EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000104907 (Gene tree)
Gene ID: 55621
Gene Symbol: TRMT1
Alias: FLJ20244|TRM1
Full Name: tRNA methyltransferase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 12,668 bases
Position: chr19:13,104,900-13,117,567
Accession: 25980
RBP type: canonical RBP
Summary: This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000221504	zf-CCCH	PF00642.24	2.6e-06	1	1
ENSP00000350352	zf-CCCH	PF00642.24	2.7e-06	1	1
ENSP00000416149	zf-CCCH	PF00642.24	2.7e-06	1	1
ENSP00000466967	zf-CCCH	PF00642.24	2.7e-06	1	1
ENSP00000350352	TRM	PF02005.16	2.6e-151	1	1
ENSP00000416149	TRM	PF02005.16	2.6e-151	1	1
ENSP00000466967	TRM	PF02005.16	2.6e-151	1	1
ENSP00000221504	TRM	PF02005.16	7.2e-142	1	1
ENSP00000465370	TRM	PF02005.16	4.8e-74	1	1
ENSP00000467938	TRM	PF02005.16	1.8e-68	1	2
ENSP00000467938	TRM	PF02005.16	1.8e-68	2	2
ENSP00000467984	TRM	PF02005.16	1.5e-08	1	1
ENSP00000221504	Met_10	PF02475.16	1.6e-05	1	1
ENSP00000350352	Met_10	PF02475.16	1.7e-05	1	1
ENSP00000416149	Met_10	PF02475.16	1.7e-05	1	1
ENSP00000466967	Met_10	PF02475.16	1.7e-05	1	1
ENSP00000467938	Met_10	PF02475.16	5.7e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28784718	TRMT1-Catalyzed tRNA Modifications Are Required for Redox Homeostasis To Ensure Proper Cellular Proliferation and Oxidative Stress Survival.	Mol Cell Biol	2017 Oct 13	Dewe JM	doi: 10.1128/MCB.00214-17

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000587633	TRMT1-209	648	-	ENSP00000466716	101 (aa)	-	K7EMZ2
ENST00000592814	TRMT1-220	985	-	ENSP00000467938	297 (aa)	-	K7EQQ8
ENST00000587487	TRMT1-208	813	-	ENSP00000465370	191 (aa)	-	K7EJX9
ENST00000588746	TRMT1-212	562	-	ENSP00000468031	85 (aa)	-	K7EQY6
ENST00000593157	TRMT1-222	2127	-	-	- (aa)	-	-
ENST00000590812	TRMT1-214	612	-	-	- (aa)	-	-
ENST00000437766	TRMT1-203	2263	-	ENSP00000416149	659 (aa)	-	Q9NXH9
ENST00000588511	TRMT1-211	2251	-	-	- (aa)	-	-
ENST00000585622	TRMT1-205	799	-	-	- (aa)	-	-
ENST00000591425	TRMT1-215	454	-	-	- (aa)	-	-
ENST00000586830	TRMT1-207	354	-	-	- (aa)	-	-
ENST00000592729	TRMT1-219	543	-	-	- (aa)	-	-
ENST00000585435	TRMT1-204	437	-	-	- (aa)	-	-
ENST00000588229	TRMT1-210	552	-	ENSP00000467984	145 (aa)	-	K7EQU7
ENST00000586224	TRMT1-206	543	-	ENSP00000468377	113 (aa)	-	K7ERR5
ENST00000592062	TRMT1-217	2579	XM_024451588	ENSP00000466967	659 (aa)	XP_024307356	Q9NXH9
ENST00000588813	TRMT1-213	522	-	-	- (aa)	-	-
ENST00000593257	TRMT1-223	408	-	-	- (aa)	-	-
ENST00000592606	TRMT1-218	592	-	-	- (aa)	-	-
ENST00000592892	TRMT1-221	554	-	-	- (aa)	-	-
ENST00000357720	TRMT1-202	2142	XM_024451587	ENSP00000350352	659 (aa)	XP_024307355	Q9NXH9
ENST00000591717	TRMT1-216	582	-	ENSP00000466966	105 (aa)	-	K7ENI9
ENST00000221504	TRMT1-201	2179	XM_024451590	ENSP00000221504	630 (aa)	XP_024307358	Q9NXH9

Gene Model

Click here to download ENSG00000104907's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000104907	rs12977417	19	13114672	A	Lymphocyte percentage of white cells	27863252	[0.019-0.038] unit decrease	0.02828188	EFO_0007993
ENSG00000104907	rs12977417	19	13114672	A	Neutrophil percentage of white cells	27863252	[0.019-0.038] unit increase	0.02883879	EFO_0007990
ENSG00000104907	rs35601737	19	13109889	?	Red cell distribution width	30595370			EFO_0005192

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000104907's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000104907	TRMT1	100	93.717	ENSAMEG00000012598	TRMT1	96	88.300	Ailuropoda_melanoleuca
ENSG00000104907	TRMT1	92	57.166	ENSACIG00000018680	trmt1	96	57.235	Amphilophus_citrinellus
ENSG00000104907	TRMT1	100	73.958	ENSAOCG00000006781	trmt1	86	66.551	Amphiprion_ocellaris
ENSG00000104907	TRMT1	100	73.958	ENSAPEG00000007712	trmt1	86	66.494	Amphiprion_percula
ENSG00000104907	TRMT1	100	75.000	ENSATEG00000001872	trmt1	84	68.641	Anabas_testudineus
ENSG00000104907	TRMT1	100	75.916	ENSACAG00000003825	TRMT1	95	67.285	Anolis_carolinensis
ENSG00000104907	TRMT1	100	93.194	ENSANAG00000023016	TRMT1	98	92.810	Aotus_nancymaae
ENSG00000104907	TRMT1	100	74.479	ENSACLG00000010073	trmt1	92	64.974	Astatotilapia_calliptera
ENSG00000104907	TRMT1	100	73.958	ENSAMXG00000012026	trmt1	85	67.820	Astyanax_mexicanus
ENSG00000104907	TRMT1	100	94.241	ENSBTAG00000019325	TRMT1	91	88.474	Bos_taurus
ENSG00000104907	TRMT1	99	46.465	WBGene00006613	trm-1	96	40.296	Caenorhabditis_elegans
ENSG00000104907	TRMT1	100	94.241	ENSCJAG00000004566	TRMT1	99	90.839	Callithrix_jacchus
ENSG00000104907	TRMT1	100	94.764	ENSCAFG00000017070	TRMT1	98	90.545	Canis_familiaris
ENSG00000104907	TRMT1	100	91.623	ENSCAFG00020005397	TRMT1	97	90.196	Canis_lupus_dingo
ENSG00000104907	TRMT1	100	93.750	ENSCHIG00000013569	TRMT1	97	88.180	Capra_hircus
ENSG00000104907	TRMT1	100	95.812	ENSTSYG00000003207	TRMT1	98	84.496	Carlito_syrichta
ENSG00000104907	TRMT1	100	89.529	ENSCAPG00000003355	TRMT1	97	81.214	Cavia_aperea
ENSG00000104907	TRMT1	100	89.529	ENSCPOG00000011754	TRMT1	97	83.307	Cavia_porcellus
ENSG00000104907	TRMT1	100	92.147	ENSCCAG00000022263	TRMT1	98	91.311	Cebus_capucinus
ENSG00000104907	TRMT1	100	96.859	ENSCATG00000039850	TRMT1	97	96.256	Cercocebus_atys
ENSG00000104907	TRMT1	100	73.298	ENSCATG00000038220	-	97	77.393	Cercocebus_atys
ENSG00000104907	TRMT1	100	92.147	ENSCLAG00000015295	TRMT1	95	87.051	Chinchilla_lanigera
ENSG00000104907	TRMT1	100	96.859	ENSCSAG00000006500	TRMT1	99	95.985	Chlorocebus_sabaeus
ENSG00000104907	TRMT1	99	78.947	ENSCPBG00000023866	TRMT1	87	70.289	Chrysemys_picta_bellii
ENSG00000104907	TRMT1	99	51.852	ENSCING00000002884	-	96	46.196	Ciona_intestinalis
ENSG00000104907	TRMT1	99	52.910	ENSCSAVG00000010927	-	100	45.911	Ciona_savignyi
ENSG00000104907	TRMT1	95	74.163	ENSCANG00000031650	-	96	74.163	Colobus_angolensis_palliatus
ENSG00000104907	TRMT1	91	89.610	ENSCANG00000040631	TRMT1	97	79.531	Colobus_angolensis_palliatus
ENSG00000104907	TRMT1	100	91.623	ENSCGRG00001022594	Trmt1	96	85.086	Cricetulus_griseus_chok1gshd
ENSG00000104907	TRMT1	100	91.623	ENSCGRG00000017732	Trmt1	96	85.086	Cricetulus_griseus_crigri
ENSG00000104907	TRMT1	99	73.298	ENSCSEG00000001643	trmt1	84	68.932	Cynoglossus_semilaevis
ENSG00000104907	TRMT1	100	75.521	ENSCVAG00000011886	trmt1	89	66.169	Cyprinodon_variegatus
ENSG00000104907	TRMT1	100	72.917	ENSDARG00000010978	trmt1	85	66.609	Danio_rerio
ENSG00000104907	TRMT1	84	62.500	ENSDNOG00000048240	-	92	63.168	Dasypus_novemcinctus
ENSG00000104907	TRMT1	100	92.670	ENSDORG00000014298	Trmt1	98	84.961	Dipodomys_ordii
ENSG00000104907	TRMT1	99	54.922	FBgn0032430	CG6388	89	47.547	Drosophila_melanogaster
ENSG00000104907	TRMT1	94	70.370	ENSETEG00000015483	-	52	82.168	Echinops_telfairi
ENSG00000104907	TRMT1	77	75.510	ENSEBUG00000003449	trmt1	82	50.712	Eptatretus_burgeri
ENSG00000104907	TRMT1	100	92.670	ENSEASG00005004050	TRMT1	97	88.567	Equus_asinus_asinus
ENSG00000104907	TRMT1	100	92.670	ENSECAG00000016149	TRMT1	97	88.889	Equus_caballus
ENSG00000104907	TRMT1	100	87.435	ENSEEUG00000014102	-	100	72.544	Erinaceus_europaeus
ENSG00000104907	TRMT1	100	71.728	ENSELUG00000021659	trmt1	85	65.278	Esox_lucius
ENSG00000104907	TRMT1	100	94.241	ENSFCAG00000000483	TRMT1	98	88.802	Felis_catus
ENSG00000104907	TRMT1	100	93.194	ENSFDAG00000007386	TRMT1	96	86.207	Fukomys_damarensis
ENSG00000104907	TRMT1	100	75.393	ENSFHEG00000012865	trmt1	88	69.565	Fundulus_heteroclitus
ENSG00000104907	TRMT1	100	60.938	ENSGMOG00000006564	trmt1	98	62.195	Gadus_morhua
ENSG00000104907	TRMT1	100	75.521	ENSGAFG00000011862	trmt1	88	68.692	Gambusia_affinis
ENSG00000104907	TRMT1	100	71.354	ENSGACG00000000227	trmt1	94	64.055	Gasterosteus_aculeatus
ENSG00000104907	TRMT1	99	78.421	ENSGAGG00000016432	TRMT1	86	69.847	Gopherus_agassizii
ENSG00000104907	TRMT1	100	99.476	ENSGGOG00000014007	TRMT1	100	99.393	Gorilla_gorilla
ENSG00000104907	TRMT1	100	63.542	ENSHBUG00000008821	trmt1	95	57.931	Haplochromis_burtoni
ENSG00000104907	TRMT1	100	93.717	ENSHGLG00000015972	TRMT1	97	86.271	Heterocephalus_glaber_female
ENSG00000104907	TRMT1	100	93.229	ENSHGLG00100018112	TRMT1	97	80.392	Heterocephalus_glaber_male
ENSG00000104907	TRMT1	99	67.016	ENSHCOG00000009447	trmt1	88	63.763	Hippocampus_comes
ENSG00000104907	TRMT1	100	73.822	ENSIPUG00000002899	trmt1	85	66.267	Ictalurus_punctatus
ENSG00000104907	TRMT1	100	93.194	ENSSTOG00000012531	TRMT1	96	89.819	Ictidomys_tridecemlineatus
ENSG00000104907	TRMT1	100	91.099	ENSJJAG00000017154	Trmt1	97	84.268	Jaculus_jaculus
ENSG00000104907	TRMT1	100	76.440	ENSKMAG00000011809	trmt1	95	67.776	Kryptolebias_marmoratus
ENSG00000104907	TRMT1	100	74.869	ENSLBEG00000012703	trmt1	84	67.426	Labrus_bergylta
ENSG00000104907	TRMT1	100	60.733	ENSLACG00000014585	TRMT1	94	57.315	Latimeria_chalumnae
ENSG00000104907	TRMT1	99	73.545	ENSLOCG00000006479	trmt1	97	63.793	Lepisosteus_oculatus
ENSG00000104907	TRMT1	100	95.288	ENSLAFG00000014072	TRMT1	99	89.392	Loxodonta_africana
ENSG00000104907	TRMT1	100	96.859	ENSMFAG00000033143	TRMT1	97	96.412	Macaca_fascicularis
ENSG00000104907	TRMT1	99	92.160	ENSMMUG00000001167	TRMT1	98	92.484	Macaca_mulatta
ENSG00000104907	TRMT1	100	97.382	ENSMNEG00000037867	TRMT1	97	96.568	Macaca_nemestrina
ENSG00000104907	TRMT1	100	96.859	ENSMLEG00000016142	TRMT1	98	95.948	Mandrillus_leucophaeus
ENSG00000104907	TRMT1	100	73.438	ENSMAMG00000004357	trmt1	85	68.237	Mastacembelus_armatus
ENSG00000104907	TRMT1	100	74.479	ENSMZEG00005014510	trmt1	85	65.499	Maylandia_zebra
ENSG00000104907	TRMT1	100	92.147	ENSMAUG00000011134	Trmt1	96	83.881	Mesocricetus_auratus
ENSG00000104907	TRMT1	100	97.382	ENSMICG00000000793	TRMT1	97	91.888	Microcebus_murinus
ENSG00000104907	TRMT1	100	92.147	ENSMOCG00000015895	Trmt1	96	84.555	Microtus_ochrogaster
ENSG00000104907	TRMT1	99	73.822	ENSMMOG00000011097	trmt1	92	66.084	Mola_mola
ENSG00000104907	TRMT1	100	85.864	ENSMODG00000011619	TRMT1	98	76.568	Monodelphis_domestica
ENSG00000104907	TRMT1	100	93.194	MGP_CAROLIEiJ_G0031304	Trmt1	96	85.079	Mus_caroli
ENSG00000104907	TRMT1	100	92.670	ENSMUSG00000001909	Trmt1	96	84.603	Mus_musculus
ENSG00000104907	TRMT1	100	92.670	MGP_SPRETEiJ_G0032422	Trmt1	96	84.603	Mus_spretus
ENSG00000104907	TRMT1	100	94.241	ENSMPUG00000004210	TRMT1	92	88.785	Mustela_putorius_furo
ENSG00000104907	TRMT1	100	95.288	ENSMLUG00000012809	TRMT1	96	88.300	Myotis_lucifugus
ENSG00000104907	TRMT1	100	94.764	ENSNGAG00000022486	Trmt1	96	85.331	Nannospalax_galili
ENSG00000104907	TRMT1	70	75.510	ENSNBRG00000024376	trmt1	85	69.552	Neolamprologus_brichardi
ENSG00000104907	TRMT1	100	92.941	ENSNLEG00000013019	-	98	96.685	Nomascus_leucogenys
ENSG00000104907	TRMT1	100	86.387	ENSMEUG00000013756	TRMT1	100	77.258	Notamacropus_eugenii
ENSG00000104907	TRMT1	100	93.194	ENSOPRG00000009471	-	80	89.858	Ochotona_princeps
ENSG00000104907	TRMT1	100	91.623	ENSODEG00000010323	TRMT1	97	86.656	Octodon_degus
ENSG00000104907	TRMT1	100	73.958	ENSONIG00000000400	trmt1	99	64.800	Oreochromis_niloticus
ENSG00000104907	TRMT1	67	61.404	ENSOANG00000029270	-	60	65.789	Ornithorhynchus_anatinus
ENSG00000104907	TRMT1	100	92.708	ENSOCUG00000021934	TRMT1	99	88.636	Oryctolagus_cuniculus
ENSG00000104907	TRMT1	100	72.251	ENSORLG00000020074	trmt1	90	62.803	Oryzias_latipes
ENSG00000104907	TRMT1	100	72.775	ENSORLG00020007561	trmt1	89	65.849	Oryzias_latipes_hni
ENSG00000104907	TRMT1	100	72.251	ENSORLG00015006547	trmt1	86	66.025	Oryzias_latipes_hsok
ENSG00000104907	TRMT1	99	73.158	ENSOMEG00000019343	trmt1	86	66.200	Oryzias_melastigma
ENSG00000104907	TRMT1	100	93.194	ENSOGAG00000025576	TRMT1	99	87.184	Otolemur_garnettii
ENSG00000104907	TRMT1	99	74.921	ENSOARG00000009397	TRMT1	91	74.127	Ovis_aries
ENSG00000104907	TRMT1	100	100.000	ENSPPAG00000031484	-	100	100.000	Pan_paniscus
ENSG00000104907	TRMT1	98	80.308	ENSPPRG00000012117	TRMT1	98	80.564	Panthera_pardus
ENSG00000104907	TRMT1	97	76.596	ENSPTIG00000008833	TRMT1	95	89.394	Panthera_tigris_altaica
ENSG00000104907	TRMT1	100	100.000	ENSPTRG00000010557	TRMT1	100	100.000	Pan_troglodytes
ENSG00000104907	TRMT1	100	81.152	ENSPTRG00000050421	-	97	72.057	Pan_troglodytes
ENSG00000104907	TRMT1	100	96.859	ENSPANG00000009247	TRMT1	97	96.895	Papio_anubis
ENSG00000104907	TRMT1	100	74.346	ENSPANG00000034058	-	95	77.686	Papio_anubis
ENSG00000104907	TRMT1	100	71.875	ENSPKIG00000005309	trmt1	84	68.522	Paramormyrops_kingsleyae
ENSG00000104907	TRMT1	100	75.916	ENSPSIG00000008762	TRMT1	86	57.450	Pelodiscus_sinensis
ENSG00000104907	TRMT1	99	72.775	ENSPMGG00000019764	trmt1	97	63.533	Periophthalmus_magnuspinnatus
ENSG00000104907	TRMT1	100	93.194	ENSPEMG00000016247	Trmt1	96	86.557	Peromyscus_maniculatus_bairdii
ENSG00000104907	TRMT1	100	71.728	ENSPMAG00000004329	trmt1	90	60.381	Petromyzon_marinus
ENSG00000104907	TRMT1	100	85.864	ENSPCIG00000019273	TRMT1	99	74.727	Phascolarctos_cinereus
ENSG00000104907	TRMT1	100	77.604	ENSPFOG00000008527	trmt1	88	69.808	Poecilia_formosa
ENSG00000104907	TRMT1	100	77.604	ENSPLAG00000018788	trmt1	87	72.201	Poecilia_latipinna
ENSG00000104907	TRMT1	100	77.604	ENSPMEG00000013120	trmt1	88	69.634	Poecilia_mexicana
ENSG00000104907	TRMT1	95	79.121	ENSPREG00000000211	trmt1	85	68.586	Poecilia_reticulata
ENSG00000104907	TRMT1	100	98.953	ENSPPYG00000009622	TRMT1	100	98.483	Pongo_abelii
ENSG00000104907	TRMT1	100	93.717	ENSPCAG00000003698	TRMT1	98	80.685	Procavia_capensis
ENSG00000104907	TRMT1	100	96.335	ENSPCOG00000008653	TRMT1	98	92.224	Propithecus_coquereli
ENSG00000104907	TRMT1	100	95.288	ENSPVAG00000015076	TRMT1	98	88.941	Pteropus_vampyrus
ENSG00000104907	TRMT1	100	61.979	ENSPNYG00000013960	trmt1	92	64.098	Pundamilia_nyererei
ENSG00000104907	TRMT1	99	74.211	ENSPNAG00000024859	trmt1	88	68.815	Pygocentrus_nattereri
ENSG00000104907	TRMT1	100	93.194	ENSRNOG00000002914	Trmt1	96	85.854	Rattus_norvegicus
ENSG00000104907	TRMT1	100	95.812	ENSRBIG00000038324	TRMT1	97	96.412	Rhinopithecus_bieti
ENSG00000104907	TRMT1	95	74.363	ENSRBIG00000037505	-	97	74.363	Rhinopithecus_bieti
ENSG00000104907	TRMT1	100	95.812	ENSRROG00000028599	TRMT1	97	96.256	Rhinopithecus_roxellana
ENSG00000104907	TRMT1	95	73.567	ENSRROG00000031847	-	96	73.567	Rhinopithecus_roxellana
ENSG00000104907	TRMT1	99	46.193	YDR120C	-	94	37.024	Saccharomyces_cerevisiae
ENSG00000104907	TRMT1	100	91.099	ENSSBOG00000028861	TRMT1	98	91.148	Saimiri_boliviensis_boliviensis
ENSG00000104907	TRMT1	100	84.293	ENSSHAG00000014381	TRMT1	97	77.038	Sarcophilus_harrisii
ENSG00000104907	TRMT1	99	72.251	ENSSFOG00015004139	trmt1	84	68.293	Scleropages_formosus
ENSG00000104907	TRMT1	100	75.000	ENSSMAG00000021136	trmt1	85	67.478	Scophthalmus_maximus
ENSG00000104907	TRMT1	100	75.000	ENSSDUG00000012740	trmt1	84	67.888	Seriola_dumerili
ENSG00000104907	TRMT1	100	75.000	ENSSLDG00000005971	trmt1	84	67.714	Seriola_lalandi_dorsalis
ENSG00000104907	TRMT1	100	85.340	ENSSARG00000005138	TRMT1	99	84.220	Sorex_araneus
ENSG00000104907	TRMT1	100	44.503	ENSSPUG00000001084	TRMT1	91	55.137	Sphenodon_punctatus
ENSG00000104907	TRMT1	100	75.521	ENSSPAG00000007153	trmt1	94	64.931	Stegastes_partitus
ENSG00000104907	TRMT1	100	95.288	ENSSSCG00000013744	TRMT1	98	90.400	Sus_scrofa
ENSG00000104907	TRMT1	100	67.179	ENSTRUG00000010700	trmt1	89	61.873	Takifugu_rubripes
ENSG00000104907	TRMT1	99	74.479	ENSTNIG00000018808	trmt1	98	66.725	Tetraodon_nigroviridis
ENSG00000104907	TRMT1	100	94.241	ENSTTRG00000006379	TRMT1	98	86.314	Tursiops_truncatus
ENSG00000104907	TRMT1	100	93.194	ENSUAMG00000022911	TRMT1	98	88.342	Ursus_americanus
ENSG00000104907	TRMT1	100	93.717	ENSUMAG00000006027	TRMT1	98	88.301	Ursus_maritimus
ENSG00000104907	TRMT1	100	95.288	ENSVVUG00000024177	TRMT1	97	89.860	Vulpes_vulpes
ENSG00000104907	TRMT1	99	74.737	ENSXETG00000033863	TRMT1	92	71.800	Xenopus_tropicalis
ENSG00000104907	TRMT1	100	76.042	ENSXCOG00000015733	trmt1	88	68.935	Xiphophorus_couchianus
ENSG00000104907	TRMT1	100	76.042	ENSXMAG00000013823	trmt1	98	68.403	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	-	IEA	Function
GO:0002940	tRNA N2-guanine methylation	21873635.	IBA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004809	tRNA (guanine-N2-)-methyltransferase activity	10982862.	EXP	Function
GO:0004809	tRNA (guanine-N2-)-methyltransferase activity	21873635.	IBA	Function
GO:0005515	protein binding	16189514.21044950.21516116.25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006400	tRNA modification	-	TAS	Process
GO:0046872	metal ion binding	-	IEA	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr19	13105521	Missense_Mutation	novel	A557T	0.37
BLCA	chr19	13110226	Silent	rs772734008	S317S	0.64
BLCA	chr19	13105559	Missense_Mutation	novel	R544Q	0.17
BLCA	chr19	13107597	Silent	NA	F520F	0.45
BLCA	chr19	13109663	Nonsense_Mutation	NA	E400*	0.29
BLCA	chr19	13112726	Missense_Mutation	NA	K283N	0.18
BLCA	chr19	13115754	Missense_Mutation	NA	E109Q	0.25
BLCA	chr19	13116419	5'UTR	novel		0.41
BLCA	chr19	13112710	Missense_Mutation	novel	E289K	0.26
BLCA	chr19	13116389	Missense_Mutation	novel	S4W	0.55
BLCA	chr19	13116189	Missense_Mutation	novel	E71K	0.49
BLCA	chr19	13116225	Missense_Mutation	novel	E59K	0.24
BRCA	chr19	13112743	Missense_Mutation	NA	G278R	0.16
BRCA	chr19	13107794	Missense_Mutation	rs772461605	T488M	0.42
BRCA	chr19	13105445	Intron	novel		0.21
BRCA	chr19	13107616	Missense_Mutation	NA	S514L	0.24
BRCA	chr19	13112724	Missense_Mutation	NA	S284I	0.32
BRCA	chr19	13112815	Missense_Mutation	novel	L254M	0.29
BRCA	chr19	13105553	Missense_Mutation	NA	R546Q	0.24
BRCA	chr19	13105521	Missense_Mutation	NA	A557S	0.5
CESC	chr19	13115316	Missense_Mutation	novel	V202M	0.53	zf-CCCH
CESC	chr19	13116292	Silent	NA	A36A	0.32
CESC	chr19	13116286	Silent	NA	E38E	0.25
CESC	chr19	13104946	Missense_Mutation	novel	G657C	0.75
CESC	chr19	13115706	Missense_Mutation	novel	E125Q	0.41
COAD	chr19	13115662	Missense_Mutation	novel	D139E	0.13
COAD	chr19	13110210	Missense_Mutation	rs542184779	R323C	0.22
COAD	chr19	13110233	Missense_Mutation	novel	S315N	0.32
COAD	chr19	13112801	Silent	novel	T258T	0.29
COAD	chr19	13107758	Missense_Mutation	rs755967021	R500H	0.32
COAD	chr19	13105381	Silent	novel	D573D	0.4
COAD	chr19	13104902	3'UTR	rs774637943		0.4
COAD	chr19	13115415	Nonsense_Mutation	NA	R169*	0.18	zf-CCCH
COAD	chr19	13109971	Silent	novel	G350G	0.17
COAD	chr19	13116176	Missense_Mutation	NA	N75T	0.23
COAD	chr19	13109992	Silent	NA	A343A	0.21
GBM	chr19	13107628	Missense_Mutation	rs781032710	R510Q	0.21
GBM	chr19	13112953	Missense_Mutation	novel	P234T	0.12	zf-CCCH
GBM	chr19	13105340	Missense_Mutation	rs748672881	R587Q	0.1
HNSC	chr19	13112974	Missense_Mutation	novel	F227L	0.19	zf-CCCH
HNSC	chr19	13109635	Missense_Mutation	novel	G409D	0.18
HNSC	chr19	13115466	Missense_Mutation	novel	E152K	0.23	zf-CCCH
HNSC	chr19	13110210	Missense_Mutation	rs542184779	R323C	0.29
HNSC	chr19	13112933	Silent	novel	T240T	0.19
HNSC	chr19	13110246	Missense_Mutation	novel	V311L	0.51
KIRC	chr19	13109968	Silent	rs139341662	C351C	0.33
KIRP	chr19	13115680	Missense_Mutation	NA	E133D	0.36
LGG	chr19	13109936	Missense_Mutation	rs768086861	A362V	0.05
LIHC	chr19	13109796	Silent	rs754696958	E383E	0.35
LUAD	chr19	13109798	Missense_Mutation	rs377647271	E383K	0.23
LUAD	chr19	13115393	Missense_Mutation	novel	G176V	0.33	zf-CCCH
LUAD	chr19	13104906	3'UTR	novel		0.05
LUAD	chr19	13112759	Silent	NA	T272T	0.15
LUSC	chr19	13105583	Missense_Mutation	novel	R536Q	0.4
LUSC	chr19	13105388	Missense_Mutation	novel	A571V	0.32
LUSC	chr19	13115733	Missense_Mutation	NA	V116F	0.31
LUSC	chr19	13116146	Missense_Mutation	novel	T85I	0.26
LUSC	chr19	13105387	Silent	NA	A571A	0.05
OV	chr19	13112738	Frame_Shift_Ins	novel	*M280Hfs40**	0.26
OV	chr19	13109402	Missense_Mutation	NA	T459I	0.29
PAAD	chr19	13116363	Missense_Mutation	novel	R13C	0.06
PCPG	chr19	13112911	Missense_Mutation	novel	A248T	0.15
PRAD	chr19	13105512	Missense_Mutation	NA	G560S	0.12
SARC	chr19	13107596	Missense_Mutation	novel	R521C	0.13
SKCM	chr19	13115440	Silent	NA	L160L	0.28
SKCM	chr19	13115393	Missense_Mutation	novel	G176E	0.17	zf-CCCH
SKCM	chr19	13105502	Missense_Mutation	NA	P563L	0.44
SKCM	chr19	13109688	Splice_Region	novel		0.25
SKCM	chr19	13116254	Missense_Mutation	NA	P49L	0.25
SKCM	chr19	13109641	Missense_Mutation	NA	F407Y	0.07
SKCM	chr19	13116054	Splice_Site	novel	X85_splice	0.25
SKCM	chr19	13109412	Missense_Mutation	NA	H456Y	0.32
SKCM	chr19	13116000	Nonsense_Mutation	NA	Q103*	0.47
SKCM	chr19	13109787	Silent	NA	H386H	0.34
SKCM	chr19	13112953	Missense_Mutation	novel	P234S	0.09	zf-CCCH
SKCM	chr19	13116348	Missense_Mutation	NA	L18F	0.39
SKCM	chr19	13112952	Missense_Mutation	novel	P234L	0.17	zf-CCCH
SKCM	chr19	13104974	Silent	NA	P647P	0.21
SKCM	chr19	13109959	Silent	novel	F354F	0.35
SKCM	chr19	13105502	Missense_Mutation	NA	P563L	0.21
SKCM	chr19	13110217	Silent	NA	F320F	0.36
STAD	chr19	13116446	Intron	novel		0.29
STAD	chr19	13109459	Missense_Mutation	rs150358822	P440L	0.24
STAD	chr19	13105433	Intron	novel		0.15
STAD	chr19	13112969	Silent	rs747124149	D228D	0.12
STAD	chr19	13110299	Missense_Mutation	NA	R293I	0.32
STAD	chr19	13107600	Silent	rs372566255	A519A	0.28
STAD	chr19	13112744	Silent	rs772203275	Y277Y	0.37
STAD	chr19	13105310	Missense_Mutation	novel	R597Q	0.18
STAD	chr19	13115367	Missense_Mutation	NA	A185T	0.13	zf-CCCH
STAD	chr19	13115364	Missense_Mutation	NA	S186A	0.22	zf-CCCH
STAD	chr19	13112743	Missense_Mutation	NA	G278R	0.27
STAD	chr19	13116165	Missense_Mutation	NA	E79K	0.08
STAD	chr19	13115694	Silent	NA	L129L	0.35
THCA	chr19	13109790	Silent	NA	E385E	0.28
UCEC	chr19	13104972	Frame_Shift_Del	rs767236600	*P648Lfs11**	0.38
UCEC	chr19	13105341	Missense_Mutation	rs374041118	R587W	0.38
UCEC	chr19	13109936	Missense_Mutation	rs768086861	A362V	0.46
UCEC	chr19	13115282	Missense_Mutation	novel	A213V	0.4	zf-CCCH
UCEC	chr19	13104971	Frame_Shift_Ins	rs761486084	*G649Wfs15**	0.49
UCEC	chr19	13110184	Silent	novel	G331G	0.11
UCEC	chr19	13110273	Missense_Mutation	rs148038210	R302C	0.5
UCEC	chr19	13109382	Missense_Mutation	rs144887143	R466W	0.21
UCEC	chr19	13109944	Silent	rs764720724	L359L	0.25
UCEC	chr19	13105327	Silent	rs528535820	P591P	0.13
UCEC	chr19	13105506	Missense_Mutation	rs149836806	R562W	0.26
UCEC	chr19	13107823	Frame_Shift_Del	novel	*L478Pfs8**	0.36
UCEC	chr19	13105349	Missense_Mutation	novel	Q584R	0.31
UCEC	chr19	13109917	Splice_Region	novel	G368G	0.37
UCEC	chr19	13110225	Missense_Mutation	novel	A318T	0.43
UCEC	chr19	13109587	Missense_Mutation	rs149382637	S425L	0.65
UCEC	chr19	13104971	Frame_Shift_Ins	rs761486084	*G649Wfs15**	0.26
UCEC	chr19	13110295	Silent	rs140807434	I294I	0.19
UCEC	chr19	13110295	Silent	rs140807434	I294I	0.36
UCEC	chr19	13112969	Silent	rs747124149	D228D	0.3
UCEC	chr19	13109613	Silent	rs201525408	S416S	0.37
UCEC	chr19	13109781	Silent	rs544448356	G388G	0.26
UCEC	chr19	13105311	Missense_Mutation	rs201873417	R597W	0.29
UCEC	chr19	13110181	Missense_Mutation	novel	Q332H	0.41
UCEC	chr19	13105286	Missense_Mutation	novel	P605H	0.61
UCEC	chr19	13109614	Missense_Mutation	novel	S416N	0.22
UCEC	chr19	13105317	Missense_Mutation	NA	A595T	0.41
UCEC	chr19	13107805	Silent	NA	N484N	0.34
UCEC	chr19	13116290	Missense_Mutation	novel	M37T	0.09
UCEC	chr19	13107771	Missense_Mutation	NA	W496G	0.48
UCEC	chr19	13110210	Missense_Mutation	rs542184779	R323C	0.39
UCEC	chr19	13105568	Missense_Mutation	novel	P541L	0.36
UCEC	chr19	13112954	Silent	novel	D233D	0.58
UCEC	chr19	13115384	Missense_Mutation	novel	S179F	0.33	zf-CCCH
UCEC	chr19	13115736	Frame_Shift_Ins	novel	*V115Sfs14**	0.21
UCEC	chr19	13105434	Intron	novel		0.28
UCEC	chr19	13105069	Missense_Mutation	rs554080215	R616C	0.62
UCEC	chr19	13115316	Missense_Mutation	novel	V202M	0.39	zf-CCCH
UCEC	chr19	13112919	Missense_Mutation	rs753496987	A245V	0.19	zf-CCCH
UCEC	chr19	13110249	Missense_Mutation	rs569347918	V310M	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
READ	DEL	0.0848	0.23023
THCA	DEL	0.016	0.10598

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00012	Kaplan-Meier Survival Analysis
STAD	0.0012	Kaplan-Meier Survival Analysis
MESO	0.04	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
UCS	0.048	Kaplan-Meier Survival Analysis
PRAD	0.015	Kaplan-Meier Survival Analysis
LUSC	0.0077	Kaplan-Meier Survival Analysis
BRCA	0.0077	Kaplan-Meier Survival Analysis
ESCA	0.039	Kaplan-Meier Survival Analysis
COAD	0.021	Kaplan-Meier Survival Analysis
PAAD	0.016	Kaplan-Meier Survival Analysis
BLCA	0.019	Kaplan-Meier Survival Analysis
CESC	0.0079	Kaplan-Meier Survival Analysis
LIHC	0.0031	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742