EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000104897 (Gene tree)
Gene ID: 8175
Gene Symbol: SF3A2
Alias: SF3a66|SAP62|PRPF11|Prp11
Full Name: splicing factor 3a subunit 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 12,176 bases
Position: chr19:2,236,504-2,248,679
Accession: 10766
RBP type: canonical RBP
Summary: This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000466634	zf-met	PF12874.7	1.1e-06	1	1
ENSP00000221494	zf-met	PF12874.7	3.2e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000587637	SF3A2-203	501	-	-	- (aa)	-	-
ENST00000589118	SF3A2-204	759	-	-	- (aa)	-	-
ENST00000592839	SF3A2-207	724	-	-	- (aa)	-	-
ENST00000592314	SF3A2-206	885	-	-	- (aa)	-	-
ENST00000586396	SF3A2-202	543	-	ENSP00000466634	135 (aa)	-	K7EMT0
ENST00000590034	SF3A2-205	573	-	-	- (aa)	-	-
ENST00000221494	SF3A2-201	1963	-	ENSP00000221494	464 (aa)	-	Q15428

Gene Model

Click here to download ENSG00000104897's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000104897	rs45521740	19	2245623	?	Body mass index	30595370			EFO_0004340

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000104897's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000104897	SF3A2	100	96.296	ENSAPOG00000003916	sf3a2	73	95.370	Acanthochromis_polyacanthus
ENSG00000104897	SF3A2	100	99.259	ENSAMEG00000005469	SF3A2	52	99.582	Ailuropoda_melanoleuca
ENSG00000104897	SF3A2	100	96.296	ENSACIG00000018153	sf3a2	73	95.370	Amphilophus_citrinellus
ENSG00000104897	SF3A2	100	96.296	ENSAOCG00000015960	sf3a2	73	95.370	Amphiprion_ocellaris
ENSG00000104897	SF3A2	100	96.296	ENSAPEG00000012336	sf3a2	73	95.370	Amphiprion_percula
ENSG00000104897	SF3A2	100	95.556	ENSATEG00000015449	sf3a2	76	93.333	Anabas_testudineus
ENSG00000104897	SF3A2	100	100.000	ENSANAG00000034031	-	89	98.919	Aotus_nancymaae
ENSG00000104897	SF3A2	100	97.037	ENSACLG00000002356	sf3a2	77	93.778	Astatotilapia_calliptera
ENSG00000104897	SF3A2	100	97.037	ENSAMXG00000032428	sf3a2	74	94.144	Astyanax_mexicanus
ENSG00000104897	SF3A2	100	99.259	ENSBTAG00000025452	SF3A2	50	99.582	Bos_taurus
ENSG00000104897	SF3A2	100	79.259	WBGene00008683	repo-1	99	77.376	Caenorhabditis_elegans
ENSG00000104897	SF3A2	100	100.000	ENSCJAG00000013206	-	100	98.707	Callithrix_jacchus
ENSG00000104897	SF3A2	100	99.259	ENSCAFG00000019414	SF3A2	50	99.582	Canis_familiaris
ENSG00000104897	SF3A2	100	99.259	ENSCAFG00020018153	SF3A2	50	99.582	Canis_lupus_dingo
ENSG00000104897	SF3A2	100	99.259	ENSCHIG00000018323	SF3A2	50	99.582	Capra_hircus
ENSG00000104897	SF3A2	100	99.259	ENSCAPG00000003402	-	90	99.451	Cavia_aperea
ENSG00000104897	SF3A2	100	99.259	ENSCPOG00000032868	SF3A2	100	94.181	Cavia_porcellus
ENSG00000104897	SF3A2	100	100.000	ENSCCAG00000009812	SF3A2	100	97.877	Cebus_capucinus
ENSG00000104897	SF3A2	100	100.000	ENSCATG00000038453	SF3A2	100	99.569	Cercocebus_atys
ENSG00000104897	SF3A2	100	99.259	ENSCLAG00000008987	SF3A2	100	95.259	Chinchilla_lanigera
ENSG00000104897	SF3A2	100	100.000	ENSCSAG00000011717	SF3A2	100	98.089	Chlorocebus_sabaeus
ENSG00000104897	SF3A2	100	99.259	ENSCPBG00000018569	SF3A2	72	97.788	Chrysemys_picta_bellii
ENSG00000104897	SF3A2	100	87.407	ENSCING00000003319	zf(matrin)-2	63	84.091	Ciona_intestinalis
ENSG00000104897	SF3A2	100	86.667	ENSCSAVG00000007862	-	59	83.636	Ciona_savignyi
ENSG00000104897	SF3A2	100	100.000	ENSCANG00000024451	SF3A2	100	99.784	Colobus_angolensis_palliatus
ENSG00000104897	SF3A2	100	99.259	ENSCGRG00000011089	Sf3a2	94	99.451	Cricetulus_griseus_crigri
ENSG00000104897	SF3A2	100	97.037	ENSCSEG00000014308	sf3a2	79	93.304	Cynoglossus_semilaevis
ENSG00000104897	SF3A2	100	97.037	ENSCVAG00000021349	sf3a2	73	95.833	Cyprinodon_variegatus
ENSG00000104897	SF3A2	100	96.296	ENSDARG00000021107	sf3a2	81	93.750	Danio_rerio
ENSG00000104897	SF3A2	100	99.259	ENSDORG00000014445	Sf3a2	52	99.163	Dipodomys_ordii
ENSG00000104897	SF3A2	100	86.029	FBgn0036314	Sf3a2	86	82.379	Drosophila_melanogaster
ENSG00000104897	SF3A2	87	100.000	ENSETEG00000016949	-	57	100.000	Echinops_telfairi
ENSG00000104897	SF3A2	100	99.259	ENSEASG00005021972	SF3A2	52	99.582	Equus_asinus_asinus
ENSG00000104897	SF3A2	100	97.778	ENSELUG00000008471	sf3a2	74	94.222	Esox_lucius
ENSG00000104897	SF3A2	100	99.259	ENSFCAG00000030476	SF3A2	55	99.163	Felis_catus
ENSG00000104897	SF3A2	79	98.113	ENSFALG00000013785	-	100	70.235	Ficedula_albicollis
ENSG00000104897	SF3A2	100	99.259	ENSFDAG00000020911	-	93	99.451	Fukomys_damarensis
ENSG00000104897	SF3A2	100	96.296	ENSFHEG00000002392	sf3a2	74	95.370	Fundulus_heteroclitus
ENSG00000104897	SF3A2	100	96.296	ENSGMOG00000012186	sf3a2	72	95.370	Gadus_morhua
ENSG00000104897	SF3A2	100	97.778	ENSGALG00000021679	SF3A2	72	97.345	Gallus_gallus
ENSG00000104897	SF3A2	100	96.296	ENSGAFG00000008478	sf3a2	73	95.370	Gambusia_affinis
ENSG00000104897	SF3A2	100	97.037	ENSGACG00000015255	sf3a2	74	96.296	Gasterosteus_aculeatus
ENSG00000104897	SF3A2	66	98.876	ENSGAGG00000008500	SF3A2	67	97.222	Gopherus_agassizii
ENSG00000104897	SF3A2	100	100.000	ENSGGOG00000006613	SF3A2	100	100.000	Gorilla_gorilla
ENSG00000104897	SF3A2	100	97.037	ENSHBUG00000021796	sf3a2	77	93.778	Haplochromis_burtoni
ENSG00000104897	SF3A2	100	99.259	ENSHGLG00000015102	SF3A2	100	93.319	Heterocephalus_glaber_female
ENSG00000104897	SF3A2	100	99.259	ENSHGLG00100000418	SF3A2	88	99.454	Heterocephalus_glaber_male
ENSG00000104897	SF3A2	100	97.037	ENSHCOG00000001223	sf3a2	77	93.750	Hippocampus_comes
ENSG00000104897	SF3A2	100	96.296	ENSIPUG00000019071	sf3a2	72	95.370	Ictalurus_punctatus
ENSG00000104897	SF3A2	100	99.259	ENSSTOG00000007495	SF3A2	100	96.815	Ictidomys_tridecemlineatus
ENSG00000104897	SF3A2	100	99.259	ENSJJAG00000010635	Sf3a2	100	97.198	Jaculus_jaculus
ENSG00000104897	SF3A2	100	96.296	ENSKMAG00000006295	sf3a2	73	95.370	Kryptolebias_marmoratus
ENSG00000104897	SF3A2	100	97.037	ENSLBEG00000000677	sf3a2	76	93.778	Labrus_bergylta
ENSG00000104897	SF3A2	100	97.778	ENSLACG00000008744	SF3A2	72	95.575	Latimeria_chalumnae
ENSG00000104897	SF3A2	100	97.778	ENSLOCG00000005835	sf3a2	70	96.296	Lepisosteus_oculatus
ENSG00000104897	SF3A2	100	100.000	ENSMFAG00000002638	SF3A2	100	99.569	Macaca_fascicularis
ENSG00000104897	SF3A2	100	100.000	ENSMMUG00000010111	SF3A2	100	99.569	Macaca_mulatta
ENSG00000104897	SF3A2	100	100.000	ENSMNEG00000036916	SF3A2	100	98.301	Macaca_nemestrina
ENSG00000104897	SF3A2	100	96.296	ENSMAMG00000009881	sf3a2	76	93.304	Mastacembelus_armatus
ENSG00000104897	SF3A2	100	97.037	ENSMZEG00005025609	sf3a2	77	93.778	Maylandia_zebra
ENSG00000104897	SF3A2	100	97.778	ENSMGAG00000001950	SF3A2	72	97.345	Meleagris_gallopavo
ENSG00000104897	SF3A2	100	99.259	ENSMAUG00000005644	-	94	99.451	Mesocricetus_auratus
ENSG00000104897	SF3A2	100	100.000	ENSMICG00000015443	SF3A2	100	96.552	Microcebus_murinus
ENSG00000104897	SF3A2	100	99.259	ENSMOCG00000007216	Sf3a2	86	78.829	Microtus_ochrogaster
ENSG00000104897	SF3A2	95	93.023	ENSMMOG00000010657	sf3a2	85	81.250	Mola_mola
ENSG00000104897	SF3A2	100	99.259	ENSMODG00000004681	SF3A2	82	98.745	Monodelphis_domestica
ENSG00000104897	SF3A2	100	95.556	ENSMALG00000020442	sf3a2	77	91.667	Monopterus_albus
ENSG00000104897	SF3A2	100	99.259	MGP_CAROLIEiJ_G0015602	-	94	99.451	Mus_caroli
ENSG00000104897	SF3A2	100	99.259	ENSMUSG00000020211	Sf3a2	94	99.451	Mus_musculus
ENSG00000104897	SF3A2	100	99.259	MGP_PahariEiJ_G0031015	-	94	99.451	Mus_pahari
ENSG00000104897	SF3A2	100	99.259	MGP_SPRETEiJ_G0016420	-	94	99.451	Mus_spretus
ENSG00000104897	SF3A2	100	99.259	ENSMPUG00000006956	SF3A2	52	98.745	Mustela_putorius_furo
ENSG00000104897	SF3A2	100	99.259	ENSMLUG00000004426	-	54	99.163	Myotis_lucifugus
ENSG00000104897	SF3A2	100	99.259	ENSNGAG00000023309	-	94	98.901	Nannospalax_galili
ENSG00000104897	SF3A2	100	97.037	ENSNBRG00000019872	sf3a2	77	93.778	Neolamprologus_brichardi
ENSG00000104897	SF3A2	100	99.259	ENSODEG00000013722	-	100	97.326	Octodon_degus
ENSG00000104897	SF3A2	100	96.296	ENSONIG00000010198	sf3a2	77	93.333	Oreochromis_niloticus
ENSG00000104897	SF3A2	100	98.519	ENSOANG00000013649	-	98	98.537	Ornithorhynchus_anatinus
ENSG00000104897	SF3A2	100	94.815	ENSORLG00000015301	sf3a2	74	94.444	Oryzias_latipes
ENSG00000104897	SF3A2	100	94.815	ENSORLG00020017235	sf3a2	74	94.444	Oryzias_latipes_hni
ENSG00000104897	SF3A2	100	94.815	ENSORLG00015017116	sf3a2	74	94.444	Oryzias_latipes_hsok
ENSG00000104897	SF3A2	100	95.556	ENSOMEG00000020860	sf3a2	74	94.907	Oryzias_melastigma
ENSG00000104897	SF3A2	100	100.000	ENSOGAG00000033389	SF3A2	100	96.336	Otolemur_garnettii
ENSG00000104897	SF3A2	100	99.259	ENSOARG00000014357	SF3A2	100	85.560	Ovis_aries
ENSG00000104897	SF3A2	100	77.778	ENSPPAG00000037864	-	50	85.356	Pan_paniscus
ENSG00000104897	SF3A2	100	99.259	ENSPPRG00000007798	SF3A2	51	99.163	Panthera_pardus
ENSG00000104897	SF3A2	100	100.000	ENSPTRG00000010227	SF3A2	100	100.000	Pan_troglodytes
ENSG00000104897	SF3A2	100	100.000	ENSPANG00000007949	SF3A2	100	99.784	Papio_anubis
ENSG00000104897	SF3A2	100	97.037	ENSPKIG00000009487	sf3a2	71	94.222	Paramormyrops_kingsleyae
ENSG00000104897	SF3A2	100	99.259	ENSPSIG00000010839	SF3A2	72	96.491	Pelodiscus_sinensis
ENSG00000104897	SF3A2	100	95.556	ENSPMGG00000017249	sf3a2	91	84.746	Periophthalmus_magnuspinnatus
ENSG00000104897	SF3A2	100	99.259	ENSPEMG00000021288	Sf3a2	52	99.582	Peromyscus_maniculatus_bairdii
ENSG00000104897	SF3A2	100	96.296	ENSPFOG00000015945	sf3a2	73	95.370	Poecilia_formosa
ENSG00000104897	SF3A2	100	96.296	ENSPLAG00000010052	sf3a2	73	95.370	Poecilia_latipinna
ENSG00000104897	SF3A2	100	96.296	ENSPMEG00000000184	sf3a2	73	95.370	Poecilia_mexicana
ENSG00000104897	SF3A2	100	96.296	ENSPREG00000017808	sf3a2	73	95.370	Poecilia_reticulata
ENSG00000104897	SF3A2	100	100.000	ENSPPYG00000009342	SF3A2	100	98.276	Pongo_abelii
ENSG00000104897	SF3A2	100	100.000	ENSPCOG00000020295	SF3A2	53	100.000	Propithecus_coquereli
ENSG00000104897	SF3A2	100	97.037	ENSPNYG00000006928	sf3a2	77	93.778	Pundamilia_nyererei
ENSG00000104897	SF3A2	100	97.037	ENSPNAG00000027582	sf3a2	72	95.833	Pygocentrus_nattereri
ENSG00000104897	SF3A2	100	99.259	ENSRNOG00000019349	Sf3a2	51	99.163	Rattus_norvegicus
ENSG00000104897	SF3A2	100	100.000	ENSRBIG00000026709	SF3A2	62	100.000	Rhinopithecus_bieti
ENSG00000104897	SF3A2	100	100.000	ENSRROG00000034440	SF3A2	100	97.877	Rhinopithecus_roxellana
ENSG00000104897	SF3A2	100	100.000	ENSSBOG00000026071	SF3A2	100	90.733	Saimiri_boliviensis_boliviensis
ENSG00000104897	SF3A2	100	99.259	ENSSHAG00000011677	-	100	98.381	Sarcophilus_harrisii
ENSG00000104897	SF3A2	82	91.892	ENSSHAG00000011646	-	77	88.372	Sarcophilus_harrisii
ENSG00000104897	SF3A2	100	97.037	ENSSFOG00015010920	sf3a2	64	92.920	Scleropages_formosus
ENSG00000104897	SF3A2	100	96.296	ENSSMAG00000002629	sf3a2	75	95.833	Scophthalmus_maximus
ENSG00000104897	SF3A2	100	96.296	ENSSDUG00000015810	sf3a2	77	93.333	Seriola_dumerili
ENSG00000104897	SF3A2	100	96.296	ENSSLDG00000010874	sf3a2	78	92.544	Seriola_lalandi_dorsalis
ENSG00000104897	SF3A2	100	96.296	ENSSPAG00000004960	sf3a2	77	92.105	Stegastes_partitus
ENSG00000104897	SF3A2	100	99.259	ENSSSCG00000039757	SF3A2	52	98.745	Sus_scrofa
ENSG00000104897	SF3A2	100	97.778	ENSTGUG00000000305	SF3A2	100	98.049	Taeniopygia_guttata
ENSG00000104897	SF3A2	100	96.296	ENSTRUG00000009045	sf3a2	75	95.370	Takifugu_rubripes
ENSG00000104897	SF3A2	100	95.556	ENSTNIG00000015318	sf3a2	75	94.907	Tetraodon_nigroviridis
ENSG00000104897	SF3A2	100	71.852	ENSTTRG00000010177	-	52	84.100	Tursiops_truncatus
ENSG00000104897	SF3A2	100	99.259	ENSVVUG00000002578	SF3A2	50	99.582	Vulpes_vulpes
ENSG00000104897	SF3A2	100	97.037	ENSXETG00000024943	sf3a2	54	96.429	Xenopus_tropicalis
ENSG00000104897	SF3A2	100	96.296	ENSXCOG00000008222	sf3a2	74	95.370	Xiphophorus_couchianus
ENSG00000104897	SF3A2	100	96.296	ENSXMAG00000029068	sf3a2	74	95.370	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000245	spliceosomal complex assembly	21873635.	IBA	Process
GO:0000389	mRNA 3'-splice site recognition	15647371.	TAS	Process
GO:0000398	mRNA splicing, via spliceosome	9731529.11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	29360106.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	17332742.20467437.22365833.24304693.26420826.30021884.	IPI	Function
GO:0005634	nucleus	29360106.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	9731529.	IDA	Component
GO:0005686	U2 snRNP	21873635.	IBA	Component
GO:0005686	U2 snRNP	11533230.	IDA	Component
GO:0006397	mRNA processing	15647371.	IMP	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0010976	positive regulation of neuron projection development	-	IEA	Process
GO:0016607	nuclear speck	-	IEA	Component
GO:0071004	U2-type prespliceosome	21873635.	IBA	Component
GO:0071005	U2-type precatalytic spliceosome	29360106.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	21873635.	IBA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component
GO:1903241	U2-type prespliceosome assembly	11533230.	IDA	Process