EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000105171 (Gene tree)
Gene ID: 10775
Gene Symbol: POP4
Alias: RPP29
Full Name: POP4 homolog, ribonuclease P/MRP subunit
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 13,239 bases
Position: chr19:29,604,017-29,617,255
Accession: 30081
RBP type: canonical RBP
Summary: This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000221770	UPF0086	PF01868.16	8.9e-27	1	1
ENSP00000465213	UPF0086	PF01868.16	7.2e-26	1	1
ENSP00000468215	UPF0086	PF01868.16	1.1e-18	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16155184	RNase P: role of distinct protein cofactors in tRNA substrate recognition and RNA-based catalysis.	Nucleic Acids Res	2005 Sep 9	Sharin E	-
14673079	Structure of Mth11/Mth Rpp29, an essential protein subunit of archaeal and eukaryotic RNase P.	Proc Natl Acad Sci U S A	2003 Dec 23	Boomershine WP	-
25361963	The L7Ae protein binds to two kink-turns in the Pyrococcus furiosus RNase P RNA.	Nucleic Acids Res	2014 Dec 1	Lai SM	doi: 10.1093/nar/gku994

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000590688	POP4-209	527	-	ENSP00000467990	150 (aa)	-	K7EQV2
ENST00000592759	POP4-213	550	-	-	- (aa)	-	-
ENST00000586823	POP4-206	575	-	ENSP00000465456	42 (aa)	-	K7EK50
ENST00000586136	POP4-203	617	-	-	- (aa)	-	-
ENST00000585603	POP4-202	3385	-	ENSP00000465213	220 (aa)	-	O95707
ENST00000592749	POP4-212	590	-	-	- (aa)	-	-
ENST00000591824	POP4-211	846	-	-	- (aa)	-	-
ENST00000586420	POP4-205	579	-	ENSP00000468215	181 (aa)	-	K7ERD7
ENST00000586173	POP4-204	629	-	-	- (aa)	-	-
ENST00000221770	POP4-201	2321	-	ENSP00000221770	96 (aa)	-	A0A0A0MQS4
ENST00000591061	POP4-210	502	-	ENSP00000468718	40 (aa)	-	K7ESH8
ENST00000588551	POP4-208	789	-	-	- (aa)	-	-
ENST00000587232	POP4-207	608	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000105171's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000105171	Inflammatory Bowel Diseases	5.41E-5	17068223

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000105171	rs7255293	19	29613291	A	Heart rate response to exercise	29769521	[0.24-0.48] bpm increase	0.363	EFO_0009184
ENSG00000105171	rs3786516	19	29609412	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000105171	rs61731483	19	29613964	?	Breast cancer specific mortality in breast cancer	30787463	[1.15-1.44]	1.2875215	EFO_0000305\|EFO_0004352

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000105171's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105171	POP4	95	69.231	ENSAPOG00000007670	pop4	99	66.316	Acanthochromis_polyacanthus
ENSG00000105171	POP4	100	83.333	ENSAMEG00000003172	-	97	76.279	Ailuropoda_melanoleuca
ENSG00000105171	POP4	100	91.667	ENSAMEG00000018329	-	99	87.615	Ailuropoda_melanoleuca
ENSG00000105171	POP4	99	72.632	ENSACIG00000008358	pop4	93	64.615	Amphilophus_citrinellus
ENSG00000105171	POP4	100	73.958	ENSAOCG00000010116	pop4	98	62.376	Amphiprion_ocellaris
ENSG00000105171	POP4	99	74.737	ENSAPEG00000002829	pop4	86	61.765	Amphiprion_percula
ENSG00000105171	POP4	100	75.000	ENSATEG00000013028	pop4	92	61.765	Anabas_testudineus
ENSG00000105171	POP4	100	85.417	ENSAPLG00000014051	POP4	100	72.464	Anas_platyrhynchos
ENSG00000105171	POP4	100	97.917	ENSANAG00000020295	POP4	100	95.000	Aotus_nancymaae
ENSG00000105171	POP4	100	70.833	ENSACLG00000000526	pop4	91	61.386	Astatotilapia_calliptera
ENSG00000105171	POP4	99	74.737	ENSAMXG00000002899	pop4	100	58.636	Astyanax_mexicanus
ENSG00000105171	POP4	100	95.833	ENSBTAG00000002223	POP4	100	90.000	Bos_taurus
ENSG00000105171	POP4	89	35.294	WBGene00007603	C15C6.4	57	30.172	Caenorhabditis_elegans
ENSG00000105171	POP4	100	96.875	ENSCJAG00000046750	POP4	100	93.333	Callithrix_jacchus
ENSG00000105171	POP4	100	94.792	ENSCAFG00000007630	POP4	99	91.160	Canis_familiaris
ENSG00000105171	POP4	100	94.792	ENSCHIG00000016743	POP4	100	89.091	Capra_hircus
ENSG00000105171	POP4	100	93.750	ENSTSYG00000003488	POP4	100	90.000	Carlito_syrichta
ENSG00000105171	POP4	81	92.308	ENSCAPG00000011105	POP4	100	65.899	Cavia_aperea
ENSG00000105171	POP4	100	93.750	ENSCPOG00000002992	POP4	100	87.273	Cavia_porcellus
ENSG00000105171	POP4	100	83.333	ENSCCAG00000034244	-	100	79.545	Cebus_capucinus
ENSG00000105171	POP4	100	96.875	ENSCCAG00000020285	-	100	95.000	Cebus_capucinus
ENSG00000105171	POP4	100	97.917	ENSCATG00000036022	POP4	100	97.917	Cercocebus_atys
ENSG00000105171	POP4	100	93.750	ENSCLAG00000013162	POP4	100	87.273	Chinchilla_lanigera
ENSG00000105171	POP4	100	98.958	ENSCSAG00000004868	POP4	100	96.789	Chlorocebus_sabaeus
ENSG00000105171	POP4	81	92.308	ENSCHOG00000002071	POP4	100	64.977	Choloepus_hoffmanni
ENSG00000105171	POP4	100	87.500	ENSCPBG00000016132	POP4	100	74.091	Chrysemys_picta_bellii
ENSG00000105171	POP4	93	40.449	ENSCING00000023871	-	96	32.000	Ciona_intestinalis
ENSG00000105171	POP4	100	98.958	ENSCANG00000005924	POP4	100	96.535	Colobus_angolensis_palliatus
ENSG00000105171	POP4	100	91.667	ENSCGRG00001017185	Pop4	100	83.182	Cricetulus_griseus_chok1gshd
ENSG00000105171	POP4	100	91.667	ENSCGRG00000008155	Pop4	100	83.182	Cricetulus_griseus_crigri
ENSG00000105171	POP4	100	62.500	ENSCSEG00000002946	pop4	92	53.695	Cynoglossus_semilaevis
ENSG00000105171	POP4	94	67.778	ENSCVAG00000018602	POP4	87	43.627	Cyprinodon_variegatus
ENSG00000105171	POP4	100	78.125	ENSDARG00000101472	pop4	100	63.182	Danio_rerio
ENSG00000105171	POP4	100	93.750	ENSDNOG00000047663	POP4	88	86.818	Dasypus_novemcinctus
ENSG00000105171	POP4	94	82.558	ENSDORG00000008577	Pop4	100	83.721	Dipodomys_ordii
ENSG00000105171	POP4	89	41.176	FBgn0035831	CG8038	70	37.931	Drosophila_melanogaster
ENSG00000105171	POP4	100	87.500	ENSETEG00000003607	POP4	100	74.654	Echinops_telfairi
ENSG00000105171	POP4	91	56.322	ENSEBUG00000008575	pop4	100	44.344	Eptatretus_burgeri
ENSG00000105171	POP4	99	61.053	ENSEBUG00000010447	pop4	81	48.325	Eptatretus_burgeri
ENSG00000105171	POP4	91	56.322	ENSEBUG00000004305	pop4	100	41.631	Eptatretus_burgeri
ENSG00000105171	POP4	100	92.157	ENSECAG00000020206	POP4	82	88.462	Equus_caballus
ENSG00000105171	POP4	81	96.154	ENSEEUG00000013109	POP4	99	68.844	Erinaceus_europaeus
ENSG00000105171	POP4	99	74.737	ENSELUG00000019812	pop4	89	64.286	Esox_lucius
ENSG00000105171	POP4	100	93.750	ENSFCAG00000001619	POP4	100	89.091	Felis_catus
ENSG00000105171	POP4	100	84.375	ENSFALG00000000206	POP4	96	70.370	Ficedula_albicollis
ENSG00000105171	POP4	100	92.708	ENSFDAG00000017859	POP4	100	87.727	Fukomys_damarensis
ENSG00000105171	POP4	85	75.610	ENSFHEG00000012745	pop4	94	55.556	Fundulus_heteroclitus
ENSG00000105171	POP4	100	77.083	ENSGMOG00000000335	pop4	99	63.184	Gadus_morhua
ENSG00000105171	POP4	100	81.250	ENSGALG00000041972	POP4	92	69.091	Gallus_gallus
ENSG00000105171	POP4	93	51.429	ENSGAFG00000003571	pop4	96	51.724	Gambusia_affinis
ENSG00000105171	POP4	100	76.042	ENSGACG00000014510	pop4	99	63.978	Gasterosteus_aculeatus
ENSG00000105171	POP4	100	87.500	ENSGAGG00000024544	POP4	79	75.000	Gopherus_agassizii
ENSG00000105171	POP4	100	100.000	ENSGGOG00000038346	POP4	99	99.083	Gorilla_gorilla
ENSG00000105171	POP4	100	70.833	ENSHBUG00000021821	pop4	91	61.386	Haplochromis_burtoni
ENSG00000105171	POP4	100	92.708	ENSHGLG00000015798	POP4	99	86.697	Heterocephalus_glaber_female
ENSG00000105171	POP4	100	92.708	ENSHGLG00100009737	POP4	100	86.364	Heterocephalus_glaber_male
ENSG00000105171	POP4	99	76.842	ENSHCOG00000020937	pop4	91	65.686	Hippocampus_comes
ENSG00000105171	POP4	100	72.917	ENSIPUG00000013652	pop4	100	60.000	Ictalurus_punctatus
ENSG00000105171	POP4	100	92.708	ENSSTOG00000011016	POP4	100	88.636	Ictidomys_tridecemlineatus
ENSG00000105171	POP4	100	93.750	ENSJJAG00000013376	Pop4	100	88.182	Jaculus_jaculus
ENSG00000105171	POP4	100	72.917	ENSKMAG00000012250	pop4	98	59.633	Kryptolebias_marmoratus
ENSG00000105171	POP4	99	70.526	ENSLBEG00000014139	pop4	91	59.804	Labrus_bergylta
ENSG00000105171	POP4	99	70.526	ENSLBEG00000018846	-	91	59.804	Labrus_bergylta
ENSG00000105171	POP4	100	72.917	ENSLACG00000008581	POP4	98	64.055	Latimeria_chalumnae
ENSG00000105171	POP4	100	86.458	ENSLOCG00000005597	pop4	100	69.091	Lepisosteus_oculatus
ENSG00000105171	POP4	100	91.667	ENSLAFG00000000084	POP4	100	88.636	Loxodonta_africana
ENSG00000105171	POP4	100	98.958	ENSMFAG00000029606	POP4	100	97.273	Macaca_fascicularis
ENSG00000105171	POP4	100	98.958	ENSMMUG00000017424	POP4	100	96.380	Macaca_mulatta
ENSG00000105171	POP4	100	98.958	ENSMNEG00000031374	POP4	100	96.380	Macaca_nemestrina
ENSG00000105171	POP4	100	98.958	ENSMLEG00000043454	POP4	100	96.364	Mandrillus_leucophaeus
ENSG00000105171	POP4	100	73.958	ENSMAMG00000011716	pop4	91	62.745	Mastacembelus_armatus
ENSG00000105171	POP4	100	70.833	ENSMZEG00005002360	pop4	91	61.386	Maylandia_zebra
ENSG00000105171	POP4	100	81.250	ENSMGAG00000005337	POP4	97	69.725	Meleagris_gallopavo
ENSG00000105171	POP4	100	93.750	ENSMAUG00000020110	Pop4	100	84.545	Mesocricetus_auratus
ENSG00000105171	POP4	100	91.667	ENSMICG00000035730	POP4	98	86.697	Microcebus_murinus
ENSG00000105171	POP4	100	73.958	ENSMMOG00000015321	pop4	91	62.376	Mola_mola
ENSG00000105171	POP4	100	93.750	ENSMODG00000029406	POP4	94	78.241	Monodelphis_domestica
ENSG00000105171	POP4	100	73.958	ENSMALG00000012571	pop4	92	63.547	Monopterus_albus
ENSG00000105171	POP4	100	91.667	MGP_CAROLIEiJ_G0029600	Pop4	100	82.353	Mus_caroli
ENSG00000105171	POP4	100	90.625	ENSMUSG00000030423	Pop4	100	82.353	Mus_musculus
ENSG00000105171	POP4	100	90.625	MGP_SPRETEiJ_G0030699	Pop4	100	82.273	Mus_spretus
ENSG00000105171	POP4	100	90.625	ENSMPUG00000008041	-	100	88.636	Mustela_putorius_furo
ENSG00000105171	POP4	100	76.289	ENSMPUG00000008063	-	100	75.566	Mustela_putorius_furo
ENSG00000105171	POP4	84	85.185	ENSMPUG00000008141	-	70	85.185	Mustela_putorius_furo
ENSG00000105171	POP4	99	70.776	ENSMLUG00000010774	POP4	99	70.776	Myotis_lucifugus
ENSG00000105171	POP4	100	95.833	ENSNGAG00000021535	-	100	95.833	Nannospalax_galili
ENSG00000105171	POP4	100	83.333	ENSMEUG00000003636	-	100	84.800	Notamacropus_eugenii
ENSG00000105171	POP4	100	96.875	ENSOPRG00000004736	POP4	99	92.424	Ochotona_princeps
ENSG00000105171	POP4	100	93.750	ENSODEG00000013025	POP4	100	86.792	Octodon_degus
ENSG00000105171	POP4	100	70.833	ENSONIG00000003458	pop4	90	60.891	Oreochromis_niloticus
ENSG00000105171	POP4	66	85.714	ENSOANG00000020512	-	100	83.871	Ornithorhynchus_anatinus
ENSG00000105171	POP4	100	96.875	ENSOCUG00000015974	POP4	100	90.909	Oryctolagus_cuniculus
ENSG00000105171	POP4	100	73.958	ENSORLG00000020317	pop4	91	59.901	Oryzias_latipes
ENSG00000105171	POP4	100	73.958	ENSORLG00015011624	pop4	91	59.804	Oryzias_latipes_hsok
ENSG00000105171	POP4	100	73.958	ENSOMEG00000002538	pop4	91	60.784	Oryzias_melastigma
ENSG00000105171	POP4	100	93.750	ENSOGAG00000011168	POP4	99	88.532	Otolemur_garnettii
ENSG00000105171	POP4	100	94.792	ENSOARG00000004041	POP4	100	88.688	Ovis_aries
ENSG00000105171	POP4	100	100.000	ENSPPAG00000040372	POP4	100	99.545	Pan_paniscus
ENSG00000105171	POP4	100	93.750	ENSPPRG00000010502	POP4	100	89.091	Panthera_pardus
ENSG00000105171	POP4	100	93.750	ENSPTIG00000016598	POP4	100	88.636	Panthera_tigris_altaica
ENSG00000105171	POP4	100	100.000	ENSPTRG00000010779	POP4	100	99.545	Pan_troglodytes
ENSG00000105171	POP4	100	98.958	ENSPANG00000008546	POP4	100	97.273	Papio_anubis
ENSG00000105171	POP4	100	83.333	ENSPKIG00000004468	pop4	87	70.202	Paramormyrops_kingsleyae
ENSG00000105171	POP4	100	88.542	ENSPSIG00000015690	POP4	100	78.713	Pelodiscus_sinensis
ENSG00000105171	POP4	100	64.583	ENSPMGG00000008608	pop4	98	58.049	Periophthalmus_magnuspinnatus
ENSG00000105171	POP4	100	93.750	ENSPEMG00000014034	-	96	82.727	Peromyscus_maniculatus_bairdii
ENSG00000105171	POP4	91	88.506	ENSPEMG00000019982	-	100	68.807	Peromyscus_maniculatus_bairdii
ENSG00000105171	POP4	99	70.526	ENSPMAG00000006265	pop4	99	58.376	Petromyzon_marinus
ENSG00000105171	POP4	100	91.667	ENSPCIG00000024738	POP4	95	77.727	Phascolarctos_cinereus
ENSG00000105171	POP4	100	73.958	ENSPFOG00000000925	pop4	91	60.099	Poecilia_formosa
ENSG00000105171	POP4	100	73.958	ENSPLAG00000003161	pop4	91	60.099	Poecilia_latipinna
ENSG00000105171	POP4	100	73.958	ENSPMEG00000002475	pop4	91	60.099	Poecilia_mexicana
ENSG00000105171	POP4	99	73.684	ENSPREG00000022403	pop4	86	59.296	Poecilia_reticulata
ENSG00000105171	POP4	100	99.091	ENSPPYG00000009805	POP4	100	99.091	Pongo_abelii
ENSG00000105171	POP4	100	92.708	ENSPCAG00000007737	POP4	99	82.192	Procavia_capensis
ENSG00000105171	POP4	100	91.667	ENSPCOG00000018055	POP4	100	89.545	Propithecus_coquereli
ENSG00000105171	POP4	100	92.708	ENSPVAG00000006069	POP4	100	87.727	Pteropus_vampyrus
ENSG00000105171	POP4	100	70.833	ENSPNYG00000020038	pop4	91	61.881	Pundamilia_nyererei
ENSG00000105171	POP4	100	75.000	ENSPNAG00000005591	pop4	100	61.818	Pygocentrus_nattereri
ENSG00000105171	POP4	100	90.625	ENSRNOG00000027646	Pop4	100	83.710	Rattus_norvegicus
ENSG00000105171	POP4	96	93.143	ENSRBIG00000044769	POP4	90	96.403	Rhinopithecus_bieti
ENSG00000105171	POP4	100	98.958	ENSRROG00000028903	POP4	100	96.818	Rhinopithecus_roxellana
ENSG00000105171	POP4	96	36.275	YBR257W	-	50	33.813	Saccharomyces_cerevisiae
ENSG00000105171	POP4	100	97.917	ENSSBOG00000032445	POP4	100	95.455	Saimiri_boliviensis_boliviensis
ENSG00000105171	POP4	100	94.792	ENSSHAG00000016888	POP4	99	78.899	Sarcophilus_harrisii
ENSG00000105171	POP4	100	78.125	ENSSFOG00015014556	pop4	90	66.337	Scleropages_formosus
ENSG00000105171	POP4	100	77.083	ENSSMAG00000016611	pop4	95	63.902	Scophthalmus_maximus
ENSG00000105171	POP4	99	72.632	ENSSDUG00000019865	pop4	82	61.765	Seriola_dumerili
ENSG00000105171	POP4	100	72.917	ENSSLDG00000001763	pop4	91	61.765	Seriola_lalandi_dorsalis
ENSG00000105171	POP4	100	91.667	ENSSARG00000004748	POP4	100	86.175	Sorex_araneus
ENSG00000105171	POP4	100	86.458	ENSSPUG00000007308	POP4	100	86.458	Sphenodon_punctatus
ENSG00000105171	POP4	99	76.842	ENSSPAG00000014364	pop4	91	63.725	Stegastes_partitus
ENSG00000105171	POP4	100	95.833	ENSSSCG00000002854	POP4	100	89.545	Sus_scrofa
ENSG00000105171	POP4	100	85.417	ENSTGUG00000008953	POP4	100	75.000	Taeniopygia_guttata
ENSG00000105171	POP4	100	70.833	ENSTNIG00000006401	pop4	100	59.113	Tetraodon_nigroviridis
ENSG00000105171	POP4	100	94.792	ENSTBEG00000002194	POP4	100	88.235	Tupaia_belangeri
ENSG00000105171	POP4	100	97.917	ENSTTRG00000005882	POP4	100	89.545	Tursiops_truncatus
ENSG00000105171	POP4	100	82.292	ENSUAMG00000014601	-	100	82.292	Ursus_americanus
ENSG00000105171	POP4	100	91.667	ENSUAMG00000003049	-	100	88.636	Ursus_americanus
ENSG00000105171	POP4	100	82.292	ENSUMAG00000013482	-	100	82.292	Ursus_maritimus
ENSG00000105171	POP4	100	91.667	ENSUMAG00000007522	-	100	88.636	Ursus_maritimus
ENSG00000105171	POP4	100	93.750	ENSVVUG00000016876	-	71	89.604	Vulpes_vulpes
ENSG00000105171	POP4	100	80.208	ENSXETG00000017598	pop4	98	64.352	Xenopus_tropicalis
ENSG00000105171	POP4	100	73.958	ENSXCOG00000017695	pop4	86	59.701	Xiphophorus_couchianus
ENSG00000105171	POP4	100	73.958	ENSXMAG00000013862	pop4	86	59.701	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000171	ribonuclease MRP activity	21873635.	IBA	Function
GO:0000172	ribonuclease MRP complex	21873635.	IBA	Component
GO:0001682	tRNA 5'-leader removal	16723659.30454648.	IDA	Process
GO:0001682	tRNA 5'-leader removal	-	TAS	Process
GO:0003723	RNA binding	10352175.	TAS	Function
GO:0004526	ribonuclease P activity	21873635.	IBA	Function
GO:0004526	ribonuclease P activity	16723659.30454648.	IDA	Function
GO:0005515	protein binding	15096576.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0006364	rRNA processing	21873635.	IBA	Process
GO:0008033	tRNA processing	10352175.	TAS	Process
GO:0030677	ribonuclease P complex	21873635.	IBA	Component
GO:0030681	multimeric ribonuclease P complex	16723659.30454648.	IDA	Component
GO:0033204	ribonuclease P RNA binding	21873635.	IBA	Function
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process