EuRBPDB

Description

Ensembl ID: ENSG00000104691 (Gene tree)
Gene ID: 7993
Gene Symbol: UBXN8
Alias: D8S2298E|REP8|UBXD6
Full Name: UBX domain protein 8
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 37,900 bases
Position: chr8:30,729,107-30,767,006
Accession: 30307
RBP type: canonical RBP
Summary: p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000483433	RNase_H	PF00075.24	9.2e-07	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000380154	UBXN8-203	1624	-	ENSP00000482772	42 (aa)	-	A0A087WZN0
ENST00000620706	UBXN8-210	654	-	-	- (aa)	-	-
ENST00000615729	UBXN8-207	702	-	ENSP00000481635	233 (aa)	-	O00124
ENST00000518059	UBXN8-204	493	-	ENSP00000480065	94 (aa)	-	A0A087WWA4
ENST00000613013	UBXN8-206	528	-	-	- (aa)	-	-
ENST00000265616	UBXN8-201	1450	XM_017013862	ENSP00000479216	270 (aa)	XP_016869351	A0A087WV67
ENST00000616306	UBXN8-208	571	-	-	- (aa)	-	-
ENST00000620074	UBXN8-209	1058	XM_011544655	ENSP00000477532	310 (aa)	XP_011542957	A0A087WT23
ENST00000341403	UBXN8-202	1202	-	ENSP00000478502	229 (aa)	-	A0A087WUA4
ENST00000522968	UBXN8-205	813	-	ENSP00000483433	248 (aa)	-	A0A087X0J2

Gene Model

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	18775313.21949850.29997244.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0007338	single fertilization	9027507.	TAS	Process
GO:0030176	integral component of endoplasmic reticulum membrane	21949850.	IDA	Component
GO:0030433	ubiquitin-dependent ERAD pathway	21949850.	IMP	Process