Description
Ensembl ID
ENSG00000104356 (Gene tree)
Gene ID
10940
Gene Symbol
POP1
Alias
N
Full Name
POP1 homolog, ribonuclease P/MRP subunit
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
42,549 bases
Position
chr8:98,117,293-98,159,841
Accession
30129
RBP type
canonical RBP
Summary
This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
RNA binding domains(RBDs)
Protein ID
Domain
Pfam ID
E-value
Domain number
Total number
ENSP00000339529POP1PF06978.114.8e-3812
ENSP00000339529POP1PF06978.114.8e-3822
ENSP00000385787POP1PF06978.114.8e-3812
ENSP00000385787POP1PF06978.114.8e-3822
ENSP00000428945POP1PF06978.111.3e-1711
ENSP00000339529POPLDPF08170.123.5e-2711
ENSP00000385787POPLDPF08170.123.5e-2711
RNA binding proteome (RBPome)
PID
Title
Method
Time
Author
Doi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
Expression
Adipose_TissueAdrenal_GlandBladderBloodBlood_VesselBrainBreastCervix_UteriColonEsophagusFallopian_TubeHeartKidneyLiverLungMuscleNerveOvaryPancreasPituitaryProstateSalivary_GlandSkinSmall_IntestineSpleenStomachTestisThyroidUterusVagina0510152025303540
Adipose_TissueAdrenal_GlandBladderBloodBlood_VesselBrainBreastCervix_UteriColonEsophagusFallopian_TubeHeartKidneyLiverLungMuscleNerveOvaryPancreasPituitaryProstateSalivary_GlandSkinSmall_IntestineSpleenStomachTestisThyroidUterusVaginaTPM
Transcripts
Transcript ID
Name
Length
RefSeq ID
Protein ID
Length
RefSeq ID
UniportKB ID
ENST00000517435POP1-203506--- (aa)--
ENST00000401707POP1-2024719XM_011516801ENSP000003857871024 (aa)XP_011515103Q99575
ENST00000522319POP1-204585-ENSP00000428945183 (aa)-E5RK39
ENST00000349693POP1-2013244-ENSP000003395291024 (aa)-Q99575
Pathways
Pathway ID
Pathway Name
Source
hsa03008Ribosome biogenesis in eukaryotesKEGG
hsa03013RNA transportKEGG
Phenotypes
ensgID
Trait
pValue
Pubmed ID
ENSG00000104356Body Height2.6670000E-005-
ENSG00000104356Platelet Function Tests3.0591600E-005-
ENSG00000104356Prion Diseases9E-622210626
Protein-Protein Interaction (PPI)


CanvasJS.com
* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl ID
Gene Symbol
Coverage
Identiy
Ortholog
Gene Symbol
Coverage
Identiy
Species
ENSG00000104356POP110048.582ENSAPOG00000008198pop110048.488Acanthochromis_polyacanthus
ENSG00000104356POP110085.714ENSAMEG00000000556POP110080.971Ailuropoda_melanoleuca
ENSG00000104356POP19049.575ENSACIG00000004169POP110046.565Amphilophus_citrinellus
ENSG00000104356POP110047.358ENSAOCG00000010991pop110047.398Amphiprion_ocellaris
ENSG00000104356POP19147.580ENSAPEG00000007607pop19648.037Amphiprion_percula
ENSG00000104356POP110045.938ENSATEG00000024814POP110046.328Anabas_testudineus
ENSG00000104356POP19263.617ENSAPLG00000014418POP110063.617Anas_platyrhynchos
ENSG00000104356POP110056.551ENSACAG00000016083POP110056.625Anolis_carolinensis
ENSG00000104356POP110090.164ENSANAG00000026360POP110093.472Aotus_nancymaae
ENSG00000104356POP110047.974ENSACLG00000010951pop110047.970Astatotilapia_calliptera
ENSG00000104356POP110045.772ENSAMXG00000014483POP110045.120Astyanax_mexicanus
ENSG00000104356POP110087.978ENSBTAG00000012596POP110080.762Bos_taurus
ENSG00000104356POP110093.066ENSCJAG00000015567POP110093.066Callithrix_jacchus
ENSG00000104356POP110090.164ENSCAFG00000000469POP110081.250Canis_familiaris
ENSG00000104356POP110090.164ENSCAFG00020026765POP110082.520Canis_lupus_dingo
ENSG00000104356POP110088.525ENSCHIG00000017066POP110080.878Capra_hircus
ENSG00000104356POP110091.257ENSTSYG00000003097POP110086.719Carlito_syrichta
ENSG00000104356POP110088.525ENSCAPG00000007251POP110078.426Cavia_aperea
ENSG00000104356POP110088.525ENSCPOG00000002901POP110081.152Cavia_porcellus
ENSG00000104356POP110096.721ENSCCAG00000018939POP110092.871Cebus_capucinus
ENSG00000104356POP110098.361ENSCATG00000040916POP110096.875Cercocebus_atys
ENSG00000104356POP110090.164ENSCLAG00000007208POP19782.520Chinchilla_lanigera
ENSG00000104356POP19096.204ENSCSAG00000012340POP19996.204Chlorocebus_sabaeus
ENSG00000104356POP19580.635ENSCHOG00000011432POP110080.225Choloepus_hoffmanni
ENSG00000104356POP110068.280ENSCPBG00000006373POP110065.272Chrysemys_picta_bellii
ENSG00000104356POP18238.132ENSCING00000008323-9036.396Ciona_intestinalis
ENSG00000104356POP110098.907ENSCANG00000001647POP110096.777Colobus_angolensis_palliatus
ENSG00000104356POP110082.514ENSCGRG00001017308Pop110076.465Cricetulus_griseus_chok1gshd
ENSG00000104356POP110072.678ENSCGRG00000010824Pop110070.898Cricetulus_griseus_crigri
ENSG00000104356POP110045.877ENSCSEG00000008737POP110046.161Cynoglossus_semilaevis
ENSG00000104356POP110047.333ENSCVAG00000022248pop110047.092Cyprinodon_variegatus
ENSG00000104356POP15153.608ENSDARG00000102087pop19448.590Danio_rerio
ENSG00000104356POP110086.631ENSDNOG00000019974POP110078.228Dasypus_novemcinctus
ENSG00000104356POP18984.663ENSDORG00000015384Pop110072.390Dipodomys_ordii
ENSG00000104356POP16132.120FBgn0026702l(1)G00457131.882Drosophila_melanogaster
ENSG00000104356POP110080.328ENSETEG00000007839POP18871.053Echinops_telfairi
ENSG00000104356POP15154.255ENSEBUG00000009897pop18846.742Eptatretus_burgeri
ENSG00000104356POP110090.164ENSEASG00005003189POP19884.277Equus_asinus_asinus
ENSG00000104356POP110091.257ENSECAG00000024236POP110084.277Equus_caballus
ENSG00000104356POP16777.778ENSEEUG00000003050-7077.778Erinaceus_europaeus
ENSG00000104356POP110047.533ENSELUG00000003526pop110047.104Esox_lucius
ENSG00000104356POP110089.617ENSFCAG00000002168POP110084.180Felis_catus
ENSG00000104356POP110060.847ENSFALG00000005711POP110060.907Ficedula_albicollis
ENSG00000104356POP110089.617ENSFDAG00000017068POP110082.715Fukomys_damarensis
ENSG00000104356POP110047.188ENSFHEG00000019518pop110047.474Fundulus_heteroclitus
ENSG00000104356POP19345.998ENSGMOG00000000659POP19845.998Gadus_morhua
ENSG00000104356POP110047.642ENSGAFG00000019770POP110047.110Gambusia_affinis
ENSG00000104356POP110046.958ENSGACG00000003499pop110046.578Gasterosteus_aculeatus
ENSG00000104356POP110064.211ENSGAGG00000011737POP19864.147Gopherus_agassizii
ENSG00000104356POP110099.121ENSGGOG00000003176POP110099.121Gorilla_gorilla
ENSG00000104356POP110047.834ENSHBUG00000021583pop110047.781Haplochromis_burtoni
ENSG00000104356POP110087.432ENSHGLG00000006029POP110082.227Heterocephalus_glaber_female
ENSG00000104356POP110087.432ENSHGLG00100016879POP110082.227Heterocephalus_glaber_male
ENSG00000104356POP19049.679ENSHCOG00000013888pop19649.679Hippocampus_comes
ENSG00000104356POP110044.918ENSIPUG00000018336pop19162.651Ictalurus_punctatus
ENSG00000104356POP110090.164ENSSTOG00000011455POP19783.887Ictidomys_tridecemlineatus
ENSG00000104356POP110087.978ENSJJAG00000013325Pop110078.516Jaculus_jaculus
ENSG00000104356POP110046.692ENSKMAG00000001346POP110046.596Kryptolebias_marmoratus
ENSG00000104356POP18948.488ENSLBEG00000024457POP19547.780Labrus_bergylta
ENSG00000104356POP19355.980ENSLACG00000012498POP19955.844Latimeria_chalumnae
ENSG00000104356POP110051.527ENSLOCG00000009817POP110051.149Lepisosteus_oculatus
ENSG00000104356POP110086.631ENSLAFG00000010770POP110083.755Loxodonta_africana
ENSG00000104356POP110098.907ENSMFAG00000000347POP110096.582Macaca_fascicularis
ENSG00000104356POP110098.907ENSMNEG00000036870POP110095.996Macaca_nemestrina
ENSG00000104356POP110098.907ENSMLEG00000034986POP110096.484Mandrillus_leucophaeus
ENSG00000104356POP110047.214ENSMAMG00000004040pop110047.214Mastacembelus_armatus
ENSG00000104356POP110048.023ENSMZEG00005025448pop110047.970Maylandia_zebra
ENSG00000104356POP110058.215ENSMGAG00000012167POP110058.846Meleagris_gallopavo
ENSG00000104356POP110084.699ENSMAUG00000017537Pop110076.878Mesocricetus_auratus
ENSG00000104356POP110090.710ENSMICG00000004361POP110087.695Microcebus_murinus
ENSG00000104356POP110083.607ENSMOCG00000006356Pop110076.465Microtus_ochrogaster
ENSG00000104356POP110044.704ENSMMOG00000018242pop110044.704Mola_mola
ENSG00000104356POP110071.429ENSMODG00000006561POP110069.729Monodelphis_domestica
ENSG00000104356POP19351.962ENSMALG00000012621POP110047.543Monopterus_albus
ENSG00000104356POP110085.792MGP_CAROLIEiJ_G0019726Pop110076.758Mus_caroli
ENSG00000104356POP110085.792ENSMUSG00000022325Pop110077.246Mus_musculus
ENSG00000104356POP110086.339MGP_PahariEiJ_G0019735Pop110077.051Mus_pahari
ENSG00000104356POP110086.885MGP_SPRETEiJ_G0020622Pop110076.660Mus_spretus
ENSG00000104356POP110089.674ENSMPUG00000015250POP110081.518Mustela_putorius_furo
ENSG00000104356POP110087.978ENSMLUG00000010204POP110077.388Myotis_lucifugus
ENSG00000104356POP110090.710ENSNGAG00000001582Pop110082.520Nannospalax_galili
ENSG00000104356POP18948.394ENSNBRG00000002356pop19448.514Neolamprologus_brichardi
ENSG00000104356POP110097.814ENSNLEG00000002541POP110097.070Nomascus_leucogenys
ENSG00000104356POP19361.169ENSMEUG00000003118POP19861.169Notamacropus_eugenii
ENSG00000104356POP110086.885ENSOPRG00000007667POP110079.199Ochotona_princeps
ENSG00000104356POP110089.071ENSODEG00000003984POP110080.409Octodon_degus
ENSG00000104356POP110048.433ENSONIG00000016445pop110048.393Oreochromis_niloticus
ENSG00000104356POP18969.512ENSOANG00000001278-9470.122Ornithorhynchus_anatinus
ENSG00000104356POP110085.561ENSOCUG00000017400POP110082.216Oryctolagus_cuniculus
ENSG00000104356POP110047.172ENSORLG00000002839pop110047.172Oryzias_latipes
ENSG00000104356POP19049.893ENSORLG00020022450POP19649.469Oryzias_latipes_hni
ENSG00000104356POP110047.793ENSORLG00015012746POP110047.843Oryzias_latipes_hsok
ENSG00000104356POP110047.969ENSOMEG00000006915pop19947.485Oryzias_melastigma
ENSG00000104356POP110086.885ENSOGAG00000001466POP110084.863Otolemur_garnettii
ENSG00000104356POP1100100.000ENSPPAG00000018410POP110099.316Pan_paniscus
ENSG00000104356POP110089.071ENSPPRG00000005002POP110084.098Panthera_pardus
ENSG00000104356POP110089.071ENSPTIG00000016527POP110084.488Panthera_tigris_altaica
ENSG00000104356POP1100100.000ENSPTRG00000020458POP110099.316Pan_troglodytes
ENSG00000104356POP110098.361ENSPANG00000009704POP110096.191Papio_anubis
ENSG00000104356POP110049.425ENSPKIG00000016325POP110048.848Paramormyrops_kingsleyae
ENSG00000104356POP110066.316ENSPSIG00000012343POP110063.725Pelodiscus_sinensis
ENSG00000104356POP19049.306ENSPMGG00000022253POP19549.573Periophthalmus_magnuspinnatus
ENSG00000104356POP19982.967ENSPEMG00000023633Pop110075.789Peromyscus_maniculatus_bairdii
ENSG00000104356POP19044.034ENSPMAG00000003209POP110043.776Petromyzon_marinus
ENSG00000104356POP110072.396ENSPCIG00000012216POP110068.147Phascolarctos_cinereus
ENSG00000104356POP110048.752ENSPFOG00000012490POP110048.219Poecilia_formosa
ENSG00000104356POP110048.607ENSPLAG00000004646POP110048.073Poecilia_latipinna
ENSG00000104356POP110048.755ENSPMEG00000019592POP110048.223Poecilia_mexicana
ENSG00000104356POP110048.654ENSPREG00000020951POP110048.316Poecilia_reticulata
ENSG00000104356POP110099.454ENSPPYG00000018777POP110097.754Pongo_abelii
ENSG00000104356POP110083.060ENSPCAG00000016662POP110075.902Procavia_capensis
ENSG00000104356POP110090.164ENSPCOG00000019420POP110087.988Propithecus_coquereli
ENSG00000104356POP110085.792ENSPVAG00000014468POP110082.732Pteropus_vampyrus
ENSG00000104356POP18949.032ENSPNYG00000004476pop19947.972Pundamilia_nyererei
ENSG00000104356POP110045.638ENSPNAG00000000265pop110043.893Pygocentrus_nattereri
ENSG00000104356POP110084.153ENSRNOG00000005243Pop110077.832Rattus_norvegicus
ENSG00000104356POP110098.361ENSRBIG00000007996POP110096.680Rhinopithecus_bieti
ENSG00000104356POP110098.907ENSRROG00000012334POP110096.875Rhinopithecus_roxellana
ENSG00000104356POP19993.874ENSSBOG00000020830POP110093.874Saimiri_boliviensis_boliviensis
ENSG00000104356POP110069.841ENSSHAG00000000296POP110068.925Sarcophilus_harrisii
ENSG00000104356POP110048.473ENSSFOG00015007429pop19947.947Scleropages_formosus
ENSG00000104356POP18753.284ENSSMAG00000010467POP19948.835Scophthalmus_maximus
ENSG00000104356POP110046.792ENSSDUG00000007817POP110047.081Seriola_dumerili
ENSG00000104356POP110046.786ENSSLDG00000012565POP110047.925Seriola_lalandi_dorsalis
ENSG00000104356POP16175.676ENSSARG00000002421-5176.471Sorex_araneus
ENSG00000104356POP110066.304ENSSPUG00000003550-10059.826Sphenodon_punctatus
ENSG00000104356POP110047.144ENSSPAG00000014955pop110047.241Stegastes_partitus
ENSG00000104356POP110087.978ENSSSCG00000006078POP110082.227Sus_scrofa
ENSG00000104356POP19257.672ENSTGUG00000012011-10057.672Taeniopygia_guttata
ENSG00000104356POP19148.520ENSTRUG00000010856pop19448.520Takifugu_rubripes
ENSG00000104356POP19249.117ENSTNIG00000013297pop19949.066Tetraodon_nigroviridis
ENSG00000104356POP19581.679ENSTBEG00000014214POP110081.679Tupaia_belangeri
ENSG00000104356POP110086.339ENSTTRG00000016071POP110080.566Tursiops_truncatus
ENSG00000104356POP19978.677ENSUAMG00000017309POP110078.776Ursus_americanus
ENSG00000104356POP110089.071ENSUMAG00000016952POP110090.283Ursus_maritimus
ENSG00000104356POP110086.885ENSVPAG00000008278POP18287.956Vicugna_pacos
ENSG00000104356POP110089.617ENSVVUG00000010994POP110082.617Vulpes_vulpes
ENSG00000104356POP110043.495ENSXCOG00000017043POP110043.008Xiphophorus_couchianus
ENSG00000104356POP110047.839ENSXMAG00000002472POP110047.303Xiphophorus_maculatus
Gene Ontology
Go ID
Go_term
PubmedID
Evidence
Category
GO:0000171ribonuclease MRP activity21873635.IBAFunction
GO:0000171ribonuclease MRP activity8918471.IDAFunction
GO:0000172ribonuclease MRP complex21873635.IBAComponent
GO:0000172ribonuclease MRP complex8918471.16723659.IDAComponent
GO:0001682tRNA 5'-leader removal16723659.30454648.IDAProcess
GO:0001682tRNA 5'-leader removal-TASProcess
GO:0003723RNA binding22658674.HDAFunction
GO:0004526ribonuclease P activity21873635.IBAFunction
GO:0004526ribonuclease P activity8918471.IDAFunction
GO:0004526ribonuclease P activity16723659.30454648.IDAFunction
GO:0005515protein binding15096576.IPIFunction
GO:0005615extracellular space22664934.HDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005655nucleolar ribonuclease P complex21873635.IBAComponent
GO:0005655nucleolar ribonuclease P complex8918471.IDAComponent
GO:0005730nucleolus-IDAComponent
GO:0008033tRNA processing21873635.IBAProcess
GO:0016078tRNA catabolic process8918471.IDAProcess
GO:0030681multimeric ribonuclease P complex16723659.30454648.IDAComponent
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEAProcess

Differential Expression

Expression in 33 cancers
ACCBLCABRCACESCCHOLCOADDLBCESCAGBMHNSCKICHKIRCKIRPLAMLLGGLIHCLUADLUSCMESOOVPAADPCPGPRADREADSARCSKCMSTADTGCTTHCATHYMUCECUCSUVM05101520
ACCBLCABRCACESCCHOLCOADDLBCESCAGBMHNSCKICHKIRCKIRPLAMLLGGLIHCLUADLUSCMESOOVPAADPCPGPRADREADSARCSKCMSTADTGCTTHCATHYMUCECUCSUVMFPKM

Mutations

Copy Number Variations (CNVs)
Cancer
Type
Freq
Q-value
KIRCAMP0.10420.15559
PRADAMP0.26423.7005e-05
SARCAMP0.28790.18425
TGCTAMP0.660.13696
THCADEL0.0080.038162

Survival Analysis
Cancer
P-value
Q-value
STAD0.017
SARC0.0013
MESO0.00037
ACC0.00038
PRAD0.027
BRCA0.0021
KIRP0.0016
COAD0.034
READ0.0084
LAML0.049
KICH0.0047
UCEC0.02
LIHC0.00011
LGG0.012
LUAD0.016
UVM0.005

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

Mpgyi