EuRBPDB

Description

Ensembl ID: ENSG00000105355 (Gene tree)
Gene ID: 10226
Gene Symbol: PLIN3
Alias: TIP47|PP17|M6PRBP1
Full Name: perilipin 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 29,435 bases
Position: chr19:4,838,334-4,867,768
Accession: 16893
RBP type: non-canonical RBP
Summary: Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17330940	Altered chaperone and protein turnover regulators expression in cultured skin fibroblasts from type 1 diabetes mellitus with nephropathy.	J Proteome Res	2007 Mar	Tessari P	-
23593007	Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein.	PLoS Pathog	2013	Vogt DA	doi: 10.1371/journal.ppat.1003302

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000592528	PLIN3-207	2154	-	ENSP00000467803	422 (aa)	-	O60664
ENST00000585479	PLIN3-202	1535	-	ENSP00000465596	433 (aa)	-	O60664
ENST00000589494	PLIN3-206	629	-	ENSP00000468096	168 (aa)	-	K7ER39
ENST00000587462	PLIN3-203	604	-	ENSP00000465117	35 (aa)	-	K7EJD0
ENST00000221957	PLIN3-201	2333	-	ENSP00000221957	434 (aa)	-	O60664
ENST00000589034	PLIN3-204	574	-	ENSP00000465975	172 (aa)	-	K7EL96
ENST00000589163	PLIN3-205	1699	-	ENSP00000468476	292 (aa)	-	K7ERZ3

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000105355	Personality Inventory	6.598e-005	-
ENSG00000105355	Blood Glucose	7.1730000E-005	-
ENSG00000105355	Platelet Function Tests	4.9054719E-006	-
ENSG00000105355	Platelet Function Tests	1.0543100E-005	-
ENSG00000105355	Platelet Function Tests	2.4523669E-006	-
ENSG00000105355	Electrocardiography	6E-6	24324551
ENSG00000105355	Trypanosoma cruzi	6E-6	24324551
ENSG00000105355	Depressive Disorder	1E-6	27723809
ENSG00000105355	Interferons	1E-6	27723809
ENSG00000105355	Hepatitis C, Chronic	1E-6	27723809

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000105355	rs72981884	19	4840787	G	Lung cancer in ever smokers	28604730	[1.18-1.46]	1.3132664	EFO_0006527\|EFO_0001071
ENSG00000105355	rs2779180	19	4841139	?	Depression in response to interferon-based therapy in chronic hepatitis C	27723809	NR	2.564103	EFO_0004220\|EFO_0007859\|EFO_0007006

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	19490898.23593007.25416956.	IPI	Function
GO:0005737	cytoplasm	9590177.	TAS	Component
GO:0005768	endosome	9590177.	TAS	Component
GO:0005794	Golgi apparatus	9590177.	TAS	Component
GO:0005811	lipid droplet	14741744.21498505.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0010008	endosome membrane	-	IEA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016192	vesicle-mediated transport	9590177.	TAS	Process
GO:0030133	transport vesicle	-	TAS	Component
GO:0045296	cadherin binding	25468996.	HDA	Function