EuRBPDB

Description

Ensembl ID: ENSG00000105063 (Gene tree)
Gene ID: 22870
Gene Symbol: PPP6R1
Alias: SAP190|KIAA1115|SAPS1
Full Name: protein phosphatase 6 regulatory subunit 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 29,217 bases
Position: chr19:55,229,779-55,258,995
Accession: 29195
RBP type: non-canonical RBP
Summary: Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000589343	PPP6R1-205	904	-	-	- (aa)	-	-
ENST00000587457	PPP6R1-204	2389	-	-	- (aa)	-	-
ENST00000591602	PPP6R1-207	520	-	-	- (aa)	-	-
ENST00000586690	PPP6R1-202	668	-	-	- (aa)	-	-
ENST00000591323	PPP6R1-206	848	-	-	- (aa)	-	-
ENST00000587283	PPP6R1-203	2953	-	ENSP00000467521	881 (aa)	-	Q9UPN7
ENST00000592242	PPP6R1-208	574	-	ENSP00000466332	157 (aa)	-	K7EM28
ENST00000412770	PPP6R1-201	3961	-	ENSP00000414202	881 (aa)	-	Q9UPN7

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000105063	Hypertrophy, Left Ventricular	5.0760000E-005	-
ENSG00000105063	Platelet Function Tests	3.2267900E-005	-
ENSG00000105063	Interleukin-12	4.7870000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000105063	rs73068668	19	55251894	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105063	PPP6R1	100	64.331	ENSG00000110075	PPP6R3	100	82.051	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0005515	protein binding	14743216.16769727.18186651.21187329.24255178.28330616.	IPI	Function
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0017048	Rho GTPase binding	25743393.	IPI	Function
GO:0019903	protein phosphatase binding	16716191.	IPI	Function
GO:0043666	regulation of phosphoprotein phosphatase activity	16716191.	IDA	Process
GO:0048208	COPII vesicle coating	-	TAS	Process