EuRBPDB

Description

Ensembl ID: ENSG00000105726 (Gene tree)
Gene ID: 57130
Gene Symbol: ATP13A1
Alias: KIAA1825|FLJ31858|CGI-152|ATP13A
Full Name: ATPase 13A1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 22,626 bases
Position: chr19:19,645,198-19,667,823
Accession: 24215
RBP type: non-canonical RBP
Summary: (ATPase 13A1) is a Protein Coding gene. Diseases associated with ATP13A1 include Cone-Rod Dystrophy, X-Linked, 1 and Kufor-Rakeb Syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. Gene Ontology (GO) annotations related to this gene include nucleotide binding and cation-transporting ATPase activity. An important paralog of this gene is ATP13A2.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21443014	[Differential protein analysis on the root response of rice with high phosphorous uptake efficiency to low phosphorous stress].	Ying Yong Sheng Tai Xue Bao	2010 Dec	Guo YC	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000497762	ATP13A1-215	575	-	-	- (aa)	-	-
ENST00000291503	ATP13A1-201	3483	-	ENSP00000291503	1086 (aa)	-	Q9HD20
ENST00000357324	ATP13A1-202	3861	-	ENSP00000349877	1204 (aa)	-	Q9HD20
ENST00000455627	ATP13A1-203	554	-	ENSP00000411891	185 (aa)	-	H7C3H2
ENST00000471063	ATP13A1-206	373	-	-	- (aa)	-	-
ENST00000467160	ATP13A1-204	2431	-	-	- (aa)	-	-
ENST00000491221	ATP13A1-210	937	-	-	- (aa)	-	-
ENST00000487364	ATP13A1-209	541	-	-	- (aa)	-	-
ENST00000473243	ATP13A1-207	4729	-	-	- (aa)	-	-
ENST00000492774	ATP13A1-211	482	-	-	- (aa)	-	-
ENST00000497156	ATP13A1-213	715	-	-	- (aa)	-	-
ENST00000474955	ATP13A1-208	927	-	-	- (aa)	-	-
ENST00000496082	ATP13A1-212	698	-	-	- (aa)	-	-
ENST00000497556	ATP13A1-214	2442	-	-	- (aa)	-	-
ENST00000469641	ATP13A1-205	4241	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000105726	Longevity	7E-6	27015805
ENSG00000105726	Cholesterol, LDL	2E-8	27002377
ENSG00000105726	Fenofibrate	2E-8	27002377

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000105726	rs3841260	19	19645265	AGCC	Response to fenofibrate (LDL cholesterol levels)	27002377	[0.028-0.106] unit decrease	0.067	EFO_0007804\|GO_1901557
ENSG00000105726	rs3841260	19	19645265	A	Platelet count	27863252	[0.053-0.081] unit increase	0.06684476	EFO_0004309
ENSG00000105726	rs3841260	19	19645265	A	Plateletcrit	27863252	[0.069-0.097] unit increase	0.08285124	EFO_0007985
ENSG00000105726	rs144193693	19	19656456	?	Reaction time	29844566	[0.005-0.0117] unit decrease	0.0083633	EFO_0008393

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105726	ATP13A1	99	95.989	ENSMUSG00000031862	Atp13a1	99	95.242	Mus_musculus
ENSG00000105726	ATP13A1	96	41.203	YEL031W	SPF1	85	44.578	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003674	molecular_function	-	ND	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0006874	cellular calcium ion homeostasis	21873635.	IBA	Process
GO:0008150	biological_process	-	ND	Process
GO:0015410	manganese-transporting ATPase activity	-	TAS	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0034220	ion transmembrane transport	-	TAS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0071421	manganese ion transmembrane transport	-	IEA	Process
GO:0099132	ATP hydrolysis coupled cation transmembrane transport	-	IEA	Process