EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000104783 (Gene tree)
Gene ID: 3783
Gene Symbol: KCNN4
Alias: KCa3.1|hSK4|hKCa4|hIKCa1|IK
Full Name: potassium calcium-activated channel subfamily N member 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 15,607 bases
Position: chr19:43,766,533-43,782,139
Accession: 6293
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000600909	KCNN4-207	1190	-	ENSP00000470339	59 (aa)	-	M0QZ70
ENST00000615047	KCNN4-209	2029	XM_005258883	ENSP00000485014	295 (aa)	XP_005258940	D1MQ08
ENST00000601549	KCNN4-208	1406	-	-	- (aa)	-	-
ENST00000262888	KCNN4-201	2244	XM_005258882	ENSP00000262888	427 (aa)	XP_005258939	O15554
ENST00000598836	KCNN4-203	1003	-	ENSP00000471900	165 (aa)	-	M0R1J0
ENST00000648053	KCNN4-210	1270	-	-	- (aa)	-	-
ENST00000599720	KCNN4-205	983	-	ENSP00000472513	57 (aa)	-	M0R2F1
ENST00000600408	KCNN4-206	648	-	ENSP00000472510	113 (aa)	-	M0R2E8
ENST00000648319	KCNN4-211	1956	-	ENSP00000496939	427 (aa)	-	UPI0000000DF3
ENST00000597184	KCNN4-202	631	-	-	- (aa)	-	-
ENST00000599107	KCNN4-204	687	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000104783's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04911	Insulin secretion	KEGG
hsa04970	Salivary secretion	KEGG
hsa04974	Protein digestion and absorption	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000104783	Breast Neoplasms	2E-10	23535729

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000104783	rs56344893	19	43778377	A	Monocyte count	27863252	[0.04-0.055] unit decrease	0.04736383	EFO_0005091
ENSG00000104783	rs563995	19	43774629	A	Mean corpuscular volume	27863252	[0.017-0.034] unit decrease	0.02572105	EFO_0004526
ENSG00000104783	rs11879798	19	43777746	A	Granulocyte percentage of myeloid white cells	27863252	[0.038-0.053] unit increase	0.04540951	EFO_0007997
ENSG00000104783	rs563995	19	43774629	A	Hemoglobin concentration	27863252	[0.017-0.034] unit increase	0.02525654	EFO_0004509
ENSG00000104783	rs11879798	19	43777746	A	Monocyte percentage of white cells	27863252	[0.04-0.054] unit decrease	0.04723772	EFO_0007989
ENSG00000104783	rs563995	19	43774629	A	Mean corpuscular hemoglobin concentration	27863252	[0.037-0.054] unit increase	0.04561461	EFO_0004528
ENSG00000104783	rs649540	19	43774627	?	White blood cell count	30595370			EFO_0004308
ENSG00000104783	rs347519	19	43769364	?	Red blood cell count	30595370			EFO_0004305
ENSG00000104783	rs1685191	19	43779080	T	Breast cancer	29059683	[0.046-0.071] unit decrease	0.0586	EFO_0000305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000104783's network

CanvasJS.com

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002376	immune system process	-	IEA	Process
GO:0005267	potassium channel activity	-	TAS	Function
GO:0005515	protein binding	10880439.12198491.18796614.27092946.29724949.	IPI	Function
GO:0005516	calmodulin binding	21873635.	IBA	Function
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	26148990.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006813	potassium ion transport	9380751.	TAS	Process
GO:0006816	calcium ion transport	18796614.	IDA	Process
GO:0006884	cell volume homeostasis	-	IEA	Process
GO:0006952	defense response	9407042.	TAS	Process
GO:0008076	voltage-gated potassium channel complex	18796614.	IC	Component
GO:0015269	calcium-activated potassium channel activity	18796614.26148990.	IDA	Function
GO:0016286	small conductance calcium-activated potassium channel activity	-	IEA	Function
GO:0019903	protein phosphatase binding	18796614.	IPI	Function
GO:0022894	Intermediate conductance calcium-activated potassium channel activity	21873635.	IBA	Function
GO:0030322	stabilization of membrane potential	18796614.	IDA	Process
GO:0031982	vesicle	25468996.	IDA	Component
GO:0043005	neuron projection	21873635.	IBA	Component
GO:0043025	neuronal cell body	21873635.	IBA	Component
GO:0045332	phospholipid translocation	-	IEA	Process
GO:0046541	saliva secretion	-	IEA	Process
GO:0050714	positive regulation of protein secretion	-	IEA	Process
GO:0050862	positive regulation of T cell receptor signaling pathway	18796614.	IDA	Process
GO:0071805	potassium ion transmembrane transport	21873635.	IBA	Process

Cancer associated literatures

Show entries

Search:

PID	Title	Article	Time	Author	Doi
28280257	Intermediate-Conductance-Ca2-Activated K Channel IKCa1 Is Upregulated and Promotes Cell Proliferation in Cervical Cancer	Med Sci Monit Basic Res	2017 Mar 10	Liu L	-
27531900	miR-497-5p inhibits cell proliferation and invasion by targeting KCa3.1 in angiosarcoma.	Oncotarget	2016 Sep 6	Chen Y	doi: 10.18632/oncotarget.11252.
27124117	Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells.	PLoS One	2016 Apr 28	Zhang P	doi: 10.1371/journal.pone.0154471
24885636	Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner.	BMC Cancer	2014 May 10	Xu H	doi: 10.1186/1471-2407-14-330.
20712009	Intermediate conductance Ca2+ activated K+ channels are expressed and functional in breast adenocarcinomas: correlation with tumour grade and metastasis status.	Histol Histopathol	2010 Oct	Haren N	doi: 10.14670/HH-25.1247.
20036632	An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1.	Biochim Biophys Acta	2010 Jun-Jul	Sassi N	doi: 10.1016/j.bbabio.2009.12.015
18367588	IK1 channel activity contributes to cisplatin sensitivity of human epidermoid cancer cells.	Am J Physiol Cell Physiol	2008 Jun	Lee EL	doi: 10.1152/ajpcell.00428.2007
17310992	Blockage of intermediate-conductance-Ca(2+) -activated K(+) channels inhibits progression of human endometrial cancer.	Oncogene	2007 Aug 2	Wang ZH	-

Showing 1 to 8 of 8 entries

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Differential Expression

Expression in 33 cancers

Mutations

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Search:

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
SARC	chr19	43766906	3'UTR	novel		0.39
UCEC	chr19	43766975	3'UTR	novel		0.53
LUAD	chr19	43767614	Missense_Mutation	novel	A405S	0.5
ESCA	chr19	43767628	Missense_Mutation	novel	A400V	0.32
HNSC	chr19	43767634	Missense_Mutation	rs201257292	T398M	0.54
CESC	chr19	43767648	Missense_Mutation	novel	E393D	0.44
LUAD	chr19	43767659	Silent	novel	R390R	0.22
LUSC	chr19	43767659	Missense_Mutation	rs200755307	R390W	0.18
SKCM	chr19	43767659	Missense_Mutation	rs200755307	R390W	0.15
UCEC	chr19	43767661	Missense_Mutation	NA	H389R	0.11

Showing 1 to 10 of 109 entries

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Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	AMP	0.0069	0.069756
KIRP	DEL	0.0417	0.11554
LAML	DEL	0.0105	1.2971e-07
LUSC	DEL	0.1896	0.002071
MESO	DEL	0.1379	0.20184
PRAD	AMP	0.0102	0.16448
READ	DEL	0.0667	0.23023
SKCM	DEL	0.1199	2.2081e-08
TGCT	DEL	0.2867	0.0046229
THCA	AMP	0.018	0.075436
THCA	DEL	0.002	0.23456
UCS	DEL	0.1964	0.12448

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0059	Kaplan-Meier Survival Analysis
MESO	0.014	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
PRAD	0.047	Kaplan-Meier Survival Analysis
LUSC	0.045	Kaplan-Meier Survival Analysis
BRCA	0.012	Kaplan-Meier Survival Analysis
TGCT	0.023	Kaplan-Meier Survival Analysis
KIRP	0.0029	Kaplan-Meier Survival Analysis
PAAD	0.00061	Kaplan-Meier Survival Analysis
BLCA	0.0042	Kaplan-Meier Survival Analysis
UCEC	0.023	Kaplan-Meier Survival Analysis
GBM	0.00011	Kaplan-Meier Survival Analysis
DLBC	0.02	Kaplan-Meier Survival Analysis
LUAD	0.014	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742