_brichardi
ENSG00000103966	EHD4	67	97.245	ENSMEUG00000006980	EHD4	100	97.245	Notamacropus_eugenii
ENSG00000103966	EHD4	99	96.654	ENSODEG00000016665	EHD4	100	96.654	Octodon_degus
ENSG00000103966	EHD4	100	77.449	ENSONIG00000001849	ehd4	98	77.449	Oreochromis_niloticus
ENSG00000103966	EHD4	100	97.043	ENSOCUG00000015759	EHD4	100	97.043	Oryctolagus_cuniculus
ENSG00000103966	EHD4	100	76.710	ENSORLG00000010433	ehd4	99	76.710	Oryzias_latipes
ENSG00000103966	EHD4	100	76.710	ENSORLG00020001245	ehd4	99	76.710	Oryzias_latipes_hni
ENSG00000103966	EHD4	100	76.710	ENSORLG00015020872	ehd4	99	76.710	Oryzias_latipes_hsok
ENSG00000103966	EHD4	100	76.895	ENSOMEG00000019758	ehd4	99	76.895	Oryzias_melastigma
ENSG00000103966	EHD4	100	97.227	ENSOGAG00000016070	EHD4	100	97.227	Otolemur_garnettii
ENSG00000103966	EHD4	100	94.640	ENSOARG00000020458	EHD4	100	94.640	Ovis_aries
ENSG00000103966	EHD4	100	99.445	ENSPPAG00000042014	EHD4	100	99.445	Pan_paniscus
ENSG00000103966	EHD4	100	97.782	ENSPPRG00000013283	EHD4	100	97.782	Panthera_pardus
ENSG00000103966	EHD4	97	97.897	ENSPTIG00000021127	EHD4	99	97.897	Panthera_tigris_altaica
ENSG00000103966	EHD4	100	99.815	ENSPTRG00000006964	EHD4	100	99.815	Pan_troglodytes
ENSG00000103966	EHD4	100	99.445	ENSPANG00000018707	EHD4	100	99.445	Papio_anubis
ENSG00000103966	EHD4	78	78.095	ENSPMGG00000013623	ehd4	99	78.095	Periophthalmus_magnuspinnatus
ENSG00000103966	EHD4	100	97.043	ENSPEMG00000015332	Ehd4	100	97.043	Peromyscus_maniculatus_bairdii
ENSG00000103966	EHD4	100	95.379	ENSPCIG00000018367	EHD4	100	95.379	Phascolarctos_cinereus
ENSG00000103966	EHD4	100	77.079	ENSPFOG00000018511	ehd4	99	77.079	Poecilia_formosa
ENSG00000103966	EHD4	100	77.079	ENSPLAG00000003565	ehd4	99	77.079	Poecilia_latipinna
ENSG00000103966	EHD4	100	77.079	ENSPMEG00000017519	ehd4	99	77.079	Poecilia_mexicana
ENSG00000103966	EHD4	100	77.079	ENSPREG00000003513	ehd4	99	77.079	Poecilia_reticulata
ENSG00000103966	EHD4	100	99.261	ENSPPYG00000006387	EHD4	100	99.261	Pongo_abelii
ENSG00000103966	EHD4	100	96.488	ENSPCAG00000014068	EHD4	100	96.488	Procavia_capensis
ENSG00000103966	EHD4	100	97.043	ENSPCOG00000023830	EHD4	100	97.043	Propithecus_coquereli
ENSG00000103966	EHD4	78	97.387	ENSPVAG00000013749	EHD4	78	97.387	Pteropus_vampyrus
ENSG00000103966	EHD4	100	77.449	ENSPNYG00000013916	ehd4	99	77.449	Pundamilia_nyererei
ENSG00000103966	EHD4	99	79.851	ENSPNAG00000019307	ehd4	98	79.851	Pygocentrus_nattereri
ENSG00000103966	EHD4	100	97.227	ENSRNOG00000007584	Ehd4	100	97.227	Rattus_norvegicus
ENSG00000103966	EHD4	100	99.630	ENSRBIG00000040681	EHD4	100	99.630	Rhinopithecus_bieti
ENSG00000103966	EHD4	100	99.630	ENSRROG00000034638	EHD4	100	99.630	Rhinopithecus_roxellana
ENSG00000103966	EHD4	100	98.891	ENSSBOG00000035819	EHD4	100	98.891	Saimiri_boliviensis_boliviensis
ENSG00000103966	EHD4	94	89.194	ENSSHAG00000007926	-	100	89.194	Sarcophilus_harrisii
ENSG00000103966	EHD4	100	77.079	ENSSMAG00000002935	ehd4	99	77.079	Scophthalmus_maximus
ENSG00000103966	EHD4	100	77.634	ENSSDUG00000010947	ehd4	99	77.634	Seriola_dumerili
ENSG00000103966	EHD4	100	77.634	ENSSLDG00000020986	ehd4	99	77.634	Seriola_lalandi_dorsalis
ENSG00000103966	EHD4	100	88.355	ENSSPUG00000004459	EHD4	100	88.355	Sphenodon_punctatus
ENSG00000103966	EHD4	100	70.795	ENSSPAG00000005490	ehd4	98	70.795	Stegastes_partitus
ENSG00000103966	EHD4	100	98.152	ENSSSCG00000020666	EHD4	100	98.152	Sus_scrofa
ENSG00000103966	EHD4	100	89.464	ENSTGUG00000010994	EHD4	100	89.464	Taeniopygia_guttata
ENSG00000103966	EHD4	99	77.425	ENSTRUG00000022398	ehd4	98	77.425	Takifugu_rubripes
ENSG00000103966	EHD4	99	77.180	ENSTNIG00000004842	ehd4	99	77.180	Tetraodon_nigroviridis
ENSG00000103966	EHD4	100	97.782	ENSTTRG00000002551	EHD4	100	97.782	Tursiops_truncatus
ENSG00000103966	EHD4	100	97.967	ENSUMAG00000011183	EHD4	100	97.967	Ursus_maritimus
ENSG00000103966	EHD4	100	98.521	ENSVVUG00000026933	EHD4	100	98.521	Vulpes_vulpes
ENSG00000103966	EHD4	100	84.104	ENSXETG00000015794	ehd4	99	84.104	Xenopus_tropicalis
ENSG00000103966	EHD4	100	76.895	ENSXMAG00000021228	EHD4	99	76.895	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	10673336.	TAS	Function
GO:0005509	calcium ion binding	-	IEA	Function
GO:0005515	protein binding	17233914.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005634	nucleus	10673336.	TAS	Component
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0006907	pinocytosis	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0030100	regulation of endocytosis	-	IEA	Process
GO:0031901	early endosome membrane	-	IEA	Component
GO:0032456	endocytic recycling	17233914.	IGI	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	-	IEA	Process
GO:0051260	protein homooligomerization	17233914.	IPI	Process
GO:0055038	recycling endosome membrane	17233914.	IDA	Component
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0071363	cellular response to growth factor stimulus	-	IEA	Process