EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000105258 (Gene tree)
Gene ID: 5438
Gene Symbol: POLR2I
Alias: RPB9|hRPB14.5
Full Name: RNA polymerase II subunit I
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 1,638 bases
Position: chr19:36,113,709-36,115,346
Accession: 9196
RBP type: canonical RBP
Summary: This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000221859	RNA_POL_M_15KD	PF02150.16	2.5e-16	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17179178	Functional organization of the Rpb5 subunit shared by the three yeast RNA polymerases.	Nucleic Acids Res	2007	Zaros C	-
24354435	RNA polymerase II subunits exhibit a broad distribution of macromolecular assembly states in the interchromatin space of cell nuclei.	J Phys Chem B	2014 Jan 16	Tycon MA	doi: 10.1021/jp4082933

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000589591	POLR2I-206	542	-	-	- (aa)	-	-
ENST00000585842	POLR2I-202	368	-	ENSP00000465455	46 (aa)	-	K7EK49
ENST00000586439	POLR2I-203	744	-	ENSP00000467134	57 (aa)	-	K7ENX4
ENST00000221859	POLR2I-201	913	-	ENSP00000221859	125 (aa)	-	P36954
ENST00000586789	POLR2I-204	993	-	-	- (aa)	-	-
ENST00000592962	POLR2I-207	493	-	ENSP00000465755	88 (aa)	-	K7EKS1
ENST00000589069	POLR2I-205	582	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000105258's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03020	RNA polymerase	KEGG
hsa05016	Huntington disease	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000105258's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105258	POLR2I	97	96.694	ENSAPOG00000012409	polr2i	96	96.694	Acanthochromis_polyacanthus
ENSG00000105258	POLR2I	100	100.000	ENSAMEG00000000993	POLR2I	100	100.000	Ailuropoda_melanoleuca
ENSG00000105258	POLR2I	97	96.694	ENSAOCG00000024378	polr2i	96	96.694	Amphiprion_ocellaris
ENSG00000105258	POLR2I	97	96.694	ENSAPEG00000021748	polr2i	96	96.694	Amphiprion_percula
ENSG00000105258	POLR2I	97	96.694	ENSATEG00000000758	polr2i	96	96.694	Anabas_testudineus
ENSG00000105258	POLR2I	100	100.000	ENSANAG00000035318	POLR2I	100	100.000	Aotus_nancymaae
ENSG00000105258	POLR2I	100	95.455	ENSACLG00000001663	polr2i	96	97.521	Astatotilapia_calliptera
ENSG00000105258	POLR2I	97	97.521	ENSAMXG00000030198	polr2i	96	97.521	Astyanax_mexicanus
ENSG00000105258	POLR2I	100	100.000	ENSBTAG00000015002	POLR2I	100	100.000	Bos_taurus
ENSG00000105258	POLR2I	97	64.706	WBGene00022400	rpb-9	74	62.097	Caenorhabditis_elegans
ENSG00000105258	POLR2I	100	100.000	ENSCJAG00000009671	POLR2I	100	100.000	Callithrix_jacchus
ENSG00000105258	POLR2I	100	100.000	ENSCAFG00000006601	POLR2I	100	100.000	Canis_familiaris
ENSG00000105258	POLR2I	100	100.000	ENSCAFG00020018113	POLR2I	100	100.000	Canis_lupus_dingo
ENSG00000105258	POLR2I	100	100.000	ENSCHIG00000011961	POLR2I	100	100.000	Capra_hircus
ENSG00000105258	POLR2I	100	100.000	ENSTSYG00000028318	-	100	100.000	Carlito_syrichta
ENSG00000105258	POLR2I	82	69.903	ENSTSYG00000031752	-	95	69.903	Carlito_syrichta
ENSG00000105258	POLR2I	100	100.000	ENSCPOG00000012097	POLR2I	100	100.000	Cavia_porcellus
ENSG00000105258	POLR2I	100	100.000	ENSCCAG00000022138	-	100	100.000	Cebus_capucinus
ENSG00000105258	POLR2I	100	98.400	ENSCCAG00000032214	-	100	98.400	Cebus_capucinus
ENSG00000105258	POLR2I	100	100.000	ENSCATG00000017413	POLR2I	100	100.000	Cercocebus_atys
ENSG00000105258	POLR2I	100	100.000	ENSCLAG00000011800	POLR2I	100	100.000	Chinchilla_lanigera
ENSG00000105258	POLR2I	100	100.000	ENSCSAG00000004254	POLR2I	100	100.000	Chlorocebus_sabaeus
ENSG00000105258	POLR2I	100	99.200	ENSCPBG00000006726	POLR2I	100	99.200	Chrysemys_picta_bellii
ENSG00000105258	POLR2I	91	83.750	ENSCSAVG00000010630	-	93	80.342	Ciona_savignyi
ENSG00000105258	POLR2I	100	100.000	ENSCANG00000031951	POLR2I	100	100.000	Colobus_angolensis_palliatus
ENSG00000105258	POLR2I	97	95.041	ENSCSEG00000002213	polr2i	96	95.041	Cynoglossus_semilaevis
ENSG00000105258	POLR2I	97	95.041	ENSCVAG00000014797	polr2i	96	95.041	Cyprinodon_variegatus
ENSG00000105258	POLR2I	97	95.868	ENSDARG00000040443	polr2i	96	95.868	Danio_rerio
ENSG00000105258	POLR2I	100	100.000	ENSDNOG00000015842	POLR2I	100	100.000	Dasypus_novemcinctus
ENSG00000105258	POLR2I	89	76.577	ENSDORG00000028728	-	95	76.577	Dipodomys_ordii
ENSG00000105258	POLR2I	77	76.042	ENSDORG00000028026	-	99	76.042	Dipodomys_ordii
ENSG00000105258	POLR2I	93	76.829	ENSDORG00000029259	-	95	78.070	Dipodomys_ordii
ENSG00000105258	POLR2I	100	100.000	ENSDORG00000001852	-	100	100.000	Dipodomys_ordii
ENSG00000105258	POLR2I	91	83.750	FBgn0004855	RpII15	91	78.632	Drosophila_melanogaster
ENSG00000105258	POLR2I	100	100.000	ENSETEG00000012679	POLR2I	100	100.000	Echinops_telfairi
ENSG00000105258	POLR2I	97	92.562	ENSEBUG00000007333	polr2i	100	95.146	Eptatretus_burgeri
ENSG00000105258	POLR2I	100	100.000	ENSEASG00005002231	POLR2I	100	100.000	Equus_asinus_asinus
ENSG00000105258	POLR2I	100	100.000	ENSECAG00000013654	POLR2I	100	100.000	Equus_caballus
ENSG00000105258	POLR2I	100	100.000	ENSEEUG00000002113	POLR2I	100	100.000	Erinaceus_europaeus
ENSG00000105258	POLR2I	97	97.521	ENSELUG00000018012	polr2i	96	97.521	Esox_lucius
ENSG00000105258	POLR2I	100	100.000	ENSFCAG00000026052	POLR2I	100	100.000	Felis_catus
ENSG00000105258	POLR2I	72	92.063	ENSFALG00000006198	POLR2I	100	92.063	Ficedula_albicollis
ENSG00000105258	POLR2I	100	100.000	ENSFDAG00000011350	POLR2I	100	100.000	Fukomys_damarensis
ENSG00000105258	POLR2I	97	94.215	ENSFHEG00000015659	polr2i	96	94.215	Fundulus_heteroclitus
ENSG00000105258	POLR2I	97	97.521	ENSGMOG00000013806	polr2i	96	97.521	Gadus_morhua
ENSG00000105258	POLR2I	100	94.400	ENSGALG00000038595	POLR2I	96	94.400	Gallus_gallus
ENSG00000105258	POLR2I	97	96.694	ENSGAFG00000001037	polr2i	96	96.694	Gambusia_affinis
ENSG00000105258	POLR2I	100	96.591	ENSGACG00000006679	polr2i	98	96.000	Gasterosteus_aculeatus
ENSG00000105258	POLR2I	100	99.200	ENSGAGG00000015806	POLR2I	100	99.200	Gopherus_agassizii
ENSG00000105258	POLR2I	100	100.000	ENSGGOG00000015426	POLR2I	100	100.000	Gorilla_gorilla
ENSG00000105258	POLR2I	100	96.629	ENSHBUG00000004140	polr2i	100	96.032	Haplochromis_burtoni
ENSG00000105258	POLR2I	82	100.000	ENSHGLG00000007388	POLR2I	100	100.000	Heterocephalus_glaber_female
ENSG00000105258	POLR2I	82	100.000	ENSHGLG00100014515	POLR2I	100	100.000	Heterocephalus_glaber_male
ENSG00000105258	POLR2I	97	97.521	ENSHCOG00000010967	polr2i	96	97.521	Hippocampus_comes
ENSG00000105258	POLR2I	97	95.868	ENSIPUG00000001127	polr2i	96	95.868	Ictalurus_punctatus
ENSG00000105258	POLR2I	100	100.000	ENSSTOG00000009411	POLR2I	100	100.000	Ictidomys_tridecemlineatus
ENSG00000105258	POLR2I	100	100.000	ENSJJAG00000014400	Polr2i	100	100.000	Jaculus_jaculus
ENSG00000105258	POLR2I	97	96.694	ENSKMAG00000001567	polr2i	96	96.694	Kryptolebias_marmoratus
ENSG00000105258	POLR2I	97	97.521	ENSLBEG00000001220	polr2i	96	97.521	Labrus_bergylta
ENSG00000105258	POLR2I	95	98.810	ENSLBEG00000028538	-	94	98.810	Labrus_bergylta
ENSG00000105258	POLR2I	100	95.200	ENSLACG00000009590	POLR2I	100	95.200	Latimeria_chalumnae
ENSG00000105258	POLR2I	97	97.521	ENSLOCG00000014818	polr2i	96	97.521	Lepisosteus_oculatus
ENSG00000105258	POLR2I	100	100.000	ENSLAFG00000015527	POLR2I	100	100.000	Loxodonta_africana
ENSG00000105258	POLR2I	100	100.000	ENSMFAG00000039443	POLR2I	100	100.000	Macaca_fascicularis
ENSG00000105258	POLR2I	82	100.000	ENSMMUG00000000522	POLR2I	100	100.000	Macaca_mulatta
ENSG00000105258	POLR2I	100	99.200	ENSMNEG00000029421	POLR2I	100	99.200	Macaca_nemestrina
ENSG00000105258	POLR2I	100	100.000	ENSMLEG00000039720	POLR2I	100	100.000	Mandrillus_leucophaeus
ENSG00000105258	POLR2I	97	95.868	ENSMAMG00000013970	polr2i	96	95.868	Mastacembelus_armatus
ENSG00000105258	POLR2I	97	97.521	ENSMZEG00005013082	polr2i	96	97.521	Maylandia_zebra
ENSG00000105258	POLR2I	100	94.400	ENSMGAG00000008576	POLR2I	100	94.400	Meleagris_gallopavo
ENSG00000105258	POLR2I	100	100.000	ENSMAUG00000001001	Polr2i	100	100.000	Mesocricetus_auratus
ENSG00000105258	POLR2I	100	100.000	ENSMICG00000010241	POLR2I	100	100.000	Microcebus_murinus
ENSG00000105258	POLR2I	100	100.000	ENSMOCG00000011984	Polr2i	100	100.000	Microtus_ochrogaster
ENSG00000105258	POLR2I	82	97.087	ENSMMOG00000004945	polr2i	100	97.087	Mola_mola
ENSG00000105258	POLR2I	100	100.000	ENSMODG00000014172	POLR2I	100	100.000	Monodelphis_domestica
ENSG00000105258	POLR2I	100	100.000	MGP_CAROLIEiJ_G0029507	Polr2i	100	100.000	Mus_caroli
ENSG00000105258	POLR2I	100	100.000	ENSMUSG00000019738	Polr2i	100	100.000	Mus_musculus
ENSG00000105258	POLR2I	100	100.000	MGP_PahariEiJ_G0012741	Polr2i	100	100.000	Mus_pahari
ENSG00000105258	POLR2I	100	100.000	MGP_SPRETEiJ_G0030603	Polr2i	100	100.000	Mus_spretus
ENSG00000105258	POLR2I	100	100.000	ENSMPUG00000005702	POLR2I	100	100.000	Mustela_putorius_furo
ENSG00000105258	POLR2I	100	100.000	ENSMLUG00000012317	POLR2I	100	100.000	Myotis_lucifugus
ENSG00000105258	POLR2I	100	100.000	ENSNGAG00000014966	Polr2i	100	100.000	Nannospalax_galili
ENSG00000105258	POLR2I	97	96.694	ENSNBRG00000000723	polr2i	96	96.694	Neolamprologus_brichardi
ENSG00000105258	POLR2I	100	100.000	ENSNLEG00000011691	POLR2I	100	100.000	Nomascus_leucogenys
ENSG00000105258	POLR2I	100	99.200	ENSOPRG00000001789	-	100	99.200	Ochotona_princeps
ENSG00000105258	POLR2I	100	98.864	ENSOPRG00000008681	-	100	98.400	Ochotona_princeps
ENSG00000105258	POLR2I	93	82.759	ENSODEG00000017901	-	88	82.759	Octodon_degus
ENSG00000105258	POLR2I	100	100.000	ENSODEG00000015015	-	100	100.000	Octodon_degus
ENSG00000105258	POLR2I	97	97.521	ENSONIG00000005397	polr2i	96	97.521	Oreochromis_niloticus
ENSG00000105258	POLR2I	100	100.000	ENSOCUG00000013044	POLR2I	100	100.000	Oryctolagus_cuniculus
ENSG00000105258	POLR2I	100	97.600	ENSOCUG00000024998	-	100	97.600	Oryctolagus_cuniculus
ENSG00000105258	POLR2I	97	95.868	ENSORLG00000013308	polr2i	96	95.868	Oryzias_latipes
ENSG00000105258	POLR2I	97	95.868	ENSORLG00020011281	polr2i	96	95.868	Oryzias_latipes_hni
ENSG00000105258	POLR2I	97	95.868	ENSORLG00015019529	polr2i	96	95.868	Oryzias_latipes_hsok
ENSG00000105258	POLR2I	97	95.868	ENSOMEG00000012586	polr2i	96	95.868	Oryzias_melastigma
ENSG00000105258	POLR2I	100	100.000	ENSOGAG00000024254	POLR2I	100	100.000	Otolemur_garnettii
ENSG00000105258	POLR2I	100	100.000	ENSOARG00000005266	POLR2I	100	100.000	Ovis_aries
ENSG00000105258	POLR2I	100	100.000	ENSPPAG00000033446	POLR2I	100	100.000	Pan_paniscus
ENSG00000105258	POLR2I	100	100.000	ENSPPRG00000007194	POLR2I	100	100.000	Panthera_pardus
ENSG00000105258	POLR2I	100	100.000	ENSPTIG00000018661	POLR2I	100	100.000	Panthera_tigris_altaica
ENSG00000105258	POLR2I	100	100.000	ENSPTRG00000010885	POLR2I	100	100.000	Pan_troglodytes
ENSG00000105258	POLR2I	100	100.000	ENSPANG00000004508	POLR2I	100	100.000	Papio_anubis
ENSG00000105258	POLR2I	97	97.521	ENSPKIG00000001086	polr2i	96	97.521	Paramormyrops_kingsleyae
ENSG00000105258	POLR2I	82	100.000	ENSPSIG00000011560	POLR2I	100	100.000	Pelodiscus_sinensis
ENSG00000105258	POLR2I	97	92.000	ENSPMGG00000016154	polr2i	96	92.000	Periophthalmus_magnuspinnatus
ENSG00000105258	POLR2I	100	100.000	ENSPEMG00000014212	Polr2i	100	100.000	Peromyscus_maniculatus_bairdii
ENSG00000105258	POLR2I	100	100.000	ENSPCIG00000015436	-	100	100.000	Phascolarctos_cinereus
ENSG00000105258	POLR2I	97	96.694	ENSPFOG00000016816	polr2i	96	96.694	Poecilia_formosa
ENSG00000105258	POLR2I	97	96.694	ENSPLAG00000010639	polr2i	96	96.694	Poecilia_latipinna
ENSG00000105258	POLR2I	97	96.694	ENSPMEG00000005956	polr2i	96	96.694	Poecilia_mexicana
ENSG00000105258	POLR2I	97	96.694	ENSPREG00000004227	polr2i	96	96.694	Poecilia_reticulata
ENSG00000105258	POLR2I	100	100.000	ENSPPYG00000009897	POLR2I	100	100.000	Pongo_abelii
ENSG00000105258	POLR2I	100	100.000	ENSPCAG00000003494	POLR2I	100	100.000	Procavia_capensis
ENSG00000105258	POLR2I	100	100.000	ENSPCOG00000018643	POLR2I	100	100.000	Propithecus_coquereli
ENSG00000105258	POLR2I	100	100.000	ENSPVAG00000012883	POLR2I	100	100.000	Pteropus_vampyrus
ENSG00000105258	POLR2I	97	97.521	ENSPNYG00000011908	polr2i	96	97.521	Pundamilia_nyererei
ENSG00000105258	POLR2I	97	97.521	ENSPNAG00000005859	polr2i	96	97.521	Pygocentrus_nattereri
ENSG00000105258	POLR2I	100	100.000	ENSRNOG00000050560	Polr2i	100	100.000	Rattus_norvegicus
ENSG00000105258	POLR2I	100	100.000	ENSRNOG00000020799	LOC103690054	100	100.000	Rattus_norvegicus
ENSG00000105258	POLR2I	100	100.000	ENSRBIG00000037225	POLR2I	100	100.000	Rhinopithecus_bieti
ENSG00000105258	POLR2I	100	100.000	ENSRROG00000042843	POLR2I	100	100.000	Rhinopithecus_roxellana
ENSG00000105258	POLR2I	89	45.045	YGL070C	RPB9	89	45.045	Saccharomyces_cerevisiae
ENSG00000105258	POLR2I	100	78.400	ENSSBOG00000022998	-	74	78.400	Saimiri_boliviensis_boliviensis
ENSG00000105258	POLR2I	100	100.000	ENSSBOG00000030799	-	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000105258	POLR2I	97	97.521	ENSSFOG00015022523	polr2i	96	97.521	Scleropages_formosus
ENSG00000105258	POLR2I	97	96.694	ENSSMAG00000003335	polr2i	96	96.694	Scophthalmus_maximus
ENSG00000105258	POLR2I	97	96.694	ENSSDUG00000005483	polr2i	96	96.694	Seriola_dumerili
ENSG00000105258	POLR2I	97	96.694	ENSSLDG00000009341	polr2i	96	96.694	Seriola_lalandi_dorsalis
ENSG00000105258	POLR2I	100	100.000	ENSSARG00000009331	POLR2I	100	100.000	Sorex_araneus
ENSG00000105258	POLR2I	100	97.727	ENSSPUG00000012658	POLR2I	100	97.600	Sphenodon_punctatus
ENSG00000105258	POLR2I	97	97.521	ENSSPAG00000015734	polr2i	96	97.521	Stegastes_partitus
ENSG00000105258	POLR2I	100	100.000	ENSSSCG00000039196	POLR2I	100	100.000	Sus_scrofa
ENSG00000105258	POLR2I	97	97.521	ENSTRUG00000022235	polr2i	96	97.521	Takifugu_rubripes
ENSG00000105258	POLR2I	97	97.521	ENSTNIG00000011737	polr2i	96	97.521	Tetraodon_nigroviridis
ENSG00000105258	POLR2I	100	100.000	ENSTTRG00000003919	POLR2I	100	100.000	Tursiops_truncatus
ENSG00000105258	POLR2I	100	100.000	ENSUAMG00000020575	POLR2I	100	100.000	Ursus_americanus
ENSG00000105258	POLR2I	100	100.000	ENSUMAG00000020809	POLR2I	100	100.000	Ursus_maritimus
ENSG00000105258	POLR2I	100	100.000	ENSVVUG00000013588	POLR2I	100	100.000	Vulpes_vulpes
ENSG00000105258	POLR2I	97	96.694	ENSXCOG00000001119	polr2i	96	96.694	Xiphophorus_couchianus
ENSG00000105258	POLR2I	97	96.694	ENSXMAG00000021278	polr2i	96	96.694	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0001193	maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter	21873635.	IBA	Process
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	21873635.	IBA	Function
GO:0005634	nucleus	9852112.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005665	RNA polymerase II, core complex	21873635.	IBA	Component
GO:0005665	RNA polymerase II, core complex	9852112.	IDA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0006283	transcription-coupled nucleotide-excision repair	21873635.	IBA	Process
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006351	transcription, DNA-templated	-	TAS	Process
GO:0006366	transcription by RNA polymerase II	9852112.	IDA	Process
GO:0006366	transcription by RNA polymerase II	-	TAS	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	21873635.	IBA	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	Process
GO:0006370	7-methylguanosine mRNA capping	-	TAS	Process
GO:0006379	mRNA cleavage	-	IEA	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	Process
GO:0016070	RNA metabolic process	-	TAS	Process
GO:0035019	somatic stem cell population maintenance	-	TAS	Process
GO:0042795	snRNA transcription by RNA polymerase II	-	TAS	Process
GO:0050434	positive regulation of viral transcription	-	TAS	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process