EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000104852 (Gene tree)
Gene ID: 6625
Gene Symbol: SNRNP70
Alias: U1-70K|Snp1|RNPU1Z|RPU1|SNRP70
Full Name: small nuclear ribonucleoprotein U1 subunit 70
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 23,474 bases
Position: chr19:49,085,140-49,108,613
Accession: 11150
RBP type: canonical RBP
Summary: (Small Nuclear Ribonucleoprotein U1 Subunit 70) is a Protein Coding gene. Diseases associated with SNRNP70 include Mixed Connective Tissue Disease and Systemic Lupus Erythematosus. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SNRNP35.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000221448	RRM_1	PF00076.22	2.1e-17	1	1
ENSP00000472998	RRM_1	PF00076.22	2.2e-17	1	1
ENSP00000470023	RRM_1	PF00076.22	2.4e-13	1	1
ENSP00000221448	U1snRNP70_N	PF12220.8	3.8e-27	1	1
ENSP00000472998	U1snRNP70_N	PF12220.8	3.9e-27	1	1
ENSP00000468828	U1snRNP70_N	PF12220.8	0.00027	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19196664	Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis.	Blood	2009 Apr 2	Yamamoto ML	doi: 10.1182/blood-2008-05-160325
21536904	Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly.	Proc Natl Acad Sci U S A	2011 May 17	Cho S	doi: 10.1073/pnas.1017700108
8253214	Evolutionary clustering and functional similarity of RNA-binding proteins.	FEBS Lett	1993 Dec 6	Fukami-Kobayashi K	-
2531275	Direct, sequence-specific binding of the human U1-70K ribonucleoprotein antigen protein to loop I of U1 small nuclear RNA.	Mol Cell Biol	1989 Oct	Surowy CS	-
2447561	The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding.	Nucleic Acids Res	1987 Dec 23	Spritz RA	-
2147422	Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3.	Genomics	1990 Oct	Spritz RA	-
1714384	Cloning of a yeast U1 snRNP 70K protein homologue: functional conservation of an RNA-binding domain between humans and yeast.	EMBO J	1991 Sep	Smith V	-
9451595	Autoepitope-mapping of the U1-70K protein with human-Drosophila chimeric proteins.	J Autoimmun	1997 Dec	Henriksson EW	-
9473574	Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation.	Brain Res Mol Brain Res	1998 Jan	Imai Y	-
8972845	In vitro reconstitution of mammalian U1 snRNPs active in splicing: the U1-C protein enhances the formation of early (E) spliceosomal complexes.	Nucleic Acids Res	1996 Dec 1	Will CL	-
12657633	The structure of the zinc finger domain from human splicing factor ZNF265 fold.	J Biol Chem	2003 Jun 20	Plambeck CA	-
11069087	Characterization of recombinant human autoantibody fragments directed toward the autoantigenic U1-70K protein.	Eur J Immunol	2000 Oct	Degen WG	-
15863726	U1 small nuclear RNP from Trypanosoma brucei: a minimal U1 snRNA with unusual protein components.	Nucleic Acids Res	2005 Apr 29	Palfi Z	-
19325628	Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.	Nature	2009 Mar 26	Pomeranz Krummel DA	doi: 10.1038/nature07851.
20722023	Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease.	Arthritis Rheum	2010 Dec	Sato T	doi: 10.1002/art.27700.
24748659	Genome-wide RNA-binding analysis of the trypanosome U1 snRNP proteins U1C and U1-70K reveals cis/trans-spliceosomal network.	Nucleic Acids Res	2014 Jun	PreuBer C	doi: 10.1093/nar/gku286
26333287	Mapping epitopes of U1-70K autoantibodies at single-amino acid resolution.	Autoimmunity	2015	Haddon DJ	doi: 10.3109/08916934.2015.1077233
29802200	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	J Biol Chem	2018 Jul 13	Bishof I	doi: 10.1074/jbc.RA118.001747
7516470	The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain.	Mol Cell Biol	1994 Jul	Romac JM	-
8076607	The association of the U1-specific 70K and C proteins with U1 snRNPs is mediated in part by common U snRNP proteins.	EMBO J	1994 Sep 1	Nelissen RL	-
20194618	HMGA1a trapping of U1 snRNP at an authentic 5' splice site induces aberrant exon skipping in sporadic Alzheimer's disease.	Mol Cell Biol	2010 May	Ohe K	doi: 10.1128/MCB.00114-10
25052091	The splicing factor U1-70K interacts with the SMN complex and is required for nuclear gem integrity.	J Cell Sci	2014 Sep 15	Stejskalova E	doi: 10.1242/jcs.155838

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000598984	SNRNP70-207	547	-	ENSP00000470023	94 (aa)	-	M0QYR1
ENST00000601411	SNRNP70-210	377	-	ENSP00000468828	33 (aa)	-	M0QX04
ENST00000544278	SNRNP70-203	3221	-	-	- (aa)	-	-
ENST00000595231	SNRNP70-204	1673	-	ENSP00000471006	166 (aa)	-	P08621
ENST00000401730	SNRNP70-202	3144	-	ENSP00000385077	166 (aa)	-	P08621
ENST00000221448	SNRNP70-201	1603	-	ENSP00000221448	428 (aa)	-	P08621
ENST00000597936	SNRNP70-205	580	-	-	- (aa)	-	-
ENST00000599687	SNRNP70-208	563	-	-	- (aa)	-	-
ENST00000598441	SNRNP70-206	1574	-	ENSP00000472998	437 (aa)	-	P08621
ENST00000601065	SNRNP70-209	1757	-	ENSP00000468952	166 (aa)	-	P08621

Gene Model

Click here to download ENSG00000104852's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000104852	rs73046792	19	49102448	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000104852	rs73046792	19	49102448	G	Systolic blood pressure	30224653	[0.27-0.44] mmHg increase	0.3554	EFO_0006335

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000104852's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000104852	SNRNP70	55	36.538	ENSG00000242389	RBMY1E	85	34.286
ENSG00000104852	SNRNP70	60	39.286	ENSG00000188529	SRSF10	81	39.286
ENSG00000104852	SNRNP70	55	36.538	ENSG00000234414	RBMY1A1	85	34.286
ENSG00000104852	SNRNP70	55	36.538	ENSG00000244395	RBMY1D	85	34.286
ENSG00000104852	SNRNP70	55	36.538	ENSG00000242875	RBMY1B	85	34.286
ENSG00000104852	SNRNP70	51	37.500	ENSG00000132819	RBM38	63	32.468
ENSG00000104852	SNRNP70	55	32.692	ENSG00000099622	CIRBP	91	34.247
ENSG00000104852	SNRNP70	51	41.667	ENSG00000265241	RBM8A	70	33.784

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000104852	SNRNP70	86	88.028	ENSAPOG00000009322	snrnp70	89	88.028	Acanthochromis_polyacanthus
ENSG00000104852	SNRNP70	100	100.000	ENSAMEG00000014468	SNRNP70	100	93.878	Ailuropoda_melanoleuca
ENSG00000104852	SNRNP70	99	89.634	ENSAOCG00000011672	snrnp70	50	83.482	Amphiprion_ocellaris
ENSG00000104852	SNRNP70	99	93.902	ENSACAG00000013276	SNRNP70	51	97.297	Anolis_carolinensis
ENSG00000104852	SNRNP70	100	100.000	ENSANAG00000036787	SNRNP70	100	100.000	Aotus_nancymaae
ENSG00000104852	SNRNP70	100	100.000	ENSBTAG00000048800	-	100	100.000	Bos_taurus
ENSG00000104852	SNRNP70	99	52.688	WBGene00004390	rnp-7	56	53.723	Caenorhabditis_elegans
ENSG00000104852	SNRNP70	100	100.000	ENSCJAG00000000193	SNRNP70	100	100.000	Callithrix_jacchus
ENSG00000104852	SNRNP70	100	100.000	ENSCAFG00000003711	SNRNP70	100	100.000	Canis_familiaris
ENSG00000104852	SNRNP70	100	100.000	ENSCAFG00020025470	SNRNP70	100	96.388	Canis_lupus_dingo
ENSG00000104852	SNRNP70	100	100.000	ENSCHIG00000018534	-	100	100.000	Capra_hircus
ENSG00000104852	SNRNP70	63	88.571	ENSTSYG00000032350	-	85	88.571	Carlito_syrichta
ENSG00000104852	SNRNP70	100	100.000	ENSCPOG00000019589	SNRNP70	100	97.059	Cavia_porcellus
ENSG00000104852	SNRNP70	100	100.000	ENSCCAG00000036551	SNRNP70	100	99.486	Cebus_capucinus
ENSG00000104852	SNRNP70	100	100.000	ENSCATG00000016149	SNRNP70	100	100.000	Cercocebus_atys
ENSG00000104852	SNRNP70	100	100.000	ENSCLAG00000007991	SNRNP70	100	98.178	Chinchilla_lanigera
ENSG00000104852	SNRNP70	100	100.000	ENSCSAG00000002759	SNRNP70	100	100.000	Chlorocebus_sabaeus
ENSG00000104852	SNRNP70	100	96.970	ENSCPBG00000014841	SNRNP70	51	99.099	Chrysemys_picta_bellii
ENSG00000104852	SNRNP70	97	71.429	ENSCSAVG00000010109	-	50	70.681	Ciona_savignyi
ENSG00000104852	SNRNP70	100	100.000	ENSCANG00000036607	SNRNP70	100	99.772	Colobus_angolensis_palliatus
ENSG00000104852	SNRNP70	100	100.000	ENSCGRG00001020676	Snrnp70	100	95.973	Cricetulus_griseus_chok1gshd
ENSG00000104852	SNRNP70	100	100.000	ENSCGRG00000018048	Snrnp70	100	95.973	Cricetulus_griseus_crigri
ENSG00000104852	SNRNP70	99	88.415	ENSCSEG00000011978	snrnp70	99	91.480	Cynoglossus_semilaevis
ENSG00000104852	SNRNP70	96	89.937	ENSCVAG00000003912	snrnp70	99	89.937	Cyprinodon_variegatus
ENSG00000104852	SNRNP70	99	86.585	ENSDARG00000077126	snrnp70	99	88.820	Danio_rerio
ENSG00000104852	SNRNP70	100	100.000	ENSDNOG00000035849	-	100	100.000	Dasypus_novemcinctus
ENSG00000104852	SNRNP70	100	100.000	ENSDORG00000010228	Snrnp70	100	95.946	Dipodomys_ordii
ENSG00000104852	SNRNP70	74	100.000	ENSETEG00000005009	SNRNP70	74	100.000	Echinops_telfairi
ENSG00000104852	SNRNP70	100	100.000	ENSEASG00005004917	SNRNP70	100	97.955	Equus_asinus_asinus
ENSG00000104852	SNRNP70	100	100.000	ENSECAG00000013936	-	100	100.000	Equus_caballus
ENSG00000104852	SNRNP70	100	97.872	ENSEEUG00000005666	SNRNP70	100	82.232	Erinaceus_europaeus
ENSG00000104852	SNRNP70	100	100.000	ENSFCAG00000042603	SNRNP70	100	91.591	Felis_catus
ENSG00000104852	SNRNP70	100	100.000	ENSFDAG00000013830	SNRNP70	96	99.682	Fukomys_damarensis
ENSG00000104852	SNRNP70	99	87.805	ENSGMOG00000011492	snrnp70	97	91.403	Gadus_morhua
ENSG00000104852	SNRNP70	99	88.415	ENSGACG00000000448	snrnp70	70	91.928	Gasterosteus_aculeatus
ENSG00000104852	SNRNP70	96	95.556	ENSGAGG00000012628	SNRNP70	99	80.000	Gopherus_agassizii
ENSG00000104852	SNRNP70	100	100.000	ENSGGOG00000008245	SNRNP70	100	100.000	Gorilla_gorilla
ENSG00000104852	SNRNP70	100	100.000	ENSHGLG00100001651	-	100	100.000	Heterocephalus_glaber_male
ENSG00000104852	SNRNP70	100	100.000	ENSSTOG00000013988	-	100	100.000	Ictidomys_tridecemlineatus
ENSG00000104852	SNRNP70	100	100.000	ENSJJAG00000002614	Snrnp70	100	95.291	Jaculus_jaculus
ENSG00000104852	SNRNP70	100	100.000	ENSLAFG00000028536	SNRNP70	100	100.000	Loxodonta_africana
ENSG00000104852	SNRNP70	100	100.000	ENSMFAG00000039824	SNRNP70	100	100.000	Macaca_fascicularis
ENSG00000104852	SNRNP70	100	100.000	ENSMMUG00000004928	SNRNP70	100	100.000	Macaca_mulatta
ENSG00000104852	SNRNP70	100	100.000	ENSMNEG00000038057	SNRNP70	100	98.974	Macaca_nemestrina
ENSG00000104852	SNRNP70	100	100.000	ENSMLEG00000030967	SNRNP70	100	100.000	Mandrillus_leucophaeus
ENSG00000104852	SNRNP70	100	100.000	ENSMAUG00000020970	Snrnp70	100	96.188	Mesocricetus_auratus
ENSG00000104852	SNRNP70	100	100.000	ENSMICG00000038437	SNRNP70	100	100.000	Microcebus_murinus
ENSG00000104852	SNRNP70	100	100.000	ENSMOCG00000012825	Snrnp70	100	95.323	Microtus_ochrogaster
ENSG00000104852	SNRNP70	75	76.716	ENSMODG00000023381	SNRNP70	100	80.000	Monodelphis_domestica
ENSG00000104852	SNRNP70	100	100.000	MGP_CAROLIEiJ_G0029714	Snrnp70	100	100.000	Mus_caroli
ENSG00000104852	SNRNP70	100	100.000	ENSMUSG00000063511	Snrnp70	100	100.000	Mus_musculus
ENSG00000104852	SNRNP70	100	100.000	MGP_PahariEiJ_G0012939	Snrnp70	100	100.000	Mus_pahari
ENSG00000104852	SNRNP70	100	100.000	MGP_SPRETEiJ_G0030812	Snrnp70	100	100.000	Mus_spretus
ENSG00000104852	SNRNP70	100	100.000	ENSMPUG00000003258	SNRNP70	100	98.182	Mustela_putorius_furo
ENSG00000104852	SNRNP70	100	100.000	ENSMLUG00000011766	SNRNP70	100	98.182	Myotis_lucifugus
ENSG00000104852	SNRNP70	100	100.000	ENSNGAG00000021191	Snrnp70	95	97.531	Nannospalax_galili
ENSG00000104852	SNRNP70	99	89.024	ENSNBRG00000003126	snrnp70	96	92.377	Neolamprologus_brichardi
ENSG00000104852	SNRNP70	100	100.000	ENSNLEG00000004899	SNRNP70	100	100.000	Nomascus_leucogenys
ENSG00000104852	SNRNP70	100	100.000	ENSODEG00000017499	SNRNP70	100	93.290	Octodon_degus
ENSG00000104852	SNRNP70	99	88.415	ENSONIG00000007822	snrnp70	52	91.928	Oreochromis_niloticus
ENSG00000104852	SNRNP70	100	97.872	ENSOANG00000005213	SNRNP70	97	99.550	Ornithorhynchus_anatinus
ENSG00000104852	SNRNP70	100	100.000	ENSOCUG00000015081	SNRNP70	85	92.268	Oryctolagus_cuniculus
ENSG00000104852	SNRNP70	100	97.895	ENSOGAG00000029310	SNRNP70	100	97.511	Otolemur_garnettii
ENSG00000104852	SNRNP70	100	100.000	ENSOARG00000012608	SNRNP70	93	100.000	Ovis_aries
ENSG00000104852	SNRNP70	100	100.000	ENSPPAG00000035067	SNRNP70	100	100.000	Pan_paniscus
ENSG00000104852	SNRNP70	100	100.000	ENSPPRG00000005579	SNRNP70	100	98.182	Panthera_pardus
ENSG00000104852	SNRNP70	100	100.000	ENSPTRG00000011277	SNRNP70	100	100.000	Pan_troglodytes
ENSG00000104852	SNRNP70	100	100.000	ENSPANG00000004068	SNRNP70	100	100.000	Papio_anubis
ENSG00000104852	SNRNP70	96	80.503	ENSPKIG00000019992	snrnp70	86	79.012	Paramormyrops_kingsleyae
ENSG00000104852	SNRNP70	100	96.970	ENSPSIG00000015251	SNRNP70	90	85.217	Pelodiscus_sinensis
ENSG00000104852	SNRNP70	96	90.566	ENSPMGG00000010153	snrnp70	77	90.062	Periophthalmus_magnuspinnatus
ENSG00000104852	SNRNP70	100	100.000	ENSPEMG00000019011	Snrnp70	100	95.333	Peromyscus_maniculatus_bairdii
ENSG00000104852	SNRNP70	99	79.878	ENSPMAG00000008502	snrnp70	97	83.422	Petromyzon_marinus
ENSG00000104852	SNRNP70	100	100.000	ENSPCIG00000007296	SNRNP70	100	88.018	Phascolarctos_cinereus
ENSG00000104852	SNRNP70	100	100.000	ENSPPYG00000010234	SNRNP70	100	99.542	Pongo_abelii
ENSG00000104852	SNRNP70	99	85.976	ENSPCOG00000023103	SNRNP70	100	90.787	Propithecus_coquereli
ENSG00000104852	SNRNP70	100	94.545	ENSPVAG00000009578	SNRNP70	100	92.955	Pteropus_vampyrus
ENSG00000104852	SNRNP70	100	100.000	ENSRBIG00000042387	SNRNP70	100	99.771	Rhinopithecus_bieti
ENSG00000104852	SNRNP70	100	100.000	ENSRROG00000033636	SNRNP70	100	100.000	Rhinopithecus_roxellana
ENSG00000104852	SNRNP70	100	100.000	ENSSBOG00000020026	SNRNP70	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000104852	SNRNP70	100	100.000	ENSSHAG00000002194	SNRNP70	100	88.710	Sarcophilus_harrisii
ENSG00000104852	SNRNP70	100	100.000	ENSSPUG00000016621	SNRNP70	52	98.649	Sphenodon_punctatus
ENSG00000104852	SNRNP70	100	100.000	ENSSSCG00000023792	-	100	100.000	Sus_scrofa
ENSG00000104852	SNRNP70	52	93.878	ENSTGUG00000016869	-	100	92.157	Taeniopygia_guttata
ENSG00000104852	SNRNP70	66	90.000	ENSTNIG00000014186	-	99	90.000	Tetraodon_nigroviridis
ENSG00000104852	SNRNP70	100	100.000	ENSTTRG00000017099	SNRNP70	100	97.506	Tursiops_truncatus
ENSG00000104852	SNRNP70	100	100.000	ENSUAMG00000016147	SNRNP70	100	98.182	Ursus_americanus
ENSG00000104852	SNRNP70	100	100.000	ENSUMAG00000001467	SNRNP70	100	100.000	Ursus_maritimus
ENSG00000104852	SNRNP70	100	96.970	ENSVPAG00000005959	-	100	80.995	Vicugna_pacos
ENSG00000104852	SNRNP70	100	100.000	ENSVVUG00000022976	SNRNP70	100	100.000	Vulpes_vulpes
ENSG00000104852	SNRNP70	99	93.293	ENSXETG00000022919	snrnp70	57	95.595	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000398	mRNA splicing, via spliceosome	9731529.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	9531537.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	2467746.	IMP	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0005515	protein binding	9447963.14561889.18559666.18951082.19928837.21988832.22365833.23602568.23793891.25719862.26124092.26828962.	IPI	Function
GO:0005634	nucleus	18559850.21113136.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	9531537.9731529.	IDA	Component
GO:0005685	U1 snRNP	21873635.	IBA	Component
GO:0005685	U1 snRNP	21113136.23793891.25555158.	IDA	Component
GO:0016607	nuclear speck	-	ISS	Component
GO:0030619	U1 snRNA binding	21113136.25555158.	IDA	Function
GO:0043462	regulation of ATPase activity	25719862.	TAS	Process
GO:0043484	regulation of RNA splicing	2467746.	IMP	Process
GO:0048026	positive regulation of mRNA splicing, via spliceosome	-	IEA	Process
GO:0061084	negative regulation of protein refolding	25719862.	TAS	Process
GO:1904715	negative regulation of chaperone-mediated autophagy	25719862.	TAS	Process