EuRBPDB

Description

Ensembl ID: ENSG00000105298 (Gene tree)
Gene ID: 58509
Gene Symbol: CACTIN
Alias: NY-REN-24|fSAPc|cactin|C19orf29
Full Name: cactin, spliceosome C complex subunit
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 16,188 bases
Position: chr19:3,610,628-3,626,815
Accession: 29938
RBP type: non-canonical RBP
Summary: (Cactin, Spliceosome C Complex Subunit) is a Protein Coding gene. An important paralog of this gene is MARVELD3.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000587175	CACTIN-205	2216	-	-	- (aa)	-	-
ENST00000591978	CACTIN-209	2283	-	-	- (aa)	-	-
ENST00000588749	CACTIN-206	391	-	ENSP00000467788	130 (aa)	-	K7EQE3
ENST00000589321	CACTIN-207	1708	-	ENSP00000466600	141 (aa)	-	K7EMQ0
ENST00000592721	CACTIN-210	1220	-	ENSP00000467149	291 (aa)	-	K7ENY9
ENST00000429344	CACTIN-203	3612	XM_011528160	ENSP00000415078	758 (aa)	XP_011526462	Q8WUQ7
ENST00000248420	CACTIN-202	2671	-	ENSP00000248420	758 (aa)	-	Q8WUQ7
ENST00000585942	CACTIN-204	2810	-	ENSP00000465751	758 (aa)	-	Q8WUQ7
ENST00000591726	CACTIN-208	699	-	ENSP00000464898	117 (aa)	-	K7EIU6
ENST00000221899	CACTIN-201	2797	-	ENSP00000221899	758 (aa)	-	Q8WUQ7

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000105298	Insulin-Like Growth Factor Binding Protein 3	6E-6	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000105298	rs12977510	19	3613474	A	Obesity-related traits	23251661	[NR] ng/mL increase	0.03	EFO_0004626

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105298	CACTIN	99	98.571	ENSMUSG00000034889	Cactin	97	90.411	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0001933	negative regulation of protein phosphorylation	20829348.	IMP	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	20829348.	IPI	Function
GO:0005634	nucleus	15302935.20829348.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0007275	multicellular organism development	-	IEA	Process
GO:0016607	nuclear speck	-	IDA	Component
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	20829348.	IMP	Process
GO:0032088	negative regulation of NF-kappaB transcription factor activity	20829348.	IDA	Process
GO:0032688	negative regulation of interferon-beta production	20829348.	IMP	Process
GO:0032717	negative regulation of interleukin-8 production	20829348.	IDA	Process
GO:0032720	negative regulation of tumor necrosis factor production	20829348.	IDA	Process
GO:0034122	negative regulation of toll-like receptor signaling pathway	20829348.	IDA	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0060339	negative regulation of type I interferon-mediated signaling pathway	20829348.	IMP	Process
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component
GO:0071222	cellular response to lipopolysaccharide	20829348.	IDA	Process
GO:0071347	cellular response to interleukin-1	20829348.	IDA	Process
GO:0071356	cellular response to tumor necrosis factor	20829348.	IDA	Process