EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000105202 (Gene tree)
Gene ID: 2091
Gene Symbol: FBL
Alias: RNU3IP1|FLRN|FIB|Nop1
Full Name: fibrillarin
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 11,962 bases
Position: chr19:39,834,453-39,846,414
Accession: 3599
RBP type: canonical RBP
Summary: This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000472419	GCD14	PF08704.10	0.00043	1	1
ENSP00000469249	GCD14	PF08704.10	0.00052	1	1
ENSP00000472726	GCD14	PF08704.10	0.00074	1	1
ENSP00000221801	GCD14	PF08704.10	0.00098	1	1
ENSP00000471350	GCD14	PF08704.10	0.0015	1	1
ENSP00000472419	Fibrillarin	PF01269.17	1.7e-108	1	1
ENSP00000221801	Fibrillarin	PF01269.17	3.7e-108	1	1
ENSP00000469249	Fibrillarin	PF01269.17	5.3e-105	1	1
ENSP00000472726	Fibrillarin	PF01269.17	4.1e-99	1	1
ENSP00000471350	Fibrillarin	PF01269.17	1.5e-86	1	1
ENSP00000471867	Fibrillarin	PF01269.17	4e-45	1	1
ENSP00000472433	Fibrillarin	PF01269.17	2.9e-40	1	1
ENSP00000472805	Fibrillarin	PF01269.17	1.8e-30	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

Show entries

Search:

PID	Title	Article	Time	Author	Doi
28994181	Age-associated dysregulation of protein metabolism in the mammalian oocyte.	Aging Cell	2017 Dec	Duncan FE	doi: 10.1111/acel.12676
26492166	A Genetic Cascade of let-7-ncl-1-fib-1 Modulates Nucleolar Size and rRNA Pool in Caenorhabditis elegans.	PLoS Genet	2015 Oct 22	Yi YH	doi: 10.1371/journal.pgen.1005580
25696992	[Cytological analysis of the reaction of the nucleolar RNA and RNA-binding proteins to oxidative stress in HeLa cells].	Tsitologiia	2014	Mironova AA	-
23591814	Involvement of phosphatidylinositol 4,5-bisphosphate in RNA polymerase I transcription.	J Cell Sci	2013 Jun 15	Yildirim S	doi: 10.1242/jcs.123661
22426501	Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription.	Int J Mol Med	2012 Jun	Dieriks B	doi: 10.3892/ijmm.2012.937
22869109	Structure of Aeropyrum pernix fibrillarin in complex with natively bound S-adenosyl-L-methionine at 1.7 resolution.	Acta Crystallogr Sect F Struct Biol Cryst Commun	2012 Aug 1	de Silva U	doi: 10.1107/S1744309112026528
21785141	Two RNA-binding sites in plant fibrillarin provide interactions with various RNA substrates.	Nucleic Acids Res	2011 Nov 1	Rakitina DV	doi: 10.1093/nar/gkr594
20147409	Relocalization of upstream binding factor to viral replication compartments is UL24 independent and follows the onset of herpes simplex virus 1 DNA synthesis.	J Virol	2010 May	Lymberopoulos MH	doi: 10.1128/JVI.02437-09
19344311	Characterization of PRMT1 from Plasmodium falciparum.	Biochem J	2009 Jun 12	Fan Q	doi: 10.1042/BJ20090185.
19331828	Fibrillarin and Nop56 interact before being co-assembled in box C/D snoRNPs.	Exp Cell Res	2009 Apr 1	Lechertier T	doi: 10.1016/j.yexcr.2009.01.016

Showing 1 to 10 of 35 entries

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Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000598417	FBL-208	581	-	ENSP00000471867	178 (aa)	-	M0R1H0
ENST00000594309	FBL-203	603	-	ENSP00000472433	182 (aa)	-	M0R2B0
ENST00000221801	FBL-201	1160	XM_005258651	ENSP00000221801	321 (aa)	XP_005258708	P22087
ENST00000599159	FBL-210	1400	-	-	- (aa)	-	-
ENST00000597224	FBL-206	732	-	ENSP00000469249	244 (aa)	-	M0QXL5
ENST00000595545	FBL-205	896	-	ENSP00000472419	229 (aa)	-	M0R299
ENST00000599134	FBL-209	500	-	ENSP00000472805	157 (aa)	-	M0R2U2
ENST00000597634	FBL-207	726	-	ENSP00000471350	228 (aa)	-	M0R0P1
ENST00000601274	FBL-211	877	-	ENSP00000472726	273 (aa)	-	M0R2Q4
ENST00000593503	FBL-202	628	-	-	- (aa)	-	-
ENST00000594443	FBL-204	805	-	ENSP00000469072	40 (aa)	-	M0QXC9

Gene Model

Click here to download ENSG00000105202's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000105202's network

CanvasJS.com

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000105202	FBL	100	87.773	ENSG00000188573	FBLL1	69	87.773

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105202	FBL	100	89.520	ENSAPOG00000015135	fbl	74	88.703	Acanthochromis_polyacanthus
ENSG00000105202	FBL	100	87.773	ENSAMEG00000007104	FBLL1	92	87.554	Ailuropoda_melanoleuca
ENSG00000105202	FBL	100	99.563	ENSAMEG00000012669	FBL	83	93.706	Ailuropoda_melanoleuca
ENSG00000105202	FBL	100	89.520	ENSACIG00000010958	fbl	80	88.841	Amphilophus_citrinellus
ENSG00000105202	FBL	100	90.393	ENSAOCG00000008806	fbl	76	90.708	Amphiprion_ocellaris
ENSG00000105202	FBL	100	90.393	ENSAPEG00000011843	fbl	76	90.708	Amphiprion_percula
ENSG00000105202	FBL	100	91.266	ENSATEG00000000569	fbl	76	90.377	Anabas_testudineus
ENSG00000105202	FBL	100	91.703	ENSACAG00000016787	-	77	90.000	Anolis_carolinensis
ENSG00000105202	FBL	93	89.202	ENSANAG00000019689	-	70	88.940	Aotus_nancymaae
ENSG00000105202	FBL	100	99.127	ENSANAG00000029424	-	91	98.467	Aotus_nancymaae
ENSG00000105202	FBL	100	89.956	ENSACLG00000005227	fbl	76	89.121	Astatotilapia_calliptera
ENSG00000105202	FBL	96	90.909	ENSAMXG00000037402	fbl	62	90.498	Astyanax_mexicanus
ENSG00000105202	FBL	100	87.773	ENSBTAG00000004657	FBLL1	80	87.179	Bos_taurus
ENSG00000105202	FBL	100	100.000	ENSBTAG00000002579	FBL	75	100.000	Bos_taurus
ENSG00000105202	FBL	100	76.419	WBGene00001423	fib-1	67	75.745	Caenorhabditis_elegans
ENSG00000105202	FBL	100	99.127	ENSCJAG00000040785	FBL	83	95.455	Callithrix_jacchus
ENSG00000105202	FBL	100	87.773	ENSCJAG00000015548	FBLL1	86	75.862	Callithrix_jacchus
ENSG00000105202	FBL	100	100.000	ENSCAFG00000005412	FBL	92	94.118	Canis_familiaris
ENSG00000105202	FBL	100	100.000	ENSCAFG00020015639	FBL	88	95.925	Canis_lupus_dingo
ENSG00000105202	FBL	99	87.225	ENSCAFG00020003509	FBLL1	76	87.013	Canis_lupus_dingo
ENSG00000105202	FBL	100	87.773	ENSCHIG00000005751	FBLL1	74	87.179	Capra_hircus
ENSG00000105202	FBL	100	100.000	ENSCHIG00000021562	FBL	72	100.000	Capra_hircus
ENSG00000105202	FBL	100	100.000	ENSTSYG00000036873	FBL	100	98.765	Carlito_syrichta
ENSG00000105202	FBL	99	87.719	ENSTSYG00000030585	FBLL1	89	87.500	Carlito_syrichta
ENSG00000105202	FBL	98	88.372	ENSCAPG00000009974	FBL	73	94.811	Cavia_aperea
ENSG00000105202	FBL	94	77.674	ENSCAPG00000008751	FBLL1	100	77.376	Cavia_aperea
ENSG00000105202	FBL	100	99.563	ENSCPOG00000010192	FBL	77	99.585	Cavia_porcellus
ENSG00000105202	FBL	100	79.039	ENSCPOG00000025737	FBLL1	71	78.723	Cavia_porcellus
ENSG00000105202	FBL	100	87.773	ENSCCAG00000033894	FBLL1	69	87.773	Cebus_capucinus
ENSG00000105202	FBL	100	99.127	ENSCCAG00000004830	FBL	99	97.806	Cebus_capucinus
ENSG00000105202	FBL	100	100.000	ENSCATG00000039255	FBL	100	99.689	Cercocebus_atys
ENSG00000105202	FBL	100	86.900	ENSCLAG00000018056	FBLL1	91	86.383	Chinchilla_lanigera
ENSG00000105202	FBL	100	99.127	ENSCLAG00000001639	FBL	98	93.884	Chinchilla_lanigera
ENSG00000105202	FBL	100	87.773	ENSCSAG00000010153	FBLL1	74	87.554	Chlorocebus_sabaeus
ENSG00000105202	FBL	100	100.000	ENSCSAG00000003783	FBL	100	99.371	Chlorocebus_sabaeus
ENSG00000105202	FBL	100	91.703	ENSCPBG00000024047	-	76	90.000	Chrysemys_picta_bellii
ENSG00000105202	FBL	100	83.843	ENSCING00000005048	-	78	82.500	Ciona_intestinalis
ENSG00000105202	FBL	100	83.406	ENSCSAVG00000002367	-	100	83.069	Ciona_savignyi
ENSG00000105202	FBL	100	100.000	ENSCANG00000042053	FBL	100	100.000	Colobus_angolensis_palliatus
ENSG00000105202	FBL	100	87.773	ENSCANG00000043304	FBLL1	78	87.554	Colobus_angolensis_palliatus
ENSG00000105202	FBL	100	87.336	ENSCGRG00001010028	Fbll1	75	86.134	Cricetulus_griseus_chok1gshd
ENSG00000105202	FBL	90	75.676	ENSCGRG00001024532	-	77	71.138	Cricetulus_griseus_chok1gshd
ENSG00000105202	FBL	100	100.000	ENSCGRG00001021702	-	95	90.816	Cricetulus_griseus_chok1gshd
ENSG00000105202	FBL	100	100.000	ENSCGRG00000012705	Fbl	95	90.816	Cricetulus_griseus_crigri
ENSG00000105202	FBL	100	89.956	ENSCSEG00000010310	fbl	77	88.703	Cynoglossus_semilaevis
ENSG00000105202	FBL	100	89.956	ENSCVAG00000015561	fbl	76	89.121	Cyprinodon_variegatus
ENSG00000105202	FBL	100	89.083	ENSDARG00000053912	fbl	76	87.500	Danio_rerio
ENSG00000105202	FBL	100	99.563	ENSDNOG00000025216	FBL	75	99.585	Dasypus_novemcinctus
ENSG00000105202	FBL	100	99.563	ENSDORG00000005756	Fbl	86	92.045	Dipodomys_ordii
ENSG00000105202	FBL	100	82.969	FBgn0003062	Fib	69	82.353	Drosophila_melanogaster
ENSG00000105202	FBL	99	44.541	FBgn0038090	CG10909	67	44.255	Drosophila_melanogaster
ENSG00000105202	FBL	100	69.869	ENSETEG00000003164	FBL	75	71.369	Echinops_telfairi
ENSG00000105202	FBL	100	86.900	ENSEBUG00000016084	fbl	97	86.325	Eptatretus_burgeri
ENSG00000105202	FBL	86	86.869	ENSEASG00005012784	FBLL1	65	86.500	Equus_asinus_asinus
ENSG00000105202	FBL	100	100.000	ENSEASG00005011787	FBL	84	90.258	Equus_asinus_asinus
ENSG00000105202	FBL	100	87.773	ENSECAG00000023600	FBLL1	70	87.234	Equus_caballus
ENSG00000105202	FBL	100	100.000	ENSECAG00000023221	FBL	93	96.865	Equus_caballus
ENSG00000105202	FBL	100	89.083	ENSELUG00000022537	fbl	92	75.926	Esox_lucius
ENSG00000105202	FBL	100	100.000	ENSFCAG00000003026	FBL	100	97.205	Felis_catus
ENSG00000105202	FBL	100	99.563	ENSFDAG00000021499	FBL	93	89.597	Fukomys_damarensis
ENSG00000105202	FBL	100	87.336	ENSFDAG00000018404	FBLL1	81	86.809	Fukomys_damarensis
ENSG00000105202	FBL	100	89.520	ENSFHEG00000010854	fbl	76	88.703	Fundulus_heteroclitus
ENSG00000105202	FBL	99	89.474	ENSGMOG00000007678	fbl	88	79.478	Gadus_morhua
ENSG00000105202	FBL	89	88.725	ENSGAFG00000008992	fbl	99	88.571	Gambusia_affinis
ENSG00000105202	FBL	100	89.520	ENSGACG00000004194	fbl	98	89.868	Gasterosteus_aculeatus
ENSG00000105202	FBL	100	86.531	ENSGAGG00000003006	-	63	85.600	Gopherus_agassizii
ENSG00000105202	FBL	100	100.000	ENSGGOG00000013076	FBL	100	99.688	Gorilla_gorilla
ENSG00000105202	FBL	100	89.956	ENSHBUG00000011229	fbl	76	89.121	Haplochromis_burtoni
ENSG00000105202	FBL	100	99.563	ENSHGLG00000009686	FBL	93	89.298	Heterocephalus_glaber_female
ENSG00000105202	FBL	100	87.773	ENSHGLG00000015259	FBLL1	77	87.234	Heterocephalus_glaber_female
ENSG00000105202	FBL	100	99.563	ENSHGLG00100015471	FBL	93	89.298	Heterocephalus_glaber_male
ENSG00000105202	FBL	100	87.773	ENSHGLG00100021287	FBLL1	93	87.234	Heterocephalus_glaber_male
ENSG00000105202	FBL	100	90.393	ENSHCOG00000021211	fbl	77	89.121	Hippocampus_comes
ENSG00000105202	FBL	100	89.956	ENSIPUG00000009464	fbl	75	88.333	Ictalurus_punctatus
ENSG00000105202	FBL	88	85.644	ENSSTOG00000031046	FBLL1	96	87.500	Ictidomys_tridecemlineatus
ENSG00000105202	FBL	100	99.563	ENSSTOG00000012486	FBL	100	95.692	Ictidomys_tridecemlineatus
ENSG00000105202	FBL	100	99.127	ENSJJAG00000018359	Fbl	74	98.755	Jaculus_jaculus
ENSG00000105202	FBL	100	87.773	ENSJJAG00000000811	Fbll1	83	86.134	Jaculus_jaculus
ENSG00000105202	FBL	100	88.646	ENSKMAG00000003716	fbl	77	87.866	Kryptolebias_marmoratus
ENSG00000105202	FBL	100	89.083	ENSLBEG00000017315	fbl	82	87.866	Labrus_bergylta
ENSG00000105202	FBL	99	70.870	ENSLACG00000014561	fbl	68	70.168	Latimeria_chalumnae
ENSG00000105202	FBL	66	91.391	ENSLOCG00000004721	fbl	99	91.083	Lepisosteus_oculatus
ENSG00000105202	FBL	100	87.336	ENSLAFG00000032132	FBLL1	99	87.554	Loxodonta_africana
ENSG00000105202	FBL	100	99.563	ENSLAFG00000000171	FBL	76	99.585	Loxodonta_africana
ENSG00000105202	FBL	100	87.773	ENSMFAG00000036422	FBLL1	83	87.554	Macaca_fascicularis
ENSG00000105202	FBL	100	100.000	ENSMFAG00000043908	FBL	100	99.689	Macaca_fascicularis
ENSG00000105202	FBL	100	87.773	ENSMMUG00000012520	FBLL1	78	87.554	Macaca_mulatta
ENSG00000105202	FBL	100	100.000	ENSMMUG00000022725	FBL	100	100.000	Macaca_mulatta
ENSG00000105202	FBL	100	100.000	ENSMNEG00000040045	FBL	99	99.051	Macaca_nemestrina
ENSG00000105202	FBL	100	100.000	ENSMLEG00000042975	FBL	99	99.051	Mandrillus_leucophaeus
ENSG00000105202	FBL	100	87.773	ENSMLEG00000040259	FBLL1	75	87.554	Mandrillus_leucophaeus
ENSG00000105202	FBL	100	90.830	ENSMAMG00000006804	fbl	78	89.912	Mastacembelus_armatus
ENSG00000105202	FBL	100	89.956	ENSMZEG00005025246	fbl	76	89.121	Maylandia_zebra
ENSG00000105202	FBL	100	87.773	ENSMAUG00000015741	Fbll1	77	86.920	Mesocricetus_auratus
ENSG00000105202	FBL	100	100.000	ENSMAUG00000003620	Fbl	93	89.145	Mesocricetus_auratus
ENSG00000105202	FBL	100	99.127	ENSMICG00000007686	FBL	92	91.837	Microcebus_murinus
ENSG00000105202	FBL	100	100.000	ENSMOCG00000012820	Fbl	78	97.189	Microtus_ochrogaster
ENSG00000105202	FBL	100	88.210	ENSMOCG00000022683	Fbll1	78	88.412	Microtus_ochrogaster
ENSG00000105202	FBL	100	89.520	ENSMMOG00000006454	fbl	82	88.841	Mola_mola
ENSG00000105202	FBL	100	92.576	ENSMODG00000013702	-	74	91.667	Monodelphis_domestica
ENSG00000105202	FBL	100	89.083	ENSMALG00000015601	fbl	82	87.866	Monopterus_albus
ENSG00000105202	FBL	100	100.000	MGP_CAROLIEiJ_G0029434	Fbl	95	89.439	Mus_caroli
ENSG00000105202	FBL	100	87.773	MGP_CAROLIEiJ_G0016207	Fbll1	77	86.250	Mus_caroli
ENSG00000105202	FBL	100	87.773	ENSMUSG00000051062	Fbll1	76	86.250	Mus_musculus
ENSG00000105202	FBL	100	100.000	ENSMUSG00000046865	Fbl	93	89.769	Mus_musculus
ENSG00000105202	FBL	100	100.000	MGP_PahariEiJ_G0012670	Fbl	95	89.769	Mus_pahari
ENSG00000105202	FBL	100	87.773	MGP_PahariEiJ_G0017343	Fbll1	75	86.555	Mus_pahari
ENSG00000105202	FBL	100	100.000	MGP_SPRETEiJ_G0030532	Fbl	93	89.769	Mus_spretus
ENSG00000105202	FBL	100	87.773	MGP_SPRETEiJ_G0017048	Fbll1	76	86.250	Mus_spretus
ENSG00000105202	FBL	100	87.336	ENSMPUG00000013045	FBLL1	89	85.294	Mustela_putorius_furo
ENSG00000105202	FBL	100	86.463	ENSMLUG00000011858	FBLL1	72	86.522	Myotis_lucifugus
ENSG00000105202	FBL	82	99.468	ENSMLUG00000030525	FBL	100	99.487	Myotis_lucifugus
ENSG00000105202	FBL	100	100.000	ENSNGAG00000022243	Fbl	82	93.750	Nannospalax_galili
ENSG00000105202	FBL	100	87.336	ENSNGAG00000012285	Fbll1	76	85.714	Nannospalax_galili
ENSG00000105202	FBL	100	89.520	ENSNBRG00000024409	fbl	81	89.076	Neolamprologus_brichardi
ENSG00000105202	FBL	100	87.773	ENSNLEG00000031565	FBLL1	68	87.773	Nomascus_leucogenys
ENSG00000105202	FBL	100	99.563	ENSNLEG00000014234	FBL	73	99.580	Nomascus_leucogenys
ENSG00000105202	FBL	100	93.013	ENSMEUG00000014684	-	77	92.017	Notamacropus_eugenii
ENSG00000105202	FBL	64	100.000	ENSOPRG00000010475	-	66	100.000	Ochotona_princeps
ENSG00000105202	FBL	70	90.625	ENSOPRG00000004127	-	98	90.244	Ochotona_princeps
ENSG00000105202	FBL	100	99.563	ENSODEG00000001001	FBL	100	96.012	Octodon_degus
ENSG00000105202	FBL	100	87.336	ENSODEG00000019199	FBLL1	73	86.809	Octodon_degus
ENSG00000105202	FBL	100	89.956	ENSONIG00000008042	fbl	73	89.121	Oreochromis_niloticus
ENSG00000105202	FBL	98	91.556	ENSOANG00000014658	-	90	90.870	Ornithorhynchus_anatinus
ENSG00000105202	FBL	100	99.127	ENSOCUG00000009027	FBL	100	98.084	Oryctolagus_cuniculus
ENSG00000105202	FBL	100	88.210	ENSOCUG00000007557	FBLL1	88	87.288	Oryctolagus_cuniculus
ENSG00000105202	FBL	100	90.393	ENSORLG00000003405	fbl	69	89.540	Oryzias_latipes
ENSG00000105202	FBL	100	90.393	ENSORLG00020022508	fbl	75	89.540	Oryzias_latipes_hni
ENSG00000105202	FBL	100	90.393	ENSORLG00015011532	fbl	74	89.540	Oryzias_latipes_hsok
ENSG00000105202	FBL	100	90.393	ENSOMEG00000019309	fbl	76	90.708	Oryzias_melastigma
ENSG00000105202	FBL	100	99.563	ENSOGAG00000006463	FBL	91	96.904	Otolemur_garnettii
ENSG00000105202	FBL	100	100.000	ENSOARG00000006339	FBL	69	100.000	Ovis_aries
ENSG00000105202	FBL	100	84.716	ENSOARG00000014603	FBLL1	90	84.549	Ovis_aries
ENSG00000105202	FBL	100	100.000	ENSPPAG00000034630	FBL	100	100.000	Pan_paniscus
ENSG00000105202	FBL	100	87.773	ENSPPAG00000015519	-	89	87.826	Pan_paniscus
ENSG00000105202	FBL	100	86.900	ENSPPRG00000020963	FBLL1	51	86.695	Panthera_pardus
ENSG00000105202	FBL	100	100.000	ENSPPRG00000002187	FBL	92	93.127	Panthera_pardus
ENSG00000105202	FBL	100	100.000	ENSPTIG00000008381	FBL	90	99.617	Panthera_tigris_altaica
ENSG00000105202	FBL	100	87.773	ENSPTRG00000046755	FBLL1	71	87.554	Pan_troglodytes
ENSG00000105202	FBL	100	100.000	ENSPTRG00000010982	FBL	100	100.000	Pan_troglodytes
ENSG00000105202	FBL	100	98.361	ENSPTRG00000040021	-	100	98.662	Pan_troglodytes
ENSG00000105202	FBL	100	100.000	ENSPANG00000004118	FBL	100	99.689	Papio_anubis
ENSG00000105202	FBL	100	87.773	ENSPANG00000024859	FBLL1	68	87.773	Papio_anubis
ENSG00000105202	FBL	100	89.956	ENSPKIG00000018971	fbl	76	88.750	Paramormyrops_kingsleyae
ENSG00000105202	FBL	100	92.576	ENSPSIG00000004704	-	94	91.250	Pelodiscus_sinensis
ENSG00000105202	FBL	96	90.909	ENSPMGG00000003564	fbl	76	90.708	Periophthalmus_magnuspinnatus
ENSG00000105202	FBL	100	100.000	ENSPEMG00000015440	-	94	90.572	Peromyscus_maniculatus_bairdii
ENSG00000105202	FBL	100	87.336	ENSPEMG00000020325	Fbll1	75	86.134	Peromyscus_maniculatus_bairdii
ENSG00000105202	FBL	100	82.533	ENSPMAG00000007777	fbl	72	82.427	Petromyzon_marinus
ENSG00000105202	FBL	100	92.576	ENSPCIG00000014607	-	74	91.667	Phascolarctos_cinereus
ENSG00000105202	FBL	100	89.083	ENSPFOG00000000133	fbl	77	88.285	Poecilia_formosa
ENSG00000105202	FBL	100	89.083	ENSPLAG00000021499	fbl	88	88.412	Poecilia_latipinna
ENSG00000105202	FBL	100	89.083	ENSPMEG00000001897	fbl	77	88.285	Poecilia_mexicana
ENSG00000105202	FBL	100	89.083	ENSPREG00000018169	fbl	77	88.285	Poecilia_reticulata
ENSG00000105202	FBL	100	100.000	ENSPPYG00000009979	FBL	100	99.381	Pongo_abelii
ENSG00000105202	FBL	100	82.533	ENSPCAG00000011523	FBL	76	83.333	Procavia_capensis
ENSG00000105202	FBL	100	87.773	ENSPCOG00000020746	FBLL1	77	87.554	Propithecus_coquereli
ENSG00000105202	FBL	100	99.127	ENSPCOG00000015915	FBL	99	95.975	Propithecus_coquereli
ENSG00000105202	FBL	100	99.563	ENSPVAG00000010849	FBL	100	96.262	Pteropus_vampyrus
ENSG00000105202	FBL	100	89.956	ENSPNYG00000014278	fbl	76	89.121	Pundamilia_nyererei
ENSG00000105202	FBL	100	90.393	ENSPNAG00000020888	fbl	75	89.474	Pygocentrus_nattereri
ENSG00000105202	FBL	100	88.210	ENSRNOG00000015303	Fbll1	82	82.331	Rattus_norvegicus
ENSG00000105202	FBL	100	100.000	ENSRNOG00000019229	Fbl	93	89.439	Rattus_norvegicus
ENSG00000105202	FBL	100	100.000	ENSRBIG00000029089	FBL	82	100.000	Rhinopithecus_bieti
ENSG00000105202	FBL	100	100.000	ENSRROG00000012374	FBL	100	99.688	Rhinopithecus_roxellana
ENSG00000105202	FBL	99	71.064	YDL014W	NOP1	72	71.064	Saccharomyces_cerevisiae
ENSG00000105202	FBL	100	99.127	ENSSBOG00000033498	FBL	76	99.170	Saimiri_boliviensis_boliviensis
ENSG00000105202	FBL	100	87.773	ENSSBOG00000019476	FBLL1	80	87.554	Saimiri_boliviensis_boliviensis
ENSG00000105202	FBL	100	92.576	ENSSHAG00000003274	-	74	91.667	Sarcophilus_harrisii
ENSG00000105202	FBL	100	90.393	ENSSFOG00015019399	fbl	76	89.167	Scleropages_formosus
ENSG00000105202	FBL	100	89.956	ENSSMAG00000011853	fbl	74	89.381	Scophthalmus_maximus
ENSG00000105202	FBL	100	89.956	ENSSDUG00000004103	fbl	73	88.703	Seriola_dumerili
ENSG00000105202	FBL	100	89.956	ENSSLDG00000002539	-	92	89.177	Seriola_lalandi_dorsalis
ENSG00000105202	FBL	100	89.956	ENSSLDG00000010053	fbl	73	88.703	Seriola_lalandi_dorsalis
ENSG00000105202	FBL	99	82.456	ENSSARG00000008709	FBL	75	82.158	Sorex_araneus
ENSG00000105202	FBL	100	89.956	ENSSPUG00000004770	-	75	88.750	Sphenodon_punctatus
ENSG00000105202	FBL	100	89.520	ENSSPAG00000019953	fbl	76	88.703	Stegastes_partitus
ENSG00000105202	FBL	100	100.000	ENSSSCG00000030510	FBL	99	96.865	Sus_scrofa
ENSG00000105202	FBL	100	88.210	ENSSSCG00000017013	FBLL1	99	74.390	Sus_scrofa
ENSG00000105202	FBL	100	89.520	ENSTRUG00000004408	fbl	79	89.083	Takifugu_rubripes
ENSG00000105202	FBL	100	89.956	ENSTNIG00000011668	fbl	77	88.703	Tetraodon_nigroviridis
ENSG00000105202	FBL	100	99.563	ENSTBEG00000007755	FBL	81	98.846	Tupaia_belangeri
ENSG00000105202	FBL	100	98.690	ENSTTRG00000003967	FBL	74	98.755	Tursiops_truncatus
ENSG00000105202	FBL	100	87.336	ENSTTRG00000016156	FBLL1	68	87.336	Tursiops_truncatus
ENSG00000105202	FBL	100	99.563	ENSUAMG00000001699	FBL	100	96.584	Ursus_americanus
ENSG00000105202	FBL	100	87.773	ENSUAMG00000023304	FBLL1	71	87.554	Ursus_americanus
ENSG00000105202	FBL	96	99.545	ENSUMAG00000019597	FBL	66	99.559	Ursus_maritimus
ENSG00000105202	FBL	100	100.000	ENSVVUG00000006111	FBL	92	94.118	Vulpes_vulpes
ENSG00000105202	FBL	100	87.773	ENSVVUG00000003074	FBLL1	80	87.446	Vulpes_vulpes
ENSG00000105202	FBL	100	90.393	ENSXETG00000017830	fbl	74	88.703	Xenopus_tropicalis
ENSG00000105202	FBL	100	89.083	ENSXCOG00000017201	fbl	70	88.412	Xiphophorus_couchianus
ENSG00000105202	FBL	100	89.083	ENSXMAG00000008522	fbl	76	88.285	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000494	box C/D snoRNA 3'-end processing	21873635.	IBA	Process
GO:0001094	TFIID-class transcription factor complex binding	17636026.	IPI	Function
GO:0001649	osteoblast differentiation	16210410.	HDA	Process
GO:0001650	fibrillar center	-	IDA	Component
GO:0001651	dense fibrillar component	-	IEA	Component
GO:0001652	granular component	-	IEA	Component
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0005515	protein binding	10837141.17498821.17636026.20926688.22720776.22916032.29568061.	IPI	Function
GO:0005634	nucleus	22720776.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	-	IEA	Component
GO:0005730	nucleolus	15494374.16687569.17158916.19208757.23203802.24352239.	IDA	Component
GO:0006364	rRNA processing	-	TAS	Process
GO:0008649	rRNA methyltransferase activity	21873635.	IBA	Function
GO:0015030	Cajal body	21873635.	IBA	Component
GO:0015030	Cajal body	16687569.	IDA	Component
GO:0016020	membrane	16210410.	HDA	Component
GO:0031167	rRNA methylation	21873635.	IBA	Process
GO:0031428	box C/D snoRNP complex	21873635.	IBA	Component
GO:0031428	box C/D snoRNP complex	17636026.	NAS	Component
GO:0032040	small-subunit processome	21873635.	IBA	Component
GO:0048254	snoRNA localization	17636026.	IMP	Process
GO:0051117	ATPase binding	17636026.	IPI	Function
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:1990258	histone glutamine methylation	21873635.	IBA	Process
GO:1990258	histone glutamine methylation	24352239.	IDA	Process
GO:1990259	histone-glutamine methyltransferase activity	21873635.	IBA	Function
GO:1990259	histone-glutamine methyltransferase activity	24352239.	IDA	Function

Cancer associated literatures

Show entries

Search:

PID	Title	Article	Time	Author	Doi
24029231	p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer.	Cancer Cell	2013 Sep 9	Marcel V	doi: 10.1016/j.ccr.2013.08.013.

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Differential Expression

Expression in 33 cancers

Mutations

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Search:

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
LUAD	chr19	39834460	3'UTR	novel		0.19
OV	chr19	39834473	3'UTR	novel		0.42
UCEC	chr19	39834491	3'UTR	novel		0.47
BRCA	chr19	39834496	3'UTR	novel		0.13
READ	chr19	39834515	3'UTR	rs764031942		0.55
COAD	chr19	39834544	Missense_Mutation	novel	K320N	0.2
UCEC	chr19	39834553	Frame_Shift_Del	NA	*K318Rfs2**	0.38
STAD	chr19	39834553	Frame_Shift_Del	NA	*K318Rfs2**	0.34
UCEC	chr19	39834553	Frame_Shift_Del	NA	*K318Rfs2**	0.11
COAD	chr19	39834553	Frame_Shift_Del	NA	*K318Rfs2**	0.09

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Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0451	0.054726
OV	AMP	0.3333	2.2539e-28
READ	DEL	0.0545	0.23023
UCS	DEL	0.1429	0.12448

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.036	Kaplan-Meier Survival Analysis
SARC	0.0022	Kaplan-Meier Survival Analysis
MESO	0.013	Kaplan-Meier Survival Analysis
ACC	0.00013	Kaplan-Meier Survival Analysis
SKCM	0.0002	Kaplan-Meier Survival Analysis
BRCA	0.0061	Kaplan-Meier Survival Analysis
ESCA	0.011	Kaplan-Meier Survival Analysis
KIRP	0.0034	Kaplan-Meier Survival Analysis
GBM	0.049	Kaplan-Meier Survival Analysis
LIHC	0.0012	Kaplan-Meier Survival Analysis
DLBC	0.018	Kaplan-Meier Survival Analysis
LUAD	0.025	Kaplan-Meier Survival Analysis
UVM	0.0032	Kaplan-Meier Survival Analysis
OV	0.015	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742