EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000105671 (Gene tree)
Gene ID: 54555
Gene Symbol: DDX49
Alias: FLJ10432|Dbp8
Full Name: DEAD-box helicase 49
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 8,959 bases
Position: chr19:18,919,675-18,928,633
Accession: 18684
RBP type: canonical RBP
Summary: (DEAD-Box Helicase 49) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX47.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000247003	ResIII	PF04851.15	3.5e-06	1	1
ENSP00000247003	DEAD	PF00270.29	9.4e-46	1	1
ENSP00000487048	DEAD	PF00270.29	9.7e-15	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000599156	DDX49-208	633	-	-	- (aa)	-	-
ENST00000599373	DDX49-209	772	-	-	- (aa)	-	-
ENST00000601803	DDX49-212	1550	-	-	- (aa)	-	-
ENST00000594021	DDX49-203	721	-	ENSP00000470440	118 (aa)	-	M0QZC0
ENST00000629999	DDX49-214	1912	-	ENSP00000487048	166 (aa)	-	M0R0K1
ENST00000596502	DDX49-205	594	-	-	- (aa)	-	-
ENST00000602113	DDX49-213	1691	-	ENSP00000469086	41 (aa)	-	M0QXD4
ENST00000598277	DDX49-206	771	-	-	- (aa)	-	-
ENST00000598972	DDX49-207	753	-	ENSP00000472084	112 (aa)	-	M0R1S3
ENST00000593361	DDX49-202	557	-	ENSP00000472289	41 (aa)	-	M0QXD4
ENST00000599981	DDX49-210	583	-	-	- (aa)	-	-
ENST00000247003	DDX49-201	1830	XM_011528083	ENSP00000247003	483 (aa)	XP_011526385	Q9Y6V7
ENST00000601772	DDX49-211	342	-	-	- (aa)	-	-
ENST00000595858	DDX49-204	1882	-	ENSP00000471292	166 (aa)	-	M0R0K1

Gene Model

Click here to download ENSG00000105671's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000105671	amyloid beta-protein (1-42)	3E-7	26252872
ENSG00000105671	Cerebrospinal Fluid	3E-6	26252872
ENSG00000105671	tau Proteins	3E-6	26252872

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000105671	rs2301659	19	18924545	G	Cerebrospinal P-tau181p levels	26252872	[NR] unit decrease	0.1186	EFO_0004763\|EFO_0006794
ENSG00000105671	rs2301659	19	18924545	G	Cerebrospinal fluid p-Tau181p:AB1-42 ratio	26252872	[NR] unit decrease	0.1679	EFO_0007709

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000105671's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000105671	DDX49	93	40.171	ENSG00000124228	DDX27	85	35.593
ENSG00000105671	DDX49	76	31.527	ENSG00000182810	DDX28	74	31.762
ENSG00000105671	DDX49	78	38.298	ENSG00000136271	DDX56	96	36.111
ENSG00000105671	DDX49	74	34.435	ENSG00000108654	DDX5	74	39.370
ENSG00000105671	DDX49	69	37.349	ENSG00000178105	DDX10	51	34.174
ENSG00000105671	DDX49	90	31.481	ENSG00000141543	EIF4A3	91	31.135
ENSG00000105671	DDX49	80	33.019	ENSG00000183258	DDX41	86	35.625
ENSG00000105671	DDX49	71	33.523	ENSG00000184735	DDX53	54	33.523
ENSG00000105671	DDX49	69	42.857	ENSG00000118197	DDX59	59	30.966
ENSG00000105671	DDX49	72	40.698	ENSG00000088205	DDX18	89	32.258
ENSG00000105671	DDX49	80	32.481	ENSG00000123136	DDX39A	92	37.079
ENSG00000105671	DDX49	71	40.909	ENSG00000079785	DDX1	54	40.909
ENSG00000105671	DDX49	79	32.468	ENSG00000161960	EIF4A1	100	35.366
ENSG00000105671	DDX49	70	42.697	ENSG00000152670	DDX4	64	33.687
ENSG00000105671	DDX49	75	33.151	ENSG00000110367	DDX6	75	32.703
ENSG00000105671	DDX49	81	35.714	ENSG00000089737	DDX24	66	33.028
ENSG00000105671	DDX49	71	44.048	ENSG00000198231	DDX42	54	34.328
ENSG00000105671	DDX49	71	39.241	ENSG00000198563	DDX39B	87	31.759
ENSG00000105671	DDX49	74	32.454	ENSG00000067048	DDX3Y	53	33.983
ENSG00000105671	DDX49	70	35.097	ENSG00000215301	DDX3X	74	35.097
ENSG00000105671	DDX49	69	31.564	ENSG00000111364	DDX55	82	36.076
ENSG00000105671	DDX49	68	32.051	ENSG00000157349	DDX19B	66	32.051
ENSG00000105671	DDX49	84	47.407	ENSG00000213782	DDX47	87	47.407
ENSG00000105671	DDX49	82	33.741	ENSG00000080007	DDX43	61	33.741
ENSG00000105671	DDX49	71	41.860	ENSG00000125485	DDX31	61	30.939
ENSG00000105671	DDX49	71	43.210	ENSG00000123064	DDX54	93	42.640
ENSG00000105671	DDX49	79	32.208	ENSG00000156976	EIF4A2	92	32.208
ENSG00000105671	DDX49	70	30.864	ENSG00000185163	DDX51	60	30.864

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105671	DDX49	91	81.050	ENSAPOG00000010961	ddx49	96	79.004	Acanthochromis_polyacanthus
ENSG00000105671	DDX49	93	100.000	ENSAMEG00000011566	DDX49	99	94.748	Ailuropoda_melanoleuca
ENSG00000105671	DDX49	90	80.778	ENSACIG00000011029	ddx49	96	78.139	Amphilophus_citrinellus
ENSG00000105671	DDX49	91	81.050	ENSAOCG00000006257	ddx49	97	78.788	Amphiprion_ocellaris
ENSG00000105671	DDX49	93	79.601	ENSAPEG00000006367	ddx49	97	78.788	Amphiprion_percula
ENSG00000105671	DDX49	94	78.901	ENSATEG00000016661	ddx49	95	78.901	Anabas_testudineus
ENSG00000105671	DDX49	81	83.969	ENSAPLG00000008420	DDX49	94	83.969	Anas_platyrhynchos
ENSG00000105671	DDX49	71	30.193	ENSAPLG00000005543	DDX51	73	30.193	Anas_platyrhynchos
ENSG00000105671	DDX49	99	97.713	ENSANAG00000031415	DDX49	99	97.713	Aotus_nancymaae
ENSG00000105671	DDX49	90	81.007	ENSACLG00000022538	ddx49	99	80.998	Astatotilapia_calliptera
ENSG00000105671	DDX49	93	76.053	ENSAMXG00000016919	ddx49	96	75.328	Astyanax_mexicanus
ENSG00000105671	DDX49	99	94.387	ENSBTAG00000000811	DDX49	99	99.074	Bos_taurus
ENSG00000105671	DDX49	93	50.000	WBGene00019219	H20J04.4	81	50.000	Caenorhabditis_elegans
ENSG00000105671	DDX49	99	96.881	ENSCJAG00000042114	DDX49	99	96.881	Callithrix_jacchus
ENSG00000105671	DDX49	99	94.033	ENSCAFG00000014512	DDX49	99	94.444	Canis_familiaris
ENSG00000105671	DDX49	93	100.000	ENSCAFG00020012375	DDX49	76	92.638	Canis_lupus_dingo
ENSG00000105671	DDX49	99	94.387	ENSCHIG00000019910	DDX49	99	94.387	Capra_hircus
ENSG00000105671	DDX49	98	95.579	ENSTSYG00000028117	DDX49	99	95.579	Carlito_syrichta
ENSG00000105671	DDX49	98	88.559	ENSCAPG00000012222	DDX49	99	88.699	Cavia_aperea
ENSG00000105671	DDX49	99	92.872	ENSCPOG00000013626	DDX49	99	92.872	Cavia_porcellus
ENSG00000105671	DDX49	100	97.321	ENSCCAG00000036092	DDX49	100	97.321	Cebus_capucinus
ENSG00000105671	DDX49	99	98.753	ENSCATG00000032577	DDX49	99	98.753	Cercocebus_atys
ENSG00000105671	DDX49	97	93.162	ENSCLAG00000012844	DDX49	99	93.162	Chinchilla_lanigera
ENSG00000105671	DDX49	99	94.802	ENSCSAG00000005251	DDX49	99	94.802	Chlorocebus_sabaeus
ENSG00000105671	DDX49	94	84.396	ENSCPBG00000012500	DDX49	95	84.396	Chrysemys_picta_bellii
ENSG00000105671	DDX49	94	60.088	ENSCING00000008831	-	99	60.088	Ciona_intestinalis
ENSG00000105671	DDX49	87	62.708	ENSCSAVG00000000522	-	99	62.708	Ciona_savignyi
ENSG00000105671	DDX49	100	92.771	ENSCANG00000030901	DDX49	100	92.771	Colobus_angolensis_palliatus
ENSG00000105671	DDX49	93	97.368	ENSCGRG00001009467	Ddx49	97	92.291	Cricetulus_griseus_chok1gshd
ENSG00000105671	DDX49	93	97.368	ENSCGRG00000011487	Ddx49	97	92.291	Cricetulus_griseus_crigri
ENSG00000105671	DDX49	95	78.821	ENSCSEG00000016139	ddx49	96	78.355	Cynoglossus_semilaevis
ENSG00000105671	DDX49	96	78.495	ENSCVAG00000010466	ddx49	98	78.495	Cyprinodon_variegatus
ENSG00000105671	DDX49	90	78.719	ENSDARG00000012899	ddx49	97	76.923	Danio_rerio
ENSG00000105671	DDX49	93	94.737	ENSDORG00000004301	Ddx49	87	95.214	Dipodomys_ordii
ENSG00000105671	DDX49	83	61.765	FBgn0010220	Dbp45A	85	49.888	Drosophila_melanogaster
ENSG00000105671	DDX49	90	64.865	ENSEBUG00000016049	ddx49	56	74.359	Eptatretus_burgeri
ENSG00000105671	DDX49	93	100.000	ENSEASG00005006560	DDX49	99	93.347	Equus_asinus_asinus
ENSG00000105671	DDX49	100	95.536	ENSECAG00000012194	DDX49	99	100.000	Equus_caballus
ENSG00000105671	DDX49	94	78.242	ENSELUG00000012963	ddx49	95	78.242	Esox_lucius
ENSG00000105671	DDX49	99	95.000	ENSFCAG00000009760	DDX49	99	95.000	Felis_catus
ENSG00000105671	DDX49	97	93.404	ENSFDAG00000011064	DDX49	99	93.404	Fukomys_damarensis
ENSG00000105671	DDX49	100	59.036	ENSFHEG00000016199	-	83	59.036	Fundulus_heteroclitus
ENSG00000105671	DDX49	94	77.851	ENSGMOG00000007556	ddx49	98	77.851	Gadus_morhua
ENSG00000105671	DDX49	94	83.736	ENSGALG00000003130	DDX49	99	85.139	Gallus_gallus
ENSG00000105671	DDX49	96	77.706	ENSGAFG00000004779	ddx49	97	77.706	Gambusia_affinis
ENSG00000105671	DDX49	95	75.328	ENSGACG00000008047	ddx49	99	76.415	Gasterosteus_aculeatus
ENSG00000105671	DDX49	99	79.332	ENSGAGG00000022213	DDX49	95	82.637	Gopherus_agassizii
ENSG00000105671	DDX49	100	99.586	ENSGGOG00000037966	DDX49	100	99.586	Gorilla_gorilla
ENSG00000105671	DDX49	90	80.778	ENSHBUG00000008991	ddx49	99	76.211	Haplochromis_burtoni
ENSG00000105671	DDX49	93	100.000	ENSHGLG00000006789	DDX49	99	94.468	Heterocephalus_glaber_female
ENSG00000105671	DDX49	97	91.277	ENSHGLG00100006283	DDX49	99	91.277	Heterocephalus_glaber_male
ENSG00000105671	DDX49	95	77.243	ENSHCOG00000008961	ddx49	99	74.737	Hippocampus_comes
ENSG00000105671	DDX49	99	75.840	ENSIPUG00000005386	ddx49	99	75.840	Ictalurus_punctatus
ENSG00000105671	DDX49	99	95.010	ENSSTOG00000006749	DDX49	99	95.010	Ictidomys_tridecemlineatus
ENSG00000105671	DDX49	94	78.242	ENSKMAG00000004909	ddx49	95	78.242	Kryptolebias_marmoratus
ENSG00000105671	DDX49	96	77.922	ENSLBEG00000027804	ddx49	96	77.922	Labrus_bergylta
ENSG00000105671	DDX49	94	79.956	ENSLACG00000008244	DDX49	95	79.956	Latimeria_chalumnae
ENSG00000105671	DDX49	93	81.920	ENSLOCG00000002119	ddx49	95	80.786	Lepisosteus_oculatus
ENSG00000105671	DDX49	99	93.154	ENSLAFG00000002934	DDX49	100	93.154	Loxodonta_africana
ENSG00000105671	DDX49	99	98.753	ENSMFAG00000044697	DDX49	99	98.753	Macaca_fascicularis
ENSG00000105671	DDX49	99	98.753	ENSMMUG00000023293	DDX49	99	98.753	Macaca_mulatta
ENSG00000105671	DDX49	99	98.545	ENSMNEG00000029654	DDX49	99	98.545	Macaca_nemestrina
ENSG00000105671	DDX49	100	94.578	ENSMLEG00000042550	DDX49	100	94.578	Mandrillus_leucophaeus
ENSG00000105671	DDX49	95	79.212	ENSMAMG00000006297	ddx49	96	78.571	Mastacembelus_armatus
ENSG00000105671	DDX49	90	81.007	ENSMZEG00005016366	ddx49	95	79.121	Maylandia_zebra
ENSG00000105671	DDX49	94	83.333	ENSMGAG00000004605	DDX49	99	84.131	Meleagris_gallopavo
ENSG00000105671	DDX49	93	100.000	ENSMAUG00000010235	Ddx49	99	91.295	Mesocricetus_auratus
ENSG00000105671	DDX49	93	100.000	ENSMICG00000003640	DDX49	100	84.940	Microcebus_murinus
ENSG00000105671	DDX49	93	97.368	ENSMOCG00000018690	Ddx49	99	92.211	Microtus_ochrogaster
ENSG00000105671	DDX49	95	78.166	ENSMMOG00000007532	ddx49	97	78.166	Mola_mola
ENSG00000105671	DDX49	95	88.865	ENSMODG00000003745	DDX49	94	88.312	Monodelphis_domestica
ENSG00000105671	DDX49	96	78.139	ENSMALG00000018053	ddx49	97	78.139	Monopterus_albus
ENSG00000105671	DDX49	93	97.368	MGP_CAROLIEiJ_G0031139	Ddx49	98	92.308	Mus_caroli
ENSG00000105671	DDX49	93	97.368	ENSMUSG00000057788	Ddx49	98	92.521	Mus_musculus
ENSG00000105671	DDX49	93	97.368	MGP_PahariEiJ_G0021604	Ddx49	98	91.525	Mus_pahari
ENSG00000105671	DDX49	93	97.368	MGP_SPRETEiJ_G0032257	Ddx49	98	92.308	Mus_spretus
ENSG00000105671	DDX49	99	96.050	ENSMPUG00000015485	DDX49	99	96.050	Mustela_putorius_furo
ENSG00000105671	DDX49	93	100.000	ENSMLUG00000012159	DDX49	99	93.111	Myotis_lucifugus
ENSG00000105671	DDX49	97	94.255	ENSNGAG00000019673	Ddx49	98	94.255	Nannospalax_galili
ENSG00000105671	DDX49	90	81.465	ENSNBRG00000022025	ddx49	95	79.560	Neolamprologus_brichardi
ENSG00000105671	DDX49	99	99.168	ENSNLEG00000006136	DDX49	99	99.168	Nomascus_leucogenys
ENSG00000105671	DDX49	92	89.640	ENSMEUG00000011888	DDX49	100	89.640	Notamacropus_eugenii
ENSG00000105671	DDX49	93	97.368	ENSOPRG00000003824	DDX49	99	92.489	Ochotona_princeps
ENSG00000105671	DDX49	99	93.139	ENSODEG00000011203	DDX49	98	93.139	Octodon_degus
ENSG00000105671	DDX49	90	81.007	ENSONIG00000012731	ddx49	95	79.121	Oreochromis_niloticus
ENSG00000105671	DDX49	93	76.316	ENSOANG00000004572	-	100	88.172	Ornithorhynchus_anatinus
ENSG00000105671	DDX49	90	81.293	ENSORLG00000008509	ddx49	98	77.516	Oryzias_latipes
ENSG00000105671	DDX49	90	81.293	ENSORLG00020014661	ddx49	97	79.075	Oryzias_latipes_hni
ENSG00000105671	DDX49	94	79.075	ENSORLG00015010071	ddx49	97	79.075	Oryzias_latipes_hsok
ENSG00000105671	DDX49	90	80.600	ENSOMEG00000003733	ddx49	100	76.546	Oryzias_melastigma
ENSG00000105671	DDX49	99	94.802	ENSOGAG00000008259	DDX49	99	94.802	Otolemur_garnettii
ENSG00000105671	DDX49	99	93.789	ENSOARG00000010119	-	99	93.789	Ovis_aries
ENSG00000105671	DDX49	100	100.000	ENSPPAG00000035217	DDX49	100	100.000	Pan_paniscus
ENSG00000105671	DDX49	99	94.792	ENSPPRG00000013274	DDX49	99	94.792	Panthera_pardus
ENSG00000105671	DDX49	99	94.595	ENSPTIG00000011259	DDX49	99	94.595	Panthera_tigris_altaica
ENSG00000105671	DDX49	100	100.000	ENSPTRG00000010725	DDX49	100	100.000	Pan_troglodytes
ENSG00000105671	DDX49	99	98.545	ENSPANG00000003161	DDX49	99	98.545	Papio_anubis
ENSG00000105671	DDX49	94	78.022	ENSPKIG00000006013	ddx49	94	78.022	Paramormyrops_kingsleyae
ENSG00000105671	DDX49	87	82.381	ENSPSIG00000008625	DDX49	96	82.381	Pelodiscus_sinensis
ENSG00000105671	DDX49	89	77.103	ENSPMGG00000017693	ddx49	96	77.103	Periophthalmus_magnuspinnatus
ENSG00000105671	DDX49	93	100.000	ENSPEMG00000009238	Ddx49	98	92.391	Peromyscus_maniculatus_bairdii
ENSG00000105671	DDX49	89	77.778	ENSPMAG00000001195	ddx49	98	75.546	Petromyzon_marinus
ENSG00000105671	DDX49	94	88.158	ENSPCIG00000001050	DDX49	88	88.158	Phascolarctos_cinereus
ENSG00000105671	DDX49	94	78.901	ENSPFOG00000000870	ddx49	96	78.901	Poecilia_formosa
ENSG00000105671	DDX49	94	78.681	ENSPLAG00000016185	ddx49	96	78.681	Poecilia_latipinna
ENSG00000105671	DDX49	95	78.821	ENSPMEG00000016243	ddx49	96	78.821	Poecilia_mexicana
ENSG00000105671	DDX49	95	78.384	ENSPREG00000011214	ddx49	96	78.384	Poecilia_reticulata
ENSG00000105671	DDX49	99	99.585	ENSPPYG00000009755	DDX49	99	99.585	Pongo_abelii
ENSG00000105671	DDX49	98	93.277	ENSPCAG00000002310	DDX49	99	93.277	Procavia_capensis
ENSG00000105671	DDX49	93	100.000	ENSPCOG00000024973	DDX49	99	94.526	Propithecus_coquereli
ENSG00000105671	DDX49	99	91.476	ENSPVAG00000015468	DDX49	99	91.476	Pteropus_vampyrus
ENSG00000105671	DDX49	94	79.780	ENSPNYG00000016672	ddx49	96	79.780	Pundamilia_nyererei
ENSG00000105671	DDX49	89	79.070	ENSPNAG00000003429	ddx49	100	74.051	Pygocentrus_nattereri
ENSG00000105671	DDX49	93	97.368	ENSRNOG00000022368	Ddx49	97	91.863	Rattus_norvegicus
ENSG00000105671	DDX49	99	98.337	ENSRBIG00000030758	DDX49	99	98.337	Rhinopithecus_bieti
ENSG00000105671	DDX49	99	98.129	ENSRROG00000032460	DDX49	99	98.129	Rhinopithecus_roxellana
ENSG00000105671	DDX49	93	55.263	YHR169W	-	98	47.664	Saccharomyces_cerevisiae
ENSG00000105671	DDX49	99	97.917	ENSSBOG00000035812	DDX49	99	97.917	Saimiri_boliviensis_boliviensis
ENSG00000105671	DDX49	94	87.500	ENSSHAG00000010982	DDX49	91	86.580	Sarcophilus_harrisii
ENSG00000105671	DDX49	94	78.901	ENSSFOG00015021150	ddx49	96	78.901	Scleropages_formosus
ENSG00000105671	DDX49	96	79.004	ENSSMAG00000021016	ddx49	96	79.004	Scophthalmus_maximus
ENSG00000105671	DDX49	94	79.121	ENSSDUG00000009696	ddx49	94	78.139	Seriola_dumerili
ENSG00000105671	DDX49	96	77.922	ENSSLDG00000006958	ddx49	96	77.922	Seriola_lalandi_dorsalis
ENSG00000105671	DDX49	93	94.737	ENSSARG00000003669	DDX49	100	95.070	Sorex_araneus
ENSG00000105671	DDX49	94	84.615	ENSSPUG00000010688	DDX49	95	84.615	Sphenodon_punctatus
ENSG00000105671	DDX49	95	78.821	ENSSPAG00000011486	ddx49	96	78.821	Stegastes_partitus
ENSG00000105671	DDX49	99	96.258	ENSSSCG00000025329	DDX49	99	96.258	Sus_scrofa
ENSG00000105671	DDX49	90	81.693	ENSTRUG00000021524	ddx49	95	79.780	Takifugu_rubripes
ENSG00000105671	DDX49	94	78.556	ENSTNIG00000010188	ddx49	95	78.556	Tetraodon_nigroviridis
ENSG00000105671	DDX49	93	100.000	ENSTBEG00000005967	-	66	97.590	Tupaia_belangeri
ENSG00000105671	DDX49	99	86.902	ENSTTRG00000003818	DDX49	99	86.902	Tursiops_truncatus
ENSG00000105671	DDX49	93	100.000	ENSUAMG00000007088	DDX49	96	95.426	Ursus_americanus
ENSG00000105671	DDX49	93	100.000	ENSUMAG00000006489	DDX49	90	98.337	Ursus_maritimus
ENSG00000105671	DDX49	99	94.617	ENSVVUG00000007767	DDX49	96	94.617	Vulpes_vulpes
ENSG00000105671	DDX49	95	83.878	ENSXETG00000010135	ddx49	99	81.002	Xenopus_tropicalis
ENSG00000105671	DDX49	82	74.564	ENSXCOG00000005756	ddx49	93	74.564	Xiphophorus_couchianus
ENSG00000105671	DDX49	95	77.729	ENSXMAG00000002554	ddx49	96	77.729	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006364	rRNA processing	-	TAS	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr19	18921693	Silent	novel	F90F	0.21
BLCA	chr19	18922694	Silent	NA	F242F	0.13
BLCA	chr19	18922658	Silent	novel	V230V	0.36
BRCA	chr19	18920583	Missense_Mutation	NA	R40Q	0.3	ResIII
BRCA	chr19	18920620	Silent	novel	K52K	0.06
BRCA	chr19	18924945	Silent	NA	I331I	0.31
BRCA	chr19	18922460	Silent	novel	R194R	0.5
BRCA	chr19	18924254	Missense_Mutation	NA	M266I	0.41
BRCA	chr19	18921939	Missense_Mutation	rs768911735	F141C	0.17
BRCA	chr19	18924945	Silent	NA	I331I	0.28
BRCA	chr19	18919697	5'UTR	novel		0.29
CESC	chr19	18921720	Silent	novel	L99L	0.28
CESC	chr19	18926374	Frame_Shift_Del	novel	*I367Qfs29**	0.33
CESC	chr19	18924669	Missense_Mutation	rs143787772	R300Q	0.46
CESC	chr19	18928134	Missense_Mutation	novel	D424H	0.23
CESC	chr19	18924960	Silent	rs760019445	V336V	0.17
COAD	chr19	18924689	Missense_Mutation	rs769709165	V307M	0.23
COAD	chr19	18920658	Missense_Mutation	novel	S65C	0.26	ResIII
COAD	chr19	18921767	Intron	novel		0.33
COAD	chr19	18926371	Missense_Mutation	novel	Q366K	0.24
COAD	chr19	18926307	Silent	novel	R344R	0.11
COAD	chr19	18928171	Missense_Mutation	NA	I436T	0.56
COAD	chr19	18924257	Frame_Shift_Del	novel	*M267Ifs15**	0.15
COAD	chr19	18927988	Silent	rs778625677	D405D	0.27
COAD	chr19	18927976	Silent	rs766091858	A401A	0.29
COAD	chr19	18921972	Splice_Region	novel		0.44
COAD	chr19	18922707	Missense_Mutation	rs753913915	E247K	0.26
COAD	chr19	18922744	Missense_Mutation	novel	K259T	0.23
COAD	chr19	18928326	3'UTR	rs374701222		0.36
ESCA	chr19	18922002	Intron	novel		0.13
GBM	chr19	18919770	Missense_Mutation	NA	S10L	0.34
GBM	chr19	18921866	Missense_Mutation	novel	L117V	0.18
GBM	chr19	18928149	Missense_Mutation	novel	R429C	0.14
GBM	chr19	18927775	Missense_Mutation	novel	L371Q	0.07
GBM	chr19	18921787	Intron	novel		0.31
HNSC	chr19	18924893	Missense_Mutation	novel	I314N	0.47
HNSC	chr19	18921800	Intron	novel		0.26
HNSC	chr19	18919689	5'UTR	novel		0.44
LIHC	chr19	18921795	Intron	novel		0.43
LIHC	chr19	18922307	Intron	novel		0.33
LIHC	chr19	18921718	Missense_Mutation	novel	L99M	0.26
LUAD	chr19	18921767	Intron	novel		0.2
LUAD	chr19	18920650	Silent	novel	Q62Q	0.09
LUAD	chr19	18922613	Silent	rs776218879	T215T	0.24
LUAD	chr19	18921731	Missense_Mutation	NA	I103T	0.26
LUSC	chr19	18919689	5'UTR	novel		0.38
LUSC	chr19	18928197	Missense_Mutation	novel	E445K	0.21
LUSC	chr19	18924246	Missense_Mutation	novel	L264V	0.44
OV	chr19	18921904	Silent	novel	G129G	0.05
OV	chr19	18921768	Intron	novel		0.09
OV	chr19	18924256	Frame_Shift_Del	novel	*M267Tfs129**	0.04
READ	chr19	18921738	Silent	rs375363974	V105V	0.45
SKCM	chr19	18921747	Missense_Mutation	novel	M108I	0.28
SKCM	chr19	18921748	Missense_Mutation	novel	D109N	0.26
SKCM	chr19	18927850	Missense_Mutation	NA	E396G	0.1
SKCM	chr19	18919689	5'UTR	novel		0.27
SKCM	chr19	18922050	Intron	novel		0.3
SKCM	chr19	18924801	Intron	novel		0.27
SKCM	chr19	18919711	5'UTR	novel		0.23
SKCM	chr19	18924972	Silent	NA	A340A	0.29
SKCM	chr19	18921718	Silent	NA	L99L	0.38
STAD	chr19	18924973	Missense_Mutation	NA	R341S	0.27
STAD	chr19	18924698	Missense_Mutation	rs763850904	R310W	0.11
STAD	chr19	18921767	Intron	novel		0.37
STAD	chr19	18924635	Missense_Mutation	novel	A289T	0.38
STAD	chr19	18922614	Missense_Mutation	rs747592114	V216M	0.23
STAD	chr19	18921694	Missense_Mutation	rs752777811	R91W	0.2
STAD	chr19	18921746	Missense_Mutation	NA	M108T	0.42
STAD	chr19	18921859	Silent	rs778840526	A114A	0.09
STAD	chr19	18922647	Missense_Mutation	NA	P227S	0.14
STAD	chr19	18924795	Intron	novel		0.18
STAD	chr19	18922617	Missense_Mutation	NA	E217K	0.29
UCEC	chr19	18927975	Missense_Mutation	rs755888557	A401V	0.55
UCEC	chr19	18924899	Missense_Mutation	rs373999531	T316M	0.24
UCEC	chr19	18924968	Missense_Mutation	rs765629684	T339M	0.43
UCEC	chr19	18927838	Missense_Mutation	rs761016118	R392Q	0.38
UCEC	chr19	18927803	Silent	rs116368644	E380E	0.33
UCEC	chr19	18919714	5'UTR	novel		0.12
UCEC	chr19	18928034	Nonsense_Mutation	novel	K421*	0.59
UCEC	chr19	18922707	Missense_Mutation	rs753913915	E247K	0.5
UCEC	chr19	18920638	Silent	novel	L58L	0.26
UCEC	chr19	18921858	Missense_Mutation	rs771624240	A114V	0.12
UCEC	chr19	18920677	Silent	novel	I71I	0.05
UCEC	chr19	18924962	Missense_Mutation	novel	G337D	0.14
UCEC	chr19	18922712	Silent	NA	D248D	0.5
UCEC	chr19	18927830	Silent	NA	N389N	0.17
UCEC	chr19	18921811	Intron	novel		0.22
UCEC	chr19	18922706	Silent	rs200119897	H246H	0.61
UCEC	chr19	18922392	Missense_Mutation	NA	I172F	0.6
UCEC	chr19	18924246	Missense_Mutation	novel	L264M	0.15
UCEC	chr19	18927988	Silent	rs778625677	D405D	0.38
UCEC	chr19	18924918	Silent	NA	N322N	0.32
UCEC	chr19	18926340	Silent	rs149848346	Y355Y	0.15
UCEC	chr19	18924826	Intron	novel		0.47
UCEC	chr19	18921791	Intron	novel		0.2
UCEC	chr19	18927827	Silent	novel	V388V	0.27
UCEC	chr19	18920628	Missense_Mutation	NA	A55V	0.27	ResIII
UCEC	chr19	18921884	Missense_Mutation	rs753844299	V123M	0.41
UCEC	chr19	18922413	Missense_Mutation	rs771078768	R179C	0.38
UCEC	chr19	18924956	Missense_Mutation	NA	R335Q	0.45
UCEC	chr19	18924763	Intron	novel		0.21
UCEC	chr19	18924974	Missense_Mutation	novel	R341H	0.4
UCEC	chr19	18921972	Splice_Region	novel		0.55
UCEC	chr19	18924974	Missense_Mutation	novel	R341H	0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
READ	DEL	0.0788	0.23023
THCA	DEL	0.012	0.090402
THYM	DEL	0.0244	0.10691

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.015	Kaplan-Meier Survival Analysis
STAD	0.028	Kaplan-Meier Survival Analysis
ACC	0.001	Kaplan-Meier Survival Analysis
HNSC	0.048	Kaplan-Meier Survival Analysis
SKCM	0.015	Kaplan-Meier Survival Analysis
LUSC	0.04	Kaplan-Meier Survival Analysis
TGCT	0.047	Kaplan-Meier Survival Analysis
PAAD	0.031	Kaplan-Meier Survival Analysis
CESC	0.00011	Kaplan-Meier Survival Analysis
LIHC	0.0017	Kaplan-Meier Survival Analysis
DLBC	0.023	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742