EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000104177 (Gene tree)
Gene ID: 50804
Gene Symbol: MYEF2
Alias: MEF-2|FLJ11213|KIAA1341|HsT18564
Full Name: myelin expression factor 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 43,887 bases
Position: chr15:48,134,631-48,178,517
Accession: 17940
RBP type: canonical RBP
Summary: (Myelin Expression Factor 2) is a Protein Coding gene. Diseases associated with MYEF2 include Albinism, Oculocutaneous, Type Vi and Lung Cancer. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Mitochondrial Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is HNRNPM.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000267836	RRM_1	PF00076.22	3.5e-55	1	3
ENSP00000267836	RRM_1	PF00076.22	3.5e-55	2	3
ENSP00000267836	RRM_1	PF00076.22	3.5e-55	3	3
ENSP00000316950	RRM_1	PF00076.22	4.2e-55	1	3
ENSP00000316950	RRM_1	PF00076.22	4.2e-55	2	3
ENSP00000316950	RRM_1	PF00076.22	4.2e-55	3	3
ENSP00000478898	RRM_1	PF00076.22	4.3e-54	1	3
ENSP00000478898	RRM_1	PF00076.22	4.3e-54	2	3
ENSP00000478898	RRM_1	PF00076.22	4.3e-54	3	3
ENSP00000453830	RRM_1	PF00076.22	3.2e-22	1	2
ENSP00000453830	RRM_1	PF00076.22	3.2e-22	2	2
ENSP00000452918	RRM_1	PF00076.22	1.6e-19	1	1
ENSP00000480281	RRM_1	PF00076.22	4.6e-19	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000267836	MYEF2-201	2958	XM_005254424	ENSP00000267836	576 (aa)	XP_005254481	A0A0A0MQW0
ENST00000561351	MYEF2-214	2598	-	ENSP00000453125	128 (aa)	-	Q9P2K5
ENST00000559862	MYEF2-207	633	-	-	- (aa)	-	-
ENST00000561151	MYEF2-212	736	-	ENSP00000452913	128 (aa)	-	Q9P2K5
ENST00000560530	MYEF2-211	2037	-	-	- (aa)	-	-
ENST00000561301	MYEF2-213	537	-	-	- (aa)	-	-
ENST00000558395	MYEF2-205	868	XM_017022290	ENSP00000453830	290 (aa)	XP_016877779	H0YN19
ENST00000558289	MYEF2-204	4516	-	-	- (aa)	-	-
ENST00000616409	MYEF2-216	1966	XM_006720553	ENSP00000478898	547 (aa)	XP_006720616	A0A087WUT0
ENST00000560172	MYEF2-209	731	-	ENSP00000452918	126 (aa)	-	H0YKS1
ENST00000557868	MYEF2-203	1029	-	-	- (aa)	-	-
ENST00000560513	MYEF2-210	679	-	-	- (aa)	-	-
ENST00000610570	MYEF2-215	2591	XM_005254427	ENSP00000480118	126 (aa)	XP_005254484	A0A087WWC8
ENST00000559057	MYEF2-206	688	-	-	- (aa)	-	-
ENST00000560157	MYEF2-208	576	-	-	- (aa)	-	-
ENST00000324324	MYEF2-202	10360	XM_005254422	ENSP00000316950	600 (aa)	XP_005254479	A0A0A0MR39
ENST00000620867	MYEF2-217	1742	-	ENSP00000480281	211 (aa)	-	A0A0C4DGV1

Gene Model

Click here to download ENSG00000104177's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000104177	Myocardial Infarction	2.9176198E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000104177	rs2470102	15	48141297	?	Skin pigmentation	29195075	NR unit decrease	3.4	EFO_0007009
ENSG00000104177	rs2470102	15	48141297	G	Skin pigmentation	28300201	[2.14-4.47] unit increase	3.31	EFO_0003784
ENSG00000104177	rs2470102	15	48141297	?	Hair color	30595370			EFO_0007822

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000104177's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000104177	MYEF2	61	33.333	ENSG00000099622	CIRBP	99	33.333
ENSG00000104177	MYEF2	66	37.805	ENSG00000174740	PABPC5	80	37.349
ENSG00000104177	MYEF2	81	35.211	ENSG00000070756	PABPC1	64	33.333
ENSG00000104177	MYEF2	99	55.556	ENSG00000099783	HNRNPM	87	54.125

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000104177	MYEF2	98	67.692	ENSAPOG00000015050	myef2	98	66.667	Acanthochromis_polyacanthus
ENSG00000104177	MYEF2	99	98.400	ENSAMEG00000001964	MYEF2	100	96.964	Ailuropoda_melanoleuca
ENSG00000104177	MYEF2	98	71.429	ENSACIG00000020446	myef2	99	63.715	Amphilophus_citrinellus
ENSG00000104177	MYEF2	98	70.400	ENSAOCG00000017431	myef2	98	66.900	Amphiprion_ocellaris
ENSG00000104177	MYEF2	98	70.400	ENSAPEG00000024834	myef2	98	66.725	Amphiprion_percula
ENSG00000104177	MYEF2	98	71.200	ENSATEG00000017892	myef2	96	67.135	Anabas_testudineus
ENSG00000104177	MYEF2	99	88.000	ENSAPLG00000008935	MYEF2	99	82.671	Anas_platyrhynchos
ENSG00000104177	MYEF2	95	88.333	ENSACAG00000004806	MYEF2	99	71.224	Anolis_carolinensis
ENSG00000104177	MYEF2	100	99.052	ENSANAG00000036558	MYEF2	100	98.611	Aotus_nancymaae
ENSG00000104177	MYEF2	98	71.200	ENSACLG00000017421	myef2	98	65.233	Astatotilapia_calliptera
ENSG00000104177	MYEF2	99	64.615	ENSAMXG00000038244	myef2	94	69.009	Astyanax_mexicanus
ENSG00000104177	MYEF2	100	98.578	ENSBTAG00000008771	MYEF2	100	95.833	Bos_taurus
ENSG00000104177	MYEF2	100	99.526	ENSCJAG00000001875	MYEF2	100	98.333	Callithrix_jacchus
ENSG00000104177	MYEF2	99	97.600	ENSCAFG00000014008	MYEF2	100	97.500	Canis_familiaris
ENSG00000104177	MYEF2	99	97.600	ENSCAFG00020022004	-	100	96.604	Canis_lupus_dingo
ENSG00000104177	MYEF2	99	98.400	ENSCHIG00000022164	MYEF2	95	98.477	Capra_hircus
ENSG00000104177	MYEF2	100	98.578	ENSTSYG00000010575	MYEF2	100	98.355	Carlito_syrichta
ENSG00000104177	MYEF2	99	89.292	ENSCAPG00000017762	MYEF2	100	88.994	Cavia_aperea
ENSG00000104177	MYEF2	100	88.043	ENSCPOG00000010584	MYEF2	100	84.463	Cavia_porcellus
ENSG00000104177	MYEF2	100	99.052	ENSCCAG00000033878	MYEF2	100	98.903	Cebus_capucinus
ENSG00000104177	MYEF2	100	99.526	ENSCATG00000039268	MYEF2	100	99.086	Cercocebus_atys
ENSG00000104177	MYEF2	99	99.200	ENSCLAG00000008328	MYEF2	100	91.736	Chinchilla_lanigera
ENSG00000104177	MYEF2	100	99.086	ENSCSAG00000010366	MYEF2	100	98.500	Chlorocebus_sabaeus
ENSG00000104177	MYEF2	80	95.238	ENSCHOG00000011348	-	67	95.238	Choloepus_hoffmanni
ENSG00000104177	MYEF2	98	91.870	ENSCPBG00000024789	MYEF2	100	79.966	Chrysemys_picta_bellii
ENSG00000104177	MYEF2	100	99.526	ENSCANG00000022275	MYEF2	100	99.269	Colobus_angolensis_palliatus
ENSG00000104177	MYEF2	99	96.800	ENSCGRG00001024080	-	100	91.667	Cricetulus_griseus_chok1gshd
ENSG00000104177	MYEF2	99	96.800	ENSCGRG00000012257	-	100	95.402	Cricetulus_griseus_crigri
ENSG00000104177	MYEF2	98	67.692	ENSCSEG00000005597	myef2	91	65.009	Cynoglossus_semilaevis
ENSG00000104177	MYEF2	97	67.188	ENSCVAG00000010801	myef2	80	64.118	Cyprinodon_variegatus
ENSG00000104177	MYEF2	99	66.929	ENSDARG00000059398	myef2	96	65.062	Danio_rerio
ENSG00000104177	MYEF2	99	99.200	ENSDNOG00000038711	MYEF2	100	95.312	Dasypus_novemcinctus
ENSG00000104177	MYEF2	100	96.682	ENSDORG00000015835	-	100	96.682	Dipodomys_ordii
ENSG00000104177	MYEF2	99	99.200	ENSETEG00000005360	MYEF2	100	87.529	Echinops_telfairi
ENSG00000104177	MYEF2	65	80.488	ENSEBUG00000016563	myef2	69	65.678	Eptatretus_burgeri
ENSG00000104177	MYEF2	99	99.200	ENSEASG00005017818	MYEF2	93	97.970	Equus_asinus_asinus
ENSG00000104177	MYEF2	99	99.200	ENSECAG00000034546	-	100	95.500	Equus_caballus
ENSG00000104177	MYEF2	99	99.200	ENSECAG00000005741	MYEF2	100	95.500	Equus_caballus
ENSG00000104177	MYEF2	78	100.000	ENSEEUG00000006405	MYEF2	78	100.000	Erinaceus_europaeus
ENSG00000104177	MYEF2	98	66.935	ENSELUG00000003712	myef2	85	65.724	Esox_lucius
ENSG00000104177	MYEF2	100	98.578	ENSFCAG00000027198	MYEF2	100	96.007	Felis_catus
ENSG00000104177	MYEF2	98	89.431	ENSFALG00000011565	MYEF2	99	81.588	Ficedula_albicollis
ENSG00000104177	MYEF2	99	99.200	ENSFDAG00000007098	MYEF2	100	97.510	Fukomys_damarensis
ENSG00000104177	MYEF2	98	67.460	ENSFHEG00000002386	myef2	98	64.085	Fundulus_heteroclitus
ENSG00000104177	MYEF2	83	65.903	ENSGMOG00000008489	myef2	52	75.524	Gadus_morhua
ENSG00000104177	MYEF2	98	88.618	ENSGALG00000032546	MYEF2	100	75.845	Gallus_gallus
ENSG00000104177	MYEF2	99	64.364	ENSGAFG00000005838	myef2	98	65.009	Gambusia_affinis
ENSG00000104177	MYEF2	98	68.000	ENSGACG00000016759	myef2	100	68.140	Gasterosteus_aculeatus
ENSG00000104177	MYEF2	98	92.683	ENSGAGG00000015265	MYEF2	100	75.382	Gopherus_agassizii
ENSG00000104177	MYEF2	100	99.526	ENSGGOG00000014968	MYEF2	100	99.306	Gorilla_gorilla
ENSG00000104177	MYEF2	98	70.635	ENSHBUG00000015847	myef2	98	67.372	Haplochromis_burtoni
ENSG00000104177	MYEF2	99	99.200	ENSHGLG00000018166	MYEF2	100	91.738	Heterocephalus_glaber_female
ENSG00000104177	MYEF2	99	99.200	ENSHGLG00100014102	MYEF2	100	98.104	Heterocephalus_glaber_male
ENSG00000104177	MYEF2	98	69.841	ENSHCOG00000001652	myef2	95	64.899	Hippocampus_comes
ENSG00000104177	MYEF2	99	65.625	ENSIPUG00000018589	myef2	85	72.449	Ictalurus_punctatus
ENSG00000104177	MYEF2	100	99.052	ENSSTOG00000007740	MYEF2	100	98.084	Ictidomys_tridecemlineatus
ENSG00000104177	MYEF2	99	97.600	ENSJJAG00000015428	-	100	96.209	Jaculus_jaculus
ENSG00000104177	MYEF2	98	69.355	ENSKMAG00000002383	myef2	100	66.207	Kryptolebias_marmoratus
ENSG00000104177	MYEF2	98	70.079	ENSLBEG00000005649	myef2	97	63.028	Labrus_bergylta
ENSG00000104177	MYEF2	94	80.488	ENSLACG00000006382	MYEF2	99	72.581	Latimeria_chalumnae
ENSG00000104177	MYEF2	87	84.058	ENSLOCG00000013241	myef2	98	69.444	Lepisosteus_oculatus
ENSG00000104177	MYEF2	100	95.612	ENSLAFG00000012990	MYEF2	100	94.167	Loxodonta_africana
ENSG00000104177	MYEF2	100	99.526	ENSMFAG00000046361	MYEF2	100	99.086	Macaca_fascicularis
ENSG00000104177	MYEF2	100	99.526	ENSMMUG00000018834	MYEF2	100	98.667	Macaca_mulatta
ENSG00000104177	MYEF2	100	99.526	ENSMNEG00000028845	MYEF2	100	98.958	Macaca_nemestrina
ENSG00000104177	MYEF2	100	99.526	ENSMLEG00000038724	MYEF2	100	99.086	Mandrillus_leucophaeus
ENSG00000104177	MYEF2	98	71.200	ENSMAMG00000011476	myef2	99	66.378	Mastacembelus_armatus
ENSG00000104177	MYEF2	98	70.635	ENSMZEG00005011832	myef2	100	65.333	Maylandia_zebra
ENSG00000104177	MYEF2	98	88.618	ENSMGAG00000006915	MYEF2	99	82.459	Meleagris_gallopavo
ENSG00000104177	MYEF2	99	96.800	ENSMAUG00000019642	-	100	91.333	Mesocricetus_auratus
ENSG00000104177	MYEF2	99	99.200	ENSMICG00000014513	MYEF2	100	98.172	Microcebus_murinus
ENSG00000104177	MYEF2	100	95.261	ENSMOCG00000006917	-	100	91.500	Microtus_ochrogaster
ENSG00000104177	MYEF2	100	83.886	ENSMOCG00000021295	-	100	83.886	Microtus_ochrogaster
ENSG00000104177	MYEF2	97	68.000	ENSMMOG00000021557	myef2	99	60.145	Mola_mola
ENSG00000104177	MYEF2	100	79.707	ENSMODG00000002744	MYEF2	83	76.898	Monodelphis_domestica
ENSG00000104177	MYEF2	98	68.702	ENSMALG00000012193	myef2	80	79.736	Monopterus_albus
ENSG00000104177	MYEF2	99	96.000	MGP_CAROLIEiJ_G0024222	Myef2	100	90.842	Mus_caroli
ENSG00000104177	MYEF2	99	96.000	ENSMUSG00000027201	Myef2	100	90.500	Mus_musculus
ENSG00000104177	MYEF2	97	93.243	ENSMUSG00000049230	Gm9833	97	82.700	Mus_musculus
ENSG00000104177	MYEF2	99	96.000	MGP_PahariEiJ_G0025667	Myef2	100	90.842	Mus_pahari
ENSG00000104177	MYEF2	97	92.727	MGP_PahariEiJ_G0025668	-	98	90.625	Mus_pahari
ENSG00000104177	MYEF2	98	77.236	MGP_SPRETEiJ_G0025142	-	99	77.812	Mus_spretus
ENSG00000104177	MYEF2	99	96.000	MGP_SPRETEiJ_G0025141	Myef2	100	90.842	Mus_spretus
ENSG00000104177	MYEF2	99	93.419	ENSMPUG00000011254	MYEF2	100	93.273	Mustela_putorius_furo
ENSG00000104177	MYEF2	99	99.200	ENSMLUG00000006781	MYEF2	56	98.561	Myotis_lucifugus
ENSG00000104177	MYEF2	100	96.682	ENSNGAG00000010756	-	100	91.667	Nannospalax_galili
ENSG00000104177	MYEF2	98	71.200	ENSNBRG00000023602	myef2	98	65.233	Neolamprologus_brichardi
ENSG00000104177	MYEF2	100	99.526	ENSNLEG00000005951	MYEF2	100	99.452	Nomascus_leucogenys
ENSG00000104177	MYEF2	72	96.414	ENSMEUG00000015210	-	82	84.858	Notamacropus_eugenii
ENSG00000104177	MYEF2	91	100.000	ENSOPRG00000003919	MYEF2	85	100.000	Ochotona_princeps
ENSG00000104177	MYEF2	99	96.800	ENSODEG00000007463	MYEF2	100	90.017	Octodon_degus
ENSG00000104177	MYEF2	100	62.305	ENSONIG00000013374	myef2	98	61.224	Oreochromis_niloticus
ENSG00000104177	MYEF2	99	73.123	ENSOANG00000007375	MYEF2	100	74.704	Ornithorhynchus_anatinus
ENSG00000104177	MYEF2	100	96.892	ENSOCUG00000013043	MYEF2	99	95.770	Oryctolagus_cuniculus
ENSG00000104177	MYEF2	94	66.195	ENSORLG00000002730	myef2	97	66.432	Oryzias_latipes
ENSG00000104177	MYEF2	94	66.018	ENSORLG00020021524	myef2	97	66.257	Oryzias_latipes_hni
ENSG00000104177	MYEF2	92	67.332	ENSORLG00015020877	myef2	95	67.568	Oryzias_latipes_hsok
ENSG00000104177	MYEF2	99	62.791	ENSOMEG00000010072	myef2	91	74.118	Oryzias_melastigma
ENSG00000104177	MYEF2	99	99.200	ENSOGAG00000010907	MYEF2	100	96.672	Otolemur_garnettii
ENSG00000104177	MYEF2	99	99.200	ENSOARG00000021027	MYEF2	100	97.268	Ovis_aries
ENSG00000104177	MYEF2	100	99.526	ENSPPAG00000041556	MYEF2	100	99.267	Pan_paniscus
ENSG00000104177	MYEF2	100	98.578	ENSPPRG00000011446	MYEF2	100	98.578	Panthera_pardus
ENSG00000104177	MYEF2	100	98.578	ENSPTIG00000018122	MYEF2	100	96.161	Panthera_tigris_altaica
ENSG00000104177	MYEF2	100	99.526	ENSPTRG00000007042	MYEF2	100	99.306	Pan_troglodytes
ENSG00000104177	MYEF2	100	99.526	ENSPANG00000017757	MYEF2	100	98.958	Papio_anubis
ENSG00000104177	MYEF2	98	64.122	ENSPKIG00000018344	MYEF2	95	64.684	Paramormyrops_kingsleyae
ENSG00000104177	MYEF2	65	84.337	ENSPKIG00000020643	myef2	76	71.014	Paramormyrops_kingsleyae
ENSG00000104177	MYEF2	98	91.870	ENSPSIG00000016637	MYEF2	99	83.922	Pelodiscus_sinensis
ENSG00000104177	MYEF2	86	71.667	ENSPMGG00000001513	myef2	91	71.667	Periophthalmus_magnuspinnatus
ENSG00000104177	MYEF2	99	96.800	ENSPEMG00000006286	-	100	95.261	Peromyscus_maniculatus_bairdii
ENSG00000104177	MYEF2	67	74.118	ENSPMAG00000001364	myef2	59	66.897	Petromyzon_marinus
ENSG00000104177	MYEF2	99	96.000	ENSPCIG00000022902	MYEF2	100	88.099	Phascolarctos_cinereus
ENSG00000104177	MYEF2	95	65.079	ENSPFOG00000001754	myef2	55	71.257	Poecilia_formosa
ENSG00000104177	MYEF2	99	61.844	ENSPLAG00000001538	myef2	98	64.831	Poecilia_latipinna
ENSG00000104177	MYEF2	100	61.101	ENSPLAG00000001814	MYEF2	97	66.480	Poecilia_latipinna
ENSG00000104177	MYEF2	99	61.844	ENSPMEG00000014953	MYEF2	98	64.654	Poecilia_mexicana
ENSG00000104177	MYEF2	99	61.844	ENSPMEG00000014250	myef2	98	64.654	Poecilia_mexicana
ENSG00000104177	MYEF2	99	61.636	ENSPREG00000010801	myef2	98	62.989	Poecilia_reticulata
ENSG00000104177	MYEF2	100	99.333	ENSPPYG00000006452	MYEF2	100	99.333	Pongo_abelii
ENSG00000104177	MYEF2	99	95.200	ENSPCAG00000016660	MYEF2	100	91.500	Procavia_capensis
ENSG00000104177	MYEF2	100	98.172	ENSPCOG00000024570	MYEF2	100	98.172	Propithecus_coquereli
ENSG00000104177	MYEF2	97	98.592	ENSPVAG00000004102	MYEF2	100	95.238	Pteropus_vampyrus
ENSG00000104177	MYEF2	98	70.635	ENSPNYG00000010879	myef2	97	66.108	Pundamilia_nyererei
ENSG00000104177	MYEF2	87	80.000	ENSPNAG00000026387	myef2	97	80.000	Pygocentrus_nattereri
ENSG00000104177	MYEF2	99	96.800	ENSRNOG00000005258	Myef2	100	90.500	Rattus_norvegicus
ENSG00000104177	MYEF2	100	99.526	ENSRBIG00000037503	MYEF2	100	99.269	Rhinopithecus_bieti
ENSG00000104177	MYEF2	100	99.526	ENSRROG00000042861	MYEF2	100	99.269	Rhinopithecus_roxellana
ENSG00000104177	MYEF2	100	99.052	ENSSBOG00000029634	MYEF2	100	99.042	Saimiri_boliviensis_boliviensis
ENSG00000104177	MYEF2	99	96.800	ENSSHAG00000011695	MYEF2	99	93.407	Sarcophilus_harrisii
ENSG00000104177	MYEF2	99	68.504	ENSSFOG00015012981	myef2	96	63.506	Scleropages_formosus
ENSG00000104177	MYEF2	99	60.000	ENSSFOG00015017915	myef2	95	59.519	Scleropages_formosus
ENSG00000104177	MYEF2	98	66.917	ENSSMAG00000021279	myef2	98	67.582	Scophthalmus_maximus
ENSG00000104177	MYEF2	98	71.654	ENSSDUG00000015983	myef2	98	67.487	Seriola_dumerili
ENSG00000104177	MYEF2	97	69.600	ENSSLDG00000021862	myef2	90	53.712	Seriola_lalandi_dorsalis
ENSG00000104177	MYEF2	99	97.600	ENSSARG00000003264	MYEF2	100	97.269	Sorex_araneus
ENSG00000104177	MYEF2	95	90.833	ENSSPUG00000011966	MYEF2	100	81.604	Sphenodon_punctatus
ENSG00000104177	MYEF2	98	70.400	ENSSPAG00000021514	myef2	98	66.375	Stegastes_partitus
ENSG00000104177	MYEF2	99	100.000	ENSSSCG00000004661	MYEF2	99	97.817	Sus_scrofa
ENSG00000104177	MYEF2	98	88.710	ENSTGUG00000007130	MYEF2	100	78.662	Taeniopygia_guttata
ENSG00000104177	MYEF2	98	70.866	ENSTRUG00000016967	myef2	83	66.160	Takifugu_rubripes
ENSG00000104177	MYEF2	98	71.654	ENSTNIG00000009526	myef2	94	69.780	Tetraodon_nigroviridis
ENSG00000104177	MYEF2	98	86.179	ENSTBEG00000002187	MYEF2	72	90.286	Tupaia_belangeri
ENSG00000104177	MYEF2	99	99.200	ENSTTRG00000008076	MYEF2	99	96.796	Tursiops_truncatus
ENSG00000104177	MYEF2	99	96.000	ENSUAMG00000020099	MYEF2	100	96.552	Ursus_americanus
ENSG00000104177	MYEF2	99	97.924	ENSUMAG00000009804	MYEF2	100	98.030	Ursus_maritimus
ENSG00000104177	MYEF2	99	99.200	ENSVPAG00000004721	MYEF2	100	98.168	Vicugna_pacos
ENSG00000104177	MYEF2	99	98.400	ENSVVUG00000014591	MYEF2	100	98.438	Vulpes_vulpes
ENSG00000104177	MYEF2	99	77.344	ENSXETG00000018412	myef2	86	68.074	Xenopus_tropicalis
ENSG00000104177	MYEF2	99	62.909	ENSXMAG00000016686	myef2	98	63.009	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	21873635.	IBA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	IEA	Function
GO:0003697	single-stranded DNA binding	-	IEA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	8455629.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0014902	myotube differentiation	8455629.	IEP	Process
GO:0030182	neuron differentiation	8455629.	IEP	Process
GO:0071014	post-mRNA release spliceosomal complex	21873635.	IBA	Component
GO:1990904	ribonucleoprotein complex	21873635.	IBA	Component
GO:2000815	regulation of mRNA stability involved in response to oxidative stress	21873635.	IBA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr15	48168780	Missense_Mutation	rs751571503	S74N	0.69
BLCA	chr15	48168646	Missense_Mutation	novel	L119I	0.3
BLCA	chr15	48142954	Missense_Mutation	novel	K586T	0.35
BLCA	chr15	48149293	Missense_Mutation	NA	R486K	0.24
BLCA	chr15	48149374	Splice_Region	novel		0.28
BLCA	chr15	48151925	Silent	novel	L386L	0.2
BLCA	chr15	48152025	Intron	novel		0.45
BLCA	chr15	48136665	3'UTR	novel		0.44
BRCA	chr15	48141261	3'UTR	novel		0.39
BRCA	chr15	48142890	3'UTR	novel		0.15
BRCA	chr15	48151503	Nonsense_Mutation	NA	R426*	0.24
BRCA	chr15	48152180	Intron	novel		0.19
BRCA	chr15	48168740	Missense_Mutation	NA	K87N	0.1
BRCA	chr15	48152492	Intron	novel		0.18
BRCA	chr15	48158203	Nonsense_Mutation	novel	L298delins*	0.08
BRCA	chr15	48149063	Nonsense_Mutation	NA	W536*	0.34
BRCA	chr15	48151108	Missense_Mutation	NA	S457C	0.32
CESC	chr15	48142568	3'UTR	novel		0.58
CESC	chr15	48158799	Missense_Mutation	NA	E281Q	0.35
CESC	chr15	48141093	3'UTR	novel		0.56
CESC	chr15	48142715	3'UTR	novel		0.09
CESC	chr15	48151503	Nonsense_Mutation	NA	R426*	0.39
CESC	chr15	48152092	Intron	novel		0.25
CESC	chr15	48151158	Silent	novel	I440I	0.44
CESC	chr15	48151521	Missense_Mutation	novel	G420S	0.24
CHOL	chr15	48142561	3'UTR	novel		0.31
COAD	chr15	48142994	Nonsense_Mutation	NA	E573*	0.32
COAD	chr15	48166004	Nonsense_Mutation	novel	E152*	0.32	RRM_1
COAD	chr15	48178140	Missense_Mutation	novel	P33L	0.32
COAD	chr15	48158781	Missense_Mutation	NA	V287F	0.14
COAD	chr15	48141316	3'UTR	novel		0.2
COAD	chr15	48135010	3'UTR	novel		0.14
COAD	chr15	48151536	Nonsense_Mutation	NA	R415*	0.29
COAD	chr15	48158046	Missense_Mutation	novel	S311F	0.25
COAD	chr15	48168710	Silent	novel	P97P	0.3
COAD	chr15	48141993	3'UTR	rs764184107		0.25
COAD	chr15	48167365	Missense_Mutation	rs372821159	A136V	0.26	RRM_1
COAD	chr15	48134999	3'UTR	novel		0.08
COAD	chr15	48152148	Intron	NA		0.43
COAD	chr15	48149369	Missense_Mutation	NA	G461C	0.45
COAD	chr15	48135049	3'UTR	novel		0.28
COAD	chr15	48142841	3'UTR	novel		0.18
COAD	chr15	48142841	3'UTR	novel		0.37
COAD	chr15	48152267	Missense_Mutation	NA	P369S	0.06
COAD	chr15	48136640	3'UTR	novel		0.93
COAD	chr15	48149174	Missense_Mutation	NA	F526V	0.18
COAD	chr15	48168740	Missense_Mutation	NA	K87N	0.16
COAD	chr15	48152808	Intron	novel		0.67
COAD	chr15	48159611	Splice_Site	NA	X239_splice	0.41
COAD	chr15	48142980	Frame_Shift_Del	novel	*A578Pfs4**	0.29
COAD	chr15	48152148	Intron	NA		0.3
COAD	chr15	48152429	Intron	novel		0.13
COAD	chr15	48135175	3'UTR	novel		0.42
DLBC	chr15	48159664	Silent	novel	V222V	0.24
ESCA	chr15	48135004	3'UTR	novel		0.33
ESCA	chr15	48149253	Silent	novel	I499I	0.37
ESCA	chr15	48142840	3'UTR	novel		0.38
ESCA	chr15	48149356	Missense_Mutation	rs200959924	S465N	0.26
ESCA	chr15	48152148	Intron	NA		0.34
ESCA	chr15	48143048	Missense_Mutation	novel	K555Q	0.22
GBM	chr15	48158793	Missense_Mutation	rs750463461	A283T	0.11
GBM	chr15	48166004	Nonsense_Mutation	novel	E152*	0.55	RRM_1
HNSC	chr15	48151487	Missense_Mutation	novel	S431F	0.29
HNSC	chr15	48135072	3'UTR	novel		0.25
HNSC	chr15	48135073	3'UTR	novel		0.25
HNSC	chr15	48149440	Intron	novel		0.26
HNSC	chr15	48152079	Intron	novel		0.53
HNSC	chr15	48178135	Missense_Mutation	novel	P35S	0.43
HNSC	chr15	48151512	Nonsense_Mutation	novel	G423*	0.35
HNSC	chr15	48142367	3'UTR	novel		0.19
HNSC	chr15	48151097	Splice_Region	novel		0.33
HNSC	chr15	48153869	Missense_Mutation	novel	G337V	0.24
HNSC	chr15	48151552	Missense_Mutation	novel	M409I	0.12
HNSC	chr15	48149272	Missense_Mutation	novel	A493G	0.16
HNSC	chr15	48168752	Nonsense_Mutation	novel	Y83*	0.14
KIRC	chr15	48149264	In_Frame_Del	novel	G492_L495del	0.16
KIRC	chr15	48136656	3'UTR	novel		0.07
KIRC	chr15	48136658	3'UTR	novel		0.07
LAML	chr15	48143061	Missense_Mutation	novel	M550I	0.05
LGG	chr15	48151523	Missense_Mutation	novel	R419L	0.11
LGG	chr15	48136620	3'UTR	novel		0.33
LGG	chr15	48141292	3'UTR	novel		0.33
LGG	chr15	48141971	3'UTR	novel		0.07
LGG	chr15	48142918	Missense_Mutation	rs750104369	R598H	0.11
LGG	chr15	48151556	Missense_Mutation	rs746581433	A408V	0.38
LIHC	chr15	48141838	3'UTR	novel		0.67
LIHC	chr15	48141244	3'UTR	novel		0.4
LIHC	chr15	48134814	3'UTR	novel		0.16
LIHC	chr15	48149500	Intron	novel		0.55
LIHC	chr15	48151153	Missense_Mutation	novel	G442E	0.36
LIHC	chr15	48152032	Intron	novel		0.33
LIHC	chr15	48165977	Missense_Mutation	NA	M161L	0.31	RRM_1
LUAD	chr15	48158213	Missense_Mutation	novel	G295W	0.29
LUAD	chr15	48151937	Missense_Mutation	NA	G382W	0.09
LUAD	chr15	48152234	Nonsense_Mutation	NA	G380*	0.49
LUAD	chr15	48149416	Intron	novel		0.38
LUAD	chr15	48158881	Silent	NA	F253F	0.1
LUAD	chr15	48152274	Missense_Mutation	novel	M366I	0.38
LUAD	chr15	48158799	Missense_Mutation	novel	E281K	0.06
LUAD	chr15	48143020	Missense_Mutation	NA	C564F	0.56
LUAD	chr15	48151995	Intron	novel		0.16
LUAD	chr15	48153774	Intron	novel		0.3
LUAD	chr15	48153880	Silent	novel	G333G	0.17
LUAD	chr15	48153881	Missense_Mutation	novel	G333V	0.14
LUAD	chr15	48149293	Missense_Mutation	NA	R486K	0.37
LUAD	chr15	48158894	Missense_Mutation	novel	L249Q	0.07
LUAD	chr15	48166128	Missense_Mutation	novel	G142C	0.12	RRM_1
LUAD	chr15	48158832	Missense_Mutation	novel	G270S	0.2
LUSC	chr15	48152323	Intron	novel		0.21
LUSC	chr15	48142900	3'UTR	novel		0.18
LUSC	chr15	48152255	Nonsense_Mutation	NA	G373*	0.1
LUSC	chr15	48152148	Intron	NA		0.18
LUSC	chr15	48142391	3'UTR	novel		0.46
LUSC	chr15	48167348	Splice_Site	novel	X141_splice	0.28
LUSC	chr15	48158180	Missense_Mutation	NA	K306E	0.3
LUSC	chr15	48158784	Missense_Mutation	novel	A286P	0.05
LUSC	chr15	48142921	Missense_Mutation	NA	D597G	0.27
LUSC	chr15	48166005	Missense_Mutation	novel	E151D	0.21	RRM_1
LUSC	chr15	48166014	Missense_Mutation	novel	F148L	0.07	RRM_1
LUSC	chr15	48165965	Missense_Mutation	NA	D165N	0.37	RRM_1
LUSC	chr15	48152151	Intron	novel		0.18
LUSC	chr15	48149281	Missense_Mutation	novel	G490A	0.53
LUSC	chr15	48149417	Intron	novel		0.62
LUSC	chr15	48143029	Nonsense_Mutation	novel	S561*	0.1
LUSC	chr15	48168732	Missense_Mutation	NA	G90V	0.27
LUSC	chr15	48158889	Missense_Mutation	novel	E251K	0.09
OV	chr15	48168656	Silent	novel	A115A	0.07
OV	chr15	48165965	Missense_Mutation	NA	D165H	0.22	RRM_1
OV	chr15	48158904	Missense_Mutation	novel	W246R	0.13
OV	chr15	48141226	3'UTR	novel		0.06
PAAD	chr15	48135034	3'UTR	novel		0.13
PAAD	chr15	48149218	Missense_Mutation	novel	G511E	0.19
PRAD	chr15	48153773	Intron	novel		0.39
PRAD	chr15	48152148	Intron	NA		0.34
PRAD	chr15	48142814	3'UTR	novel		0.31
READ	chr15	48149213	Missense_Mutation	rs756119377	G513R	0.41
READ	chr15	48165948	Silent	NA	P170P	0.34
READ	chr15	48152111	Intron	novel		0.3
READ	chr15	48142561	3'UTR	novel		0.48
READ	chr15	48134681	3'UTR	novel		0.2
READ	chr15	48134737	3'UTR	novel		0.37
READ	chr15	48134647	3'UTR	novel		0.29
READ	chr15	48158859	Missense_Mutation	rs778146267	R261W	0.33
SKCM	chr15	48151486	Silent	novel	S431S	0.28
SKCM	chr15	48158020	Missense_Mutation	novel	H320N	0.05
SKCM	chr15	48141291	3'UTR	novel		0.57
SKCM	chr15	48153855	Missense_Mutation	NA	G342R	0.4
SKCM	chr15	48153789	Splice_Region	rs758538104		0.23
SKCM	chr15	48142945	Missense_Mutation	novel	G589D	0.39
SKCM	chr15	48159744	Missense_Mutation	rs749890396	G196R	0.31	RRM_1
SKCM	chr15	48151564	Silent	NA	Y405Y	0.24
SKCM	chr15	48152000	Intron	novel		0.52
SKCM	chr15	48165979	Missense_Mutation	rs371575787	T160I	0.29	RRM_1
SKCM	chr15	48159704	Missense_Mutation	NA	P209L	0.29
STAD	chr15	48152148	Intron	NA		0.38
STAD	chr15	48142841	3'UTR	novel		0.23
STAD	chr15	48152148	Intron	NA		0.14
STAD	chr15	48152204	Intron	novel		0.31
STAD	chr15	48167365	Missense_Mutation	rs372821159	A136V	0.14	RRM_1
STAD	chr15	48158805	Missense_Mutation	novel	T279A	0.27
STAD	chr15	48141281	3'UTR	novel		0.34
STAD	chr15	48149252	Missense_Mutation	rs773720672	D500N	0.08
STAD	chr15	48149365	Missense_Mutation	NA	G462E	0.26
STAD	chr15	48142137	3'UTR	novel		0.38
STAD	chr15	48149046	Missense_Mutation	NA	K542I	0.26
STAD	chr15	48159634	Silent	NA	G232G	0.05
STAD	chr15	48152148	Intron	NA		0.21
STAD	chr15	48143005	Missense_Mutation	NA	F569C	0.25
STAD	chr15	48158841	Missense_Mutation	NA	D267N	0.24
STAD	chr15	48142840	3'UTR	novel		0.57
STAD	chr15	48142974	Nonsense_Mutation	NA	C579*	0.11
STAD	chr15	48142841	3'UTR	novel		0.15
STAD	chr15	48167365	Missense_Mutation	rs372821159	A136V	0.22	RRM_1
STAD	chr15	48142888	3'UTR	novel		0.3
STAD	chr15	48141314	3'UTR	novel		0.27
STAD	chr15	48152148	Intron	NA		0.24
STAD	chr15	48152148	Intron	NA		0.45
STAD	chr15	48142416	3'UTR	novel		0.3
STAD	chr15	48168676	Missense_Mutation	NA	Y109H	0.29
STAD	chr15	48142411	3'UTR	novel		0.29
STAD	chr15	48152148	Intron	NA		0.14
TGCT	chr15	48158011	Missense_Mutation	novel	K323E	0.21
TGCT	chr15	48149415	Intron	novel		0.17
THCA	chr15	48142378	3'UTR	novel		0.13
THCA	chr15	48152219	Intron	novel		0.35
UCEC	chr15	48135004	3'UTR	novel		0.36
UCEC	chr15	48142684	3'UTR	novel		0.27
UCEC	chr15	48134647	3'UTR	novel		0.41
UCEC	chr15	48142863	3'UTR	novel		0.29
UCEC	chr15	48152347	Intron	novel		0.39
UCEC	chr15	48168735	Missense_Mutation	rs138524718	S89L	0.34
UCEC	chr15	48140933	3'UTR	rs533615990		0.33
UCEC	chr15	48141838	3'UTR	novel		0.6
UCEC	chr15	48151537	Silent	novel	E414E	0.24
UCEC	chr15	48142555	3'UTR	novel		0.53
UCEC	chr15	48141240	3'UTR	novel		0.35
UCEC	chr15	48153632	Intron	novel		0.44
UCEC	chr15	48152241	Silent	novel	I377I	0.04
UCEC	chr15	48136552	3'UTR	novel		0.49
UCEC	chr15	48142919	Missense_Mutation	novel	R598C	0.39
UCEC	chr15	48166004	Nonsense_Mutation	novel	E152*	0.36	RRM_1
UCEC	chr15	48168817	Nonsense_Mutation	novel	E62*	0.37
UCEC	chr15	48141100	3'UTR	novel		0.24
UCEC	chr15	48141590	3'UTR	novel		0.18
UCEC	chr15	48168745	Missense_Mutation	novel	D86Y	0.33
UCEC	chr15	48159703	Silent	rs752883834	P209P	0.29
UCEC	chr15	48141914	3'UTR	novel		0.15
UCEC	chr15	48141980	3'UTR	novel		0.38
UCEC	chr15	48166004	Nonsense_Mutation	novel	E152*	0.4	RRM_1
UCEC	chr15	48142390	3'UTR	novel		0.11
UCEC	chr15	48165939	Silent	NA	I173I	0.11
UCEC	chr15	48134739	3'UTR	novel		0.1
UCEC	chr15	48134708	3'UTR	novel		0.36
UCEC	chr15	48149253	Silent	rs531820709	I499I	0.08
UCEC	chr15	48152207	Intron	novel		0.15
UCEC	chr15	48142841	3'UTR	novel		0.64
UCEC	chr15	48152147	Intron	novel		0.39
UCEC	chr15	48142561	3'UTR	novel		0.23
UCEC	chr15	48134807	3'UTR	novel		0.36
UCEC	chr15	48151953	Intron	novel		0.43
UCEC	chr15	48165943	Missense_Mutation	novel	N172T	0.42	RRM_1
UCEC	chr15	48152147	Intron	novel		0.21
UCEC	chr15	48141643	3'UTR	novel		0.56
UCEC	chr15	48153858	Missense_Mutation	novel	G341S	0.23
UCEC	chr15	48142841	3'UTR	novel		0.29
UCEC	chr15	48135049	3'UTR	novel		0.31
UCEC	chr15	48152148	Intron	NA		0.43
UCEC	chr15	48134997	3'UTR	novel		0.37
UCEC	chr15	48142927	Missense_Mutation	novel	R595H	0.37
UCEC	chr15	48152147	Intron	novel		0.24
UCEC	chr15	48149252	Missense_Mutation	rs773720672	D500N	0.26
UCEC	chr15	48151474	Splice_Region	NA	L435L	0.16
UCEC	chr15	48152148	Intron	NA		0.4
UCEC	chr15	48152212	Intron	novel		0.26
UCEC	chr15	48142442	3'UTR	novel		0.44
UCEC	chr15	48142840	3'UTR	novel		0.35
UCEC	chr15	48149229	Silent	rs747275125	S507S	0.2
UCEC	chr15	48141228	3'UTR	novel		0.37
UCEC	chr15	48149252	Missense_Mutation	rs773720672	D500N	0.4
UCEC	chr15	48142020	3'UTR	novel		0.42
UCEC	chr15	48149336	Nonsense_Mutation	novel	G472*	0.36
UCEC	chr15	48153846	Missense_Mutation	NA	I345V	0.37
UCEC	chr15	48167365	Missense_Mutation	rs372821159	A136V	0.18	RRM_1
UCEC	chr15	48142703	3'UTR	novel		0.41
UCEC	chr15	48142561	3'UTR	novel		0.38
UCEC	chr15	48141033	3'UTR	rs553993673		0.26
UCEC	chr15	48141867	3'UTR	novel		0.1
UCEC	chr15	48153593	Intron	novel		0.29
UCEC	chr15	48151999	Intron	novel		0.26
UCEC	chr15	48152279	Nonsense_Mutation	NA	G365*	0.29
UCEC	chr15	48166026	Splice_Region	novel	G144G	0.19
UCEC	chr15	48152148	Intron	NA		0.42
UCEC	chr15	48134778	3'UTR	novel		0.32
UCEC	chr15	48152480	Intron	novel		0.38
UCEC	chr15	48134752	3'UTR	novel		0.15
UCEC	chr15	48136511	3'UTR	novel		0.25
UCEC	chr15	48153570	Intron	novel		0.43
UCEC	chr15	48153874	Silent	novel	G335G	0.19
UCEC	chr15	48158025	Missense_Mutation	rs190142072	R318H	0.21
UCEC	chr15	48168649	Missense_Mutation	novel	D118N	0.25
UCEC	chr15	48135192	3'UTR	novel		0.33
UCEC	chr15	48151902	Silent	NA	G393G	0.31
UCEC	chr15	48152014	Intron	novel		0.21
UCEC	chr15	48136600	3'UTR	novel		0.5
UCEC	chr15	48142414	3'UTR	novel		0.36
UCEC	chr15	48153860	Missense_Mutation	rs370931661	P340L	0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2	0.079424
CESC	DEL	0.1864	0.00049652
HNSC	DEL	0.1533	0.11567
KICH	AMP	0.2727	0.21756
KIRP	DEL	0.1042	0.2062
LUAD	DEL	0.3624	6.8561e-07
PAAD	DEL	0.1141	0.13216
READ	DEL	0.4364	0.025797
SARC	DEL	0.1712	0.18974

Survival Analysis

Cancer	P-value	Q-value
THYM	0.025	Kaplan-Meier Survival Analysis
PRAD	0.025	Kaplan-Meier Survival Analysis
PAAD	0.00017	Kaplan-Meier Survival Analysis
PCPG	0.013	Kaplan-Meier Survival Analysis
LAML	0.02	Kaplan-Meier Survival Analysis
GBM	0.029	Kaplan-Meier Survival Analysis
LIHC	0.011	Kaplan-Meier Survival Analysis
LGG	0.022	Kaplan-Meier Survival Analysis
UVM	0.038	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742