EuRBPDB

Description

Ensembl ID: ENSG00000105447 (Gene tree)
Gene ID: 83743
Gene Symbol: GRWD1
Alias: WDR28|GRWD|RRB1
Full Name: glutamate rich WD repeat containing 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 11,250 bases
Position: chr19:48,445,773-48,457,022
Accession: 21270
RBP type: non-canonical RBP
Summary: This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000253237	GRWD1-201	5571	-	ENSP00000253237	446 (aa)	-	Q9BQ67
ENST00000598711	GRWD1-202	881	-	ENSP00000468943	228 (aa)	-	M0QX71
ENST00000599949	GRWD1-203	518	-	-	- (aa)	-	-

Gene Model

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105447	GRWD1	100	92.544	ENSMUSG00000053801	Grwd1	100	91.480	Mus_musculus
ENSG00000105447	GRWD1	99	34.581	YMR131C		86	35.808	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003682	chromatin binding	25990725.	IDA	Function
GO:0003688	DNA replication origin binding	25990725.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	17041588.18832067.23349634.25990725.	IPI	Function
GO:0005634	nucleus	25990725.	IDA	Component
GO:0005694	chromosome	-	IEA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006260	DNA replication	25990725.	IMP	Process
GO:0006334	nucleosome assembly	25990725.	IDA	Process
GO:0006334	nucleosome assembly	27552915.	IMP	Process
GO:0006337	nucleosome disassembly	27552915.	IMP	Process
GO:0032991	protein-containing complex	23349634.	IDA	Component
GO:0042393	histone binding	25990725.	IDA	Function