EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000105373 (Gene tree)
Gene ID: 29997
Gene Symbol: NOP53
Alias: PICT-1|PICT1|GLTSCR2
Full Name: NOP53 ribosome biogenesis factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 11,545 bases
Position: chr19:47,745,522-47,757,066
Accession: 4333
RBP type: canonical RBP
Summary: (NOP53 Ribosome Biogenesis Factor) is a Protein Coding gene. Diseases associated with NOP53 include Human Herpesvirus 8. Among its related pathways are PI3K / Akt Signaling and Translational Control.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000246802	Nop53	PF07767.11	6.3e-104	1	1
ENSP00000468948	Nop53	PF07767.11	1.6e-40	1	1
ENSP00000470263	Nop53	PF07767.11	6.2e-32	1	2
ENSP00000470263	Nop53	PF07767.11	6.2e-32	2	2
ENSP00000470190	Nop53	PF07767.11	4.1e-27	1	1
ENSP00000470773	Nop53	PF07767.11	7.4e-21	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24928548	Gene expression analysis in MCF-7 breast cancer cells treated with recombinant bromelain.	Appl Biochem Biotechnol	2014 Aug	Fouz N	doi: 10.1007/s12010-014-0947-6
9207027	Location of the internal ribosome entry site in the 5' non-coding region of the immunoglobulin heavy-chain binding protein (BiP) mRNA: evidence for specific RNA-protein interactions.	Nucleic Acids Res	1997 Jul 15	Yang Q	-
8419928	Apolipoprotein B mRNA editing is associated with UV crosslinking of proteins to the editing site.	Proc Natl Acad Sci U S A	1993 Jan 1	Navaratnam N	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000595143	NOP53-204	810	-	ENSP00000468948	265 (aa)	-	M0QX73
ENST00000598285	NOP53-206	265	-	-	- (aa)	-	-
ENST00000599582	NOP53-210	626	-	-	- (aa)	-	-
ENST00000599253	NOP53-209	689	-	-	- (aa)	-	-
ENST00000594182	NOP53-202	303	-	ENSP00000470773	99 (aa)	-	M0QZU5
ENST00000597985	NOP53-205	656	-	ENSP00000470263	200 (aa)	-	M0QZ34
ENST00000598681	NOP53-207	1358	-	-	- (aa)	-	-
ENST00000594525	NOP53-203	876	-	-	- (aa)	-	-
ENST00000600266	NOP53-211	666	-	-	- (aa)	-	-
ENST00000246802	NOP53-201	1528	-	ENSP00000246802	478 (aa)	-	Q9NZM5
ENST00000600410	NOP53-212	4185	-	-	- (aa)	-	-
ENST00000598959	NOP53-208	501	-	ENSP00000470190	149 (aa)	-	M0QYZ9

Gene Model

Click here to download ENSG00000105373's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000105373's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105373	NOP53	99	67.857	ENSAPOG00000006446	nop53	97	46.652	Acanthochromis_polyacanthus
ENSG00000105373	NOP53	92	95.588	ENSAMEG00000015214	NOP53	100	80.325	Ailuropoda_melanoleuca
ENSG00000105373	NOP53	97	68.675	ENSACIG00000002467	nop53	98	46.910	Amphilophus_citrinellus
ENSG00000105373	NOP53	99	67.857	ENSAOCG00000007002	nop53	97	46.537	Amphiprion_ocellaris
ENSG00000105373	NOP53	99	67.857	ENSAPEG00000024564	nop53	97	46.652	Amphiprion_percula
ENSG00000105373	NOP53	90	66.154	ENSATEG00000021860	nop53	97	46.916	Anabas_testudineus
ENSG00000105373	NOP53	91	77.647	ENSACAG00000011362	-	100	58.305	Anolis_carolinensis
ENSG00000105373	NOP53	98	100.000	ENSANAG00000007933	NOP53	100	86.057	Aotus_nancymaae
ENSG00000105373	NOP53	99	67.857	ENSACLG00000011832	nop53	97	47.084	Astatotilapia_calliptera
ENSG00000105373	NOP53	99	69.412	ENSAMXG00000014883	nop53	89	49.289	Astyanax_mexicanus
ENSG00000105373	NOP53	99	95.294	ENSBTAG00000021192	NOP53	91	84.091	Bos_taurus
ENSG00000105373	NOP53	96	100.000	ENSCJAG00000011385	NOP53	100	92.531	Callithrix_jacchus
ENSG00000105373	NOP53	98	94.937	ENSCAFG00000004080	NOP53	100	84.058	Canis_familiaris
ENSG00000105373	NOP53	99	94.048	ENSCHIG00000009393	NOP53	100	85.177	Capra_hircus
ENSG00000105373	NOP53	92	94.118	ENSTSYG00000036631	NOP53	99	77.684	Carlito_syrichta
ENSG00000105373	NOP53	98	93.750	ENSCAPG00000013148	NOP53	100	82.071	Cavia_aperea
ENSG00000105373	NOP53	98	92.500	ENSCPOG00000015665	NOP53	100	82.427	Cavia_porcellus
ENSG00000105373	NOP53	97	97.436	ENSCCAG00000025477	NOP53	100	93.724	Cebus_capucinus
ENSG00000105373	NOP53	97	100.000	ENSCATG00000032842	NOP53	100	96.653	Cercocebus_atys
ENSG00000105373	NOP53	98	96.250	ENSCLAG00000001860	NOP53	100	81.535	Chinchilla_lanigera
ENSG00000105373	NOP53	100	96.862	ENSCSAG00000002928	NOP53	100	96.862	Chlorocebus_sabaeus
ENSG00000105373	NOP53	96	79.221	ENSCPBG00000009047	NOP53	95	59.611	Chrysemys_picta_bellii
ENSG00000105373	NOP53	72	60.811	ENSCING00000021395	-	96	33.565	Ciona_intestinalis
ENSG00000105373	NOP53	72	64.865	ENSCSAVG00000006009	-	95	35.581	Ciona_savignyi
ENSG00000105373	NOP53	97	100.000	ENSCANG00000039648	NOP53	100	89.121	Colobus_angolensis_palliatus
ENSG00000105373	NOP53	98	91.358	ENSCGRG00001019033	Nop53	100	79.668	Cricetulus_griseus_chok1gshd
ENSG00000105373	NOP53	99	69.048	ENSCSEG00000014834	nop53	89	45.070	Cynoglossus_semilaevis
ENSG00000105373	NOP53	99	71.429	ENSCVAG00000005940	nop53	97	47.761	Cyprinodon_variegatus
ENSG00000105373	NOP53	99	75.000	ENSDARG00000100452	nop53	100	55.080	Danio_rerio
ENSG00000105373	NOP53	98	98.750	ENSDNOG00000005165	NOP53	91	86.192	Dasypus_novemcinctus
ENSG00000105373	NOP53	72	83.770	ENSDORG00000016339	-	100	83.103	Dipodomys_ordii
ENSG00000105373	NOP53	80	88.608	ENSETEG00000003679	-	57	77.880	Echinops_telfairi
ENSG00000105373	NOP53	97	70.000	ENSEBUG00000012747	nop53	91	43.119	Eptatretus_burgeri
ENSG00000105373	NOP53	98	93.750	ENSEASG00005004345	NOP53	96	84.583	Equus_asinus_asinus
ENSG00000105373	NOP53	98	95.000	ENSECAG00000026850	NOP53	96	84.330	Equus_caballus
ENSG00000105373	NOP53	91	98.485	ENSEEUG00000005287	NOP53	87	98.485	Erinaceus_europaeus
ENSG00000105373	NOP53	99	71.429	ENSELUG00000001525	nop53	89	48.492	Esox_lucius
ENSG00000105373	NOP53	98	93.750	ENSFCAG00000010861	NOP53	100	84.124	Felis_catus
ENSG00000105373	NOP53	99	81.034	ENSFDAG00000010478	NOP53	100	68.894	Fukomys_damarensis
ENSG00000105373	NOP53	99	73.494	ENSFHEG00000017763	nop53	94	47.034	Fundulus_heteroclitus
ENSG00000105373	NOP53	99	69.880	ENSGMOG00000014299	nop53	88	45.585	Gadus_morhua
ENSG00000105373	NOP53	97	70.513	ENSGALG00000039473	NOP53	77	53.518	Gallus_gallus
ENSG00000105373	NOP53	99	72.826	ENSGAFG00000013301	nop53	95	46.186	Gambusia_affinis
ENSG00000105373	NOP53	99	59.459	ENSGACG00000005766	nop53	88	48.000	Gasterosteus_aculeatus
ENSG00000105373	NOP53	97	100.000	ENSGGOG00000005462	NOP53	100	94.969	Gorilla_gorilla
ENSG00000105373	NOP53	95	94.937	ENSGGOG00000024728	-	100	84.937	Gorilla_gorilla
ENSG00000105373	NOP53	99	67.857	ENSHBUG00000023625	nop53	97	47.084	Haplochromis_burtoni
ENSG00000105373	NOP53	98	92.500	ENSHGLG00000018240	NOP53	100	79.167	Heterocephalus_glaber_female
ENSG00000105373	NOP53	99	92.593	ENSHGLG00100015613	NOP53	100	86.614	Heterocephalus_glaber_male
ENSG00000105373	NOP53	99	67.470	ENSHCOG00000017133	nop53	89	45.872	Hippocampus_comes
ENSG00000105373	NOP53	99	74.118	ENSIPUG00000008154	nop53	78	52.029	Ictalurus_punctatus
ENSG00000105373	NOP53	99	95.062	ENSSTOG00000022092	NOP53	100	83.473	Ictidomys_tridecemlineatus
ENSG00000105373	NOP53	97	97.468	ENSJJAG00000007854	Nop53	100	81.042	Jaculus_jaculus
ENSG00000105373	NOP53	90	69.231	ENSKMAG00000020756	nop53	97	45.861	Kryptolebias_marmoratus
ENSG00000105373	NOP53	98	68.675	ENSLBEG00000011432	nop53	89	46.882	Labrus_bergylta
ENSG00000105373	NOP53	95	75.000	ENSLACG00000018320	NOP53	100	50.868	Latimeria_chalumnae
ENSG00000105373	NOP53	95	68.675	ENSLOCG00000014178	nop53	88	51.429	Lepisosteus_oculatus
ENSG00000105373	NOP53	97	100.000	ENSMFAG00000045103	NOP53	100	96.653	Macaca_fascicularis
ENSG00000105373	NOP53	100	97.000	ENSMMUG00000013348	NOP53	100	97.000	Macaca_mulatta
ENSG00000105373	NOP53	97	100.000	ENSMNEG00000042540	NOP53	96	96.862	Macaca_nemestrina
ENSG00000105373	NOP53	97	100.000	ENSMLEG00000032475	NOP53	100	80.625	Mandrillus_leucophaeus
ENSG00000105373	NOP53	99	72.414	ENSMAMG00000012652	nop53	97	48.085	Mastacembelus_armatus
ENSG00000105373	NOP53	99	67.857	ENSMZEG00005005033	nop53	96	44.783	Maylandia_zebra
ENSG00000105373	NOP53	99	90.476	ENSMAUG00000012617	Nop53	100	80.208	Mesocricetus_auratus
ENSG00000105373	NOP53	98	96.203	ENSMICG00000005580	NOP53	95	88.249	Microcebus_murinus
ENSG00000105373	NOP53	98	93.750	ENSMOCG00000008367	Nop53	100	81.971	Microtus_ochrogaster
ENSG00000105373	NOP53	98	72.840	ENSMMOG00000006515	nop53	96	45.770	Mola_mola
ENSG00000105373	NOP53	98	90.000	ENSMODG00000008721	NOP53	92	68.432	Monodelphis_domestica
ENSG00000105373	NOP53	97	72.500	ENSMALG00000020350	nop53	92	47.722	Monopterus_albus
ENSG00000105373	NOP53	98	93.827	MGP_CAROLIEiJ_G0029218	Nop53	100	80.785	Mus_caroli
ENSG00000105373	NOP53	99	93.827	ENSMUSG00000041560	Nop53	100	80.992	Mus_musculus
ENSG00000105373	NOP53	99	93.827	MGP_PahariEiJ_G0021074	-	100	77.660	Mus_pahari
ENSG00000105373	NOP53	99	93.827	MGP_SPRETEiJ_G0030298	Nop53	100	80.165	Mus_spretus
ENSG00000105373	NOP53	98	96.296	ENSMPUG00000004456	NOP53	100	84.362	Mustela_putorius_furo
ENSG00000105373	NOP53	80	96.203	ENSMLUG00000027066	-	100	81.784	Myotis_lucifugus
ENSG00000105373	NOP53	96	96.154	ENSNGAG00000019894	Nop53	100	80.745	Nannospalax_galili
ENSG00000105373	NOP53	91	53.086	ENSNBRG00000002057	nop53	93	41.176	Neolamprologus_brichardi
ENSG00000105373	NOP53	100	97.699	ENSNLEG00000003143	NOP53	100	97.699	Nomascus_leucogenys
ENSG00000105373	NOP53	89	90.323	ENSNLEG00000028326	-	100	71.645	Nomascus_leucogenys
ENSG00000105373	NOP53	89	82.456	ENSMEUG00000002525	-	96	60.057	Notamacropus_eugenii
ENSG00000105373	NOP53	98	92.405	ENSODEG00000006707	NOP53	100	80.665	Octodon_degus
ENSG00000105373	NOP53	99	67.857	ENSONIG00000016624	nop53	97	47.084	Oreochromis_niloticus
ENSG00000105373	NOP53	99	72.289	ENSORLG00000008659	nop53	96	46.304	Oryzias_latipes
ENSG00000105373	NOP53	97	71.084	ENSORLG00020019916	nop53	93	43.913	Oryzias_latipes_hni
ENSG00000105373	NOP53	99	71.084	ENSORLG00015001315	nop53	97	47.414	Oryzias_latipes_hsok
ENSG00000105373	NOP53	99	72.289	ENSOMEG00000018244	nop53	97	46.767	Oryzias_melastigma
ENSG00000105373	NOP53	92	95.588	ENSOGAG00000024300	NOP53	89	95.588	Otolemur_garnettii
ENSG00000105373	NOP53	99	87.302	ENSOARG00000011414	NOP53	100	64.930	Ovis_aries
ENSG00000105373	NOP53	96	89.286	ENSPPAG00000029337	-	100	82.636	Pan_paniscus
ENSG00000105373	NOP53	100	97.280	ENSPPAG00000002927	-	100	97.280	Pan_paniscus
ENSG00000105373	NOP53	99	100.000	ENSPPAG00000032995	-	100	83.648	Pan_paniscus
ENSG00000105373	NOP53	98	92.500	ENSPPRG00000008954	NOP53	100	83.299	Panthera_pardus
ENSG00000105373	NOP53	97	100.000	ENSPTRG00000043520	-	100	92.887	Pan_troglodytes
ENSG00000105373	NOP53	95	89.189	ENSPTRG00000052493	-	100	82.636	Pan_troglodytes
ENSG00000105373	NOP53	100	98.954	ENSPTRG00000011215	NOP53	100	98.954	Pan_troglodytes
ENSG00000105373	NOP53	100	96.025	ENSPANG00000002964	NOP53	100	96.025	Papio_anubis
ENSG00000105373	NOP53	97	71.250	ENSPKIG00000000127	nop53	88	50.827	Paramormyrops_kingsleyae
ENSG00000105373	NOP53	99	72.289	ENSPMGG00000021579	nop53	88	48.349	Periophthalmus_magnuspinnatus
ENSG00000105373	NOP53	98	95.000	ENSPEMG00000006856	Nop53	100	82.365	Peromyscus_maniculatus_bairdii
ENSG00000105373	NOP53	67	43.258	ENSPMAG00000001501	-	87	43.404	Petromyzon_marinus
ENSG00000105373	NOP53	77	71.053	ENSPMAG00000009638	-	100	58.462	Petromyzon_marinus
ENSG00000105373	NOP53	95	88.608	ENSPCIG00000016718	NOP53	100	66.736	Phascolarctos_cinereus
ENSG00000105373	NOP53	90	75.904	ENSPFOG00000002839	nop53	89	49.415	Poecilia_formosa
ENSG00000105373	NOP53	90	75.904	ENSPLAG00000006675	nop53	89	49.415	Poecilia_latipinna
ENSG00000105373	NOP53	66	47.778	ENSPLAG00000009285	-	71	46.862	Poecilia_latipinna
ENSG00000105373	NOP53	66	47.778	ENSPMEG00000006978	nop53	71	46.862	Poecilia_mexicana
ENSG00000105373	NOP53	90	75.904	ENSPMEG00000009589	nop53	89	48.946	Poecilia_mexicana
ENSG00000105373	NOP53	99	75.904	ENSPREG00000008711	nop53	88	45.116	Poecilia_reticulata
ENSG00000105373	NOP53	93	98.551	ENSPPYG00000010181	NOP53	100	90.377	Pongo_abelii
ENSG00000105373	NOP53	98	97.500	ENSPCAG00000007692	NOP53	100	81.064	Procavia_capensis
ENSG00000105373	NOP53	98	98.750	ENSPCOG00000016124	NOP53	100	93.701	Propithecus_coquereli
ENSG00000105373	NOP53	81	95.000	ENSPVAG00000014671	NOP53	84	79.545	Pteropus_vampyrus
ENSG00000105373	NOP53	99	67.857	ENSPNYG00000001341	nop53	97	47.084	Pundamilia_nyererei
ENSG00000105373	NOP53	98	73.171	ENSPNAG00000012520	nop53	89	50.351	Pygocentrus_nattereri
ENSG00000105373	NOP53	99	96.296	ENSRNOG00000013023	Nop53	100	81.120	Rattus_norvegicus
ENSG00000105373	NOP53	97	100.000	ENSRBIG00000036427	NOP53	100	95.607	Rhinopithecus_bieti
ENSG00000105373	NOP53	97	100.000	ENSRROG00000042298	NOP53	100	95.816	Rhinopithecus_roxellana
ENSG00000105373	NOP53	97	98.718	ENSSBOG00000033115	NOP53	100	93.958	Saimiri_boliviensis_boliviensis
ENSG00000105373	NOP53	98	87.500	ENSSHAG00000002239	NOP53	100	67.813	Sarcophilus_harrisii
ENSG00000105373	NOP53	99	73.494	ENSSFOG00015007062	gltscr2	96	49.891	Scleropages_formosus
ENSG00000105373	NOP53	99	69.048	ENSSMAG00000000212	nop53	89	47.031	Scophthalmus_maximus
ENSG00000105373	NOP53	99	69.880	ENSSDUG00000010575	nop53	97	46.482	Seriola_dumerili
ENSG00000105373	NOP53	99	69.880	ENSSLDG00000000140	nop53	94	46.552	Seriola_lalandi_dorsalis
ENSG00000105373	NOP53	91	92.000	ENSSARG00000014109	NOP53	83	80.769	Sorex_araneus
ENSG00000105373	NOP53	95	77.632	ENSSPUG00000004420	NOP53	98	48.188	Sphenodon_punctatus
ENSG00000105373	NOP53	99	69.880	ENSSPAG00000000318	nop53	97	45.905	Stegastes_partitus
ENSG00000105373	NOP53	98	96.250	ENSSSCG00000022774	NOP53	100	83.716	Sus_scrofa
ENSG00000105373	NOP53	99	69.048	ENSTRUG00000004944	nop53	89	47.100	Takifugu_rubripes
ENSG00000105373	NOP53	58	48.101	ENSTNIG00000014330	nop53	93	44.141	Tetraodon_nigroviridis
ENSG00000105373	NOP53	70	72.464	ENSTNIG00000001535	-	96	73.529	Tetraodon_nigroviridis
ENSG00000105373	NOP53	96	95.000	ENSTBEG00000008708	NOP53	80	91.339	Tupaia_belangeri
ENSG00000105373	NOP53	99	96.296	ENSTTRG00000011831	NOP53	100	82.268	Tursiops_truncatus
ENSG00000105373	NOP53	92	97.015	ENSUAMG00000028254	NOP53	100	81.818	Ursus_americanus
ENSG00000105373	NOP53	62	86.585	ENSUMAG00000023832	-	59	87.678	Ursus_maritimus
ENSG00000105373	NOP53	80	85.782	ENSVVUG00000023365	NOP53	78	82.732	Vulpes_vulpes
ENSG00000105373	NOP53	100	75.000	ENSXETG00000002782	nop53	99	50.107	Xenopus_tropicalis
ENSG00000105373	NOP53	98	76.829	ENSXCOG00000004436	nop53	97	46.444	Xiphophorus_couchianus
ENSG00000105373	NOP53	98	76.829	ENSXMAG00000002589	nop53	97	44.093	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000027	ribosomal large subunit assembly	21873635.	IBA	Process
GO:0000027	ribosomal large subunit assembly	24120868.	IMP	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	25956029.	IMP	Process
GO:0001650	fibrillar center	27729611.	IDA	Component
GO:0001932	regulation of protein phosphorylation	15355975.	IMP	Process
GO:0002039	p53 binding	22522597.	IPI	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	15355975.20042497.21167305.24556985.25956029.27323397.27729611.27824081.27829214.	IPI	Function
GO:0005654	nucleoplasm	22522597.24923447.27323397.	IDA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	20042497.22522597.24923447.25956029.27323397.27829214.	IDA	Component
GO:0005829	cytosol	24923447.	IDA	Component
GO:0006281	DNA repair	21741933.	IMP	Process
GO:0006364	rRNA processing	21873635.	IBA	Process
GO:0006974	cellular response to DNA damage stimulus	27829214.	IMP	Process
GO:0007095	mitotic G2 DNA damage checkpoint	21741933.	IMP	Process
GO:0008097	5S rRNA binding	21873635.	IBA	Function
GO:0008097	5S rRNA binding	24120868.	IDA	Function
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	16971513.	IMP	Process
GO:0031333	negative regulation of protein complex assembly	25956029.	IMP	Process
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	22522597.	IMP	Process
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	25818168.27323397.	IMP	Process
GO:0033553	rDNA heterochromatin	27729611.	IDA	Component
GO:0039535	regulation of RIG-I signaling pathway	27824081.	IMP	Process
GO:0042802	identical protein binding	24735870.	IDA	Function
GO:0042981	regulation of apoptotic process	21167305.	IMP	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0050821	protein stabilization	15355975.	IMP	Process
GO:0051726	regulation of cell cycle	21167305.	IMP	Process
GO:0051898	negative regulation of protein kinase B signaling	27729611.	IMP	Process
GO:0071456	cellular response to hypoxia	22522597.	IMP	Process
GO:1901796	regulation of signal transduction by p53 class mediator	22522597.24120868.24556985.27829214.	IMP	Process
GO:1901797	negative regulation of signal transduction by p53 class mediator	-	IEA	Process
GO:1901837	negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	27729611.	IMP	Process
GO:1902570	protein localization to nucleolus	-	IEA	Process
GO:1903006	positive regulation of protein K63-linked deubiquitination	27824081.	IMP	Process
GO:1903715	regulation of aerobic respiration	24556985.	IMP	Process
GO:1990173	protein localization to nucleoplasm	25818168.27323397.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22522597	Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses.	Cell Death Differ	2012 Oct	Lee S	doi: 10.1038/cdd.2012.40
21741933	Involvement of GLTSCR2 in the DNA Damage Response.	Am J Pathol	2011 Sep	Kim JY	doi: 10.1016/j.ajpath.2011.05.041
21804542	Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.	Nat Med	2011 Jul 31	Sasaki M	doi: 10.1038/nm.2392.
23920125	Down-regulation and aberrant cytoplasmic expression of GLTSCR2 in prostatic adenocarcinomas.	Cancer Lett	2013 Oct 28	Kim JY	doi: 10.1016/j.canlet.2013.07.035
20042497	GLTSCR2/PICT-1, a putative tumor suppressor gene product, induces the nucleolar targeting of the Kaposi's sarcoma-associated herpesvirus KS-Bcl-2 protein.	J Virol	2010 Mar	Kalt I	doi: 10.1128/JVI.00757-09
17657248	The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death.	Cell Death Differ	2007 Nov	Yim JH	-
25818168	GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical cancer.	J Cell Mol Med	2015 Jun	Kim JY	doi: 10.1111/jcmm.12474
25118835	The expression of GLTSCR2 in cervical intra-epithelial lesion and cancer.	Arch Gynecol Obstet	2015 Feb	Zhang J	doi: 10.1007/s00404-014-3415-1
26903295	c-Jun N-terminal kinase regulates the nucleoplasmic translocation and stability of nucleolar GLTSCR2 protein.	Biochem Biophys Res Commun	2016 Mar 25	Lee S	doi: 10.1016/j.bbrc.2016.02.070
24054033	Downregulation of GLTSCR2 expression is correlated with breast cancer progression.	Pathol Res Pract	2013 Nov	Moon A	doi: 10.1016/j.prp.2013.07.010
25956029	The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis.	Am J Pathol	2015 Jul	Kim JY	doi: 10.1016/j.ajpath.2015.03.016
24045667	PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression.	Br J Cancer	2013 Oct 15	Uchi R	doi: 10.1038/bjc.2013.561
29617699	Abnormal Expression of PICT-1 and Its Codon 389 Polymorphism Is a Risk Factor for Human Endometrial Cancer.	Oncology	2018	Yoshimoto M	doi: 10.1159/000487189

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr19	47745546	5'UTR	rs757604840		0.18
BLCA	chr19	47757123	3'Flank	novel		0.47
BLCA	chr19	47756594	Missense_Mutation	novel	E455K	0.38
BLCA	chr19	47745724	Silent	novel	P55P	0.29
BRCA	chr19	47756531	Missense_Mutation	rs377217052	E434K	0.16
BRCA	chr19	47745546	5'UTR	rs757604840		0.1
BRCA	chr19	47755977	Intron	novel		0.33
CESC	chr19	47750237	Missense_Mutation	rs761652099	R117W	0.08
CESC	chr19	47750257	Silent	novel	E123E	0.35
CESC	chr19	47754564	Missense_Mutation	rs375712695	R268Q	0.38
COAD	chr19	47756687	Splice_Site	NA	X458_splice	0.29
COAD	chr19	47751058	Frame_Shift_Ins	novel	*Q185Pfs27**	0.16
COAD	chr19	47746998	Missense_Mutation	novel	L86F	0.06
COAD	chr19	47750215	Silent	NA	S109S	0.27
COAD	chr19	47751079	Silent	NA	R190R	0.16
COAD	chr19	47745641	Missense_Mutation	novel	T28A	0.38	Nop53
COAD	chr19	47745570	Missense_Mutation	novel	G4E	0.33	Nop53
COAD	chr19	47757108	3'Flank	rs181591027		0.33
COAD	chr19	47747024	Missense_Mutation	NA	K94N	0.24
COAD	chr19	47750914	Silent	novel	L135L	0.08
COAD	chr19	47757128	3'Flank	novel		0.44
COAD	chr19	47745582	Missense_Mutation	NA	V8G	0.49	Nop53
GBM	chr19	47745665	Missense_Mutation	rs755612274	R36W	0.26	Nop53
GBM	chr19	47756591	Nonsense_Mutation	rs141718194	R454*	0.42
HNSC	chr19	47745545	5'UTR	novel		0.34
HNSC	chr19	47752592	Silent	novel	S250S	0.24
KIRC	chr19	47757082	3'Flank	novel		0.65
KIRP	chr19	47745662	Silent	novel	R35R	0.41
KIRP	chr19	47757069	3'Flank	rs776906246		0.48
LGG	chr19	47745724	Silent	novel	P55P	0.27
LGG	chr19	47745646	Silent	rs763122158	S29S	0.39
LUAD	chr19	47745675	Missense_Mutation	novel	R39P	0.15	Nop53
LUAD	chr19	47757004	Nonstop_Mutation	novel	479Lext?	0.95
LUAD	chr19	47752587	Missense_Mutation	novel	P249A	0.19
LUAD	chr19	47750948	Missense_Mutation	novel	R147W	0.33
LUSC	chr19	47750240	Missense_Mutation	novel	V118I	0.45
LUSC	chr19	47745632	Silent	novel	L25L	0.12
LUSC	chr19	47755776	Missense_Mutation	novel	D417V	0.79
LUSC	chr19	47751550	Missense_Mutation	NA	D210A	0.25
LUSC	chr19	47756605	Splice_Site	novel	X459_splice	0.07
LUSC	chr19	47755810	Silent	novel	L428L	0.21
LUSC	chr19	47745608	Missense_Mutation	rs770730864	D17Y	0.29	Nop53
LUSC	chr19	47756721	Missense_Mutation	novel	E469D	0.08
OV	chr19	47745606	Missense_Mutation	NA	S16T	0.12	Nop53
OV	chr19	47751023	Missense_Mutation	novel	L172F	0.24
OV	chr19	47745562	Translation_Start_Site	novel	M1?	0.11
PAAD	chr19	47756708	Missense_Mutation	novel	V465G	0.18
PAAD	chr19	47751005	Missense_Mutation	rs755859075	R166C	0.13
PAAD	chr19	47752518	Missense_Mutation	rs745569085	A226T	0.17
PAAD	chr19	47752565	Silent	novel	A241A	0.18
PAAD	chr19	47754865	Missense_Mutation	rs536507041	R343W	0.13
PRAD	chr19	47756598	Missense_Mutation	novel	R456I	0.3
PRAD	chr19	47757029	3'UTR	rs372634116		0.3
READ	chr19	47754843	Silent	rs763843406	E335E	0.24
READ	chr19	47750193	Missense_Mutation	NA	R102I	0.37
SARC	chr19	47745580	Silent	novel	G7G	0.32
SKCM	chr19	47745546	5'UTR	rs757604840		0.35
SKCM	chr19	47752591	Missense_Mutation	novel	S250F	0.56
SKCM	chr19	47750233	Silent	novel	P115P	0.5
SKCM	chr19	47750234	Missense_Mutation	novel	L116F	0.49
SKCM	chr19	47750995	Silent	NA	P162P	0.53
SKCM	chr19	47750265	Missense_Mutation	NA	S126F	0.34
SKCM	chr19	47745554	5'UTR	rs754441565		0.29
SKCM	chr19	47756691	Silent	novel	F459F	0.39
SKCM	chr19	47747031	Missense_Mutation	NA	G97R	0.31
STAD	chr19	47751534	Missense_Mutation	NA	P205S	0.15
STAD	chr19	47757067	3'Flank	rs375601413		0.12
STAD	chr19	47745661	Silent	novel	L34L	0.08
THCA	chr19	47751079	Silent	NA	R190R	0.46
UCEC	chr19	47751056	Missense_Mutation	rs368183644	G183R	0.5
UCEC	chr19	47752512	Missense_Mutation	rs748772854	R224W	0.28
UCEC	chr19	47756535	Missense_Mutation	novel	G435D	0.1
UCEC	chr19	47756695	Missense_Mutation	rs764039740	R461C	0.46
UCEC	chr19	47756688	Splice_Region	NA	K458K	0.21
UCEC	chr19	47755778	Missense_Mutation	novel	V418M	0.62
UCEC	chr19	47755897	Intron	novel		0.28
UCEC	chr19	47750277	Missense_Mutation	rs779428264	A130V	0.22
UCEC	chr19	47752512	Missense_Mutation	rs748772854	R224W	0.45
UCEC	chr19	47755788	Missense_Mutation	novel	S421N	0.31
UCEC	chr19	47754804	Silent	rs562399482	A322A	0.56
UCEC	chr19	47754553	Silent	rs775835010	V264V	0.53
UCEC	chr19	47756546	Nonsense_Mutation	NA	R439*	0.5
UCEC	chr19	47756552	Missense_Mutation	rs777866172	R441W	0.37
UCEC	chr19	47756696	Missense_Mutation	rs148148148	R461H	0.27
UCEC	chr19	47750209	Silent	novel	K107K	0.39
UCEC	chr19	47754762	Silent	novel	E308E	0.56
UCEC	chr19	47756696	Missense_Mutation	rs148148148	R461H	0.17
UCEC	chr19	47756546	Nonsense_Mutation	NA	R439*	0.28
UCEC	chr19	47745588	Missense_Mutation	NA	G10V	0.11	Nop53
UCEC	chr19	47751566	Missense_Mutation	novel	E215D	0.19
UCEC	chr19	47755787	Missense_Mutation	novel	S421R	0.33
UCEC	chr19	47756585	Missense_Mutation	novel	E452K	0.4

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.0949	0.027508
KIRP	DEL	0.0486	0.054726
LUAD	DEL	0.2655	1.5526e-05
LUSC	DEL	0.2196	1.1877e-06
OV	DEL	0.4801	2.441e-17
PAAD	DEL	0.0924	0.035089
READ	DEL	0.097	0.23023
TGCT	DEL	0.2933	0.0046229
UCS	DEL	0.2321	0.12448

Survival Analysis

Cancer	P-value	Q-value
THYM	0.02	Kaplan-Meier Survival Analysis
MESO	0.042	Kaplan-Meier Survival Analysis
ACC	0.0088	Kaplan-Meier Survival Analysis
BRCA	0.0031	Kaplan-Meier Survival Analysis
COAD	0.0075	Kaplan-Meier Survival Analysis
PAAD	0.0032	Kaplan-Meier Survival Analysis
PCPG	0.031	Kaplan-Meier Survival Analysis
BLCA	0.016	Kaplan-Meier Survival Analysis
KICH	0.0062	Kaplan-Meier Survival Analysis
UCEC	0.00049	Kaplan-Meier Survival Analysis
LGG	0.0026	Kaplan-Meier Survival Analysis
OV	0.025	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742